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Protein

Transcription factor IIIB 90 kDa subunit

Gene

BRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61ZincBy similarity
Metal bindingi9 – 91ZincBy similarity
Metal bindingi25 – 251ZincBy similarity
Metal bindingi28 – 281ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2 – 3332TFIIB-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • gene expression Source: Reactome
  • regulation of mRNA stability Source: Ensembl
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • rRNA transcription Source: ProtInc
  • transcription from RNA polymerase III promoter Source: Reactome
  • transcription initiation from RNA polymerase III promoter Source: ProtInc
  • tRNA transcription Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIB 90 kDa subunit
Short name:
TFIIIB90
Short name:
hTFIIIB90
Alternative name(s):
B-related factor 1
Short name:
BRF-1
Short name:
hBRF
TAF3B2
TATA box-binding protein-associated factor, RNA polymerase III, subunit 2
Gene namesi
Name:BRF1
Synonyms:BRF, GTF3B, TAF3B2, TAF3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:11551. BRF1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • transcription factor TFIIIB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Cerebellofaciodental syndrome (CFDS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by cerebellar hypoplasia, delayed development and intellectual disability, as well as facial dysmorphic features, short stature, microcephaly, and dental anomalies.

See also OMIM:616202
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti223 – 2231R → W in CFDS. 1 Publication
VAR_072710
Natural varianti226 – 2261S → L in CFDS. 1 Publication
VAR_072711
Natural varianti259 – 2591T → M in CFDS. 1 Publication
VAR_072712
Natural varianti292 – 2921P → H in CFDS. 1 Publication
VAR_072713

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation

Organism-specific databases

MIMi616202. phenotype.
PharmGKBiPA164741296.

Polymorphism and mutation databases

BioMutaiBRF1.
DMDMi20455319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Transcription factor IIIB 90 kDa subunitPRO_0000119347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei365 – 3651Phosphothreonine2 Publications
Modified residuei450 – 4501Phosphoserine1 Publication
Modified residuei553 – 5531Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92994.
PaxDbiQ92994.
PRIDEiQ92994.

PTM databases

PhosphoSiteiQ92994.

Expressioni

Gene expression databases

BgeeiQ92994.
CleanExiHS_BRF1.
ExpressionAtlasiQ92994. baseline.
GenevisibleiQ92994. HS.

Interactioni

Subunit structurei

TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1.1 Publication

Protein-protein interaction databases

BioGridi109227. 14 interactions.
IntActiQ92994. 2 interactions.
MINTiMINT-2859415.

Structurei

3D structure databases

ProteinModelPortaliQ92994.
SMRiQ92994. Positions 99-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati91 – 172821Add
BLAST
Repeati185 – 269852Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.Curated
Contains 1 TFIIB-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2 – 3332TFIIB-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
GeneTreeiENSGT00390000010349.
HOGENOMiHOG000198688.
HOVERGENiHBG023540.
InParanoidiQ92994.
KOiK15196.
OMAiHSASARK.
OrthoDBiEOG74TWZD.
PhylomeDBiQ92994.
TreeFamiTF324046.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR029529. Brf1.
IPR011665. BRF1_TBP-bd_dom.
IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PTHR11618:SF4. PTHR11618:SF4. 1 hit.
PfamiPF07741. BRF1. 1 hit.
PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92994-1) [UniParc]FASTAAdd to basket

Also known as: hBRF1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG
60 70 80 90 100
SSAVGQFVSL DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL
110 120 130 140 150
QLNQHCLDTA FNFFKMAVSR HLTRGRKMAH VIAACLYLVC RTEGTPHMLL
160 170 180 190 200
DLSDLLQVNV YVLGKTFLLL ARELCINAPA IDPCLYIPRF AHLLEFGEKN
210 220 230 240 250
HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH DFRRTVKEVI
260 270 280 290 300
SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
310 320 330 340 350
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG
360 370 380 390 400
STEDTASSLC GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE
410 420 430 440 450
WGGRPPALGS LLDPLPTAAS LGISDSIREC ISSQSSDPKD ASGDGELDLS
460 470 480 490 500
GIDDLEIDRY ILNESEARVK AELWMRENAE YLREQREKEA RIAKEKELGI
510 520 530 540 550
YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY SVLRGLSSAG
560 570 580 590 600
GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
610 620 630 640 650
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE
660 670
DGEPCVSALQ MMGSNDYGCD GDEDDGY
Length:677
Mass (Da):73,840
Last modified:February 1, 1997 - v1
Checksum:i5866304B879EC1DE
GO
Isoform 2 (identifier: Q92994-2) [UniParc]FASTAAdd to basket

Also known as: hBRF2

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.
     293-338: SYTAGQRKLR...EIELENSRPK → IEEGGQTEAR...CGRGGFTLCP
     339-677: Missing.

