ID   SNPC3_HUMAN             Reviewed;         411 AA.
AC   Q92966; D3DRI8; Q2VPI6; Q5T285;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 178.
DE   RecName: Full=snRNA-activating protein complex subunit 3;
DE            Short=SNAPc subunit 3;
DE   AltName: Full=Proximal sequence element-binding transcription factor subunit beta;
DE            Short=PSE-binding factor subunit beta;
DE            Short=PTF subunit beta;
DE   AltName: Full=Small nuclear RNA-activating complex polypeptide 3;
DE   AltName: Full=snRNA-activating protein complex 50 kDa subunit;
DE            Short=SNAPc 50 kDa subunit;
GN   Name=SNAPC3; Synonyms=SNAP50;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Teratocarcinoma;
RX   PubMed=9003788; DOI=10.1002/j.1460-2075.1996.tb01104.x;
RA   Henry R.W., Ma B., Sadowski C.L., Kobayashi R., Hernandez N.;
RT   "Cloning and characterization of SNAP50, a subunit of the snRNA-activating
RT   protein complex SNAPc.";
RL   EMBO J. 15:7129-7136(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8816454; DOI=10.1128/mcb.16.10.5419;
RA   Bai L., Wang Z., Yoon J.B., Roeder R.G.;
RT   "Cloning and characterization of the beta subunit of human proximal
RT   sequence element-binding transcription factor and its involvement in
RT   transcription of small nuclear RNA genes by RNA polymerases II and III.";
RL   Mol. Cell. Biol. 16:5419-5426(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INTERACTION WITH SNAPC1.
RX   PubMed=11056176; DOI=10.1074/jbc.m009301200;
RA   Ma B., Hernandez N.;
RT   "A map of protein-protein contacts within the small nuclear RNA-activating
RT   protein complex SNAPc.";
RL   J. Biol. Chem. 276:5027-5035(2001).
RN   [7]
RP   FUNCTION, AND INTERACTION WITH SNAPC1.
RX   PubMed=12621023; DOI=10.1074/jbc.m204247200;
RA   Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.;
RT   "The small nuclear RNA-activating protein 190 Myb DNA binding domain
RT   stimulates TATA box-binding protein-TATA box recognition.";
RL   J. Biol. Chem. 278:18649-18657(2003).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic kidney;
RX   PubMed=17525332; DOI=10.1126/science.1140321;
RA   Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA   Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA   Gygi S.P., Elledge S.J.;
RT   "ATM and ATR substrate analysis reveals extensive protein networks
RT   responsive to DNA damage.";
RL   Science 316:1160-1166(2007).
CC   -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC       both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC       proximal sequence element (PSE), a non-TATA-box basal promoter element
CC       common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC       TATA box. {ECO:0000269|PubMed:12621023}.
CC   -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC       SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
CC       {ECO:0000269|PubMed:11056176, ECO:0000269|PubMed:12621023}.
CC   -!- INTERACTION:
CC       Q92966; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-1760638, EBI-1104570;
CC       Q92966; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-1760638, EBI-10181988;
CC       Q92966; Q9BPX1: HSD17B14; NbExp=4; IntAct=EBI-1760638, EBI-742664;
CC       Q92966; P04792: HSPB1; NbExp=3; IntAct=EBI-1760638, EBI-352682;
CC       Q92966; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-1760638, EBI-715394;
CC       Q92966; O60333-2: KIF1B; NbExp=3; IntAct=EBI-1760638, EBI-10975473;
CC       Q92966; I6L9F6: NEFL; NbExp=3; IntAct=EBI-1760638, EBI-10178578;
CC       Q92966; Q8NI38: NFKBID; NbExp=6; IntAct=EBI-1760638, EBI-10271199;
CC       Q92966; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-1760638, EBI-396669;
CC       Q92966; Q16533: SNAPC1; NbExp=4; IntAct=EBI-1760638, EBI-11915024;
CC       Q92966; Q16560-2: SNRNP35; NbExp=3; IntAct=EBI-1760638, EBI-12938570;
CC       Q92966; O95801: TTC4; NbExp=3; IntAct=EBI-1760638, EBI-1050890;
CC       Q92966; Q05086-3: UBE3A; NbExp=3; IntAct=EBI-1760638, EBI-11026619;
CC       Q92966; O76024: WFS1; NbExp=3; IntAct=EBI-1760638, EBI-720609;
CC       Q92966; Q6ZNG0: ZNF620; NbExp=3; IntAct=EBI-1760638, EBI-4395669;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the SNAPC3/SRD2 family. {ECO:0000305}.
