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Q92AP4 (PUR2_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:lin1876
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151460

Regions

Domain108 – 314207ATP-grasp
Nucleotide binding134 – 19562ATP By similarity

Sites

Metal binding2841Magnesium or manganese By similarity
Metal binding2861Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92AP4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: DACFD3493C1D3C5A

FASTA42045,672
        10         20         30         40         50         60 
MNLLVVGSGG REHAISKKLL ESNNVEKVYC APGNDGMRLD DIQLVAISET DKVGLIDFAK 

        70         80         90        100        110        120 
KADVSFVIVG PEVPLLEGVV DAFEEAGIKA FGPKANAALI EGSKDFAKQF MEKYAIPTAA 

       130        140        150        160        170        180 
SRTFTDYAEA KAYLDERGVP IVIKADGLAA GKGVTVALEM EEAVLALKDM MLEEKFGDAS 

       190        200        210        220        230        240 
LKVVIEDFLA GEEFSLMAFV NGEEVYPMAI AQDHKRAYEG DKGPNTGGMG AYSPVPHISE 

       250        260        270        280        290        300 
DVVNEAVEKI LRPAAKGMVQ EDRYFRGILY AGLILTTEGP KVIEFNARFG DPETQVVLPR 

       310        320        330        340        350        360 
LESDFAALIA ALLNNEKPEV RFKKEGITLG VVLASAGYPE HYEKGNKLTG LNDIREDVAI 

       370        380        390        400        410        420 
YHAGTKQNEN GEFVSSGGRV LLLAKEAETM SDARTLLYPE MQKLDNPNFF YRMDIGTKAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596170 Genomic DNA. Translation: CAC97106.1.
PIRAB1667.
RefSeqNP_471210.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92AP4.
SMRQ92AP4. Positions 1-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin1876.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC97106; CAC97106; CAC97106.
GeneID1130556.
KEGGlin:lin1876.
PATRIC20300557. VBILisInn102668_1920.

Organism-specific databases

GenoListLIN1876.
CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033464.
KOK01945.
OMADPEAMNV.
OrthoDBEOG69SKD1.
ProtClustDBPRK00885.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_LISIN
AccessionPrimary (citable) accession number: Q92AP4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways