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Q92994

- TF3B_HUMAN

UniProt

Q92994 - TF3B_HUMAN

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Protein
Transcription factor IIIB 90 kDa subunit
Gene
BRF1, BRF, GTF3B, TAF3B2, TAF3C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Zinc By similarity
Metal bindingi9 – 91Zinc By similarity
Metal bindingi25 – 251Zinc By similarity
Metal bindingi28 – 281Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2 – 3332TFIIB-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. gene expression Source: Reactome
  2. positive regulation of transcription, DNA-templated Source: InterPro
  3. rRNA transcription Source: ProtInc
  4. regulation of mRNA stability Source: Ensembl
  5. tRNA transcription Source: ProtInc
  6. transcription from RNA polymerase III promoter Source: Reactome
  7. transcription initiation from RNA polymerase III promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIB 90 kDa subunit
Short name:
TFIIIB90
Short name:
hTFIIIB90
Alternative name(s):
B-related factor 1
Short name:
BRF-1
Short name:
hBRF
TAF3B2
TATA box-binding protein-associated factor, RNA polymerase III, subunit 2
Gene namesi
Name:BRF1
Synonyms:BRF, GTF3B, TAF3B2, TAF3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:11551. BRF1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. transcription factor TFIIIB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164741296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Transcription factor IIIB 90 kDa subunit
PRO_0000119347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei365 – 3651Phosphothreonine2 Publications
Modified residuei450 – 4501Phosphoserine1 Publication
Modified residuei553 – 5531Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92994.
PaxDbiQ92994.
PRIDEiQ92994.

PTM databases

PhosphoSiteiQ92994.

Expressioni

Gene expression databases

ArrayExpressiQ92994.
BgeeiQ92994.
CleanExiHS_BRF1.
GenevestigatoriQ92994.

Organism-specific databases

HPAiHPA051918.

Interactioni

Subunit structurei

TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1.1 Publication

Protein-protein interaction databases

BioGridi109227. 14 interactions.
IntActiQ92994. 2 interactions.
MINTiMINT-2859415.
STRINGi9606.ENSP00000329029.

Structurei

3D structure databases

ProteinModelPortaliQ92994.
SMRiQ92994. Positions 3-44, 99-267, 448-492.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati91 – 172821
Add
BLAST
Repeati185 – 269852
Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOVERGENiHBG023540.
InParanoidiQ92994.
KOiK15196.
OMAiKTELWMK.
OrthoDBiEOG74TWZD.
PhylomeDBiQ92994.
TreeFamiTF324046.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR029529. Brf1.
IPR011665. BRF1_TBP-bd_dom.
IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PTHR11618:SF4. PTHR11618:SF4. 1 hit.
PfamiPF07741. BRF1. 1 hit.
PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92994-1) [UniParc]FASTAAdd to Basket

Also known as: hBRF1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG    50
SSAVGQFVSL DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL 100
QLNQHCLDTA FNFFKMAVSR HLTRGRKMAH VIAACLYLVC RTEGTPHMLL 150
DLSDLLQVNV YVLGKTFLLL ARELCINAPA IDPCLYIPRF AHLLEFGEKN 200
HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH DFRRTVKEVI 250
SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK 300
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG 350
STEDTASSLC GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE 400
WGGRPPALGS LLDPLPTAAS LGISDSIREC ISSQSSDPKD ASGDGELDLS 450
GIDDLEIDRY ILNESEARVK AELWMRENAE YLREQREKEA RIAKEKELGI 500
YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY SVLRGLSSAG 550
GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP 600
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE 650
DGEPCVSALQ MMGSNDYGCD GDEDDGY 677
Length:677
Mass (Da):73,840
Last modified:February 1, 1997 - v1
Checksum:i5866304B879EC1DE
GO
Isoform 2 (identifier: Q92994-2) [UniParc]FASTAAdd to Basket

Also known as: hBRF2

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.
     293-338: SYTAGQRKLR...EIELENSRPK → IEEGGQTEAR...CGRGGFTLCP
     339-677: Missing.

Show »
Length:134
Mass (Da):15,159
Checksum:i0F56B878F16C484B
GO
Isoform 3 (identifier: Q92994-3) [UniParc]FASTAAdd to Basket

Also known as: hBRF3

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.

Show »
Length:473
Mass (Da):51,798
Checksum:iEF95D8EDB737C5C4
GO
Isoform 4 (identifier: Q92994-4) [UniParc]FASTAAdd to Basket

Also known as: hBRF4

The sequence of this isoform differs from the canonical sequence as follows:
     159-242: NVYVLGKTFL...LLVAARMHDF → DSLRPASFPT...HLPMLGTVGC
     243-677: Missing.

Show »
Length:242
Mass (Da):25,922
Checksum:iB6FC691408BA8E26
GO
Isoform 5 (identifier: Q92994-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-89: Missing.

Show »
Length:650
Mass (Da):71,119
Checksum:iEC6958C644660237
GO
Isoform 6 (identifier: Q92994-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-208: NVYVLGKTFL...KNHEVSMTAL → DSLRPASFPT...CPVRKFWSVG
     209-677: Missing.

Show »
Length:208
Mass (Da):22,309
Checksum:i8761AE32A65FFE89
GO
Isoform 7 (identifier: Q92994-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Show »
Length:562
Mass (Da):61,812
Checksum:i9C25CDA5DFE0F90E
GO
Isoform 8 (identifier: Q92994-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     459-459: R → RRDLSMPRCAKAKSQPHFPVLAQ

Note: No experimental confirmation available.

Show »
Length:584
Mass (Da):64,275
Checksum:i9365EBA805C92B88
GO
Isoform 9 (identifier: Q92994-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-238: Missing.

Note: No experimental confirmation available.

Show »
Length:439
Mass (Da):47,978
Checksum:i340FA6DDD52479DC
GO

Sequence cautioni

The sequence AAC50170.1 differs from that shown. Reason: Frameshift at positions 344 and 405.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti542 – 5421V → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035723

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 238238Missing in isoform 9.
VSP_045045Add
BLAST
Alternative sequencei1 – 204204Missing in isoform 2 and isoform 3.
VSP_006396Add
BLAST
Alternative sequencei1 – 115115Missing in isoform 7 and isoform 8.
VSP_044244Add
BLAST
Alternative sequencei63 – 8927Missing in isoform 5.
VSP_014697Add
BLAST
Alternative sequencei159 – 24284NVYVL…RMHDF → DSLRPASFPTWGCDLGVVTR VVTGVYPRCASRISVAGLCC LPSQEVLVCRMRGLHDMGVT VRDLWECGSPWQEGHLPMLG TVGC in isoform 4.
VSP_006399Add
BLAST
Alternative sequencei159 – 20850NVYVL…SMTAL → DSLRPASFPTWGCDLGVVTR VVTGVYPRCLHASQWPVCAA CPVRKFWSVG in isoform 6.
VSP_043835Add
BLAST
Alternative sequencei209 – 677469Missing in isoform 6.
VSP_043836Add
BLAST
Alternative sequencei243 – 677435Missing in isoform 4.
VSP_006400Add
BLAST
Alternative sequencei293 – 33846SYTAG…NSRPK → IEEGGQTEAREPPQASSWEG PSTTRRRSQLWHGCPGCGRG GFTLCP in isoform 2.
VSP_006397Add
BLAST
Alternative sequencei339 – 677339Missing in isoform 2.
VSP_006398Add
BLAST
Alternative sequencei459 – 4591R → RRDLSMPRCAKAKSQPHFPV LAQ in isoform 8.
VSP_045046

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881N → D in AAC50170. 1 Publication
Sequence conflicti151 – 1511D → V in AAC50170. 1 Publication
Sequence conflicti224 – 2241R → G in AAC50170. 1 Publication
Sequence conflicti231 – 2311A → G in AAC50170. 1 Publication
Sequence conflicti339 – 3402AK → R in AAC50170. 1 Publication
Sequence conflicti437 – 4371D → N in BAH11919. 1 Publication
Sequence conflicti446 – 4461E → G in BAG53298. 1 Publication
Sequence conflicti594 – 5941P → T in AAC50170. 1 Publication
Sequence conflicti618 – 6181G → E in AAC50170. 1 Publication
Sequence conflicti640 – 6401E → G in BAG53298. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28838 mRNA. Translation: AAC50170.1. Frameshift.
U75276 mRNA. Translation: AAB38876.1.
AJ297406 mRNA. Translation: CAC04512.1.
AJ297407 mRNA. Translation: CAC04513.1.
AJ297408 mRNA. Translation: CAC04514.1.
AK096471 mRNA. Translation: BAG53298.1.
AK294899 mRNA. Translation: BAH11919.1.
AK295579 mRNA. Translation: BAG58477.1.
AL512355 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81908.1.
CH471061 Genomic DNA. Translation: EAW81911.1.
BC016743 mRNA. Translation: AAH16743.1.
BC071637 mRNA. Translation: AAH71637.1.
BC086856 mRNA. Translation: AAH86856.1.
BC103859 mRNA. Translation: AAI03860.1.
CCDSiCCDS10001.1. [Q92994-1]
CCDS42001.1. [Q92994-3]
CCDS55949.1. [Q92994-9]
CCDS55950.1. [Q92994-7]
CCDS55951.1. [Q92994-8]
CCDS55952.1. [Q92994-5]
CCDS55953.1. [Q92994-6]
PIRiI39065.
RefSeqiNP_001229715.1. NM_001242786.1. [Q92994-8]
NP_001229716.1. NM_001242787.1. [Q92994-7]
NP_001229717.1. NM_001242788.1. [Q92994-5]
NP_001229718.1. NM_001242789.1. [Q92994-9]
NP_001229719.1. NM_001242790.1. [Q92994-6]
NP_001510.2. NM_001519.3. [Q92994-1]
NP_663718.1. NM_145685.2. [Q92994-3]
XP_005267620.1. XM_005267563.1. [Q92994-3]
UniGeneiHs.424484.

Genome annotation databases

EnsembliENST00000327359; ENSP00000329029; ENSG00000185024. [Q92994-7]
ENST00000379937; ENSP00000369269; ENSG00000185024. [Q92994-5]
ENST00000392557; ENSP00000376340; ENSG00000185024. [Q92994-3]
ENST00000440513; ENSP00000388877; ENSG00000185024. [Q92994-8]
ENST00000446501; ENSP00000389859; ENSG00000185024. [Q92994-9]
ENST00000546474; ENSP00000448323; ENSG00000185024. [Q92994-1]
ENST00000548421; ENSP00000446707; ENSG00000185024. [Q92994-6]
GeneIDi2972.
KEGGihsa:2972.
UCSCiuc001yql.2. human. [Q92994-1]
uc001yqr.3. human. [Q92994-6]
uc010axg.1. human. [Q92994-5]

Polymorphism databases

DMDMi20455319.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28838 mRNA. Translation: AAC50170.1 . Frameshift.
U75276 mRNA. Translation: AAB38876.1 .
AJ297406 mRNA. Translation: CAC04512.1 .
AJ297407 mRNA. Translation: CAC04513.1 .
AJ297408 mRNA. Translation: CAC04514.1 .
AK096471 mRNA. Translation: BAG53298.1 .
AK294899 mRNA. Translation: BAH11919.1 .
AK295579 mRNA. Translation: BAG58477.1 .
AL512355 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81908.1 .
CH471061 Genomic DNA. Translation: EAW81911.1 .
BC016743 mRNA. Translation: AAH16743.1 .
BC071637 mRNA. Translation: AAH71637.1 .
BC086856 mRNA. Translation: AAH86856.1 .
BC103859 mRNA. Translation: AAI03860.1 .
CCDSi CCDS10001.1. [Q92994-1 ]
CCDS42001.1. [Q92994-3 ]
CCDS55949.1. [Q92994-9 ]
CCDS55950.1. [Q92994-7 ]
CCDS55951.1. [Q92994-8 ]
CCDS55952.1. [Q92994-5 ]
CCDS55953.1. [Q92994-6 ]
PIRi I39065.
RefSeqi NP_001229715.1. NM_001242786.1. [Q92994-8 ]
NP_001229716.1. NM_001242787.1. [Q92994-7 ]
NP_001229717.1. NM_001242788.1. [Q92994-5 ]
NP_001229718.1. NM_001242789.1. [Q92994-9 ]
NP_001229719.1. NM_001242790.1. [Q92994-6 ]
NP_001510.2. NM_001519.3. [Q92994-1 ]
NP_663718.1. NM_145685.2. [Q92994-3 ]
XP_005267620.1. XM_005267563.1. [Q92994-3 ]
UniGenei Hs.424484.

