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Q929X1

- PANE_LISIN

UniProt

Q929X1 - PANE_LISIN

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Protein

Putative 2-dehydropantoate 2-reductase

Gene

lin2152

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071NADP; via amide nitrogenBy similarity
Binding sitei107 – 1071SubstrateBy similarity
Active sitei187 – 1871Proton donorBy similarity
Binding sitei191 – 1911SubstrateBy similarity
Binding sitei195 – 1951SubstrateBy similarity
Binding sitei251 – 2511SubstrateBy similarity
Binding sitei263 – 2631NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:lin2152
OrganismiListeria innocua serovar 6a (strain CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002513: Chromosome

Organism-specific databases

GenoListiLIN2152.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Putative 2-dehydropantoate 2-reductasePRO_0000157314Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272626.lin2152.

Structurei

3D structure databases

ProteinModelPortaliQ929X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiQEVAFLI.
OrthoDBiEOG68SVW3.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q929X1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENQINVGII GAGAMGLLYA ANFADKSKLT LFTHRKEQAD LLNQKGISLI
60 70 80 90 100
DNETTKNIHI HAAQITEEEQ LTKQQLLIIA VKQYSLNEII PILQKLPTKI
110 120 130 140 150
PILFIQNGAG HLERLSELGT TRTILLGISE HGAGREDDTT VIWRGHGRTK
160 170 180 190 200
YSIFQGELND DLKELLTSSP AFPIEKHANY QAIIQEKLFI NAVINPLTAV
210 220 230 240 250
LGVQNGKLLE NQEWHRLLIR VVNEVETVLP IENALEKVET ICRTTALNFS
260 270 280 290 300
SMALDCMNER MTEIDGIVLP ILEKGDKTET SLPTLRTLYQ IIKGLEGERH

V
Length:301
Mass (Da):33,684
Last modified:December 1, 2001 - v1
Checksum:i9C550E518C238E92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596171 Genomic DNA. Translation: CAC97382.1.
PIRiAF1701.
RefSeqiNP_471486.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC97382; CAC97382; CAC97382.
GeneIDi1130881.
KEGGilin:lin2152.
PATRICi20301123. VBILisInn102668_2200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596171 Genomic DNA. Translation: CAC97382.1 .
PIRi AF1701.
RefSeqi NP_471486.1. NC_003212.1.

3D structure databases

ProteinModelPortali Q929X1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272626.lin2152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC97382 ; CAC97382 ; CAC97382 .
GeneIDi 1130881.
KEGGi lin:lin2152.
PATRICi 20301123. VBILisInn102668_2200.

Organism-specific databases

GenoListi LIN2152.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi QEVAFLI.
OrthoDBi EOG68SVW3.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP 11262.

Entry informationi

Entry nameiPANE_LISIN
AccessioniPrimary (citable) accession number: Q929X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3