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Q929H5 (SYW_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:lin2301
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136642

Regions

Motif11 – 199"HIGH" region HAMAP-Rule MF_00140
Motif193 – 1975"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site1961ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q929H5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6050DC94C9337B73

FASTA33136,975
        10         20         30         40         50         60 
MKKVIFSGIQ PSGQLTLGNY IGALKQFGQF QDEYECFYCI VDEHAITVPQ DRLKLREQTR 

        70         80         90        100        110        120 
SLAALYLAVG LDPEKATLFI QSEVAAHAQA AWILQCNVYI GELERMTQFK DKSDGKAGVS 

       130        140        150        160        170        180 
AGLLTYPPLM AADILLYQTN LVPVGEDQKQ HIELTRDLAE RFNKKHADIF TMPEVFIPKQ 

       190        200        210        220        230        240 
GARVMSLQDP TKKMSKSDAN LKNAIFLLDP PATIRKKIKS AVTDSSGIIE YNKEEKPGVS 

       250        260        270        280        290        300 
NLLTIYSVIT GETIANIEEK YVGKGYGDFK TDLAELVVAE LEQIQERYYA YLESEELDNI 

       310        320        330 
LDAGAEKAAR VANKTLKKME NGVGLGRKRR K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596171 Genomic DNA. Translation: CAC97529.1.
PIRAI1719.
RefSeqNP_471633.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ929H5.
SMRQ929H5. Positions 3-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin2301.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC97529; CAC97529; CAC97529.
GeneID1131052.
KEGGlin:lin2301.
PATRIC20301439. VBILisInn102668_2352.

Organism-specific databases

GenoListLIN2301.
CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAGWGQFKP.
OrthoDBEOG686NJQ.
ProtClustDBPRK00927.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_LISIN
AccessionPrimary (citable) accession number: Q929H5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries