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Q92963

- RIT1_HUMAN

UniProt

Q92963 - RIT1_HUMAN

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Protein

GTP-binding protein Rit1

Gene

RIT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.2 Publications

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358GTPBy similarity
Nucleotide bindingi75 – 795GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

  1. calmodulin binding Source: ProtInc
  2. GTP binding Source: ProtInc

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. neurotrophin TRK receptor signaling pathway Source: Reactome
  3. Ras protein signal transduction Source: UniProtKB
  4. signal transduction Source: ProtInc
  5. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_12077. Signalling to p38 via RIT and RIN.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rit1
Alternative name(s):
Ras-like protein expressed in many tissues
Ras-like without CAAX protein 1
Gene namesi
Name:RIT1
Synonyms:RIBB, RIT, ROC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10023. RIT1.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Noonan syndrome 8 (NS8) [MIM:615355]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571A → G in NS8; results in increased ELK1 transcriptional activation. 1 Publication
VAR_070150
Natural varianti81 – 811E → G in NS8; results in increased ELK1 transcriptional activation. 1 Publication
VAR_070151
Natural varianti82 – 821F → L in NS8; results in increased ELK1 transcriptional activation. 1 Publication
VAR_070152
Natural varianti95 – 951G → A in NS8; results in increased ELK1 transcriptional activation. 1 Publication
VAR_070157

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi35 – 351S → N: Dominant negative. Loss of interaction with MLLT4, RLF and RALGDS. 1 Publication
Mutagenesisi53 – 531T → S: Loss of interaction with MLLT4, RLF and RALGDS; when associated with L-79. 1 Publication
Mutagenesisi55 – 551E → G: Loss of interaction with MLLT4, but not with RLF and RALGDS; when associated with L-79. 1 Publication
Mutagenesisi79 – 791Q → L: Constitutively active. Dramatic reduction of the rate of GTP hydrolysis. Loss of interaction with MLLT4, RLF and RALGDS; when associated with S-53. Loss of interaction with MLLT4; when associated with G-55. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi615355. phenotype.
Orphaneti648. Noonan syndrome.
PharmGKBiPA35528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219GTP-binding protein Rit1PRO_0000082725Add
BLAST

Proteomic databases

MaxQBiQ92963.
PaxDbiQ92963.
PRIDEiQ92963.

PTM databases

PhosphoSiteiQ92963.

Expressioni

Tissue specificityi

Expressed in many tissues.

Gene expression databases

BgeeiQ92963.
CleanExiHS_RIT1.
ExpressionAtlasiQ92963. baseline and differential.
GenevestigatoriQ92963.

Organism-specific databases

HPAiHPA053249.

Interactioni

Subunit structurei

Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RLFQ131293EBI-365845,EBI-958266

Protein-protein interaction databases

BioGridi111948. 10 interactions.
IntActiQ92963. 10 interactions.
STRINGi9606.ENSP00000357306.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KLZX-ray2.30A19-189[»]
ProteinModelPortaliQ92963.
SMRiQ92963. Positions 21-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118778.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ92963.
KOiK07832.
OMAiLKSPFRK.
OrthoDBiEOG7QVM41.
PhylomeDBiQ92963.
TreeFamiTF315072.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92963-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSGTRPVGS CCSSPAGLSR EYKLVMLGAG GVGKSAMTMQ FISHRFPEDH
60 70 80 90 100
DPTIEDAYKI RIRIDDEPAN LDILDTAGQA EFTAMRDQYM RAGEGFIICY
110 120 130 140 150
SITDRRSFHE VREFKQLIYR VRRTDDTPVV LVGNKSDLKQ LRQVTKEEGL
160 170 180 190 200
ALAREFSCPF FETSAAYRYY IDDVFHALVR EIRRKEKEAV LAMEKKSKPK
210
NSVWKRLKSP FRKKKDSVT
Length:219
Mass (Da):25,145
Last modified:February 1, 1997 - v1
Checksum:i7F957871F836AE92
GO
Isoform 2 (identifier: Q92963-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:183
Mass (Da):21,633
Checksum:i61CFC2E07B180267
GO
Isoform 3 (identifier: Q92963-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MERWLFLGATEEGPKRTM

