Reviewed,
UniProtKB/Swiss-Prot Q92997 (DVL3_HUMAN)
Last modified
February 9, 2010.
Version 96.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Segment polarity protein dishevelled homolog DVL-3 Short name=Dishevelled-3 Alternative name(s): DSH homolog 3 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 716 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| Subunit structure | Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 By similarity. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Ref.6 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the DSH family. Contains 1 DEP domain. Contains 1 DIX domain. Contains 1 PDZ (DHR) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Wnt signaling pathway |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Molecular function | Developmental protein |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | Wnt receptor signaling pathway Inferred from direct assay. Source: UniProtKB heart development Ref.1Traceable author statement. Source: ProtInc intracellular signaling cascadeInferred from electronic annotation. Source: InterPro nervous system development Ref.1Traceable author statement. Source: ProtInc positive regulation of transcription, DNA-dependentInferred from direct assay. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | beta-catenin binding Inferred from direct assay. Source: UniProtKB signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| LRRFIP2 | Q9Y608 | 1 | EBI-739789,EBI-1023718 | |
| PRPF3 | O43395 | 1 | EBI-739789,EBI-744322 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 716 | 716 | Segment polarity protein dishevelled homolog DVL-3 | PRO_0000145749 | |||||
Regions | |||||||||
| Domain | 1 – 82 | 82 | DIX | ||||||
| Domain | 249 – 321 | 73 | PDZ | ||||||
| Domain | 422 – 496 | 75 | DEP | ||||||
Amino acid modifications | |||||||||
| Modified residue | 346 | 1 | Phosphothreonine Ref.7 | ||||||
Natural variations | |||||||||
| Natural variant | 216 | 1 | R → T in a breast cancer sample; somatic mutation. Ref.8 | VAR_036116 | |||||
| Natural variant | 433 | 1 | W → L: dbSNP rs17853048. Ref.5 | VAR_025519 | |||||
Experimental info | |||||||||
| Sequence conflict | 2 | 1 | G → D in AAB47447. Ref.1 | ||||||
| Sequence conflict | 76 | 1 | S → Y in AAB84228. Ref.2 | ||||||
| Sequence conflict | 102 | 1 | P → S in AAB47447. Ref.1 | ||||||
| Sequence conflict | 151 | 1 | G → W in AAB47447. Ref.1 | ||||||
| Sequence conflict | 182 | 1 | S → R in AAB47447. Ref.1 | ||||||
| Sequence conflict | 218 | 1 | K → N in AAB47447. Ref.1 | ||||||
| Sequence conflict | 222 | 1 | R → W in AAB47447. Ref.1 | ||||||
| Sequence conflict | 230 | 1 | E → D in AAB47447. Ref.1 | ||||||
| Sequence conflict | 233 | 1 | S → C in AAB47447. Ref.1 | ||||||
| Sequence conflict | 236 | 1 | S → T in AAB47447. Ref.1 | ||||||
| Sequence conflict | 239 | 1 | T → S in AAB47447. Ref.1 | ||||||
| Sequence conflict | 242 | 1 | T → A in AAB47447. Ref.1 | ||||||
| Sequence conflict | 303 | 1 | N → K in AAB47447. Ref.1 | ||||||
| Sequence conflict | 431 | 1 | R → C in AAB47447. Ref.1 | ||||||
| Sequence conflict | 450 | 1 | W → C in AAB47447. Ref.1 | ||||||
| Sequence conflict | 465 | 1 | R → P in AAB47447. Ref.1 | ||||||
| Sequence conflict | 472 | 1 | L → V in AAB47447. Ref.1 | ||||||
| Sequence conflict | 543 | 1 | P → R in AAB65244. Ref.3 | ||||||
| Sequence conflict | 553 – 554 | 2 | FP → LG in AAB65244. Ref.3 | ||||||
| Sequence conflict | 629 | 1 | A → T in AAB47447. Ref.1 | ||||||
| Sequence conflict | 633 | 1 | S → I in AAB47447. Ref.1 | ||||||
