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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:lin1386
OrganismiListeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000002513 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669651 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PRIDEiQ92C05

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272626.lin1386

Structurei

3D structure databases

ProteinModelPortaliQ92C05
SMRiQ92C05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q92C05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHRYLPMT EQDEKEMLEV IGVKSIDDLF QDIPEKIRFK RDYDLKPAKS
60 70 80 90 100
EPALLRELSK LASKNANTSE YASFLGAGVY SHYIPTVVDH VISRSEFYTA
110 120 130 140 150
YTPYQPEISQ GELQAIFEFQ TMIAELTGMD LANSSMYDGG TALAEAAMLA
160 170 180 190 200
SGHTKRKKIL ISGAVHPESI NVLKTYATGQ HIEVEVIPEV DGKTDIDVLK
210 220 230 240 250
KALSDDIAGF VVQYPNFYGQ VEPLAELEKL VHENNSLLLV SSNPLSLGLL
260 270 280 290 300
TPPGEFGADI VVGDSQVFGI PESFGGPHCG FFAVTNKLMR KVPGRLVGET
310 320 330 340 350
VDENGKRGYV LTLQAREQHI RRDKATSNIC SNQALNALAS SVAMATLGKT
360 370 380 390 400
GLVEMAKQNL DKSHYAKQKF RENGFEVLFS DGFFNEFVVK LSKPIKEVNE
410 420 430 440
SLLDEGIIGG YDLGFYDAKY EQHMLVAVTE MRTKEEIDAF VASLEGVK
Length:448
Mass (Da):49,481
Last modified:December 1, 2001 - v1
Checksum:i279B292B8DD2C8A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596168 Genomic DNA Translation: CAC96617.1
PIRiAI1605
RefSeqiWP_003766769.1, NC_003212.1

Genome annotation databases

EnsemblBacteriaiCAC96617; CAC96617; CAC96617
KEGGilin:lin1386

Similar proteinsi

Entry informationi

Entry nameiGCSPA_LISIN
AccessioniPrimary (citable) accession number: Q92C05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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