Show »
Length:134
Mass (Da):15,159
Checksum:i0F56B878F16C484B
GO
Isoform 3 (identifier: Q92994-3) [UniParc]FASTAAdd to basket

Also known as: hBRF3

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.

Show »
Length:473
Mass (Da):51,798
Checksum:iEF95D8EDB737C5C4
GO
Isoform 4 (identifier: Q92994-4) [UniParc]FASTAAdd to basket

Also known as: hBRF4

The sequence of this isoform differs from the canonical sequence as follows:
     159-242: NVYVLGKTFL...LLVAARMHDF → DSLRPASFPT...HLPMLGTVGC
     243-677: Missing.

Show »
Length:242
Mass (Da):25,922
Checksum:iB6FC691408BA8E26
GO
Isoform 5 (identifier: Q92994-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-89: Missing.

Show »
Length:650
Mass (Da):71,119
Checksum:iEC6958C644660237
GO
Isoform 6 (identifier: Q92994-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-208: NVYVLGKTFL...KNHEVSMTAL → DSLRPASFPT...CPVRKFWSVG
     209-677: Missing.

Show »
Length:208
Mass (Da):22,309
Checksum:i8761AE32A65FFE89
GO
Isoform 7 (identifier: Q92994-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Show »
Length:562
Mass (Da):61,812
Checksum:i9C25CDA5DFE0F90E
GO
Isoform 8 (identifier: Q92994-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     459-459: R → RRDLSMPRCAKAKSQPHFPVLAQ

Note: No experimental confirmation available.
Show »
Length:584
Mass (Da):64,275
Checksum:i9365EBA805C92B88
GO
Isoform 9 (identifier: Q92994-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-238: Missing.

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):47,978
Checksum:i340FA6DDD52479DC
GO

Sequence cautioni

The sequence AAC50170.1 differs from that shown. Reason: Frameshift at positions 344 and 405. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881N → D in AAC50170 (PubMed:7624363).Curated
Sequence conflicti151 – 1511D → V in AAC50170 (PubMed:7624363).Curated
Sequence conflicti224 – 2241R → G in AAC50170 (PubMed:7624363).Curated
Sequence conflicti231 – 2311A → G in AAC50170 (PubMed:7624363).Curated
Sequence conflicti339 – 3402AK → R in AAC50170 (PubMed:7624363).Curated
Sequence conflicti437 – 4371D → N in BAH11919 (PubMed:14702039).Curated
Sequence conflicti446 – 4461E → G in BAG53298 (PubMed:14702039).Curated
Sequence conflicti594 – 5941P → T in AAC50170 (PubMed:7624363).Curated
Sequence conflicti618 – 6181G → E in AAC50170 (PubMed:7624363).Curated
Sequence conflicti640 – 6401E → G in BAG53298 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti223 – 2231R → W in CFDS. 1 Publication
VAR_072710
Natural varianti226 – 2261S → L in CFDS. 1 Publication
VAR_072711
Natural varianti259 – 2591T → M in CFDS. 1 Publication
VAR_072712
Natural varianti292 – 2921P → H in CFDS. 1 Publication
VAR_072713
Natural varianti542 – 5421V → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035723

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 238238Missing in isoform 9. 1 PublicationVSP_045045Add
BLAST
Alternative sequencei1 – 204204Missing in isoform 2 and isoform 3. 2 PublicationsVSP_006396Add
BLAST
Alternative sequencei1 – 115115Missing in isoform 7 and isoform 8. 1 PublicationVSP_044244Add
BLAST
Alternative sequencei63 – 8927Missing in isoform 5. 1 PublicationVSP_014697Add
BLAST
Alternative sequencei159 – 24284NVYVL…RMHDF → DSLRPASFPTWGCDLGVVTR VVTGVYPRCASRISVAGLCC LPSQEVLVCRMRGLHDMGVT VRDLWECGSPWQEGHLPMLG TVGC in isoform 4. 1 PublicationVSP_006399Add
BLAST
Alternative sequencei159 – 20850NVYVL…SMTAL → DSLRPASFPTWGCDLGVVTR VVTGVYPRCLHASQWPVCAA CPVRKFWSVG in isoform 6. 1 PublicationVSP_043835Add
BLAST
Alternative sequencei209 – 677469Missing in isoform 6. 1 PublicationVSP_043836Add
BLAST
Alternative sequencei243 – 677435Missing in isoform 4. 1 PublicationVSP_006400Add
BLAST
Alternative sequencei293 – 33846SYTAG…NSRPK → IEEGGQTEAREPPQASSWEG PSTTRRRSQLWHGCPGCGRG GFTLCP in isoform 2. 2 PublicationsVSP_006397Add
BLAST
Alternative sequencei339 – 677339Missing in isoform 2. 2 PublicationsVSP_006398Add
BLAST
Alternative sequencei459 – 4591R → RRDLSMPRCAKAKSQPHFPV LAQ in isoform 8. 1 PublicationVSP_045046

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28838 mRNA. Translation: AAC50170.1. Frameshift.
U75276 mRNA. Translation: AAB38876.1.
AJ297406 mRNA. Translation: CAC04512.1.
AJ297407 mRNA. Translation: CAC04513.1.
AJ297408 mRNA. Translation: CAC04514.1.
AK096471 mRNA. Translation: BAG53298.1.
AK294899 mRNA. Translation: BAH11919.1.
AK295579 mRNA. Translation: BAG58477.1.
AL512355 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81908.1.
CH471061 Genomic DNA. Translation: EAW81911.1.
BC016743 mRNA. Translation: AAH16743.1.
BC071637 mRNA. Translation: AAH71637.1.
BC086856 mRNA. Translation: AAH86856.1.
BC103859 mRNA. Translation: AAI03860.1.
CCDSiCCDS10001.1. [Q92994-1]
CCDS42001.1. [Q92994-3]
CCDS55949.1. [Q92994-9]
CCDS55950.1. [Q92994-7]
CCDS55951.1. [Q92994-8]
CCDS55952.1. [Q92994-5]
CCDS55953.1. [Q92994-6]
PIRiI39065.
RefSeqiNP_001229715.1. NM_001242786.1. [Q92994-8]
NP_001229716.1. NM_001242787.1. [Q92994-7]
NP_001229717.1. NM_001242788.1. [Q92994-5]
NP_001229718.1. NM_001242789.1. [Q92994-9]
NP_001229719.1. NM_001242790.1. [Q92994-6]
NP_001510.2. NM_001519.3. [Q92994-1]
NP_663718.1. NM_145685.2. [Q92994-3]
XP_005267620.1. XM_005267563.2. [Q92994-3]
UniGeneiHs.424484.

Genome annotation databases

EnsembliENST00000327359; ENSP00000329029; ENSG00000185024. [Q92994-7]
ENST00000379937; ENSP00000369269; ENSG00000185024. [Q92994-5]
ENST00000392557; ENSP00000376340; ENSG00000185024. [Q92994-3]
ENST00000440513; ENSP00000388877; ENSG00000185024. [Q92994-8]
ENST00000446501; ENSP00000389859; ENSG00000185024. [Q92994-9]
ENST00000546474; ENSP00000448323; ENSG00000185024. [Q92994-1]
ENST00000548421; ENSP00000446707; ENSG00000185024. [Q92994-6]
GeneIDi2972.
KEGGihsa:2972.
UCSCiuc001yql.2. human. [Q92994-1]
uc001yqr.3. human. [Q92994-6]
uc010axg.1. human. [Q92994-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28838 mRNA. Translation: AAC50170.1. Frameshift.
U75276 mRNA. Translation: AAB38876.1.
AJ297406 mRNA. Translation: CAC04512.1.
AJ297407 mRNA. Translation: CAC04513.1.
AJ297408 mRNA. Translation: CAC04514.1.
AK096471 mRNA. Translation: BAG53298.1.
AK294899 mRNA. Translation: BAH11919.1.
AK295579 mRNA. Translation: BAG58477.1.
AL512355 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81908.1.
CH471061 Genomic DNA. Translation: EAW81911.1.
BC016743 mRNA. Translation: AAH16743.1.
BC071637 mRNA. Translation: AAH71637.1.
BC086856 mRNA. Translation: AAH86856.1.
BC103859 mRNA. Translation: AAI03860.1.
CCDSiCCDS10001.1. [Q92994-1]
CCDS42001.1. [Q92994-3]
CCDS55949.1. [Q92994-9]
CCDS55950.1. [Q92994-7]
CCDS55951.1. [Q92994-8]
CCDS55952.1. [Q92994-5]
CCDS55953.1. [Q92994-6]
PIRiI39065.
RefSeqiNP_001229715.1. NM_001242786.1. [Q92994-8]
NP_001229716.1. NM_001242787.1. [Q92994-7]
NP_001229717.1. NM_001242788.1. [Q92994-5]
NP_001229718.1. NM_001242789.1. [Q92994-9]
NP_001229719.1. NM_001242790.1. [Q92994-6]
NP_001510.2. NM_001519.3. [Q92994-1]
NP_663718.1. NM_145685.2. [Q92994-3]
XP_005267620.1. XM_005267563.2. [Q92994-3]
UniGeneiHs.424484.

