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Q92966

- SNPC3_HUMAN

UniProt

Q92966 - SNPC3_HUMAN

Protein

snRNA-activating protein complex subunit 3

Gene

SNAPC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: ProtInc

    GO - Biological processi

    1. gene expression Source: Reactome
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. snRNA transcription Source: ProtInc
    4. transcription from RNA polymerase III promoter Source: Reactome
    5. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    snRNA-activating protein complex subunit 3
    Short name:
    SNAPc subunit 3
    Alternative name(s):
    Proximal sequence element-binding transcription factor subunit beta
    Short name:
    PSE-binding factor subunit beta
    Short name:
    PTF subunit beta
    Small nuclear RNA-activating complex polypeptide 3
    snRNA-activating protein complex 50 kDa subunit
    Short name:
    SNAPc 50 kDa subunit
    Gene namesi
    Name:SNAPC3
    Synonyms:SNAP50
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:11136. SNAPC3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: HPA
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35984.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411snRNA-activating protein complex subunit 3PRO_0000072024Add
    BLAST

    Proteomic databases

    MaxQBiQ92966.
    PaxDbiQ92966.
    PRIDEiQ92966.

    PTM databases

    PhosphoSiteiQ92966.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92966.
    BgeeiQ92966.
    CleanExiHS_SNAPC3.
    GenevestigatoriQ92966.

    Organism-specific databases

    HPAiHPA053145.

    Interactioni

    Subunit structurei

    Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.2 Publications

    Protein-protein interaction databases

    BioGridi112503. 5 interactions.
    IntActiQ92966. 3 interactions.
    STRINGi9606.ENSP00000370191.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92966.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SNAPC3/SRD2 family.Curated

    Phylogenomic databases

    eggNOGiNOG312262.
    HOGENOMiHOG000146435.
    HOVERGENiHBG071400.
    InParanoidiQ92966.
    KOiK15210.
    OMAiNIFYPVI.
    OrthoDBiEOG73RBB7.
    PhylomeDBiQ92966.
    TreeFamiTF317705.

    Family and domain databases

    InterProiIPR022042. snRNA-activating_su3.
    [Graphical view]
    PANTHERiPTHR13421. PTHR13421. 1 hit.
    PfamiPF12251. zf-SNAP50_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92966-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL    50
    WRGRLRGAGD LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL 100
    RAVCGLDKLK CLEDGEDPEV IPENTDLVTL GVRKRFLEHR EETITIDRAC 150
    RQETFVYEME SHAIGKKPEN SADMIEEGEL ILSVNILYPV IFHKHKEHKP 200
    YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE HISKDLYKSA 250
    FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND 300
    LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW 350
    TRKCFVCKMY TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL 400
    AYPYVDPGTF N 411
    Length:411
    Mass (Da):46,753
    Last modified:February 1, 1997 - v1
    Checksum:i920584BE4CFA366A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti398 – 3981E → A.
    Corresponds to variant rs3087653 [ dbSNP | Ensembl ].
    VAR_051366

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U71300 mRNA. Translation: AAC50948.1.
    U66413 mRNA. Translation: AAD09214.1.
    AL441925 Genomic DNA. Translation: CAI13285.1.
    CH471071 Genomic DNA. Translation: EAW58681.1.
    CH471071 Genomic DNA. Translation: EAW58682.1.
    BC014985 mRNA. Translation: AAH14985.1.
    BC108743 mRNA. Translation: AAI08744.1.
    BC121011 mRNA. Translation: AAI21012.1.
    BC121012 mRNA. Translation: AAI21013.1.
    CCDSiCCDS6478.1.
    RefSeqiNP_001034786.1. NM_001039697.1.
    UniGeneiHs.546299.

    Genome annotation databases

    EnsembliENST00000380821; ENSP00000370200; ENSG00000164975.
    ENST00000467062; ENSP00000436699; ENSG00000164975.
    ENST00000490969; ENSP00000432393; ENSG00000164975.
    GeneIDi6619.
    KEGGihsa:6619.
    UCSCiuc003zlt.3. human.

    Polymorphism databases

    DMDMi8134719.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U71300 mRNA. Translation: AAC50948.1 .
    U66413 mRNA. Translation: AAD09214.1 .
    AL441925 Genomic DNA. Translation: CAI13285.1 .
    CH471071 Genomic DNA. Translation: EAW58681.1 .
    CH471071 Genomic DNA. Translation: EAW58682.1 .
    BC014985 mRNA. Translation: AAH14985.1 .
    BC108743 mRNA. Translation: AAI08744.1 .
    BC121011 mRNA. Translation: AAI21012.1 .
    BC121012 mRNA. Translation: AAI21013.1 .
    CCDSi CCDS6478.1.
    RefSeqi NP_001034786.1. NM_001039697.1.
    UniGenei Hs.546299.

    3D structure databases

    ProteinModelPortali Q92966.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112503. 5 interactions.
    IntActi Q92966. 3 interactions.
    STRINGi 9606.ENSP00000370191.

    PTM databases

    PhosphoSitei Q92966.

    Polymorphism databases

    DMDMi 8134719.

    Proteomic databases

    MaxQBi Q92966.
    PaxDbi Q92966.
    PRIDEi Q92966.

    Protocols and materials databases

    DNASUi 6619.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380821 ; ENSP00000370200 ; ENSG00000164975 .
    ENST00000467062 ; ENSP00000436699 ; ENSG00000164975 .
    ENST00000490969 ; ENSP00000432393 ; ENSG00000164975 .
    GeneIDi 6619.
    KEGGi hsa:6619.
    UCSCi uc003zlt.3. human.

    Organism-specific databases

    CTDi 6619.
    GeneCardsi GC09P015412.
    HGNCi HGNC:11136. SNAPC3.
    HPAi HPA053145.
    MIMi 602348. gene.
    neXtProti NX_Q92966.
    PharmGKBi PA35984.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312262.
    HOGENOMi HOG000146435.
    HOVERGENi HBG071400.
    InParanoidi Q92966.
    KOi K15210.
    OMAi NIFYPVI.
    OrthoDBi EOG73RBB7.
    PhylomeDBi Q92966.
    TreeFami TF317705.

    Enzyme and pathway databases

    Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

    Miscellaneous databases

    ChiTaRSi SNAPC3. human.
    GeneWikii SNAPC3.
    GenomeRNAii 6619.
    NextBioi 25775.
    PROi Q92966.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92966.
    Bgeei Q92966.
    CleanExi HS_SNAPC3.
    Genevestigatori Q92966.

    Family and domain databases

    InterProi IPR022042. snRNA-activating_su3.
    [Graphical view ]
    PANTHERi PTHR13421. PTHR13421. 1 hit.
    Pfami PF12251. zf-SNAP50_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc."
      Henry R.W., Ma B., Sadowski C.L., Kobayashi R., Hernandez N.
      EMBO J. 15:7129-7136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Teratocarcinoma.
    2. "Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III."
      Bai L., Wang Z., Yoon J.B., Roeder R.G.
      Mol. Cell. Biol. 16:5419-5426(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc."
      Ma B., Hernandez N.
      J. Biol. Chem. 276:5027-5035(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNAPC1.
    7. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
      Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
      J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SNAPC1.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.

    Entry informationi

    Entry nameiSNPC3_HUMAN
    AccessioniPrimary (citable) accession number: Q92966
    Secondary accession number(s): D3DRI8, Q2VPI6, Q5T285
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3