Reviewed,
UniProtKB/Swiss-Prot Q92BI0 (LDH2_LISIN)
Last modified
November 25, 2008.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: L-lactate dehydrogenase 2 Short name=L-LDH 2 EC=1.1.1.27 | ||||
| Gene names |
| ||||
| Organism | Listeria innocua [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1642 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria |
Protein attributes
| Sequence length | 311 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-lactate + NAD(+) = pyruvate + NADH. |
| Pathway | Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the LDH/MDH superfamily. LDH family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Glycolysis |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | anaerobic glycolysis Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: HAMAP |
| Molecular function | L-lactate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 311 | 311 | L-lactate dehydrogenase 2 | PRO_0000168362 | |||||
Regions | |||||||||
| Nucleotide binding | 12 – 40 | 29 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 177 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 90 | 1 | Substrate By similarity | ||||||
| Binding site | 122 | 1 | NAD or substrate By similarity | ||||||
| Binding site | 153 | 1 | Substrate By similarity | ||||||
| Binding site | 230 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. Cossart P.Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIP 11262 / Serovar 6a. |
Cross-references
Sequence databases | |
|---|---|
| AL596169 Genomic DNA. Translation: CAC96800.1. | |
| PIR | AH1628. |
| RefSeq | NP_470905.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LDB based on UniProtKB P00344. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1130186. |
| GenomeReviews | Gene locus lin1569 in contig AL592022_GR. |
| KEGG | lin:lin1569. |
| NMPDR | fig|272626.1.peg.1558. |
Organism-specific databases | |
| ListiList | LIN01569. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q92BI0. |
Enzyme and pathway databases | |
| BioCyc | LINN272626:LIN1569-MON. |
Family and domain databases | |
| HAMAP | MF_00488. [Tree] |
| InterPro | IPR001557. L-lactate/malate_DHase. IPR011304. L-lactate_DHase. IPR001236. Lactate/malate_DHase. IPR015955. Lactate_DHase/Glyco_Ohase_4_C. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000102. Lac_mal_DH. 1 hit. |
| PRINTS | PR00086. LLDHDRGNASE. |
| TIGRFAMs | TIGR01771. L-LDH-NAD. 1 hit. |
| PROSITE | PS00064. L_LDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LDH2_LISIN | ||||||||
| Accession | Primary (citable) accession number: Q92BI0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


