Segment polarity protein dishevelled homolog DVL-3

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Reviewed, UniProtKB/Swiss-Prot Q92997 (DVL3_HUMAN)

Last modified February 9, 2010. Version 96. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Segment polarity protein dishevelled homolog DVL-3
      Short name=Dishevelled-3
Alternative name(s):
    DSH homolog 3

Gene names

Name:	DVL3
Synonyms:	KIAA0208

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	716 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May play a role in the signal transduction pathway mediated by multiple Wnt genes.
Subunit structure	Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 By similarity. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Ref.6
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the DSH family. Contains 1 DEP domain. Contains 1 DIX domain. Contains 1 PDZ (DHR) domain.

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Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from direct assay. Source: UniProtKB heart development Ref.1 Traceable author statement. Source: ProtInc intracellular signaling cascade Inferred from electronic annotation. Source: InterPro nervous system development Ref.1 Traceable author statement. Source: ProtInc positive regulation of transcription, DNA-dependent Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-catenin binding Inferred from direct assay. Source: UniProtKB signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
LRRFIP2	Q9Y608	1	EBI-739789,EBI-1023718
PRPF3	O43395	1	EBI-739789,EBI-744322

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 716

716

Segment polarity protein dishevelled homolog DVL-3

PRO_0000145749

Regions

Domain

1 – 82

DIX

Domain

249 – 321

PDZ

Domain

422 – 496

DEP

Amino acid modifications

Modified residue

346

Phosphothreonine Ref.7

Natural variations

Natural variant

216

R → T in a breast cancer sample; somatic mutation. Ref.8

VAR_036116

Natural variant

433

W → L: dbSNP rs17853048. Ref.5

VAR_025519

Experimental info

Sequence conflict

G → D in AAB47447. Ref.1

Sequence conflict

S → Y in AAB84228. Ref.2

Sequence conflict

102

P → S in AAB47447. Ref.1

Sequence conflict

151

G → W in AAB47447. Ref.1

Sequence conflict

182

S → R in AAB47447. Ref.1

Sequence conflict

218

K → N in AAB47447. Ref.1

Sequence conflict

222

R → W in AAB47447. Ref.1

Sequence conflict

230

E → D in AAB47447. Ref.1

Sequence conflict

233

S → C in AAB47447. Ref.1

Sequence conflict

236

S → T in AAB47447. Ref.1

Sequence conflict

239

T → S in AAB47447. Ref.1

Sequence conflict

242

T → A in AAB47447. Ref.1

Sequence conflict

303

N → K in AAB47447. Ref.1

Sequence conflict

431

R → C in AAB47447. Ref.1

Sequence conflict

450

W → C in AAB47447. Ref.1

Sequence conflict

465

R → P in AAB47447. Ref.1

Sequence conflict

472

L → V in AAB47447. Ref.1

Sequence conflict

543

P → R in AAB65244. Ref.3

Sequence conflict

553 – 554

FP → LG in AAB65244. Ref.3

Sequence conflict

629

A → T in AAB47447. Ref.1

Sequence conflict

633

S → I in AAB47447. Ref.1

Sequence conflict

682 – 716

PPGRD…FVDVM → LRAATWPQCPRN in BAA13199. Ref.4

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Sequences

Sequence

Length

Mass (Da)

Tools

Q92997-1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: B1A55EBF9507D06E
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FASTA

716

78,055

        10         20         30         40         50         60 
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 

        70         80         90        100        110        120 
SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP PPMERTGGIG DSRPPSFHPH 

       130        140        150        160        170        180 
AGGGSQENLD NDTETDSLVS AQRERPRRRD GPEHATRLNG TAKGERRREP GGYDSSSTLM 

       190        200        210        220        230        240 
SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 

       250        260        270        280        290        300 
STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 

       310        320        330        340        350        360 
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA 

       370        380        390        400        410        420 
WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA 

       430        440        450        460        470        480 
SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT 