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DR   EMBL; U71300; AAC50948.1; -; mRNA.
DR   EMBL; U66413; AAD09214.1; -; mRNA.
DR   EMBL; AL441925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58681.1; -; Genomic_DNA.
DR   EMBL; CH471071; EAW58682.1; -; Genomic_DNA.
DR   EMBL; BC014985; AAH14985.1; -; mRNA.
DR   EMBL; BC108743; AAI08744.1; -; mRNA.
DR   EMBL; BC121011; AAI21012.1; -; mRNA.
DR   EMBL; BC121012; AAI21013.1; -; mRNA.
DR   CCDS; CCDS6478.1; -.
DR   RefSeq; NP_001034786.1; NM_001039697.1.
DR   RefSeq; XP_016870545.1; XM_017015056.1.
DR   RefSeq; XP_016870546.1; XM_017015057.1.
DR   PDB; 7XUR; EM; 3.49 A; B=1-411.
DR   PDB; 7ZWC; EM; 3.20 A; b=1-411.
DR   PDB; 7ZWD; EM; 3.00 A; b=1-411.
DR   PDB; 7ZX7; EM; 3.40 A; b=1-411.
DR   PDB; 7ZX8; EM; 3.00 A; b=1-411.
DR   PDB; 7ZXE; EM; 3.50 A; b=1-411.
DR   PDB; 8ITY; EM; 3.90 A; 3=1-411.
DR   PDB; 8IUE; EM; 4.10 A; 3=1-411.
DR   PDB; 8IUH; EM; 3.40 A; 3=1-411.
DR   PDBsum; 7XUR; -.
DR   PDBsum; 7ZWC; -.
DR   PDBsum; 7ZWD; -.
DR   PDBsum; 7ZX7; -.
DR   PDBsum; 7ZX8; -.
DR   PDBsum; 7ZXE; -.
DR   PDBsum; 8ITY; -.
DR   PDBsum; 8IUE; -.
DR   PDBsum; 8IUH; -.
DR   AlphaFoldDB; Q92966; -.
DR   EMDB; EMD-14996; -.
DR   EMDB; EMD-14997; -.
DR   EMDB; EMD-15006; -.
DR   EMDB; EMD-15007; -.
DR   EMDB; EMD-15009; -.
DR   EMDB; EMD-33477; -.
DR   EMDB; EMD-35712; -.
DR   EMDB; EMD-35719; -.
DR   EMDB; EMD-35722; -.
DR   SMR; Q92966; -.
DR   BioGRID; 112503; 25.
DR   CORUM; Q92966; -.
DR   IntAct; Q92966; 20.
DR   MINT; Q92966; -.
DR   STRING; 9606.ENSP00000370200; -.
DR   iPTMnet; Q92966; -.
DR   PhosphoSitePlus; Q92966; -.
DR   BioMuta; SNAPC3; -.
DR   DMDM; 8134719; -.
DR   EPD; Q92966; -.
DR   jPOST; Q92966; -.
DR   MassIVE; Q92966; -.
DR   MaxQB; Q92966; -.
DR   PaxDb; 9606-ENSP00000370200; -.
DR   PeptideAtlas; Q92966; -.
DR   ProteomicsDB; 75633; -.
DR   Pumba; Q92966; -.
DR   Antibodypedia; 10045; 162 antibodies from 23 providers.
DR   DNASU; 6619; -.
DR   Ensembl; ENST00000380821.8; ENSP00000370200.3; ENSG00000164975.16.
DR   Ensembl; ENST00000467062.5; ENSP00000436699.1; ENSG00000164975.16.
DR   Ensembl; ENST00000490969.5; ENSP00000432393.1; ENSG00000164975.16.
DR   Ensembl; ENST00000610884.4; ENSP00000483273.1; ENSG00000164975.16.
DR   GeneID; 6619; -.
DR   KEGG; hsa:6619; -.
DR   MANE-Select; ENST00000380821.8; ENSP00000370200.3; NM_001039697.2; NP_001034786.1.
DR   UCSC; uc003zlt.4; human.
DR   AGR; HGNC:11136; -.
DR   CTD; 6619; -.
DR   DisGeNET; 6619; -.
DR   GeneCards; SNAPC3; -.
DR   HGNC; HGNC:11136; SNAPC3.
DR   HPA; ENSG00000164975; Low tissue specificity.
DR   MIM; 602348; gene.
DR   neXtProt; NX_Q92966; -.
DR   OpenTargets; ENSG00000164975; -.
DR   PharmGKB; PA35984; -.
DR   VEuPathDB; HostDB:ENSG00000164975; -.
DR   eggNOG; KOG2664; Eukaryota.
DR   GeneTree; ENSGT00390000005708; -.
DR   HOGENOM; CLU_041861_0_1_1; -.
DR   InParanoid; Q92966; -.
DR   OMA; VHRDDCL; -.
DR   OrthoDB; 978987at2759; -.
DR   PhylomeDB; Q92966; -.
DR   TreeFam; TF317705; -.
DR   PathwayCommons; Q92966; -.
DR   Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
DR   Reactome; R-HSA-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR   SignaLink; Q92966; -.
DR   BioGRID-ORCS; 6619; 766 hits in 1170 CRISPR screens.
DR   ChiTaRS; SNAPC3; human.
DR   GeneWiki; SNAPC3; -.
DR   GenomeRNAi; 6619; -.
DR   Pharos; Q92966; Tbio.
DR   PRO; PR:Q92966; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q92966; Protein.
DR   Bgee; ENSG00000164975; Expressed in ganglionic eminence and 204 other cell types or tissues.
DR   ExpressionAtlas; Q92966; baseline and differential.
DR   GO; GO:0016604; C:nuclear body; IDA:HPA.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR   GO; GO:0019185; C:snRNA-activating protein complex; IBA:GO_Central.
DR   GO; GO:0003681; F:bent DNA binding; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR   GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; NAS:ARUK-UCL.
DR   GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009301; P:snRNA transcription; TAS:ProtInc.
DR   GO; GO:0042795; P:snRNA transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0042796; P:snRNA transcription by RNA polymerase III; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; TAS:ProtInc.
DR   InterPro; IPR022042; snRNA-activating_su3.
DR   PANTHER; PTHR13421; SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3; 1.
DR   PANTHER; PTHR13421:SF16; SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3; 1.
DR   Pfam; PF12251; SNAPC3; 1.
DR   Genevisible; Q92966; HS.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..411
FT                   /note="snRNA-activating protein complex subunit 3"
FT                   /id="PRO_0000072024"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         398
FT                   /note="E -> A (in dbSNP:rs3087653)"
FT                   /id="VAR_051366"
FT   STRAND          32..37
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           44..54
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   TURN            55..57
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           77..90
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           94..103
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   TURN            106..108
FT                   /evidence="ECO:0007829|PDB:8IUH"
FT   HELIX           128..143
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           151..160
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          162..165
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          169..173
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          181..187
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           193..196
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          201..206
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   TURN            212..218
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           222..225
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           243..246
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          250..253
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          255..260
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          263..267
FT                   /evidence="ECO:0007829|PDB:7XUR"
FT   HELIX           271..279
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          289..291
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          293..295
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           298..300
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          309..313
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   TURN            314..316
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          317..327
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          331..333
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          337..339
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          341..345
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   TURN            355..357
FT                   /evidence="ECO:0007829|PDB:8IUH"
FT   STRAND          358..361
FT                   /evidence="ECO:0007829|PDB:8IUH"
FT   STRAND          363..368
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          373..379
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   HELIX           381..388
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          389..393
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   STRAND          395..398
FT                   /evidence="ECO:0007829|PDB:7XUR"
FT   STRAND          400..403
FT                   /evidence="ECO:0007829|PDB:7ZWC"
FT   TURN            407..409
FT                   /evidence="ECO:0007829|PDB:7ZWC"
SQ   SEQUENCE   411 AA;  46753 MW;  920584BE4CFA366A CRC64;
     MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL WRGRLRGAGD
     LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL RAVCGLDKLK CLEDGEDPEV
     IPENTDLVTL GVRKRFLEHR EETITIDRAC RQETFVYEME SHAIGKKPEN SADMIEEGEL
     ILSVNILYPV IFHKHKEHKP YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE
     HISKDLYKSA FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND
     LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW TRKCFVCKMY
     TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL AYPYVDPGTF N
//