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Q92BR0

- END4_LISIN

UniProt

Q92BR0 - END4_LISIN

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Protein

Probable endonuclease 4

Gene

nfo

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.UniRule annotation

Cofactori

Binds 3 zinc ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Zinc 1UniRule annotation
Metal bindingi110 – 1101Zinc 1UniRule annotation
Metal bindingi145 – 1451Zinc 1UniRule annotation
Metal bindingi145 – 1451Zinc 2UniRule annotation
Metal bindingi179 – 1791Zinc 2UniRule annotation
Metal bindingi182 – 1821Zinc 3UniRule annotation
Metal bindingi214 – 2141Zinc 2UniRule annotation
Metal bindingi227 – 2271Zinc 3UniRule annotation
Metal bindingi229 – 2291Zinc 3UniRule annotation
Metal bindingi259 – 2591Zinc 2UniRule annotation

GO - Molecular functioni

  1. deoxyribonuclease IV (phage-T4-induced) activity Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endonuclease 4UniRule annotation (EC:3.1.21.2UniRule annotation)
Alternative name(s):
Endodeoxyribonuclease IVUniRule annotation
Endonuclease IVUniRule annotation
Gene namesi
Name:nfoUniRule annotation
Ordered Locus Names:lin1487
OrganismiListeria innocua serovar 6a (strain CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002513: Chromosome

Organism-specific databases

GenoListiLIN1487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Probable endonuclease 4PRO_0000190846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272626.lin1487.

Structurei

3D structure databases

ProteinModelPortaliQ92BR0.
SMRiQ92BR0. Positions 2-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AP endonuclease 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0648.
HOGENOMiHOG000224895.
KOiK01151.
OMAiIAWLKSE.
OrthoDBiEOG6Z0QCM.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00152. Nfo.
InterProiIPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR21445. PTHR21445. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SMARTiSM00518. AP2Ec. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00587. nfo. 1 hit.
PROSITEiPS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92BR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRLGSHVSM SGKKMLLGAS EEAASYGSNT FMIYTGAPQN TRRKPIEELN
60 70 80 90 100
IEAGLEHMKA HDMADIVVHA PYIINIGNSV KPETFELGVN FLQSEIERTR
110 120 130 140 150
ALGAKQIVLH PGAHVGEGAD KGIKQIIQGL NEALIHDQDV QIALETMAGK
160 170 180 190 200
GSECGRTFEE LAQIIDGVTH NELLSVTFDT CHTHDAGYDI VNDFDGVLNE
210 220 230 240 250
FDKIIGIDRL KVLHINDSKN ERGAHKDRHA NIGFGHIGFD ALHYIVHHPQ
260 270 280 290
LSNIPKILET PYVGEDKASK KAPYKWEIAM LRNGEFDPDL LNKIQNS
Length:297
Mass (Da):32,843
Last modified:December 1, 2001 - v1
Checksum:iE2AAA1025C402002
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596168 Genomic DNA. Translation: CAC96718.1.
PIRiAF1618.
RefSeqiNP_470823.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC96718; CAC96718; CAC96718.
GeneIDi1130094.
KEGGilin:lin1487.
PATRICi20299707. VBILisInn102668_1520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596168 Genomic DNA. Translation: CAC96718.1 .
PIRi AF1618.
RefSeqi NP_470823.1. NC_003212.1.

3D structure databases

ProteinModelPortali Q92BR0.
SMRi Q92BR0. Positions 2-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272626.lin1487.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC96718 ; CAC96718 ; CAC96718 .
GeneIDi 1130094.
KEGGi lin:lin1487.
PATRICi 20299707. VBILisInn102668_1520.

Organism-specific databases

GenoListi LIN1487.

Phylogenomic databases

eggNOGi COG0648.
HOGENOMi HOG000224895.
KOi K01151.
OMAi IAWLKSE.
OrthoDBi EOG6Z0QCM.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00152. Nfo.
InterProi IPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view ]
PANTHERi PTHR21445. PTHR21445. 1 hit.
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
SMARTi SM00518. AP2Ec. 1 hit.
[Graphical view ]
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR00587. nfo. 1 hit.
PROSITEi PS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP 11262.

Entry informationi

Entry nameiEND4_LISIN
AccessioniPrimary (citable) accession number: Q92BR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3