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Q929X1

- PANE_LISIN

UniProt

Q929X1 - PANE_LISIN

Protein

Putative 2-dehydropantoate 2-reductase

Gene

lin2152

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei107 – 1071NADP; via amide nitrogenBy similarity
    Binding sitei107 – 1071SubstrateBy similarity
    Active sitei187 – 1871Proton donorBy similarity
    Binding sitei191 – 1911SubstrateBy similarity
    Binding sitei195 – 1951SubstrateBy similarity
    Binding sitei251 – 2511SubstrateBy similarity
    Binding sitei263 – 2631NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Ordered Locus Names:lin2152
    OrganismiListeria innocua serovar 6a (strain CLIP 11262)
    Taxonomic identifieri272626 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000002513: Chromosome

    Organism-specific databases

    GenoListiLIN2152.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Putative 2-dehydropantoate 2-reductasePRO_0000157314Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272626.lin2152.

    Structurei

    3D structure databases

    ProteinModelPortaliQ929X1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050222.
    KOiK00077.
    OMAiQEVAFLI.
    OrthoDBiEOG68SVW3.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q929X1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENQINVGII GAGAMGLLYA ANFADKSKLT LFTHRKEQAD LLNQKGISLI    50
    DNETTKNIHI HAAQITEEEQ LTKQQLLIIA VKQYSLNEII PILQKLPTKI 100
    PILFIQNGAG HLERLSELGT TRTILLGISE HGAGREDDTT VIWRGHGRTK 150
    YSIFQGELND DLKELLTSSP AFPIEKHANY QAIIQEKLFI NAVINPLTAV 200
    LGVQNGKLLE NQEWHRLLIR VVNEVETVLP IENALEKVET ICRTTALNFS 250
    SMALDCMNER MTEIDGIVLP ILEKGDKTET SLPTLRTLYQ IIKGLEGERH 300
    V 301
    Length:301
    Mass (Da):33,684
    Last modified:December 1, 2001 - v1
    Checksum:i9C550E518C238E92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596171 Genomic DNA. Translation: CAC97382.1.
    PIRiAF1701.
    RefSeqiNP_471486.1. NC_003212.1.

    Genome annotation databases

    EnsemblBacteriaiCAC97382; CAC97382; CAC97382.
    GeneIDi1130881.
    KEGGilin:lin2152.
    PATRICi20301123. VBILisInn102668_2200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596171 Genomic DNA. Translation: CAC97382.1 .
    PIRi AF1701.
    RefSeqi NP_471486.1. NC_003212.1.

    3D structure databases

    ProteinModelPortali Q929X1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272626.lin2152.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC97382 ; CAC97382 ; CAC97382 .
    GeneIDi 1130881.
    KEGGi lin:lin2152.
    PATRICi 20301123. VBILisInn102668_2200.

    Organism-specific databases

    GenoListi LIN2152.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050222.
    KOi K00077.
    OMAi QEVAFLI.
    OrthoDBi EOG68SVW3.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIP 11262.

    Entry informationi

    Entry nameiPANE_LISIN
    AccessioniPrimary (citable) accession number: Q929X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3