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Q92AD2 (FTHS_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:lin1990
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199356

Regions

Nucleotide binding69 – 768ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92AD2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 564CCF35EE18A878

FASTA56060,157
        10         20         30         40         50         60 
MSNKVKSDIE IASVAEILPV TTIAEHLGLD ADALELYGKY KAKLSYDTIH SLKDKEQGKL 

        70         80         90        100        110        120 
VLVTAINPTP AGEGKSTVTV GLGDALSKKD KKTVIALREP SLGPTMGIKG GATGGGYAQV 

       130        140        150        160        170        180 
IPMEDINLHF TGDFHAITAA NNALSAFIDN HMQQGNDLGI DGRRIVWKRV VDLNDRALRK 

       190        200        210        220        230        240 
VVVGLGGPIQ GVPREDGFDI TVASEIMAII CLASDLKDLK KRLSEIVIGY NYKKEPITVG 

       250        260        270        280        290        300 
EMGYEGALTL LLKDALKPNL VQTLEHTPAI VHGGPFANIA HGCNSVSATS TALKLGEYVV 

       310        320        330        340        350        360 
TEAGFGADLG AEKFLDIKVP ALGKAPDCVV IVATIRALKM HGGALKTELS EENVDALAKG 

       370        380        390        400        410        420 
FTNLQKHTES IQTFGIPYVV AINKFITDSD AEVAKLEQLC EEHGIPFSLT EVWEKGGDGG 

       430        440        450        460        470        480 
LELADKVIAA VESGEEDYKR IYDDAWSIEE KLEAIVTKVY GGIGVELSSK AQKQIVEFKK 

       490        500        510        520        530        540 
YGWDRYPICM AKTQYSLSDD PTLLGRPTDF VIHIREFIPK LGAGFVVALT GDVMTMPGLP 

       550        560 
KKPAALNMDV DENGNAQGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596170 Genomic DNA. Translation: CAC97220.1.
PIRAD1681.
RefSeqNP_471324.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92AD2.
SMRQ92AD2. Positions 8-558.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin1990.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC97220; CAC97220; CAC97220.
GeneID1130691.
KEGGlin:lin1990.
PATRIC20300791. VBILisInn102668_2034.

Organism-specific databases

GenoListLIN1990.
CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LISIN
AccessionPrimary (citable) accession number: Q92AD2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways