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Q929G2 (HEMH_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:lin2314
OrganismListeria innocua [Complete proteome] [HAMAP]
Taxonomic identifier1642 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Ferrochelatase HAMAP MF_00323
PRO_0000175159

Sites

Metal binding1821Iron By similarity
Metal binding2631Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q929G2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: CF18A90227223F52

FASTA30935,205
        10         20         30         40         50         60 
MTKKVGLLVM AYGTPYKDED IERYYTDIRH GHKPSEEMIA DLRGRYHAIG GLSPLAKITE 

        70         80         90        100        110        120 
AQAYGLEKAL NDAQDEVEFK AYIGLKHIEP FIEDAVEAMH KDGIEEAISI VLAPHYSSFS 

       130        140        150        160        170        180 
VEAYNKRAKD AADKLGGIHI QAINDWYKQP KFIQMWADRI NETAKQIPAE ELIDTVLIVS 

       190        200        210        220        230        240 
AHSLPEKIKQ HNDPYPDQLQ ETADLIFDKV AVPHYALGWQ SEGKTGEPWL GPDVQDLTRE 

       250        260        270        280        290        300 
LYGREKYKHF IYTPVGFVAE HLEVLYDNDY ECKVVTDEVG AAYHRPPMPN ADPEFLEVLR 


TVVWDAYTK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL596171 Genomic DNA. Translation: CAC97542.1.
PIRAF1721.
RefSeqNP_471646.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ929G2.
SMRQ929G2. Positions 3-303.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1131066.
GenomeReviewsGene locus lin2314 in contig AL592022_GR.
KEGGlin:lin2314.
NMPDRfig|272626.1.peg.2299.
PATRIC20301465. VBILisInn102668_2365.

Organism-specific databases

GenoListLIN2314.
CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMASWYDEPK.
ProtClustDBPRK12435.

Enzyme and pathway databases

BioCycLINN272626:LIN2314-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_LISIN
AccessionPrimary (citable) accession number: Q929G2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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