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Q92AP3 (PUR9_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:lin1877
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192101

Sequences

Sequence LengthMass (Da)Tools
Q92AP3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 49C4E225E505CDF8

FASTA50954,898
        10         20         30         40         50         60 
MKRALISVSD KNGIVPFAEK LVELGVEIIS TGGTKAAFEQ AGVPVTGIEA VTEFPEMLDG 

        70         80         90        100        110        120 
RVKTLHPAIH GGLLARRDTA EHMEAIAAHD IKPIDLVIVN LYPFQETIQK PGVTLEEAIE 

       130        140        150        160        170        180 
NIDIGGPSML RSAAKNYAAV TVVVDTADYD TVLTELQEHG ATTFETRQRL AAKVFRHTAA 

       190        200        210        220        230        240 
YDALIAEYLT DVTGETFPEK VTLTYNRKQV LRYGENPHQD AAFYTEPRAI ENSISAAKQL 

       250        260        270        280        290        300 
HGKELSYNNI RDADAALKIA SEFKEPVAVA VKHMNPCGVG VGETIEEAYL KAYEADEISI 

       310        320        330        340        350        360 
FGGIVALNKE VDAKTAEHMS KIFLEIIIAP SFSEAGFAIL AKKKNIRLLT VPFAGNVEGF 

       370        380        390        400        410        420 
EKTSVNGGLL IQANDALVED TTSYEVVTEK QPTNSEMKAL LAQWKIVKHV KSNAIVVGSD 

       430        440        450        460        470        480 
KQTLGIGAGQ MNRIGSALIA LEQAGEKAKG AVLASDAFFP MDDTVEAAAK AGITAIIQPG 

       490        500 
GSIKDKESIA MADKYGISMV LTHVRHFKH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596170 Genomic DNA. Translation: CAC97107.1.
PIRAC1667.
RefSeqNP_471211.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92AP3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin1877.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC97107; CAC97107; CAC97107.
GeneID1130557.
KEGGlin:lin1877.
PATRIC20300559. VBILisInn102668_1921.

Organism-specific databases

GenoListLIN1877.
CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_LISIN
AccessionPrimary (citable) accession number: Q92AP3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways