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Q92AZ9 (SYL_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:lin1769
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length803 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 803803Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152037

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif575 – 5795"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5781ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92AZ9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FD0E91E47CAD608C

FASTA80391,903
        10         20         30         40         50         60 
MTFNHKKMEP KWQQYWSEHN TFKTTEDKDK ENFYALDMFP YPSGAGLHVG HPEGYTATDI 

        70         80         90        100        110        120 
LSRMKRMQGK NVLHPIGWDA FGLPAEQYAI DTGNDPEEFT ALNIANFTRQ IKSLGFSYDW 

       130        140        150        160        170        180 
DREINTTDPE YYKWTQWIFE KLYENGLAYE AEIAVNWCPA LGTVLANEEV IDGKSERGGF 

       190        200        210        220        230        240 
PVFRKPMRQW MLKITAYADR LLDDLELVDW PENIKDMQRN WIGRSEGAEV TFKIKDSDET 

       250        260        270        280        290        300 
FNVFTTRPDT LFGATYTVFA PEHELIEKIT TPEQKEAVEA YKKQVELKSE LERTDLAKDK 

       310        320        330        340        350        360 
TGVFTGAYAI NPINGEEVPI WIADYVLIQY GTGAIMAVPA HDERDFEFAQ QFGLNIRPVL 

       370        380        390        400        410        420 
EGGDVTKEAF TGDGPHINSD FLNGLAKAEA ITAAIDWLEK EGIGSRKITY RLRDWLFSRQ 

       430        440        450        460        470        480 
RYWGEPIPVI HWEDGETTLV PEDELPLLLP KATEIKPSGT GESPLANLHD WVNVTDENGR 

       490        500        510        520        530        540 
KGRRETNTMP QWAGSSWYFL RYIDPKNSEA IADKEKLAEW LPVDVYIGGA EHAVLHLLYA 

       550        560        570        580        590        600 
RFWHKFLYDI GVVPTKEPFQ KLFNQGMILG ENNEKMSKSR GNVVNPDEVV EKYGADTLRL 

       610        620        630        640        650        660 
YEMFMGPLEA SIAWNENGLE GARKFLDRIW RLLVTEEGTL AEKVTTDANA NLEKAYHHMV 

       670        680        690        700        710        720 
KTVTNHYENL RFNTGISQLM IFINEAYKRD TIPKQYVEGF VQLLSPIAPH LAEELWEILG 

       730        740        750        760        770        780 
HTETISYVAW PTYDETKLVE DEVEIVLQVN GKVKSKITVA KSLGKEELEK LAHEDDKIKE 

       790        800 
NIDGKTIRKV IVVPGKLVNI VAN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596169 Genomic DNA. Translation: CAC97000.1.
PIRAH1653.
RefSeqNP_471105.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92AZ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin1769.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC97000; CAC97000; CAC97000.
GeneID1130434.
KEGGlin:lin1769.
PATRIC20300293. VBILisInn102668_1813.

Organism-specific databases

GenoListLIN1769.
CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_LISIN
AccessionPrimary (citable) accession number: Q92AZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries