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Q92994

- TF3B_HUMAN

UniProt

Q92994 - TF3B_HUMAN

Protein

Transcription factor IIIB 90 kDa subunit

Gene

BRF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61ZincBy similarity
    Metal bindingi9 – 91ZincBy similarity
    Metal bindingi25 – 251ZincBy similarity
    Metal bindingi28 – 281ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri2 – 3332TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. gene expression Source: Reactome
    2. positive regulation of transcription, DNA-templated Source: InterPro
    3. regulation of mRNA stability Source: Ensembl
    4. rRNA transcription Source: ProtInc
    5. transcription from RNA polymerase III promoter Source: Reactome
    6. transcription initiation from RNA polymerase III promoter Source: ProtInc
    7. tRNA transcription Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor IIIB 90 kDa subunit
    Short name:
    TFIIIB90
    Short name:
    hTFIIIB90
    Alternative name(s):
    B-related factor 1
    Short name:
    BRF-1
    Short name:
    hBRF
    TAF3B2
    TATA box-binding protein-associated factor, RNA polymerase III, subunit 2
    Gene namesi
    Name:BRF1
    Synonyms:BRF, GTF3B, TAF3B2, TAF3C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:11551. BRF1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. transcription factor TFIIIB complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164741296.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 677677Transcription factor IIIB 90 kDa subunitPRO_0000119347Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei365 – 3651Phosphothreonine2 Publications
    Modified residuei450 – 4501Phosphoserine1 Publication
    Modified residuei553 – 5531Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ92994.
    PaxDbiQ92994.
    PRIDEiQ92994.

    PTM databases

    PhosphoSiteiQ92994.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92994.
    BgeeiQ92994.
    CleanExiHS_BRF1.
    GenevestigatoriQ92994.

    Organism-specific databases

    HPAiHPA051918.

    Interactioni

    Subunit structurei

    TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1.1 Publication

    Protein-protein interaction databases

    BioGridi109227. 14 interactions.
    IntActiQ92994. 2 interactions.
    MINTiMINT-2859415.
    STRINGi9606.ENSP00000329029.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92994.
    SMRiQ92994. Positions 3-44, 99-267, 448-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati91 – 172821Add
    BLAST
    Repeati185 – 269852Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.Curated
    Contains 1 TFIIB-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri2 – 3332TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1405.
    HOVERGENiHBG023540.
    InParanoidiQ92994.
    KOiK15196.
    OMAiKTELWMK.
    OrthoDBiEOG74TWZD.
    PhylomeDBiQ92994.
    TreeFamiTF324046.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR029529. Brf1.
    IPR011665. BRF1_TBP-bd_dom.
    IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PTHR11618:SF4. PTHR11618:SF4. 1 hit.
    PfamiPF07741. BRF1. 1 hit.
    PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view]
    PRINTSiPR00685. TIFACTORIIB.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequences (9)i

    Sequence statusi: Complete.

    This entry describes 9 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92994-1) [UniParc]FASTAAdd to Basket

    Also known as: hBRF1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG    50
    SSAVGQFVSL DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL 100
    QLNQHCLDTA FNFFKMAVSR HLTRGRKMAH VIAACLYLVC RTEGTPHMLL 150
    DLSDLLQVNV YVLGKTFLLL ARELCINAPA IDPCLYIPRF AHLLEFGEKN 200
    HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH DFRRTVKEVI 250
    SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK 300
    LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG 350
    STEDTASSLC GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE 400
    WGGRPPALGS LLDPLPTAAS LGISDSIREC ISSQSSDPKD ASGDGELDLS 450
    GIDDLEIDRY ILNESEARVK AELWMRENAE YLREQREKEA RIAKEKELGI 500
    YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY SVLRGLSSAG 550
    GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP 600
    AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE 650
    DGEPCVSALQ MMGSNDYGCD GDEDDGY 677
    Length:677
    Mass (Da):73,840
    Last modified:February 1, 1997 - v1
    Checksum:i5866304B879EC1DE
    GO
    Isoform 2 (identifier: Q92994-2) [UniParc]FASTAAdd to Basket

    Also known as: hBRF2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-204: Missing.
         293-338: SYTAGQRKLR...EIELENSRPK → IEEGGQTEAR...CGRGGFTLCP
         339-677: Missing.

    Show »
    Length:134
    Mass (Da):15,159
    Checksum:i0F56B878F16C484B
    GO
    Isoform 3 (identifier: Q92994-3) [UniParc]FASTAAdd to Basket

    Also known as: hBRF3

    The sequence of this isoform differs from the canonical sequence as follows:
         1-204: Missing.

    Show »
    Length:473
    Mass (Da):51,798
    Checksum:iEF95D8EDB737C5C4
    GO
    Isoform 4 (identifier: Q92994-4) [UniParc]FASTAAdd to Basket

    Also known as: hBRF4

    The sequence of this isoform differs from the canonical sequence as follows:
         159-242: NVYVLGKTFL...LLVAARMHDF → DSLRPASFPT...HLPMLGTVGC
         243-677: Missing.

    Show »
    Length:242
    Mass (Da):25,922
    Checksum:iB6FC691408BA8E26
    GO
    Isoform 5 (identifier: Q92994-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         63-89: Missing.

    Show »
    Length:650
    Mass (Da):71,119
    Checksum:iEC6958C644660237
    GO
    Isoform 6 (identifier: Q92994-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         159-208: NVYVLGKTFL...KNHEVSMTAL → DSLRPASFPT...CPVRKFWSVG
         209-677: Missing.

    Show »
    Length:208
    Mass (Da):22,309
    Checksum:i8761AE32A65FFE89
    GO
    Isoform 7 (identifier: Q92994-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.

    Show »
    Length:562
    Mass (Da):61,812
    Checksum:i9C25CDA5DFE0F90E
    GO
    Isoform 8 (identifier: Q92994-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         459-459: R → RRDLSMPRCAKAKSQPHFPVLAQ

    Note: No experimental confirmation available.

    Show »
    Length:584
    Mass (Da):64,275
    Checksum:i9365EBA805C92B88
    GO
    Isoform 9 (identifier: Q92994-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-238: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:439
    Mass (Da):47,978
    Checksum:i340FA6DDD52479DC
    GO

    Sequence cautioni

    The sequence AAC50170.1 differs from that shown. Reason: Frameshift at positions 344 and 405.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881N → D in AAC50170. (PubMed:7624363)Curated
    Sequence conflicti151 – 1511D → V in AAC50170. (PubMed:7624363)Curated
    Sequence conflicti224 – 2241R → G in AAC50170. (PubMed:7624363)Curated
    Sequence conflicti231 – 2311A → G in AAC50170. (PubMed:7624363)Curated
    Sequence conflicti339 – 3402AK → R in AAC50170. (PubMed:7624363)Curated
    Sequence conflicti437 – 4371D → N in BAH11919. (PubMed:14702039)Curated
    Sequence conflicti446 – 4461E → G in BAG53298. (PubMed:14702039)Curated
    Sequence conflicti594 – 5941P → T in AAC50170. (PubMed:7624363)Curated
    Sequence conflicti618 – 6181G → E in AAC50170. (PubMed:7624363)Curated
    Sequence conflicti640 – 6401E → G in BAG53298. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti542 – 5421V → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035723

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 238238Missing in isoform 9. 1 PublicationVSP_045045Add
    BLAST
    Alternative sequencei1 – 204204Missing in isoform 2 and isoform 3. 2 PublicationsVSP_006396Add
    BLAST
    Alternative sequencei1 – 115115Missing in isoform 7 and isoform 8. 1 PublicationVSP_044244Add
    BLAST
    Alternative sequencei63 – 8927Missing in isoform 5. 1 PublicationVSP_014697Add
    BLAST
    Alternative sequencei159 – 24284NVYVL…RMHDF → DSLRPASFPTWGCDLGVVTR VVTGVYPRCASRISVAGLCC LPSQEVLVCRMRGLHDMGVT VRDLWECGSPWQEGHLPMLG TVGC in isoform 4. 1 PublicationVSP_006399Add
    BLAST
    Alternative sequencei159 – 20850NVYVL…SMTAL → DSLRPASFPTWGCDLGVVTR VVTGVYPRCLHASQWPVCAA CPVRKFWSVG in isoform 6. 1 PublicationVSP_043835Add
    BLAST
    Alternative sequencei209 – 677469Missing in isoform 6. 1 PublicationVSP_043836Add
    BLAST
    Alternative sequencei243 – 677435Missing in isoform 4. 1 PublicationVSP_006400Add
    BLAST
    Alternative sequencei293 – 33846SYTAG…NSRPK → IEEGGQTEAREPPQASSWEG PSTTRRRSQLWHGCPGCGRG GFTLCP in isoform 2. 2 PublicationsVSP_006397Add
    BLAST
    Alternative sequencei339 – 677339Missing in isoform 2. 2 PublicationsVSP_006398Add
    BLAST
    Alternative sequencei459 – 4591R → RRDLSMPRCAKAKSQPHFPV LAQ in isoform 8. 1 PublicationVSP_045046