3D structure databases

ProteinModelPortali Q92994.
SMRi Q92994. Positions 3-44, 99-267, 448-492.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109227. 14 interactions.
IntActi Q92994. 2 interactions.
MINTi MINT-2859415.
STRINGi 9606.ENSP00000329029.

PTM databases

PhosphoSitei Q92994.

Polymorphism databases

DMDMi 20455319.

Proteomic databases

MaxQBi Q92994.
PaxDbi Q92994.
PRIDEi Q92994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327359 ; ENSP00000329029 ; ENSG00000185024 . [Q92994-7 ]
ENST00000379937 ; ENSP00000369269 ; ENSG00000185024 . [Q92994-5 ]
ENST00000392557 ; ENSP00000376340 ; ENSG00000185024 . [Q92994-3 ]
ENST00000440513 ; ENSP00000388877 ; ENSG00000185024 . [Q92994-8 ]
ENST00000446501 ; ENSP00000389859 ; ENSG00000185024 . [Q92994-9 ]
ENST00000546474 ; ENSP00000448323 ; ENSG00000185024 . [Q92994-1 ]
ENST00000548421 ; ENSP00000446707 ; ENSG00000185024 . [Q92994-6 ]
GeneIDi 2972.
KEGGi hsa:2972.
UCSCi uc001yql.2. human. [Q92994-1 ]
uc001yqr.3. human. [Q92994-6 ]
uc010axg.1. human. [Q92994-5 ]

Organism-specific databases

CTDi 2972.
GeneCardsi GC14M105675.
HGNCi HGNC:11551. BRF1.
HPAi HPA051918.
MIMi 604902. gene.
neXtProti NX_Q92994.
PharmGKBi PA164741296.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1405.
HOVERGENi HBG023540.
InParanoidi Q92994.
KOi K15196.
OMAi KTELWMK.
OrthoDBi EOG74TWZD.
PhylomeDBi Q92994.
TreeFami TF324046.

Enzyme and pathway databases

Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

Miscellaneous databases

ChiTaRSi BRF1. human.
GeneWikii BRF1_(gene).
GenomeRNAii 2972.
NextBioi 11787.
PROi Q92994.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92994.
Bgeei Q92994.
CleanExi HS_BRF1.
Genevestigatori Q92994.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR029529. Brf1.
IPR011665. BRF1_TBP-bd_dom.
IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
PTHR11618:SF4. PTHR11618:SF4. 1 hit.
Pfami PF07741. BRF1. 1 hit.
PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains."
    Wang Z., Roeder R.G.
    Proc. Natl. Acad. Sci. U.S.A. 92:7026-7030(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 264-281; 314-338; 441-469 AND 471-488.
  2. "RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB."
    Mital R., Kobayashi R., Hernandez N.
    Mol. Cell. Biol. 16:7031-7042(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 248-254; 263-280; 313-320; 343-348; 380-396; 440-449; 471-488; 514-527; 538-561 AND 570-602.
  3. "Alternatively spliced hBRF variants function at different RNA polymerase III promoters."
    McCulloch V., Hardin P., Peng W., Ruppert J.M., Lobo-Ruppert S.M.
    EMBO J. 19:4134-4143(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7; 8 AND 9).
    Tissue: Brain and Hippocampus.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5 AND 6).
    Tissue: Brain, Skin and Testis.
  8. "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo."
    Fairley J.A., Scott P.H., White R.J.
    EMBO J. 22:5841-5850(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BDP1.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365 AND SER-450, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-542.

Entry informationi

Entry nameiTF3B_HUMAN
AccessioniPrimary (citable) accession number: Q92994
Secondary accession number(s): B3KU36
, B4DIG5, B7Z2N3, F5H5Z7, F8WA46, Q13223, Q3SYD9, Q5PR24, Q6IQ02, Q96KX3, Q9HCW6, Q9HCW7, Q9HCW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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