Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transportin-1

Gene

TNPO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.By similarity4 Publications

GO - Molecular functioni

  • nuclear localization sequence binding Source: ProtInc
  • poly(A) RNA binding Source: UniProtKB
  • protein transporter activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083312-MONOMER.
ReactomeiR-HSA-450513. Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
R-HSA-5620924. Intraflagellar transport.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transportin-1
Alternative name(s):
Importin beta-2
Karyopherin beta-2
M9 region interaction protein
Short name:
MIP
Gene namesi
Name:TNPO1
Synonyms:KPNB2, MIP1, TRN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6401. TNPO1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nuclear membrane Source: GO_Central
  • nuclear periphery Source: GO_Central
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3842.
OpenTargetsiENSG00000083312.
PharmGKBiPA30192.

Polymorphism and mutation databases

BioMutaiTNPO1.
DMDMi259016171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207651 – 898Transportin-1Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q92973-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ92973.
MaxQBiQ92973.
PaxDbiQ92973.
PeptideAtlasiQ92973.
PRIDEiQ92973.

PTM databases

iPTMnetiQ92973.
PhosphoSitePlusiQ92973.
SwissPalmiQ92973.

Expressioni

Gene expression databases

BgeeiENSG00000083312.
CleanExiHS_TNPO1.
ExpressionAtlasiQ92973. baseline and differential.
GenevisibleiQ92973. HS.

Organism-specific databases

HPAiCAB016325.

Interactioni

Subunit structurei

Binds HNRPA1, HNRPA2, HNRNPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM 3 domain). Interacts with SNAI1 (via zinc fingers); the interaction mediates SNAI1 nuclear import. Interacts with SNAI2 (via zinc fingers).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629932EBI-286693,EBI-401755
RANP628262EBI-286693,EBI-286642

Protein-protein interaction databases

BioGridi110040. 72 interactors.
DIPiDIP-29335N.
IntActiQ92973. 39 interactors.
MINTiMINT-94165.
STRINGi9606.ENSP00000336712.

