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Q92C05 (GCSPA_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:lin1386
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166965

Sequences

Sequence LengthMass (Da)Tools
Q92C05 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 279B292B8DD2C8A8

FASTA44849,481
        10         20         30         40         50         60 
MAKHRYLPMT EQDEKEMLEV IGVKSIDDLF QDIPEKIRFK RDYDLKPAKS EPALLRELSK 

        70         80         90        100        110        120 
LASKNANTSE YASFLGAGVY SHYIPTVVDH VISRSEFYTA YTPYQPEISQ GELQAIFEFQ 

       130        140        150        160        170        180 
TMIAELTGMD LANSSMYDGG TALAEAAMLA SGHTKRKKIL ISGAVHPESI NVLKTYATGQ 

       190        200        210        220        230        240 
HIEVEVIPEV DGKTDIDVLK KALSDDIAGF VVQYPNFYGQ VEPLAELEKL VHENNSLLLV 

       250        260        270        280        290        300 
SSNPLSLGLL TPPGEFGADI VVGDSQVFGI PESFGGPHCG FFAVTNKLMR KVPGRLVGET 

       310        320        330        340        350        360 
VDENGKRGYV LTLQAREQHI RRDKATSNIC SNQALNALAS SVAMATLGKT GLVEMAKQNL 

       370        380        390        400        410        420 
DKSHYAKQKF RENGFEVLFS DGFFNEFVVK LSKPIKEVNE SLLDEGIIGG YDLGFYDAKY 

       430        440 
EQHMLVAVTE MRTKEEIDAF VASLEGVK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596168 Genomic DNA. Translation: CAC96617.1.
PIRAI1605.
RefSeqNP_470722.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92C05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin1386.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC96617; CAC96617; CAC96617.
GeneID1129982.
KEGGlin:lin1386.
PATRIC20299503. VBILisInn102668_1418.

Organism-specific databases

GenoListLIN1386.
CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_LISIN
AccessionPrimary (citable) accession number: Q92C05
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families