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Protein

snRNA-activating protein complex subunit 3

Gene

SNAPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • snRNA transcription Source: ProtInc
  • snRNA transcription by RNA polymerase II Source: Reactome
  • transcription by RNA polymerase II Source: ProtInc
  • transcription by RNA polymerase III Source: ProtInc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 3
Short name:
SNAPc subunit 3
Alternative name(s):
Proximal sequence element-binding transcription factor subunit beta
Short name:
PSE-binding factor subunit beta
Short name:
PTF subunit beta
Small nuclear RNA-activating complex polypeptide 3
snRNA-activating protein complex 50 kDa subunit
Short name:
SNAPc 50 kDa subunit
Gene namesi
Name:SNAPC3
Synonyms:SNAP50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000164975.15
HGNCiHGNC:11136 SNAPC3
MIMi602348 gene
neXtProtiNX_Q92966

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164975
PharmGKBiPA35984

Polymorphism and mutation databases

BioMutaiSNAPC3
DMDMi8134719

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720241 – 411snRNA-activating protein complex subunit 3Add BLAST411

Proteomic databases

EPDiQ92966
MaxQBiQ92966
PaxDbiQ92966
PeptideAtlasiQ92966
PRIDEiQ92966

PTM databases

iPTMnetiQ92966
PhosphoSitePlusiQ92966

Expressioni

Gene expression databases

BgeeiENSG00000164975
CleanExiHS_SNAPC3
ExpressionAtlasiQ92966 baseline and differential
GenevisibleiQ92966 HS

Organism-specific databases

HPAiHPA053145
HPA066031

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112503, 8 interactors
CORUMiQ92966
IntActiQ92966, 10 interactors
MINTiQ92966
STRINGi9606.ENSP00000370200

Structurei

3D structure databases

ProteinModelPortaliQ92966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAPC3/SRD2 family.Curated

Phylogenomic databases

eggNOGiKOG2664 Eukaryota
ENOG411090A LUCA
GeneTreeiENSGT00390000005708
HOGENOMiHOG000146435
HOVERGENiHBG071400
InParanoidiQ92966
KOiK15210
OMAiQTAKMED
OrthoDBiEOG091G0BC6
PhylomeDBiQ92966
TreeFamiTF317705

Family and domain databases

InterProiView protein in InterPro
IPR022042 snRNA-activating_su3
PANTHERiPTHR13421 PTHR13421, 1 hit
PfamiView protein in Pfam
PF12251 zf-SNAP50_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q92966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL
60 70 80 90 100
WRGRLRGAGD LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL
110 120 130 140 150
RAVCGLDKLK CLEDGEDPEV IPENTDLVTL GVRKRFLEHR EETITIDRAC
160 170 180 190 200
RQETFVYEME SHAIGKKPEN SADMIEEGEL ILSVNILYPV IFHKHKEHKP
210 220 230 240 250
YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE HISKDLYKSA
260 270 280 290 300
FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND
310 320 330 340 350
LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW
360 370 380 390 400
TRKCFVCKMY TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL
410
AYPYVDPGTF N
Length:411
Mass (Da):46,753
Last modified:February 1, 1997 - v1
Checksum:i920584BE4CFA366A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051366398E → A. Corresponds to variant dbSNP:rs3087653Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71300 mRNA Translation: AAC50948.1
U66413 mRNA Translation: AAD09214.1
AL441925 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58681.1
CH471071 Genomic DNA Translation: EAW58682.1
BC014985 mRNA Translation: AAH14985.1
BC108743 mRNA Translation: AAI08744.1
BC121011 mRNA Translation: AAI21012.1
BC121012 mRNA Translation: AAI21013.1
CCDSiCCDS6478.1
RefSeqiNP_001034786.1, NM_001039697.1
XP_016870545.1, XM_017015056.1
XP_016870546.1, XM_017015057.1
UniGeneiHs.546299

Genome annotation databases

EnsembliENST00000380821; ENSP00000370200; ENSG00000164975
ENST00000467062; ENSP00000436699; ENSG00000164975
ENST00000490969; ENSP00000432393; ENSG00000164975
ENST00000610884; ENSP00000483273; ENSG00000164975
GeneIDi6619
KEGGihsa:6619
UCSCiuc003zlt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNPC3_HUMAN
AccessioniPrimary (citable) accession number: Q92966
Secondary accession number(s): D3DRI8, Q2VPI6, Q5T285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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