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28838 mRNA. Translation: AAC50170.1. Frameshift.
    U75276 mRNA. Translation: AAB38876.1.
    AJ297406 mRNA. Translation: CAC04512.1.
    AJ297407 mRNA. Translation: CAC04513.1.
    AJ297408 mRNA. Translation: CAC04514.1.
    AK096471 mRNA. Translation: BAG53298.1.
    AK294899 mRNA. Translation: BAH11919.1.
    AK295579 mRNA. Translation: BAG58477.1.
    AL512355 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81908.1.
    CH471061 Genomic DNA. Translation: EAW81911.1.
    BC016743 mRNA. Translation: AAH16743.1.
    BC071637 mRNA. Translation: AAH71637.1.
    BC086856 mRNA. Translation: AAH86856.1.
    BC103859 mRNA. Translation: AAI03860.1.
    CCDSiCCDS10001.1. [Q92994-1]
    CCDS42001.1. [Q92994-3]
    CCDS55949.1. [Q92994-9]
    CCDS55950.1. [Q92994-7]
    CCDS55951.1. [Q92994-8]
    CCDS55952.1. [Q92994-5]
    CCDS55953.1. [Q92994-6]
    PIRiI39065.
    RefSeqiNP_001229715.1. NM_001242786.1. [Q92994-8]
    NP_001229716.1. NM_001242787.1. [Q92994-7]
    NP_001229717.1. NM_001242788.1. [Q92994-5]
    NP_001229718.1. NM_001242789.1. [Q92994-9]
    NP_001229719.1. NM_001242790.1. [Q92994-6]
    NP_001510.2. NM_001519.3. [Q92994-1]
    NP_663718.1. NM_145685.2. [Q92994-3]
    XP_005267620.1. XM_005267563.1. [Q92994-3]
    UniGeneiHs.424484.

    Genome annotation databases

    EnsembliENST00000327359; ENSP00000329029; ENSG00000185024. [Q92994-7]
    ENST00000379937; ENSP00000369269; ENSG00000185024. [Q92994-5]
    ENST00000392557; ENSP00000376340; ENSG00000185024. [Q92994-3]
    ENST00000440513; ENSP00000388877; ENSG00000185024. [Q92994-8]
    ENST00000446501; ENSP00000389859; ENSG00000185024. [Q92994-9]
    ENST00000546474; ENSP00000448323; ENSG00000185024. [Q92994-1]
    ENST00000548421; ENSP00000446707; ENSG00000185024. [Q92994-6]
    GeneIDi2972.
    KEGGihsa:2972.
    UCSCiuc001yql.2. human. [Q92994-1]
    uc001yqr.3. human. [Q92994-6]
    uc010axg.1. human. [Q92994-5]

    Polymorphism databases

    DMDMi20455319.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28838 mRNA. Translation: AAC50170.1 . Frameshift.
    U75276 mRNA. Translation: AAB38876.1 .
    AJ297406 mRNA. Translation: CAC04512.1 .
    AJ297407 mRNA. Translation: CAC04513.1 .
    AJ297408 mRNA. Translation: CAC04514.1 .
    AK096471 mRNA. Translation: BAG53298.1 .
    AK294899 mRNA. Translation: BAH11919.1 .
    AK295579 mRNA. Translation: BAG58477.1 .
    AL512355 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81908.1 .
    CH471061 Genomic DNA. Translation: EAW81911.1 .
    BC016743 mRNA. Translation: AAH16743.1 .
    BC071637 mRNA. Translation: AAH71637.1 .
    BC086856 mRNA. Translation: AAH86856.1 .
    BC103859 mRNA. Translation: AAI03860.1 .
    CCDSi CCDS10001.1. [Q92994-1 ]
    CCDS42001.1. [Q92994-3 ]
    CCDS55949.1. [Q92994-9 ]
    CCDS55950.1. [Q92994-7 ]
    CCDS55951.1. [Q92994-8 ]
    CCDS55952.1. [Q92994-5 ]
    CCDS55953.1. [Q92994-6 ]
    PIRi I39065.
    RefSeqi NP_001229715.1. NM_001242786.1. [Q92994-8 ]
    NP_001229716.1. NM_001242787.1. [Q92994-7 ]
    NP_001229717.1. NM_001242788.1. [Q92994-5 ]
    NP_001229718.1. NM_001242789.1. [Q92994-9 ]
    NP_001229719.1. NM_001242790.1. [Q92994-6 ]
    NP_001510.2. NM_001519.3. [Q92994-1 ]
    NP_663718.1. NM_145685.2. [Q92994-3 ]
    XP_005267620.1. XM_005267563.1. [Q92994-3 ]
    UniGenei Hs.424484.