Structurei

Secondary structure

1898
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 30Combined sources14
Beta strandi31 – 33Combined sources3
Helixi35 – 48Combined sources14
Beta strandi49 – 51Combined sources3
Helixi52 – 63Combined sources12
Helixi70 – 83Combined sources14
Turni84 – 86Combined sources3
Helixi88 – 90Combined sources3
Helixi93 – 104Combined sources12
Turni105 – 108Combined sources4
Helixi112 – 128Combined sources17
Turni129 – 133Combined sources5
Beta strandi134 – 136Combined sources3
Helixi137 – 145Combined sources9
Helixi147 – 149Combined sources3
Helixi150 – 167Combined sources18
Helixi170 – 173Combined sources4
Beta strandi175 – 178Combined sources4
Helixi180 – 187Combined sources8
Turni188 – 192Combined sources5
Helixi196 – 207Combined sources12
Turni208 – 213Combined sources6
Helixi215 – 218Combined sources4
Helixi221 – 232Combined sources12
Helixi237 – 253Combined sources17
Helixi255 – 258Combined sources4
Helixi259 – 261Combined sources3
Helixi262 – 273Combined sources12
Beta strandi275 – 277Combined sources3
Helixi278 – 291Combined sources14
Beta strandi294 – 296Combined sources3
Helixi297 – 301Combined sources5
Turni302 – 304Combined sources3
Helixi305 – 315Combined sources11
Helixi320 – 327Combined sources8
Helixi340 – 342Combined sources3
Helixi367 – 370Combined sources4
Helixi383 – 398Combined sources16
Helixi399 – 402Combined sources4
Helixi403 – 414Combined sources12
Beta strandi416 – 418Combined sources3
Helixi419 – 431Combined sources13
Turni432 – 436Combined sources5
Helixi437 – 440Combined sources4
Helixi441 – 443Combined sources3
Helixi444 – 454Combined sources11
Helixi460 – 472Combined sources13
Helixi474 – 479Combined sources6
Turni482 – 485Combined sources4
Helixi486 – 497Combined sources12
Beta strandi498 – 500Combined sources3
Helixi502 – 519Combined sources18
Helixi520 – 526Combined sources7
Helixi527 – 540Combined sources14
Helixi543 – 560Combined sources18
Helixi561 – 564Combined sources4
Helixi567 – 583Combined sources17
Helixi591 – 605Combined sources15
Helixi606 – 612Combined sources7
Helixi613 – 636Combined sources24
Turni638 – 640Combined sources3
Helixi647 – 663Combined sources17
Helixi664 – 667Combined sources4
Helixi668 – 672Combined sources5
Helixi676 – 683Combined sources8
Helixi689 – 705Combined sources17
Helixi707 – 709Combined sources3
Helixi711 – 713Combined sources3
Helixi714 – 723Combined sources10
Helixi727 – 729Combined sources3
Helixi730 – 747Combined sources18
Helixi748 – 755Combined sources8
Helixi756 – 766Combined sources11
Beta strandi768 – 770Combined sources3
Helixi773 – 789Combined sources17
Helixi791 – 794Combined sources4
Helixi795 – 797Combined sources3
Helixi798 – 810Combined sources13
Helixi816 – 831Combined sources16
Helixi833 – 835Combined sources3
Helixi837 – 839Combined sources3
Helixi840 – 848Combined sources9
Helixi855 – 880Combined sources26
Helixi881 – 883Combined sources3
Helixi886 – 894Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QBKX-ray3.00B9-898[»]
2H4MX-ray3.05A/B376-898[»]
A/B9-343[»]
2OT8X-ray3.10A/B9-331[»]
A/B375-898[»]
2QMRX-ray3.00A/B/C/D9-898[»]
2Z5JX-ray3.40A9-898[»]
2Z5KX-ray2.60A9-898[»]
2Z5MX-ray3.00A9-898[»]
2Z5NX-ray3.20A9-898[»]
2Z5OX-ray3.20A9-898[»]
4FDDX-ray2.30A9-331[»]
A375-898[»]
4FQ3X-ray3.00A9-898[»]
4JLQX-ray3.05A9-331[»]
A375-898[»]
4OO6X-ray2.70A375-898[»]
A9-331[»]
5J3VX-ray3.05A/B9-331[»]
A/B375-898[»]
ProteinModelPortaliQ92973.
SMRiQ92973.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92973.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 46HEAT 11 PublicationAdd BLAST28
Domaini41 – 109Importin N-terminalPROSITE-ProRule annotationAdd BLAST69
Repeati51 – 89HEAT 21 PublicationAdd BLAST39
Repeati98 – 131HEAT 31 PublicationAdd BLAST34
Repeati137 – 174HEAT 41 PublicationAdd BLAST38
Repeati181 – 211HEAT 51 PublicationAdd BLAST31
Repeati224 – 251HEAT 61 PublicationAdd BLAST28
Repeati263 – 290HEAT 71 PublicationAdd BLAST28
Repeati306 – 397HEAT 81 PublicationAdd BLAST92
Repeati405 – 433HEAT 91 PublicationAdd BLAST29
Repeati445 – 472HEAT 101 PublicationAdd BLAST28
Repeati486 – 519HEAT 111 PublicationAdd BLAST34
Repeati527 – 560HEAT 121 PublicationAdd BLAST34
Repeati568 – 606HEAT 131 PublicationAdd BLAST39
Repeati614 – 665HEAT 141 PublicationAdd BLAST52
Repeati676 – 707HEAT 151 PublicationAdd BLAST32
Repeati715 – 748HEAT 161 PublicationAdd BLAST34
Repeati756 – 791HEAT 171 PublicationAdd BLAST36
Repeati799 – 832HEAT 181 PublicationAdd BLAST34
Repeati841 – 872HEAT 191 PublicationAdd BLAST32
Repeati875 – 895HEAT 201 PublicationAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi358 – 376Asp/Glu-rich (acidic)Add BLAST19

Sequence similaritiesi

Contains 20 HEAT repeats.1 Publication
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2023. Eukaryota.
ENOG410XPK2. LUCA.
GeneTreeiENSGT00550000074720.
HOGENOMiHOG000203940.
HOVERGENiHBG058963.
InParanoidiQ92973.
KOiK18752.
OMAiTHTIKSG.
OrthoDBiEOG091G01O2.
PhylomeDBiQ92973.
TreeFamiTF300825.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92973-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ
60 70 80 90 100
YPDFNNYLIF VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK
110 120 130 140 150
SECLNNIGDS SPLIRATVGI LITTIASKGE LQNWPDLLPK LCSLLDSEDY
160 170 180 190 200
NTCEGAFGAL QKICEDSAEI LDSDVLDRPL NIMIPKFLQF FKHSSPKIRS
210 220 230 240 250
HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR KNVCRALVML
260 270 280 290 300
LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV
310 320 330 340 350
LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS
360 370 380 390 400
RTVAQQHDED GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD
410 420 430 440 450
ELLPHILPLL KELLFHHEWV VKESGILVLG AIAEGCMQGM IPYLPELIPH
460 470 480 490 500
LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ PPDTYLKPLM TELLKRILDS
510 520 530 540 550
NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK YQHKNLLILY
560 570 580 590 600
DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS
610 620 630 640 650
VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI
660 670 680 690 700
VALDLLSGLA EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG
710 720 730 740 750
DLTKACFQHV KPCIADFMPI LGTNLNPEFI SVCNNATWAI GEISIQMGIE
760 770 780 790 800
MQPYIPMVLH QLVEIINRPN TPKTLLENTA ITIGRLGYVC PQEVAPMLQQ
810 820 830 840 850
FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF IFFCDAVASW
860 870 880 890
INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV
Length:898
Mass (Da):102,355
Last modified:September 22, 2009 - v2
Checksum:i7B880D9E7CA6798F
GO
Isoform 2 (identifier: Q92973-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVWDRQTKM → M

Show »
Length:890
Mass (Da):101,310
Checksum:i4762DB4895472D10
GO
Isoform 3 (identifier: Q92973-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-118: Missing.

Show »
Length:848
Mass (Da):96,901
Checksum:i6DF034D06DC572B4
GO

Sequence cautioni

The sequence AAC50723 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH40340 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104L → S in AAB68948 (Ref. 3) Curated1
Sequence conflicti225I → T in AAC50723 (PubMed:8808633).Curated1
Sequence conflicti669Q → L in AAB68948 (Ref. 3) Curated1
Sequence conflicti880F → L in BAG62638 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01445534D → E.Corresponds to variant rs25661dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380281 – 9MVWDRQTKM → M in isoform 2. 2 Publications9
Alternative sequenceiVSP_03802969 – 118Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70322 mRNA. Translation: AAC50723.1. Different initiation.
U72069 mRNA. Translation: AAB58254.1.
U72395 mRNA. Translation: AAB68948.1.
AK301021 mRNA. Translation: BAG62638.1.
BC040340 mRNA. Translation: AAH40340.1. Different initiation.
CCDSiCCDS4016.1. [Q92973-2]
CCDS43329.1. [Q92973-1]
RefSeqiNP_002261.3. NM_002270.3. [Q92973-1]
NP_694858.1. NM_153188.2. [Q92973-2]
XP_005248557.1. XM_005248500.2. [Q92973-2]
UniGeneiHs.482497.

