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Protein

Ninjurin-1

Gene

NINJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.

GO - Biological processi

  • cell adhesion Source: ProtInc
  • hyaloid vascular plexus regression Source: Ensembl
  • nervous system development Source: ProtInc
  • positive regulation of cell-matrix adhesion Source: Ensembl
  • tissue regeneration Source: InterPro

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-1
Alternative name(s):
Nerve injury-induced protein 1
Gene namesi
Name:NINJ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000131669.9.
HGNCiHGNC:7824. NINJ1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 80ExtracellularSequence analysisAdd BLAST80
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 120CytoplasmicSequence analysisAdd BLAST19
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 152ExtracellularSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4814.
OpenTargetsiENSG00000131669.
PharmGKBiPA31631.

Polymorphism and mutation databases

BioMutaiNINJ1.
DMDMi317373398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596431 – 152Ninjurin-1Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei21PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ92982.
PaxDbiQ92982.
PeptideAtlasiQ92982.
PRIDEiQ92982.

PTM databases

PhosphoSitePlusiQ92982.

Expressioni

Tissue specificityi

Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.

Inductioni

By nerve injury both in dorsal root ganglion neurons and in Schwann cells.

Gene expression databases

BgeeiENSG00000131669.
CleanExiHS_NINJ1.
GenevisibleiQ92982. HS.

Organism-specific databases

HPAiHPA045063.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-2802124,EBI-10171697

Protein-protein interaction databases

BioGridi110879. 2 interactors.
CORUMiQ92982.
IntActiQ92982. 18 interactors.
STRINGi9606.ENSP00000364595.

Structurei

3D structure databases

ProteinModelPortaliQ92982.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIJ. Eukaryota.
ENOG4111RPK. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ92982.
OMAiNINHYAN.
OrthoDBiEOG091G0W0Q.
PhylomeDBiQ92982.
TreeFamiTF323538.

Family and domain databases

InterProiView protein in InterPro
IPR007007. Ninjurin.
IPR015639. Ninjurin1.
PANTHERiPTHR12316. PTHR12316. 1 hit.
PTHR12316:SF23. PTHR12316:SF23. 1 hit.
PfamiView protein in Pfam
PF04923. Ninjurin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSGTEEYEL NGGLPPGTPG SPDASPARWG WRHGPINVNH YASKKSAAES
60 70 80 90 100
MLDIALLMAN ASQLKAVVEQ GPSFAFYVPL VVLISISLVL QIGVGVLLIF
110 120 130 140 150
LVKYDLNNPA KHAKLDFLNN LATGLVFIIV VVNIFITAFG VQKPLMDMAP

QQ
Length:152
Mass (Da):16,345
Last modified:January 11, 2011 - v2
Checksum:iFEACA99450187855
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025549110A → D3 PublicationsCorresponds to variant dbSNP:rs2275848Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72661 mRNA. Translation: AAB17560.1.
U91512 mRNA. Translation: AAC14593.1.
AF029251 Genomic DNA. Translation: AAC39574.1.
BT007164 mRNA. Translation: AAP35828.1.
AL451065 Genomic DNA. No translation available.
CH471089 Genomic DNA. Translation: EAW62856.1.
BC000298 mRNA. Translation: AAH00298.1.
BC004440 mRNA. Translation: AAH04440.1.
BC019336 mRNA. Translation: AAH19336.2.
BC048212 mRNA. Translation: AAH48212.1.
CCDSiCCDS6703.1.
RefSeqiNP_004139.2. NM_004148.3.
UniGeneiHs.494457.

Genome annotation databases

EnsembliENST00000375446; ENSP00000364595; ENSG00000131669.
GeneIDi4814.
KEGGihsa:4814.
UCSCiuc004atg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiNINJ1_HUMAN
AccessioniPrimary (citable) accession number: Q92982
Secondary accession number(s): Q6GU89, Q8WUV5, Q9BT07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families