    3D structure databases

    ProteinModelPortali Q92994.
    SMRi Q92994. Positions 3-44, 99-267, 448-492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109227. 14 interactions.
    IntActi Q92994. 2 interactions.
    MINTi MINT-2859415.
    STRINGi 9606.ENSP00000329029.

    PTM databases

    PhosphoSitei Q92994.

    Polymorphism databases

    DMDMi 20455319.

    Proteomic databases

    MaxQBi Q92994.
    PaxDbi Q92994.
    PRIDEi Q92994.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327359 ; ENSP00000329029 ; ENSG00000185024 . [Q92994-7 ]
    ENST00000379937 ; ENSP00000369269 ; ENSG00000185024 . [Q92994-5 ]
    ENST00000392557 ; ENSP00000376340 ; ENSG00000185024 . [Q92994-3 ]
    ENST00000440513 ; ENSP00000388877 ; ENSG00000185024 . [Q92994-8 ]
    ENST00000446501 ; ENSP00000389859 ; ENSG00000185024 . [Q92994-9 ]
    ENST00000546474 ; ENSP00000448323 ; ENSG00000185024 . [Q92994-1 ]
    ENST00000548421 ; ENSP00000446707 ; ENSG00000185024 . [Q92994-6 ]
    GeneIDi 2972.
    KEGGi hsa:2972.
    UCSCi uc001yql.2. human. [Q92994-1 ]
    uc001yqr.3. human. [Q92994-6 ]
    uc010axg.1. human. [Q92994-5 ]

    Organism-specific databases

    CTDi 2972.
    GeneCardsi GC14M105675.
    HGNCi HGNC:11551. BRF1.
    HPAi HPA051918.
    MIMi 604902. gene.
    neXtProti NX_Q92994.
    PharmGKBi PA164741296.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1405.
    HOVERGENi HBG023540.
    InParanoidi Q92994.
    KOi K15196.
    OMAi KTELWMK.
    OrthoDBi EOG74TWZD.
    PhylomeDBi Q92994.
    TreeFami TF324046.

    Enzyme and pathway databases

    Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

    Miscellaneous databases

    ChiTaRSi BRF1. human.
    GeneWikii BRF1_(gene).
    GenomeRNAii 2972.
    NextBioi 11787.
    PROi Q92994.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92994.
    Bgeei Q92994.
    CleanExi HS_BRF1.
    Genevestigatori Q92994.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR029529. Brf1.
    IPR011665. BRF1_TBP-bd_dom.
    IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    PTHR11618:SF4. PTHR11618:SF4. 1 hit.
    Pfami PF07741. BRF1. 1 hit.
    PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view ]
    PRINTSi PR00685. TIFACTORIIB.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains."
      Wang Z., Roeder R.G.
      Proc. Natl. Acad. Sci. U.S.A. 92:7026-7030(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 264-281; 314-338; 441-469 AND 471-488.
    2. "RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB."
      Mital R., Kobayashi R., Hernandez N.
      Mol. Cell. Biol. 16:7031-7042(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 248-254; 263-280; 313-320; 343-348; 380-396; 440-449; 471-488; 514-527; 538-561 AND 570-602.
    3. "Alternatively spliced hBRF variants function at different RNA polymerase III promoters."
      McCulloch V., Hardin P., Peng W., Ruppert J.M., Lobo-Ruppert S.M.
      EMBO J. 19:4134-4143(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7; 8 AND 9).
      Tissue: Brain and Hippocampus.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5 AND 6).
      Tissue: Brain, Skin and Testis.
    8. "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo."
      Fairley J.A., Scott P.H., White R.J.
      EMBO J. 22:5841-5850(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BDP1.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365 AND SER-450, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-542.

    Entry informationi

    Entry nameiTF3B_HUMAN
    AccessioniPrimary (citable) accession number: Q92994
    Secondary accession number(s): B3KU36
    , B4DIG5, B7Z2N3, F5H5Z7, F8WA46, Q13223, Q3SYD9, Q5PR24, Q6IQ02, Q96KX3, Q9HCW6, Q9HCW7, Q9HCW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3