Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q92995 (UBP13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 13

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 13
Isopeptidase T-3
Short name=ISOT-3
Ubiquitin thiolesterase 13
Ubiquitin-specific-processing protease 13
Gene names
Name:USP13
Synonyms:ISOT3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length863 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Tissue specificity

Highly expressed in ovary and testes.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 2 UBA domains.

Contains 1 UBP-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 863863Ubiquitin carboxyl-terminal hydrolase 13
PRO_0000080635

Regions

Domain652 – 69342UBA 1
Domain727 – 76741UBA 2
Zinc finger209 – 28173UBP-type

Sites

Active site3451Nucleophile By similarity
Active site8231Proton acceptor By similarity

Amino acid modifications

Modified residue1141Phosphoserine Ref.5
Modified residue1221Phosphothreonine Ref.4 Ref.5

Experimental info

Sequence conflict961V → A in AAC63405. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q92995 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 988713ADF8C0B938

FASTA86397,327
        10         20         30         40         50         60 
MQRRGALFGM PGGSGGRKMA AGDIGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 

        70         80         90        100        110        120 
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 

       130        140        150        160        170        180 
DTDDDLNSDD YEYEDEAKLV IFPDHYEIAL PNIEELPALV TIACDAVLSS KSPYRKQDPD 

       190        200        210        220        230        240 
TWENELPVSK YANNLTQLDN GVRIPPSGWK CARCDLRENL WLNLTDGSVL CGKWFFDSSG 

       250        260        270        280        290        300 
GNGHALEHYR DMGYPLAVKL GTITPDGADV YSFQEEEPVL DPHLAKHLAH FGIDMLHMHG 

       310        320        330        340        350        360 
TENGLQDNDI KLRVSEWEVI QESGTKLKPM YGPGYTGLKN LGNSCYLSSV MQAIFSIPEF 

       370        380        390        400        410        420 
QRAYVGNLPR IFDYSPLDPT QDFNTQMTKL GHGLLSGQYS KPPVKSELIE QVMKEEHKPQ 

       430        440        450        460        470        480 
QNGISPRMFK AFVSKSHPEF SSNRQQDAQE FFLHLVNLVE RNRIGSENPS DVFRFLVEER 

       490        500        510        520        530        540 
IQCCQTRKVR YTERVDYLMQ LPVAMEAATN KDELIAYELT RREAEANRRP LPELVRAKIP 

       550        560        570        580        590        600 
FSACLQAFSE PENVDDFWSS ALQAKSAGVK TSRFASFPEY LVVQIKKFTF GLDWVPKKFD 

       610        620        630        640        650        660 
VSIDMPDLLD INHLRARGLQ PGEEELPDIS PPIVIPDDSK DRLMNQLIDP SDIDESSVMQ 

       670        680        690        700        710        720 
LAEMGFPLEA CRKAVYFTGN MGAEVAFNWI IVHMEEPDFA EPLTMPGYGG AASAGASVFG 

       730        740        750        760        770        780 
ASGLDNQPPE EIVAIITSMG FQRNQAIQAL RATNNNLERA LDWIFSHPEF EEDSDFVIEM 

       790        800        810        820        830        840 
ENNANANIIS EAKPEGPRVK DGSGTYELFA FISHMGTSTM SGHYICHIKK EGRWVIYNDH 

       850        860 
KVCASERPPK DLGYMYFYRR IPS 

« Hide

References

« Hide 'large scale' references
[1]"The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)."
Timms K.M., Ansari-Lari M.A., Morris W., Brown S.N., Gibbs R.A.
Gene 217:101-106(1998) [PubMed: 9841226] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[5]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114 AND THR-122, MASS SPECTROMETRY.
Tissue: Leukemic T-cell.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U75362 mRNA. Translation: AAC63405.1.
CH471052 Genomic DNA. Translation: EAW78383.1.
CH471052 Genomic DNA. Translation: EAW78384.1.
BC016146 mRNA. Translation: AAH16146.1.
IPIIPI00024401.
RefSeqNP_003931.2. NM_003940.2.
UniGeneHs.175322.

3D structure databases

ProteinModelPortalQ92995.
SMRQ92995. Positions 23-863.
ModBaseSearch...

Protein-protein interaction databases

IntActQ92995. 26 interactions.
MINTMINT-1195142.
STRINGQ92995.

Protein family/group databases

MEROPSC19.012.

PTM databases

PhosphoSiteQ92995.

Polymorphism databases

DMDM209572692.

Proteomic databases

PRIDEQ92995.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263966; ENSP00000263966; ENSG00000058056.
GeneID8975.
KEGGhsa:8975.
UCSCuc003fkg.1. human.

Organism-specific databases

CTD8975.
GeneCardsGC03P179370.
H-InvDBHIX0003883.
HGNCHGNC:12611. USP13.
HPAHPA004827.
MIM603591. gene.
neXtProtNX_Q92995.
PharmGKBPA37237.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG17331.
GeneTreeENSGT00390000000874.
HOGENOMHBG746888.
HOVERGENHBG002833.
InParanoidQ92995.
OMAPDTWENE.
OrthoDBEOG46DM24.
PhylomeDBQ92995.

Gene expression databases

ArrayExpressQ92995.
BgeeQ92995.
CleanExHS_USP13.
GenevestigatorQ92995.
GermOnlineENSG00000058056. Homo sapiens.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR009060. UBA-like.
IPR000449. UBA/transl_elong_EF1B_N.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR016652. Ubiquitinyl_hydrolase.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KOK11836.
PfamPF00627. UBA. 2 hits.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PIRSFPIRSF016308. UBP. 1 hit.
SMARTSM00165. UBA. 2 hits.
SM00290. ZnF_UBP. 1 hit.
[Graphical view]
SUPFAMSSF46934. UBA_like. 1 hit.
PROSITEPS50030. UBA. 2 hits.
PS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio33685.
SOURCESearch...

Entry information

Entry nameUBP13_HUMAN
AccessionPrimary (citable) accession number: Q92995
Secondary accession number(s): D3DNS2, Q96B25
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: January 25, 2012
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families