##gff-version 3 Q92995 UniProtKB Chain 1 863 . . . ID=PRO_0000080635;Note=Ubiquitin carboxyl-terminal hydrolase 13 Q92995 UniProtKB Domain 336 861 . . . Note=USP Q92995 UniProtKB Domain 652 693 . . . Note=UBA 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 Q92995 UniProtKB Domain 727 767 . . . Note=UBA 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 Q92995 UniProtKB Zinc finger 187 295 . . . Note=UBP-type%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 Q92995 UniProtKB Active site 345 345 . . . Note=Nucleophile;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92995 UniProtKB Active site 823 823 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10092,ECO:0000255|PROSITE-ProRule:PRU10093 Q92995 UniProtKB Binding site 211 211 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 Q92995 UniProtKB Binding site 214 214 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 Q92995 UniProtKB Binding site 231 231 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 Q92995 UniProtKB Binding site 244 244 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00502 Q92995 UniProtKB Modified residue 114 114 . . . Note=Phosphoserine%3B by AURKB;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:32772043,ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332,PMID:32772043 Q92995 UniProtKB Modified residue 122 122 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692 Q92995 UniProtKB Cross-link 311 311 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q92995 UniProtKB Cross-link 405 405 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q92995 UniProtKB Alternative sequence 1 65 . . . ID=VSP_043954;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q92995 UniProtKB Mutagenesis 221 221 . . . Note=Does not abolish ability to stabilize SIAH2. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21659512;Dbxref=PMID:21659512 Q92995 UniProtKB Mutagenesis 233 233 . . . Note=Does not abolish ability to stabilize SIAH2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21659512;Dbxref=PMID:21659512 Q92995 UniProtKB Mutagenesis 273 273 . . . Note=Impairs ability to stabilize SIAH2. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21659512;Dbxref=PMID:21659512 Q92995 UniProtKB Mutagenesis 345 345 . . . Note=Abolishes deubiquitinating activity. Does not abolish ability to stabilize SIAH2. Does not abolish ability to stabilize SIAH2%3B when associated with A-814 and A-823. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21659512,ECO:0000269|PubMed:21811243,ECO:0000269|PubMed:33592542;Dbxref=PMID:21659512,PMID:21811243,PMID:33592542 Q92995 UniProtKB Mutagenesis 664 664 . . . Note=Impairs ability to stabilize SIAH2 and STAT1. Abolishes ability to stabilize SIAH2 and STAT1%3B when associated with E-739. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21659512;Dbxref=PMID:21659512 Q92995 UniProtKB Mutagenesis 739 739 . . . Note=Impairs ability to stabilize SIAH2 and STAT1. Abolishes ability to stabilize SIAH2 and STAT1%3B when associated with E-664. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21659512;Dbxref=PMID:21659512 Q92995 UniProtKB Mutagenesis 814 814 . . . Note=Does not abolish ability to stabilize SIAH2%3B when associated with A-345 and A-823. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21659512;Dbxref=PMID:21659512 Q92995 UniProtKB Mutagenesis 823 823 . . . Note=Does not abolish ability to stabilize SIAH2%3B when associated with A-345 and A-814. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21659512;Dbxref=PMID:21659512 Q92995 UniProtKB Sequence conflict 96 96 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92995 UniProtKB Sequence conflict 293 293 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92995 UniProtKB Sequence conflict 305 305 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92995 UniProtKB Sequence conflict 325 325 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92995 UniProtKB Sequence conflict 338 338 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92995 UniProtKB Turn 191 194 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Beta strand 212 214 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Beta strand 217 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Turn 224 226 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Beta strand 229 231 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Helix 244 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Beta strand 256 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Beta strand 269 272 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Turn 273 275 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Beta strand 277 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Helix 284 290 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Helix 296 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L80 Q92995 UniProtKB Helix 656 662 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC Q92995 UniProtKB Helix 669 678 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC Q92995 UniProtKB Helix 683 692 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC Q92995 UniProtKB Helix 693 695 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC Q92995 UniProtKB Beta strand 697 700 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC Q92995 UniProtKB Beta strand 710 714 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC Q92995 UniProtKB Helix 730 739 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC Q92995 UniProtKB Helix 743 753 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC Q92995 UniProtKB Helix 757 765 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LBC