Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ninjurin-1

Gene

NINJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.

GO - Biological processi

  • cell adhesion Source: ProtInc
  • hyaloid vascular plexus regression Source: Ensembl
  • nervous system development Source: ProtInc
  • positive regulation of cell-matrix adhesion Source: Ensembl
  • tissue regeneration Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-1
Alternative name(s):
Nerve injury-induced protein 1
Gene namesi
Name:NINJ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:7824. NINJ1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8080ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Topological domaini102 – 12019CytoplasmicSequence analysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Topological domaini142 – 15211ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31631.

Polymorphism and mutation databases

BioMutaiNINJ1.
DMDMi317373398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Ninjurin-1PRO_0000159643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei21 – 211PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92982.
MaxQBiQ92982.
PaxDbiQ92982.
PeptideAtlasiQ92982.
PRIDEiQ92982.

Expressioni

Tissue specificityi

Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.

Inductioni

By nerve injury both in dorsal root ganglion neurons and in Schwann cells.

Gene expression databases

BgeeiQ92982.
CleanExiHS_NINJ1.
GenevisibleiQ92982. HS.

Organism-specific databases

HPAiHPA045063.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-2802124,EBI-10171697

Protein-protein interaction databases

BioGridi110879. 2 interactions.
IntActiQ92982. 17 interactions.
STRINGi9606.ENSP00000364595.

Structurei

3D structure databases

ProteinModelPortaliQ92982.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIJ. Eukaryota.
ENOG4111RPK. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ92982.
OMAiIFIVKWN.
OrthoDBiEOG7QK0F5.
PhylomeDBiQ92982.
TreeFamiTF323538.

Family and domain databases

InterProiIPR007007. Ninjurin.
IPR015639. Ninjurin1.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PTHR12316:SF19. PTHR12316:SF19. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSGTEEYEL NGGLPPGTPG SPDASPARWG WRHGPINVNH YASKKSAAES
60 70 80 90 100
MLDIALLMAN ASQLKAVVEQ GPSFAFYVPL VVLISISLVL QIGVGVLLIF
110 120 130 140 150
LVKYDLNNPA KHAKLDFLNN LATGLVFIIV VVNIFITAFG VQKPLMDMAP

QQ
Length:152
Mass (Da):16,345
Last modified:January 11, 2011 - v2
Checksum:iFEACA99450187855
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101A → D.3 Publications
Corresponds to variant rs2275848 [ dbSNP | Ensembl ].
VAR_025549

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72661 mRNA. Translation: AAB17560.1.
U91512 mRNA. Translation: AAC14593.1.
AF029251 Genomic DNA. Translation: AAC39574.1.
BT007164 mRNA. Translation: AAP35828.1.
AL451065 Genomic DNA. Translation: CAI95111.1.
CH471089 Genomic DNA. Translation: EAW62856.1.
BC000298 mRNA. Translation: AAH00298.1.
BC004440 mRNA. Translation: AAH04440.1.
BC019336 mRNA. Translation: AAH19336.2.
BC048212 mRNA. Translation: AAH48212.1.
CCDSiCCDS6703.1.
RefSeqiNP_004139.2. NM_004148.3.
UniGeneiHs.494457.

Genome annotation databases

EnsembliENST00000375446; ENSP00000364595; ENSG00000131669.
GeneIDi4814.
KEGGihsa:4814.
UCSCiuc004atg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72661 mRNA. Translation: AAB17560.1.
U91512 mRNA. Translation: AAC14593.1.
AF029251 Genomic DNA. Translation: AAC39574.1.
BT007164 mRNA. Translation: AAP35828.1.
AL451065 Genomic DNA. Translation: CAI95111.1.
CH471089 Genomic DNA. Translation: EAW62856.1.
BC000298 mRNA. Translation: AAH00298.1.
BC004440 mRNA. Translation: AAH04440.1.
BC019336 mRNA. Translation: AAH19336.2.
BC048212 mRNA. Translation: AAH48212.1.
CCDSiCCDS6703.1.
RefSeqiNP_004139.2. NM_004148.3.
UniGeneiHs.494457.

3D structure databases

ProteinModelPortaliQ92982.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110879. 2 interactions.
IntActiQ92982. 17 interactions.
STRINGi9606.ENSP00000364595.

Polymorphism and mutation databases

BioMutaiNINJ1.
DMDMi317373398.

Proteomic databases

EPDiQ92982.
MaxQBiQ92982.
PaxDbiQ92982.
PeptideAtlasiQ92982.
PRIDEiQ92982.

Protocols and materials databases

DNASUi4814.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375446; ENSP00000364595; ENSG00000131669.
GeneIDi4814.
KEGGihsa:4814.
UCSCiuc004atg.4. human.

Organism-specific databases

CTDi4814.
GeneCardsiNINJ1.
H-InvDBHIX0008176.
HGNCiHGNC:7824. NINJ1.
HPAiHPA045063.
MIMi602062. gene.
neXtProtiNX_Q92982.
PharmGKBiPA31631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWIJ. Eukaryota.
ENOG4111RPK. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ92982.
OMAiIFIVKWN.
OrthoDBiEOG7QK0F5.
PhylomeDBiQ92982.
TreeFamiTF323538.

Miscellaneous databases

ChiTaRSiNINJ1. human.
GeneWikiiNINJ1.
GenomeRNAii4814.
PROiQ92982.
SOURCEiSearch...

Gene expression databases

BgeeiQ92982.
CleanExiHS_NINJ1.
GenevisibleiQ92982. HS.

Family and domain databases

InterProiIPR007007. Ninjurin.
IPR015639. Ninjurin1.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PTHR12316:SF19. PTHR12316:SF19. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth."
    Araki T., Milbrandt J.
    Neuron 17:353-361(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-110.
  2. "The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI)."
    Chadwick B.P., Heath S.K., Williamson J., Obermayr F., Patel L., Sheer D., Frischauf A.-M.
    Genomics 47:58-63(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ASP-110.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-110.
    Tissue: Lung and Skin.
  7. "Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule."
    Araki T., Zimonjic D.B., Popescu N.C., Milbrandt J.
    J. Biol. Chem. 272:21373-21380(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNINJ1_HUMAN
AccessioniPrimary (citable) accession number: Q92982
Secondary accession number(s): Q6GU89, Q8WUV5, Q9BT07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.