Genome annotation databases

EnsembliENST00000337273; ENSP00000336712; ENSG00000083312. [Q92973-1]
ENST00000506351; ENSP00000425118; ENSG00000083312. [Q92973-2]
ENST00000523768; ENSP00000428899; ENSG00000083312. [Q92973-3]
GeneIDi3842.
KEGGihsa:3842.
UCSCiuc003kci.5. human. [Q92973-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70322 mRNA. Translation: AAC50723.1. Different initiation.
U72069 mRNA. Translation: AAB58254.1.
U72395 mRNA. Translation: AAB68948.1.
AK301021 mRNA. Translation: BAG62638.1.
BC040340 mRNA. Translation: AAH40340.1. Different initiation.
CCDSiCCDS4016.1. [Q92973-2]
CCDS43329.1. [Q92973-1]
RefSeqiNP_002261.3. NM_002270.3. [Q92973-1]
NP_694858.1. NM_153188.2. [Q92973-2]
XP_005248557.1. XM_005248500.2. [Q92973-2]
UniGeneiHs.482497.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QBKX-ray3.00B9-898[»]
2H4MX-ray3.05A/B376-898[»]
A/B9-343[»]
2OT8X-ray3.10A/B9-331[»]
A/B375-898[»]
2QMRX-ray3.00A/B/C/D9-898[»]
2Z5JX-ray3.40A9-898[»]
2Z5KX-ray2.60A9-898[»]
2Z5MX-ray3.00A9-898[»]
2Z5NX-ray3.20A9-898[»]
2Z5OX-ray3.20A9-898[»]
4FDDX-ray2.30A9-331[»]
A375-898[»]
4FQ3X-ray3.00A9-898[»]
4JLQX-ray3.05A9-331[»]
A375-898[»]
4OO6X-ray2.70A375-898[»]
A9-331[»]
5J3VX-ray3.05A/B9-331[»]
A/B375-898[»]
ProteinModelPortaliQ92973.
SMRiQ92973.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110040. 72 interactors.
DIPiDIP-29335N.
IntActiQ92973. 39 interactors.
MINTiMINT-94165.
STRINGi9606.ENSP00000336712.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ92973.
PhosphoSitePlusiQ92973.
SwissPalmiQ92973.

Polymorphism and mutation databases

BioMutaiTNPO1.
DMDMi259016171.

Proteomic databases

EPDiQ92973.
MaxQBiQ92973.
PaxDbiQ92973.
PeptideAtlasiQ92973.
PRIDEiQ92973.

Protocols and materials databases

DNASUi3842.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337273; ENSP00000336712; ENSG00000083312. [Q92973-1]
ENST00000506351; ENSP00000425118; ENSG00000083312. [Q92973-2]
ENST00000523768; ENSP00000428899; ENSG00000083312. [Q92973-3]
GeneIDi3842.
KEGGihsa:3842.
UCSCiuc003kci.5. human. [Q92973-1]

Organism-specific databases

CTDi3842.
DisGeNETi3842.
GeneCardsiTNPO1.
HGNCiHGNC:6401. TNPO1.
HPAiCAB016325.
MIMi602901. gene.
neXtProtiNX_Q92973.
OpenTargetsiENSG00000083312.
PharmGKBiPA30192.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2023. Eukaryota.
ENOG410XPK2. LUCA.
GeneTreeiENSGT00550000074720.
HOGENOMiHOG000203940.
HOVERGENiHBG058963.
InParanoidiQ92973.
KOiK18752.
OMAiTHTIKSG.
OrthoDBiEOG091G01O2.
PhylomeDBiQ92973.
TreeFamiTF300825.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083312-MONOMER.
ReactomeiR-HSA-450513. Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
R-HSA-5620924. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiTNPO1. human.
EvolutionaryTraceiQ92973.
GeneWikiiTransportin_1.
GenomeRNAii3842.
PROiQ92973.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000083312.
CleanExiHS_TNPO1.
ExpressionAtlasiQ92973. baseline and differential.
GenevisibleiQ92973. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNPO1_HUMAN
AccessioniPrimary (citable) accession number: Q92973
Secondary accession number(s): B4DVC6, Q92957, Q92975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.