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Q92AH7 (PYRE_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:lin1945
OrganismListeria innocua [Complete proteome] [HAMAP]
Taxonomic identifier1642 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMagnesium
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionorotate phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110706

Regions

Region122 – 13095-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1261Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92AH7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 52B8390FB730C1D3

FASTA20922,919
        10         20         30         40         50         60 
MSIEKQVAEQ LLEIKAVFLK PNEPFTWASG IKSPIYCDNR LTLGFPKVRQ FIAKSLAEKI 

        70         80         90        100        110        120 
KENFGEVDVV AGTATAGIPH AAWVSDLLDL PMVYVRSKAK EHGKGNQIEG PLTKGQKVVV 

       130        140        150        160        170        180 
IEDLISTGGS SLKAVEALEE AGAEVLGIAA IFTYGLDKGK KLLEESNTKL VTLTNYDELI 

       190        200 
EVALNKNYVT TEDMATLKEW KKNPEVWGK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL596170 Genomic DNA. Translation: CAC97175.1.
PIRAG1675.
RefSeqNP_471279.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92AH7.
SMRQ92AH7. Positions 1-208.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1130638.
GenomeReviewsGene locus lin1945 in contig AL592022_GR.
KEGGlin:lin1945.
NMPDRfig|272626.1.peg.1932.
PATRIC20300701. VBILisInn102668_1989.

Organism-specific databases

GenoListLIN1945.
CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMALPMTYVR.
ProtClustDBPRK00455.

Enzyme and pathway databases

BioCycLINN272626:LIN1945-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_LISIN
AccessionPrimary (citable) accession number: Q92AH7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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