3D structure databases

ProteinModelPortaliQ92994.
SMRiQ92994. Positions 99-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109227. 14 interactions.
IntActiQ92994. 2 interactions.
MINTiMINT-2859415.

PTM databases

PhosphoSiteiQ92994.

Polymorphism and mutation databases

BioMutaiBRF1.
DMDMi20455319.

Proteomic databases

MaxQBiQ92994.
PaxDbiQ92994.
PRIDEiQ92994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327359; ENSP00000329029; ENSG00000185024. [Q92994-7]
ENST00000379937; ENSP00000369269; ENSG00000185024. [Q92994-5]
ENST00000392557; ENSP00000376340; ENSG00000185024. [Q92994-3]
ENST00000440513; ENSP00000388877; ENSG00000185024. [Q92994-8]
ENST00000446501; ENSP00000389859; ENSG00000185024. [Q92994-9]
ENST00000546474; ENSP00000448323; ENSG00000185024. [Q92994-1]
ENST00000548421; ENSP00000446707; ENSG00000185024. [Q92994-6]
GeneIDi2972.
KEGGihsa:2972.
UCSCiuc001yql.2. human. [Q92994-1]
uc001yqr.3. human. [Q92994-6]
uc010axg.1. human. [Q92994-5]

Organism-specific databases

CTDi2972.
GeneCardsiGC14M105675.
HGNCiHGNC:11551. BRF1.
MIMi604902. gene.
616202. phenotype.
neXtProtiNX_Q92994.
PharmGKBiPA164741296.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1405.
GeneTreeiENSGT00390000010349.
HOGENOMiHOG000198688.
HOVERGENiHBG023540.
InParanoidiQ92994.
KOiK15196.
OMAiHSASARK.
OrthoDBiEOG74TWZD.
PhylomeDBiQ92994.
TreeFamiTF324046.

Enzyme and pathway databases

ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

Miscellaneous databases

ChiTaRSiBRF1. human.
GeneWikiiBRF1_(gene).
GenomeRNAii2972.
NextBioi11787.
PROiQ92994.
SOURCEiSearch...

Gene expression databases

BgeeiQ92994.
CleanExiHS_BRF1.
ExpressionAtlasiQ92994. baseline.
GenevisibleiQ92994. HS.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR029529. Brf1.
IPR011665. BRF1_TBP-bd_dom.
IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PTHR11618:SF4. PTHR11618:SF4. 1 hit.
PfamiPF07741. BRF1. 1 hit.
PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains."
    Wang Z., Roeder R.G.
    Proc. Natl. Acad. Sci. U.S.A. 92:7026-7030(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 264-281; 314-338; 441-469 AND 471-488.
  2. "RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB."
    Mital R., Kobayashi R., Hernandez N.
    Mol. Cell. Biol. 16:7031-7042(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 248-254; 263-280; 313-320; 343-348; 380-396; 440-449; 471-488; 514-527; 538-561 AND 570-602.
  3. "Alternatively spliced hBRF variants function at different RNA polymerase III promoters."
    McCulloch V., Hardin P., Peng W., Ruppert J.M., Lobo-Ruppert S.M.
    EMBO J. 19:4134-4143(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7; 8 AND 9).
    Tissue: Brain and Hippocampus.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5 AND 6).
    Tissue: Brain, Skin and Testis.
  8. "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo."
    Fairley J.A., Scott P.H., White R.J.
    EMBO J. 22:5841-5850(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BDP1.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365 AND SER-450, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. Cited for: INVOLVEMENT IN CFDS, VARIANTS CFDS TRP-223; LEU-226; MET-259 AND HIS-292.
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-542.

Entry informationi

Entry nameiTF3B_HUMAN
AccessioniPrimary (citable) accession number: Q92994
Secondary accession number(s): B3KU36
, B4DIG5, B7Z2N3, F5H5Z7, F8WA46, Q13223, Q3SYD9, Q5PR24, Q6IQ02, Q96KX3, Q9HCW6, Q9HCW7, Q9HCW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.