       490        500        510        520        530        540 
VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY 

       550        560        570        580        590        600 
PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 

       610        620        630        640        650        660 
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH PSYGPPGVPP 

       670        680        690        700        710 
LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene." Pizzuti A., Amati F., Calabrese G., Mari A., Colosimo A., Silani V., Giardino L., Ratti A., Penso D., Calza L., Palka G., Scarlato G., Novelli G., Dallapiccola B. Hum. Mol. Genet. 5:953-958(1996) [PubMed: 8817329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas." Bui T.D., Beier D.R., Jonssen M., Smith K., Dorrington S.M., Kaklamanis L., Kearney L., Regan R., Sussman D.J., Harris A.L. Biochem. Biophys. Res. Commun. 239:510-516(1997) [PubMed: 9344861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Human dishevelled genes constitute a DHR-containing multigene family." Semenov M.V., Snyder M. Genomics 42:302-310(1997) [PubMed: 9192851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-433. Tissue: Brain.
[6]	"Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis." Liu J., Bang A.G., Kintner C., Orth A.P., Chanda S.K., Ding S., Schultz P.G. Proc. Natl. Acad. Sci. U.S.A. 102:1927-1932(2005) [PubMed: 15677333] [Abstract] Cited for: INTERACTION WITH LRRFIP2.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-346, MASS SPECTROMETRY. Tissue: T-cell.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-216.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	U49262 mRNA. Translation: AAB47447.1. U75651 mRNA. Translation: AAB84228.1. AF006013 mRNA. Translation: AAB65244.1. D86963 mRNA. Translation: BAA13199.2. Different initiation. BC032459 mRNA. Translation: AAH32459.1.
IPI	IPI00643141.
PIR	JC5763.
RefSeq	NP_004414.3.
UniGene	Hs.388116
3D structure databases
SMR	Q92997. Positions 2-80, 247-335, 406-496.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92997. 20 interactions.
STRING	Q92997.
PTM databases
PhosphoSite	Q92997.
Proteomic databases
PRIDE	Q92997.
Genome annotation databases
Ensembl	ENST00000313143; ENSP00000316054; ENSG00000161202; Homo sapiens. [Genome view]
GeneID	1857.
KEGG	hsa:1857.
UCSC	uc003fms.1. human.
Organism-specific databases
CTD	1857.
GeneCards	GC03P185357.
H-InvDB	HIX0003920.
HGNC	HGNC:3087. DVL3.
HPA	CAB001712.
MIM	601368. gene.
PharmGKB	PA27543.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13158.
HOGENOM	HBG717800.
HOVERGEN	Q92997.
InParanoid	Q92997.
OMA	IHSDMAT.
OrthoDB	EOG9B8MZF.
PhylomeDB	Q92997.
Gene expression databases
ArrayExpress	Q92997.
Bgee	Q92997.
CleanEx	HS_DVL3.
Genevestigator	Q92997.
GermOnline	ENSG00000161202. Homo sapiens.
Family and domain databases
InterPro	IPR000591. DEP_dom. IPR008339. Dishevell. IPR003351. Dishevelled. IPR008342. Dishevelled_3_C. IPR001158. DIX. IPR015506. Dsh. IPR001478. PDZ/DHR/GLGF. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHER	PTHR10878. Dsh. 1 hit.
Pfam	PF00610. DEP. 1 hit. PF02377. Dishevelled. 1 hit. PF00778. DIX. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
PRINTS	PR01760. DISHEVELLED. PR01763. DISHEVELLED3.
SMART	SM00021. DAX. 1 hit. SM00049. DEP. 1 hit. SM00228. PDZ. 1 hit. [Graphical view]
PROSITE	PS50186. DEP. 1 hit. PS50841. DIX. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	7609.
SOURCE	Search...

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Entry information

Entry name

DVL3_HUMAN

Accession

Primary (citable) accession number: Q92997
Secondary accession number(s): O14642

Q92607

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	February 9, 2010
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents