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Q92BR0

- END4_LISIN

UniProt

Q92BR0 - END4_LISIN

Protein

Probable endonuclease 4

Gene

nfo

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.UniRule annotation

    Cofactori

    Binds 3 zinc ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi69 – 691Zinc 1UniRule annotation
    Metal bindingi110 – 1101Zinc 1UniRule annotation
    Metal bindingi145 – 1451Zinc 1UniRule annotation
    Metal bindingi145 – 1451Zinc 2UniRule annotation
    Metal bindingi179 – 1791Zinc 2UniRule annotation
    Metal bindingi182 – 1821Zinc 3UniRule annotation
    Metal bindingi214 – 2141Zinc 2UniRule annotation
    Metal bindingi227 – 2271Zinc 3UniRule annotation
    Metal bindingi229 – 2291Zinc 3UniRule annotation
    Metal bindingi259 – 2591Zinc 2UniRule annotation

    GO - Molecular functioni

    1. deoxyribonuclease IV (phage-T4-induced) activity Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable endonuclease 4UniRule annotation (EC:3.1.21.2UniRule annotation)
    Alternative name(s):
    Endodeoxyribonuclease IVUniRule annotation
    Endonuclease IVUniRule annotation
    Gene namesi
    Name:nfoUniRule annotation
    Ordered Locus Names:lin1487
    OrganismiListeria innocua serovar 6a (strain CLIP 11262)
    Taxonomic identifieri272626 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000002513: Chromosome

    Organism-specific databases

    GenoListiLIN1487.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Probable endonuclease 4PRO_0000190846Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272626.lin1487.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92BR0.
    SMRiQ92BR0. Positions 2-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AP endonuclease 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0648.
    HOGENOMiHOG000224895.
    KOiK01151.
    OMAiIAWLKSE.
    OrthoDBiEOG6Z0QCM.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00152. Nfo.
    InterProiIPR001719. AP_endonuc_2.
    IPR018246. AP_endonuc_F2_Zn_BS.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view]
    PANTHERiPTHR21445. PTHR21445. 1 hit.
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    SMARTiSM00518. AP2Ec. 1 hit.
    [Graphical view]
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR00587. nfo. 1 hit.
    PROSITEiPS00729. AP_NUCLEASE_F2_1. 1 hit.
    PS00730. AP_NUCLEASE_F2_2. 1 hit.
    PS00731. AP_NUCLEASE_F2_3. 1 hit.
    PS51432. AP_NUCLEASE_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92BR0-1 [UniParc]FASTAAdd to Basket

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    MLRLGSHVSM SGKKMLLGAS EEAASYGSNT FMIYTGAPQN TRRKPIEELN    50
    IEAGLEHMKA HDMADIVVHA PYIINIGNSV KPETFELGVN FLQSEIERTR 100
    ALGAKQIVLH PGAHVGEGAD KGIKQIIQGL NEALIHDQDV QIALETMAGK 150
    GSECGRTFEE LAQIIDGVTH NELLSVTFDT CHTHDAGYDI VNDFDGVLNE 200
    FDKIIGIDRL KVLHINDSKN ERGAHKDRHA NIGFGHIGFD ALHYIVHHPQ 250
    LSNIPKILET PYVGEDKASK KAPYKWEIAM LRNGEFDPDL LNKIQNS 297
    Length:297
    Mass (Da):32,843
    Last modified:December 1, 2001 - v1
    Checksum:iE2AAA1025C402002
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596168 Genomic DNA. Translation: CAC96718.1.
    PIRiAF1618.
    RefSeqiNP_470823.1. NC_003212.1.

    Genome annotation databases

    EnsemblBacteriaiCAC96718; CAC96718; CAC96718.
    GeneIDi1130094.
    KEGGilin:lin1487.
    PATRICi20299707. VBILisInn102668_1520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596168 Genomic DNA. Translation: CAC96718.1 .
    PIRi AF1618.
    RefSeqi NP_470823.1. NC_003212.1.

    3D structure databases

    ProteinModelPortali Q92BR0.
    SMRi Q92BR0. Positions 2-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272626.lin1487.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC96718 ; CAC96718 ; CAC96718 .
    GeneIDi 1130094.
    KEGGi lin:lin1487.
    PATRICi 20299707. VBILisInn102668_1520.

    Organism-specific databases

    GenoListi LIN1487.

    Phylogenomic databases

    eggNOGi COG0648.
    HOGENOMi HOG000224895.
    KOi K01151.
    OMAi IAWLKSE.
    OrthoDBi EOG6Z0QCM.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00152. Nfo.
    InterProi IPR001719. AP_endonuc_2.
    IPR018246. AP_endonuc_F2_Zn_BS.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view ]
    PANTHERi PTHR21445. PTHR21445. 1 hit.
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    SMARTi SM00518. AP2Ec. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR00587. nfo. 1 hit.
    PROSITEi PS00729. AP_NUCLEASE_F2_1. 1 hit.
    PS00730. AP_NUCLEASE_F2_2. 1 hit.
    PS00731. AP_NUCLEASE_F2_3. 1 hit.
    PS51432. AP_NUCLEASE_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIP 11262.

    Entry informationi

    Entry nameiEND4_LISIN
    AccessioniPrimary (citable) accession number: Q92BR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3