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Protein

snRNA-activating protein complex subunit 3

Gene

SNAPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.1 Publication

GO - Molecular functioni

  • DNA binding Source: ProtInc

GO - Biological processi

  • gene expression Source: Reactome
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • snRNA transcription Source: ProtInc
  • transcription from RNA polymerase III promoter Source: Reactome
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 3
Short name:
SNAPc subunit 3
Alternative name(s):
Proximal sequence element-binding transcription factor subunit beta
Short name:
PSE-binding factor subunit beta
Short name:
PTF subunit beta
Small nuclear RNA-activating complex polypeptide 3
snRNA-activating protein complex 50 kDa subunit
Short name:
SNAPc 50 kDa subunit
Gene namesi
Name:SNAPC3
Synonyms:SNAP50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11136. SNAPC3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35984.

Polymorphism and mutation databases

BioMutaiSNAPC3.
DMDMi8134719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411snRNA-activating protein complex subunit 3PRO_0000072024Add
BLAST

Proteomic databases

MaxQBiQ92966.
PaxDbiQ92966.
PRIDEiQ92966.

PTM databases

PhosphoSiteiQ92966.

Expressioni

Gene expression databases

BgeeiQ92966.
CleanExiHS_SNAPC3.
ExpressionAtlasiQ92966. baseline and differential.
GenevestigatoriQ92966.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP57L1Q8IYX83EBI-1760638,EBI-1104570
CEP57L1Q8IYX8-23EBI-1760638,EBI-10181988
HSD17B14Q9BPX13EBI-1760638,EBI-742664

Protein-protein interaction databases

BioGridi112503. 8 interactions.
IntActiQ92966. 5 interactions.
STRINGi9606.ENSP00000370191.

Structurei

3D structure databases

ProteinModelPortaliQ92966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAPC3/SRD2 family.Curated

Phylogenomic databases

eggNOGiNOG312262.
GeneTreeiENSGT00390000005708.
HOGENOMiHOG000146435.
HOVERGENiHBG071400.
InParanoidiQ92966.
KOiK15210.
OMAiNIFYPVI.
OrthoDBiEOG73RBB7.
PhylomeDBiQ92966.
TreeFamiTF317705.

Family and domain databases

InterProiIPR022042. snRNA-activating_su3.
[Graphical view]
PANTHERiPTHR13421. PTHR13421. 1 hit.
PfamiPF12251. zf-SNAP50_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL
60 70 80 90 100
WRGRLRGAGD LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL
110 120 130 140 150
RAVCGLDKLK CLEDGEDPEV IPENTDLVTL GVRKRFLEHR EETITIDRAC
160 170 180 190 200
RQETFVYEME SHAIGKKPEN SADMIEEGEL ILSVNILYPV IFHKHKEHKP
210 220 230 240 250
YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE HISKDLYKSA
260 270 280 290 300
FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND
310 320 330 340 350
LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW
360 370 380 390 400
TRKCFVCKMY TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL
410
AYPYVDPGTF N
Length:411
Mass (Da):46,753
Last modified:February 1, 1997 - v1
Checksum:i920584BE4CFA366A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti398 – 3981E → A.
Corresponds to variant rs3087653 [ dbSNP | Ensembl ].
VAR_051366

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71300 mRNA. Translation: AAC50948.1.
U66413 mRNA. Translation: AAD09214.1.
AL441925 Genomic DNA. Translation: CAI13285.1.
CH471071 Genomic DNA. Translation: EAW58681.1.
CH471071 Genomic DNA. Translation: EAW58682.1.
BC014985 mRNA. Translation: AAH14985.1.
BC108743 mRNA. Translation: AAI08744.1.
BC121011 mRNA. Translation: AAI21012.1.
BC121012 mRNA. Translation: AAI21013.1.
CCDSiCCDS6478.1.
RefSeqiNP_001034786.1. NM_001039697.1.
UniGeneiHs.546299.

Genome annotation databases

EnsembliENST00000380821; ENSP00000370200; ENSG00000164975.
ENST00000467062; ENSP00000436699; ENSG00000164975.
ENST00000490969; ENSP00000432393; ENSG00000164975.
ENST00000610884; ENSP00000483273; ENSG00000164975.
GeneIDi6619.
KEGGihsa:6619.
UCSCiuc003zlt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71300 mRNA. Translation: AAC50948.1.
U66413 mRNA. Translation: AAD09214.1.
AL441925 Genomic DNA. Translation: CAI13285.1.
CH471071 Genomic DNA. Translation: EAW58681.1.
CH471071 Genomic DNA. Translation: EAW58682.1.
BC014985 mRNA. Translation: AAH14985.1.
BC108743 mRNA. Translation: AAI08744.1.
BC121011 mRNA. Translation: AAI21012.1.
BC121012 mRNA. Translation: AAI21013.1.
CCDSiCCDS6478.1.
RefSeqiNP_001034786.1. NM_001039697.1.
UniGeneiHs.546299.

3D structure databases

ProteinModelPortaliQ92966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112503. 8 interactions.
IntActiQ92966. 5 interactions.
STRINGi9606.ENSP00000370191.

PTM databases

PhosphoSiteiQ92966.

Polymorphism and mutation databases

BioMutaiSNAPC3.
DMDMi8134719.

Proteomic databases

MaxQBiQ92966.
PaxDbiQ92966.
PRIDEiQ92966.

Protocols and materials databases

DNASUi6619.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380821; ENSP00000370200; ENSG00000164975.
ENST00000467062; ENSP00000436699; ENSG00000164975.
ENST00000490969; ENSP00000432393; ENSG00000164975.
ENST00000610884; ENSP00000483273; ENSG00000164975.
GeneIDi6619.
KEGGihsa:6619.
UCSCiuc003zlt.3. human.

Organism-specific databases

CTDi6619.
GeneCardsiGC09P015412.
HGNCiHGNC:11136. SNAPC3.
MIMi602348. gene.
neXtProtiNX_Q92966.
PharmGKBiPA35984.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG312262.
GeneTreeiENSGT00390000005708.
HOGENOMiHOG000146435.
HOVERGENiHBG071400.
InParanoidiQ92966.
KOiK15210.
OMAiNIFYPVI.
OrthoDBiEOG73RBB7.
PhylomeDBiQ92966.
TreeFamiTF317705.

Enzyme and pathway databases

ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSiSNAPC3. human.
GeneWikiiSNAPC3.
GenomeRNAii6619.
NextBioi25775.
PROiQ92966.
SOURCEiSearch...

Gene expression databases

BgeeiQ92966.
CleanExiHS_SNAPC3.
ExpressionAtlasiQ92966. baseline and differential.
GenevestigatoriQ92966.

Family and domain databases

InterProiIPR022042. snRNA-activating_su3.
[Graphical view]
PANTHERiPTHR13421. PTHR13421. 1 hit.
PfamiPF12251. zf-SNAP50_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc."
    Henry R.W., Ma B., Sadowski C.L., Kobayashi R., Hernandez N.
    EMBO J. 15:7129-7136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Teratocarcinoma.
  2. "Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III."
    Bai L., Wang Z., Yoon J.B., Roeder R.G.
    Mol. Cell. Biol. 16:5419-5426(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc."
    Ma B., Hernandez N.
    J. Biol. Chem. 276:5027-5035(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNAPC1.
  7. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
    Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
    J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SNAPC1.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.

Entry informationi

Entry nameiSNPC3_HUMAN
AccessioniPrimary (citable) accession number: Q92966
Secondary accession number(s): D3DRI8, Q2VPI6, Q5T285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.