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Q92BR0 (END4_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable endonuclease 4

EC=3.1.21.2
Alternative name(s):
Endodeoxyribonuclease IV
Endonuclease IV
Gene names
Name:nfo
Ordered Locus Names:lin1487
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin By similarity. HAMAP-Rule MF_00152

Catalytic activity

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products. HAMAP-Rule MF_00152

Cofactor

Binds 3 zinc ions By similarity. HAMAP-Rule MF_00152

Sequence similarities

Belongs to the AP endonuclease 2 family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   LigandMetal-binding
Zinc
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

deoxyribonuclease IV (phage-T4-induced) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Probable endonuclease 4 HAMAP-Rule MF_00152
PRO_0000190846

Sites

Metal binding691Zinc 1 By similarity
Metal binding1101Zinc 1 By similarity
Metal binding1451Zinc 1 By similarity
Metal binding1451Zinc 2 By similarity
Metal binding1791Zinc 2 By similarity
Metal binding1821Zinc 3 By similarity
Metal binding2141Zinc 2 By similarity
Metal binding2271Zinc 3 By similarity
Metal binding2291Zinc 3 By similarity
Metal binding2591Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92BR0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E2AAA1025C402002

FASTA29732,843
        10         20         30         40         50         60 
MLRLGSHVSM SGKKMLLGAS EEAASYGSNT FMIYTGAPQN TRRKPIEELN IEAGLEHMKA 

        70         80         90        100        110        120 
HDMADIVVHA PYIINIGNSV KPETFELGVN FLQSEIERTR ALGAKQIVLH PGAHVGEGAD 

       130        140        150        160        170        180 
KGIKQIIQGL NEALIHDQDV QIALETMAGK GSECGRTFEE LAQIIDGVTH NELLSVTFDT 

       190        200        210        220        230        240 
CHTHDAGYDI VNDFDGVLNE FDKIIGIDRL KVLHINDSKN ERGAHKDRHA NIGFGHIGFD 

       250        260        270        280        290 
ALHYIVHHPQ LSNIPKILET PYVGEDKASK KAPYKWEIAM LRNGEFDPDL LNKIQNS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596168 Genomic DNA. Translation: CAC96718.1.
PIRAF1618.
RefSeqNP_470823.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92BR0.
SMRQ92BR0. Positions 2-295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin1487.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC96718; CAC96718; CAC96718.
GeneID1130094.
KEGGlin:lin1487.
PATRIC20299707. VBILisInn102668_1520.

Organism-specific databases

GenoListLIN1487.
CMRSearch...

Phylogenomic databases

eggNOGCOG0648.
HOGENOMHOG000224895.
KOK01151.
OMAIAWLKSE.
OrthoDBEOG6Z0QCM.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00152. Nfo.
InterProIPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERPTHR21445. PTHR21445. 1 hit.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SMARTSM00518. AP2Ec. 1 hit.
[Graphical view]
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR00587. nfo. 1 hit.
PROSITEPS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEND4_LISIN
AccessionPrimary (citable) accession number: Q92BR0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families