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Protein

Glycerol kinase

Gene

glpK

Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13SubstrateUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei267ATPUniRule annotation1
Binding sitei310ATP; via carbonyl oxygenUniRule annotation1
Binding sitei314ATP; via amide nitrogenUniRule annotation1
Binding sitei329ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi411 – 415ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:lin1573
OrganismiListeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000002513 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000594631 – 497Glycerol kinaseAdd BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231Phosphohistidine; by HPrUniRule annotation1

Post-translational modificationi

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer and homodimer (in equilibrium).UniRule annotation

Protein-protein interaction databases

STRINGi272626.lin1573.

Structurei

3D structure databases

ProteinModelPortaliQ92BH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 84Substrate bindingUniRule annotation2
Regioni245 – 246Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HMR. Bacteria.
COG0554. LUCA.
HOGENOMiHOG000222134.
KOiK00864.
OMAiWWLTGGP.
OrthoDBiPOG091H02FA.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92BH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKYILALD QGTTSSRAMI IDEEGEVIGV AQEEFDQIFP KPGWVEHSAN
60 70 80 90 100
EIWASILAVI AGVLLKTNIS SKEIAGIGIT NQRETTVIWD KESGNPIYNA
110 120 130 140 150
IVWQSRQTED ICKQLRKDGY EDTIRSKTGL LIDPYFAGTK ARWILDHVDG
160 170 180 190 200
AQERAEKGEL LFGTIDTWLV WKLTGGRAHI TDYSNASRTL LYNIYDLEWD
210 220 230 240 250
DELLKMLNIP RAMLPEVRPS SEVYADTVPY HFFGEEVPVA GIAGDQQAAL
260 270 280 290 300
FGQGCFEKGM AKNTYGTGCF LLMNTGEKAV RSENGLLTTL AWGLDGKVEY
310 320 330 340 350
ALEGSIFVAG SAIQWLRDGL RMVRQSSDSE NYASRIESSD GVYVVPAFVG
360 370 380 390 400
LGAPYWDSDV RGAVFGLTRG TEKEQFIRAT LESLAYQTRD VLYAMEQDSG
410 420 430 440 450
ISLKTLRVDG GASANNFLMQ FQSDILGVPV ERPENKETTV LGAAFLAGLA
460 470 480 490
VGVWKDKNEI KKHWKLDKRF EVEMKDDQRE DLYEGWHKAV KAAQAFK
Length:497
Mass (Da):55,436
Last modified:December 1, 2001 - v1
Checksum:iD4126042AD2F6F74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596169 Genomic DNA. Translation: CAC96804.1.
PIRiAD1629.
RefSeqiWP_003771956.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC96804; CAC96804; CAC96804.
KEGGilin:lin1573.
PATRICi20299883. VBILisInn102668_1608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596169 Genomic DNA. Translation: CAC96804.1.
PIRiAD1629.
RefSeqiWP_003771956.1. NC_003212.1.

3D structure databases

ProteinModelPortaliQ92BH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272626.lin1573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC96804; CAC96804; CAC96804.
KEGGilin:lin1573.
PATRICi20299883. VBILisInn102668_1608.

Phylogenomic databases

eggNOGiENOG4108HMR. Bacteria.
COG0554. LUCA.
HOGENOMiHOG000222134.
KOiK00864.
OMAiWWLTGGP.
OrthoDBiPOG091H02FA.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK_LISIN
AccessioniPrimary (citable) accession number: Q92BH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.