Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92966 (SNPC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
snRNA-activating protein complex subunit 3

Short name=SNAPc subunit 3
Alternative name(s):
Proximal sequence element-binding transcription factor subunit beta
Short name=PSE-binding factor subunit beta
Short name=PTF subunit beta
Small nuclear RNA-activating complex polypeptide 3
snRNA-activating protein complex 50 kDa subunit
Short name=SNAPc 50 kDa subunit
Gene names
Name:SNAPC3
Synonyms:SNAP50
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. Ref.7

Subunit structure

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1. Ref.6 Ref.7

Subcellular location

Nucleus.

Sequence similarities

Belongs to the SNAPC3/SRD2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411snRNA-activating protein complex subunit 3
PRO_0000072024

Natural variations

Natural variant3981E → A.
Corresponds to variant rs3087653 [ dbSNP | Ensembl ].
VAR_051366

Sequences

Sequence LengthMass (Da)Tools
Q92966 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 920584BE4CFA366A

FASTA41146,753
        10         20         30         40         50         60 
MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL WRGRLRGAGD 

        70         80         90        100        110        120 
LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL RAVCGLDKLK CLEDGEDPEV 

       130        140        150        160        170        180 
IPENTDLVTL GVRKRFLEHR EETITIDRAC RQETFVYEME SHAIGKKPEN SADMIEEGEL 

       190        200        210        220        230        240 
ILSVNILYPV IFHKHKEHKP YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE 

       250        260        270        280        290        300 
HISKDLYKSA FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND 

       310        320        330        340        350        360 
LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW TRKCFVCKMY 

       370        380        390        400        410 
TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL AYPYVDPGTF N 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc."
Henry R.W., Ma B., Sadowski C.L., Kobayashi R., Hernandez N.
EMBO J. 15:7129-7136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Teratocarcinoma.
[2]"Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III."
Bai L., Wang Z., Yoon J.B., Roeder R.G.
Mol. Cell. Biol. 16:5419-5426(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc."
Ma B., Hernandez N.
J. Biol. Chem. 276:5027-5035(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SNAPC1.
[7]"The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SNAPC1.
[8]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U71300 mRNA. Translation: AAC50948.1.
U66413 mRNA. Translation: AAD09214.1.
AL441925 Genomic DNA. Translation: CAI13285.1.
CH471071 Genomic DNA. Translation: EAW58681.1.
CH471071 Genomic DNA. Translation: EAW58682.1.
BC014985 mRNA. Translation: AAH14985.1.
BC108743 mRNA. Translation: AAI08744.1.
BC121011 mRNA. Translation: AAI21012.1.
BC121012 mRNA. Translation: AAI21013.1.
RefSeqNP_001034786.1. NM_001039697.1.
UniGeneHs.546299.

3D structure databases

ProteinModelPortalQ92966.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112503. 5 interactions.
IntActQ92966. 3 interactions.
STRING9606.ENSP00000370191.

PTM databases

PhosphoSiteQ92966.

Polymorphism databases

DMDM8134719.

Proteomic databases

PaxDbQ92966.
PRIDEQ92966.

Protocols and materials databases

DNASU6619.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380821; ENSP00000370200; ENSG00000164975.
ENST00000467062; ENSP00000436699; ENSG00000164975.
ENST00000490969; ENSP00000432393; ENSG00000164975.
GeneID6619.
KEGGhsa:6619.
UCSCuc003zlt.3. human.

Organism-specific databases

CTD6619.
GeneCardsGC09P015412.
HGNCHGNC:11136. SNAPC3.
HPAHPA053145.
MIM602348. gene.
neXtProtNX_Q92966.
PharmGKBPA35984.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG312262.
HOGENOMHOG000146435.
HOVERGENHBG071400.
InParanoidQ92966.
KOK15210.
OMAMLHYDAE.
OrthoDBEOG73RBB7.
PhylomeDBQ92966.
TreeFamTF317705.

Enzyme and pathway databases

ReactomeREACT_1788. Transcription.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ92966.
BgeeQ92966.
CleanExHS_SNAPC3.
GenevestigatorQ92966.

Family and domain databases

InterProIPR022042. snRNA-activating_su3.
[Graphical view]
PANTHERPTHR13421. PTHR13421. 1 hit.
PfamPF12251. zf-SNAP50_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSNAPC3. human.
GeneWikiSNAPC3.
GenomeRNAi6619.
NextBio25775.
PROQ92966.
SOURCESearch...

Entry information

Entry nameSNPC3_HUMAN
AccessionPrimary (citable) accession number: Q92966
Secondary accession number(s): D3DRI8, Q2VPI6, Q5T285
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM