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Q92AD2

- FTHS_LISIN

UniProt

Q92AD2 - FTHS_LISIN

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, lin1990
Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:lin1990
OrganismiListeria innocua serovar 6a (strain CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002513: Chromosome

Organism-specific databases

GenoListiLIN1990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199356Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272626.lin1990.

Structurei

3D structure databases

ProteinModelPortaliQ92AD2.
SMRiQ92AD2. Positions 8-558.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92AD2-1 [UniParc]FASTAAdd to Basket

« Hide

MSNKVKSDIE IASVAEILPV TTIAEHLGLD ADALELYGKY KAKLSYDTIH    50
SLKDKEQGKL VLVTAINPTP AGEGKSTVTV GLGDALSKKD KKTVIALREP 100
SLGPTMGIKG GATGGGYAQV IPMEDINLHF TGDFHAITAA NNALSAFIDN 150
HMQQGNDLGI DGRRIVWKRV VDLNDRALRK VVVGLGGPIQ GVPREDGFDI 200
TVASEIMAII CLASDLKDLK KRLSEIVIGY NYKKEPITVG EMGYEGALTL 250
LLKDALKPNL VQTLEHTPAI VHGGPFANIA HGCNSVSATS TALKLGEYVV 300
TEAGFGADLG AEKFLDIKVP ALGKAPDCVV IVATIRALKM HGGALKTELS 350
EENVDALAKG FTNLQKHTES IQTFGIPYVV AINKFITDSD AEVAKLEQLC 400
EEHGIPFSLT EVWEKGGDGG LELADKVIAA VESGEEDYKR IYDDAWSIEE 450
KLEAIVTKVY GGIGVELSSK AQKQIVEFKK YGWDRYPICM AKTQYSLSDD 500
PTLLGRPTDF VIHIREFIPK LGAGFVVALT GDVMTMPGLP KKPAALNMDV 550
DENGNAQGLF 560
Length:560
Mass (Da):60,157
Last modified:December 1, 2001 - v1
Checksum:i564CCF35EE18A878
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596170 Genomic DNA. Translation: CAC97220.1.
PIRiAD1681.
RefSeqiNP_471324.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC97220; CAC97220; CAC97220.
GeneIDi1130691.
KEGGilin:lin1990.
PATRICi20300791. VBILisInn102668_2034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596170 Genomic DNA. Translation: CAC97220.1 .
PIRi AD1681.
RefSeqi NP_471324.1. NC_003212.1.

3D structure databases

ProteinModelPortali Q92AD2.
SMRi Q92AD2. Positions 8-558.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272626.lin1990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC97220 ; CAC97220 ; CAC97220 .
GeneIDi 1130691.
KEGGi lin:lin1990.
PATRICi 20300791. VBILisInn102668_2034.

Organism-specific databases

GenoListi LIN1990.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP 11262.

Entry informationi

Entry nameiFTHS_LISIN
AccessioniPrimary (citable) accession number: Q92AD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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