Ubiquitin carboxyl-terminal hydrolase 13

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Reviewed, UniProtKB/Swiss-Prot Q92995 (UBP13_HUMAN)

Last modified June 16, 2009. Version 70. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 13
    EC=3.1.2.15
Alternative name(s):
    Ubiquitin thioesterase 13
    Ubiquitin-specific-processing protease 13
    Deubiquitinating enzyme 13
    Isopeptidase T-3
      Short name=ISOT-3

Gene names

Name:	USP13
Synonyms:	ISOT3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	863 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Catalytic activity

Ubiquitin C-terminal thioester + H₂O = ubiquitin + a thiol.

Tissue specificity

Highly expressed in ovary and testes.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 2 UBA domains.

Contains 1 UBP-type zinc finger.

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Ontologies

Keywords
Biological process	Ubl conjugation pathway
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	cysteine-type endopeptidase activity Traceable author statement. Source: ProtInc ubiquitin thiolesterase activity Inferred from electronic annotation. Source: EC ubiquitin-specific protease activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 863

863

Ubiquitin carboxyl-terminal hydrolase 13

PRO_0000080635

Regions

Domain

652 – 693

UBA 1

Domain

727 – 767

UBA 2

Zinc finger

209 – 281

UBP-type

Sites

Active site

345

By similarity

Active site

814

By similarity

Active site

823

By similarity

Amino acid modifications

Modified residue

122

Phosphothreonine Ref.4

Experimental info

Sequence conflict

V → A in AAC63405. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q92995-1 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 988713ADF8C0B938
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FASTA

863

97,327

        10         20         30         40         50         60 
MQRRGALFGM PGGSGGRKMA AGDIGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 

        70         80         90        100        110        120 
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 

       130        140        150        160        170        180 
DTDDDLNSDD YEYEDEAKLV IFPDHYEIAL PNIEELPALV TIACDAVLSS KSPYRKQDPD 

       190        200        210        220        230        240 
TWENELPVSK YANNLTQLDN GVRIPPSGWK CARCDLRENL WLNLTDGSVL CGKWFFDSSG 

       250        260        270        280        290        300 
GNGHALEHYR DMGYPLAVKL GTITPDGADV YSFQEEEPVL DPHLAKHLAH FGIDMLHMHG 

       310        320        330        340        350        360 
TENGLQDNDI KLRVSEWEVI QESGTKLKPM YGPGYTGLKN LGNSCYLSSV MQAIFSIPEF 

       370        380        390        400        410        420 
QRAYVGNLPR IFDYSPLDPT QDFNTQMTKL GHGLLSGQYS KPPVKSELIE QVMKEEHKPQ 

       430        440        450        460        470        480 
QNGISPRMFK AFVSKSHPEF SSNRQQDAQE FFLHLVNLVE RNRIGSENPS DVFRFLVEER 

       490        500        510        520        530        540 
IQCCQTRKVR YTERVDYLMQ LPVAMEAATN KDELIAYELT RREAEANRRP LPELVRAKIP 

       550        560        570        580        590        600 
FSACLQAFSE PENVDDFWSS ALQAKSAGVK TSRFASFPEY LVVQIKKFTF GLDWVPKKFD 

       610        620        630        640        650        660 
VSIDMPDLLD INHLRARGLQ PGEEELPDIS PPIVIPDDSK DRLMNQLIDP SDIDESSVMQ 

       670        680        690        700        710        720 
LAEMGFPLEA CRKAVYFTGN MGAEVAFNWI IVHMEEPDFA EPLTMPGYGG AASAGASVFG 

       730        740        750        760        770        780 
ASGLDNQPPE EIVAIITSMG FQRNQAIQAL RATNNNLERA LDWIFSHPEF EEDSDFVIEM 

       790        800        810        820        830        840 
ENNANANIIS EAKPEGPRVK DGSGTYELFA FISHMGTSTM SGHYICHIKK EGRWVIYNDH 

       850        860 
KVCASERPPK DLGYMYFYRR IPS

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)." Timms K.M., Ansari-Lari M.A., Morris W., Brown S.N., Gibbs R.A. Gene 217:101-106(1998) [PubMed: 9841226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, MASS SPECTROMETRY.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

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Cross-references

Sequence databases
	U75362 mRNA. Translation: AAC63405.1. CH471052 Genomic DNA. Translation: EAW78383.1. BC016146 mRNA. Translation: AAH16146.1.
IPI	IPI00024401.
RefSeq	NP_003931.2.
UniGene	Hs.591319
3D structure databases
SMR	Q92995. Positions 188-301.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92995. 7 interactions.
Protein family/group databases
MEROPS	C19.012.
PTM databases
PhosphoSite	Q92995.
Proteomic databases
PRIDE	Q92995.
Genome annotation databases
Ensembl	ENSG00000058056. Homo sapiens. [Contig view]
GeneID	8975.
KEGG	hsa:8975.
Organism-specific databases
GeneCards	GC03P180853.
H-InvDB	HIX0003883.
HGNC	HGNC:12611. USP13.
HPA	HPA004827.
MIM	603591. gene.
PharmGKB	PA134939640.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q92995.
HOVERGEN	Q92995.
OMA	Q92995. IDESSVM.
Enzyme and pathway databases
BRENDA	3.1.2.15. 247.
Gene expression databases
ArrayExpress	Q92995.
Bgee	Q92995.
CleanEx	HS_USP13.
GermOnline	ENSG00000058056. Homo sapiens.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. IPR016652. Ubiquitinyl_hydrolase. IPR001607. Znf_UBP. [Graphical view]
Pfam	PF00627. UBA. 2 hits. PF00443. UCH. 1 hit. PF02148. zf-UBP. 1 hit. [Graphical view]
PIRSF	PIRSF016308. UBP. 1 hit.
SMART	SM00165. UBA. 2 hits. SM00290. ZnF_UBP. 1 hit. [Graphical view]
PROSITE	PS50030. UBA. 2 hits. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS50271. ZF_UBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33685.
SOURCE	Search...

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Entry information

Entry name

UBP13_HUMAN

Accession

Primary (citable) accession number: Q92995
Secondary accession number(s): Q96B25

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 14, 2008
Last modified:	June 16, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents