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Q92966

- SNPC3_HUMAN

UniProt

Q92966 - SNPC3_HUMAN

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Protein
snRNA-activating protein complex subunit 3
Gene
SNAPC3, SNAP50
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.1 Publication

GO - Molecular functioni

  1. DNA binding Source: ProtInc

GO - Biological processi

  1. gene expression Source: Reactome
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. snRNA transcription Source: ProtInc
  4. transcription from RNA polymerase II promoter Source: ProtInc
  5. transcription from RNA polymerase III promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 3
Short name:
SNAPc subunit 3
Alternative name(s):
Proximal sequence element-binding transcription factor subunit beta
Short name:
PSE-binding factor subunit beta
Short name:
PTF subunit beta
Small nuclear RNA-activating complex polypeptide 3
snRNA-activating protein complex 50 kDa subunit
Short name:
SNAPc 50 kDa subunit
Gene namesi
Name:SNAPC3
Synonyms:SNAP50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:11136. SNAPC3.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35984.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411snRNA-activating protein complex subunit 3
PRO_0000072024Add
BLAST

Proteomic databases

MaxQBiQ92966.
PaxDbiQ92966.
PRIDEiQ92966.

PTM databases

PhosphoSiteiQ92966.

Expressioni

Gene expression databases

ArrayExpressiQ92966.
BgeeiQ92966.
CleanExiHS_SNAPC3.
GenevestigatoriQ92966.

Organism-specific databases

HPAiHPA053145.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.2 Publications

Protein-protein interaction databases

BioGridi112503. 5 interactions.
IntActiQ92966. 3 interactions.
STRINGi9606.ENSP00000370191.

Structurei

3D structure databases

ProteinModelPortaliQ92966.

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAPC3/SRD2 family.

Phylogenomic databases

eggNOGiNOG312262.
HOGENOMiHOG000146435.
HOVERGENiHBG071400.
InParanoidiQ92966.
KOiK15210.
OMAiNIFYPVI.
OrthoDBiEOG73RBB7.
PhylomeDBiQ92966.
TreeFamiTF317705.

Family and domain databases

InterProiIPR022042. snRNA-activating_su3.
[Graphical view]
PANTHERiPTHR13421. PTHR13421. 1 hit.
PfamiPF12251. zf-SNAP50_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92966-1 [UniParc]FASTAAdd to Basket

« Hide

MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL    50
WRGRLRGAGD LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL 100
RAVCGLDKLK CLEDGEDPEV IPENTDLVTL GVRKRFLEHR EETITIDRAC 150
RQETFVYEME SHAIGKKPEN SADMIEEGEL ILSVNILYPV IFHKHKEHKP 200
YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE HISKDLYKSA 250
FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND 300
LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW 350
TRKCFVCKMY TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL 400
AYPYVDPGTF N 411
Length:411
Mass (Da):46,753
Last modified:February 1, 1997 - v1
Checksum:i920584BE4CFA366A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti398 – 3981E → A.
Corresponds to variant rs3087653 [ dbSNP | Ensembl ].
VAR_051366

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U71300 mRNA. Translation: AAC50948.1.
U66413 mRNA. Translation: AAD09214.1.
AL441925 Genomic DNA. Translation: CAI13285.1.
CH471071 Genomic DNA. Translation: EAW58681.1.
CH471071 Genomic DNA. Translation: EAW58682.1.
BC014985 mRNA. Translation: AAH14985.1.
BC108743 mRNA. Translation: AAI08744.1.
BC121011 mRNA. Translation: AAI21012.1.
BC121012 mRNA. Translation: AAI21013.1.
CCDSiCCDS6478.1.
RefSeqiNP_001034786.1. NM_001039697.1.
UniGeneiHs.546299.

Genome annotation databases

EnsembliENST00000380821; ENSP00000370200; ENSG00000164975.
ENST00000467062; ENSP00000436699; ENSG00000164975.
ENST00000490969; ENSP00000432393; ENSG00000164975.
GeneIDi6619.
KEGGihsa:6619.
UCSCiuc003zlt.3. human.

Polymorphism databases

DMDMi8134719.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U71300 mRNA. Translation: AAC50948.1 .
U66413 mRNA. Translation: AAD09214.1 .
AL441925 Genomic DNA. Translation: CAI13285.1 .
CH471071 Genomic DNA. Translation: EAW58681.1 .
CH471071 Genomic DNA. Translation: EAW58682.1 .
BC014985 mRNA. Translation: AAH14985.1 .
BC108743 mRNA. Translation: AAI08744.1 .
BC121011 mRNA. Translation: AAI21012.1 .
BC121012 mRNA. Translation: AAI21013.1 .
CCDSi CCDS6478.1.
RefSeqi NP_001034786.1. NM_001039697.1.
UniGenei Hs.546299.

3D structure databases

ProteinModelPortali Q92966.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112503. 5 interactions.
IntActi Q92966. 3 interactions.
STRINGi 9606.ENSP00000370191.

PTM databases

PhosphoSitei Q92966.

Polymorphism databases

DMDMi 8134719.

Proteomic databases

MaxQBi Q92966.
PaxDbi Q92966.
PRIDEi Q92966.

Protocols and materials databases

DNASUi 6619.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380821 ; ENSP00000370200 ; ENSG00000164975 .
ENST00000467062 ; ENSP00000436699 ; ENSG00000164975 .
ENST00000490969 ; ENSP00000432393 ; ENSG00000164975 .
GeneIDi 6619.
KEGGi hsa:6619.
UCSCi uc003zlt.3. human.

Organism-specific databases

CTDi 6619.
GeneCardsi GC09P015412.
HGNCi HGNC:11136. SNAPC3.
HPAi HPA053145.
MIMi 602348. gene.
neXtProti NX_Q92966.
PharmGKBi PA35984.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312262.
HOGENOMi HOG000146435.
HOVERGENi HBG071400.
InParanoidi Q92966.
KOi K15210.
OMAi NIFYPVI.
OrthoDBi EOG73RBB7.
PhylomeDBi Q92966.
TreeFami TF317705.

Enzyme and pathway databases

Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSi SNAPC3. human.
GeneWikii SNAPC3.
GenomeRNAii 6619.
NextBioi 25775.
PROi Q92966.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92966.
Bgeei Q92966.
CleanExi HS_SNAPC3.
Genevestigatori Q92966.

Family and domain databases

InterProi IPR022042. snRNA-activating_su3.
[Graphical view ]
PANTHERi PTHR13421. PTHR13421. 1 hit.
Pfami PF12251. zf-SNAP50_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc."
    Henry R.W., Ma B., Sadowski C.L., Kobayashi R., Hernandez N.
    EMBO J. 15:7129-7136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Teratocarcinoma.
  2. "Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III."
    Bai L., Wang Z., Yoon J.B., Roeder R.G.
    Mol. Cell. Biol. 16:5419-5426(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc."
    Ma B., Hernandez N.
    J. Biol. Chem. 276:5027-5035(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNAPC1.
  7. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
    Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
    J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SNAPC1.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.

Entry informationi

Entry nameiSNPC3_HUMAN
AccessioniPrimary (citable) accession number: Q92966
Secondary accession number(s): D3DRI8, Q2VPI6, Q5T285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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