| Sequence conflict | 682 – 716 | 35 | PPGRD…FVDVM → LRAATWPQCPRN in BAA13199. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene." Pizzuti A., Amati F., Calabrese G., Mari A., Colosimo A., Silani V., Giardino L., Ratti A., Penso D., Calza L., Palka G., Scarlato G., Novelli G., Dallapiccola B. Hum. Mol. Genet. 5:953-958(1996) [PubMed: 8817329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas." Bui T.D., Beier D.R., Jonssen M., Smith K., Dorrington S.M., Kaklamanis L., Kearney L., Regan R., Sussman D.J., Harris A.L. Biochem. Biophys. Res. Commun. 239:510-516(1997) [PubMed: 9344861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [3] | "Human dishevelled genes constitute a DHR-containing multigene family." Semenov M.V., Snyder M. Genomics 42:302-310(1997) [PubMed: 9192851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-433. Tissue: Brain. |
| [6] | "Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis." Liu J., Bang A.G., Kintner C., Orth A.P., Chanda S.K., Ding S., Schultz P.G. Proc. Natl. Acad. Sci. U.S.A. 102:1927-1932(2005) [PubMed: 15677333] [Abstract] Cited for: INTERACTION WITH LRRFIP2. |
| [7] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-346, MASS SPECTROMETRY. Tissue: T-cell. |
| [8] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-216. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U49262 mRNA. Translation: AAB47447.1. U75651 mRNA. Translation: AAB84228.1. AF006013 mRNA. Translation: AAB65244.1. D86963 mRNA. Translation: BAA13199.2. Different initiation. BC032459 mRNA. Translation: AAH32459.1. |
| IPI | IPI00643141. |
| PIR | JC5763. |
| RefSeq | NP_004414.3. |
| UniGene | Hs.388116 |
3D structure databases | |
| SMR | Q92997. Positions 2-80, 247-335, 406-496. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q92997. 20 interactions. |
| STRING | Q92997. |
PTM databases | |
| PhosphoSite | Q92997. |
Proteomic databases | |
| PRIDE | Q92997. |
Genome annotation databases | |
| Ensembl | ENST00000313143; ENSP00000316054; ENSG00000161202; Homo sapiens. [Genome view] |
| GeneID | 1857. |
| KEGG | hsa:1857. |
| UCSC | uc003fms.1. human. |
Organism-specific databases | |
| CTD | 1857. |
| GeneCards | GC03P185357. |
| H-InvDB | HIX0003920. |
| HGNC | HGNC:3087. DVL3. |
| HPA | CAB001712. |
| MIM | 601368. gene. |
| PharmGKB | PA27543. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG13158. |
| HOGENOM | HBG717800. |
| HOVERGEN | Q92997. |
| InParanoid | Q92997. |
| OMA | IHSDMAT. |
| OrthoDB | EOG9B8MZF. |
| PhylomeDB | Q92997. |
Gene expression databases | |
| ArrayExpress | Q92997. |
| Bgee | Q92997. |
| CleanEx | HS_DVL3. |
| Genevestigator | Q92997. |
| GermOnline | ENSG00000161202. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000591. DEP_dom. IPR008339. Dishevell. IPR003351. Dishevelled. IPR008342. Dishevelled_3_C. IPR001158. DIX. IPR015506. Dsh. IPR001478. PDZ/DHR/GLGF. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view] |
| Gene3D | G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. |
| PANTHER | PTHR10878. Dsh. 1 hit. |
| Pfam | PF00610. DEP. 1 hit. PF02377. Dishevelled. 1 hit. PF00778. DIX. 1 hit. PF00595. PDZ. 1 hit. [Graphical view] |
| PRINTS | PR01760. DISHEVELLED. PR01763. DISHEVELLED3. |
| SMART | SM00021. DAX. 1 hit. SM00049. DEP. 1 hit. SM00228. PDZ. 1 hit. [Graphical view] |
| PROSITE | PS50186. DEP. 1 hit. PS50841. DIX. 1 hit. PS50106. PDZ. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 7609. |
| SOURCE | Search... |
Entry information
| Entry name | DVL3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q92997 Secondary accession number(s): O14642 Q92607 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


