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Q92BR0

- END4_LISIN

UniProt

Q92BR0 - END4_LISIN

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Protein
Probable endonuclease 4
Gene
nfo, lin1487
Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.UniRule annotation

Cofactori

Binds 3 zinc ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Zinc 1 By similarity
Metal bindingi110 – 1101Zinc 1 By similarity
Metal bindingi145 – 1451Zinc 1 By similarity
Metal bindingi145 – 1451Zinc 2 By similarity
Metal bindingi179 – 1791Zinc 2 By similarity
Metal bindingi182 – 1821Zinc 3 By similarity
Metal bindingi214 – 2141Zinc 2 By similarity
Metal bindingi227 – 2271Zinc 3 By similarity
Metal bindingi229 – 2291Zinc 3 By similarity
Metal bindingi259 – 2591Zinc 2 By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. deoxyribonuclease IV (phage-T4-induced) activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endonuclease 4 (EC:3.1.21.2)
Alternative name(s):
Endodeoxyribonuclease IV
Endonuclease IV
Gene namesi
Name:nfo
Ordered Locus Names:lin1487
OrganismiListeria innocua serovar 6a (strain CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002513: Chromosome

Organism-specific databases

GenoListiLIN1487.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Probable endonuclease 4UniRule annotation
PRO_0000190846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272626.lin1487.

Structurei

3D structure databases

ProteinModelPortaliQ92BR0.
SMRiQ92BR0. Positions 2-295.

Family & Domainsi

Sequence similaritiesi

Belongs to the AP endonuclease 2 family.

Phylogenomic databases

eggNOGiCOG0648.
HOGENOMiHOG000224895.
KOiK01151.
OMAiIAWLKSE.
OrthoDBiEOG6Z0QCM.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00152. Nfo.
InterProiIPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR21445. PTHR21445. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SMARTiSM00518. AP2Ec. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00587. nfo. 1 hit.
PROSITEiPS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92BR0-1 [UniParc]FASTAAdd to Basket

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MLRLGSHVSM SGKKMLLGAS EEAASYGSNT FMIYTGAPQN TRRKPIEELN    50
IEAGLEHMKA HDMADIVVHA PYIINIGNSV KPETFELGVN FLQSEIERTR 100
ALGAKQIVLH PGAHVGEGAD KGIKQIIQGL NEALIHDQDV QIALETMAGK 150
GSECGRTFEE LAQIIDGVTH NELLSVTFDT CHTHDAGYDI VNDFDGVLNE 200
FDKIIGIDRL KVLHINDSKN ERGAHKDRHA NIGFGHIGFD ALHYIVHHPQ 250
LSNIPKILET PYVGEDKASK KAPYKWEIAM LRNGEFDPDL LNKIQNS 297
Length:297
Mass (Da):32,843
Last modified:December 1, 2001 - v1
Checksum:iE2AAA1025C402002
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596168 Genomic DNA. Translation: CAC96718.1.
PIRiAF1618.
RefSeqiNP_470823.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC96718; CAC96718; CAC96718.
GeneIDi1130094.
KEGGilin:lin1487.
PATRICi20299707. VBILisInn102668_1520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596168 Genomic DNA. Translation: CAC96718.1 .
PIRi AF1618.
RefSeqi NP_470823.1. NC_003212.1.

3D structure databases

ProteinModelPortali Q92BR0.
SMRi Q92BR0. Positions 2-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272626.lin1487.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC96718 ; CAC96718 ; CAC96718 .
GeneIDi 1130094.
KEGGi lin:lin1487.
PATRICi 20299707. VBILisInn102668_1520.

Organism-specific databases

GenoListi LIN1487.

Phylogenomic databases

eggNOGi COG0648.
HOGENOMi HOG000224895.
KOi K01151.
OMAi IAWLKSE.
OrthoDBi EOG6Z0QCM.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00152. Nfo.
InterProi IPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view ]
PANTHERi PTHR21445. PTHR21445. 1 hit.
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
SMARTi SM00518. AP2Ec. 1 hit.
[Graphical view ]
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR00587. nfo. 1 hit.
PROSITEi PS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP 11262.

Entry informationi

Entry nameiEND4_LISIN
AccessioniPrimary (citable) accession number: Q92BR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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