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):27,148
Checksum:iB6B991C6D3668388
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351S → T Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 Publication
VAR_070149
Natural varianti57 – 571A → G in NS8; results in increased ELK1 transcriptional activation. 1 Publication
VAR_070150
Natural varianti81 – 811E → G in NS8; results in increased ELK1 transcriptional activation. 1 Publication
VAR_070151
Natural varianti82 – 821F → L in NS8; results in increased ELK1 transcriptional activation. 1 Publication
VAR_070152
Natural varianti82 – 821F → V Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 Publication
VAR_070153
Natural varianti83 – 831T → P Probable disease-associated mutation found in patients with features of Noonan syndrome.
VAR_070154
Natural varianti89 – 891Y → H Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 Publication
VAR_070155
Natural varianti90 – 901M → I Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 Publication
VAR_070156
Natural varianti95 – 951G → A in NS8; results in increased ELK1 transcriptional activation. 1 Publication
VAR_070157

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 2. 1 PublicationVSP_045306Add
BLAST
Alternative sequencei1 – 11M → MERWLFLGATEEGPKRTM in isoform 3. CuratedVSP_047114

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U71203 mRNA. Translation: AAB42213.1.
Y07566 mRNA. Translation: CAA68851.1.
U78165 mRNA. Translation: AAB64246.1.
AF084462 mRNA. Translation: AAD13021.1.
AF493923 mRNA. Translation: AAM12637.1.
AK298768 mRNA. Translation: BAG60910.1.
AK314239 mRNA. Translation: BAG36908.1.
CR407639 mRNA. Translation: CAG28567.1.
AL139128, AL355388 Genomic DNA. Translation: CAH69943.1.
AL355388, AL139128 Genomic DNA. Translation: CAH72621.1.
CH471121 Genomic DNA. Translation: EAW53024.1.
BC104186 mRNA. Translation: AAI04187.1.
BC104187 mRNA. Translation: AAI04188.1.
CCDSiCCDS1123.1. [Q92963-1]
CCDS58036.1. [Q92963-2]
CCDS58037.1. [Q92963-3]
RefSeqiNP_001243749.1. NM_001256820.1. [Q92963-2]
NP_001243750.1. NM_001256821.1. [Q92963-3]
NP_008843.1. NM_006912.5. [Q92963-1]
UniGeneiHs.491234.

Genome annotation databases

EnsembliENST00000368322; ENSP00000357305; ENSG00000143622. [Q92963-3]
ENST00000368323; ENSP00000357306; ENSG00000143622. [Q92963-1]
ENST00000539040; ENSP00000441950; ENSG00000143622. [Q92963-2]
GeneIDi6016.
KEGGihsa:6016.
UCSCiuc001fmh.2. human. [Q92963-1]

Polymorphism databases

DMDMi38258628.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U71203 mRNA. Translation: AAB42213.1 .
Y07566 mRNA. Translation: CAA68851.1 .
U78165 mRNA. Translation: AAB64246.1 .
AF084462 mRNA. Translation: AAD13021.1 .
AF493923 mRNA. Translation: AAM12637.1 .
AK298768 mRNA. Translation: BAG60910.1 .
AK314239 mRNA. Translation: BAG36908.1 .
CR407639 mRNA. Translation: CAG28567.1 .
AL139128 , AL355388 Genomic DNA. Translation: CAH69943.1 .
AL355388 , AL139128 Genomic DNA. Translation: CAH72621.1 .
CH471121 Genomic DNA. Translation: EAW53024.1 .
BC104186 mRNA. Translation: AAI04187.1 .
BC104187 mRNA. Translation: AAI04188.1 .
CCDSi CCDS1123.1. [Q92963-1 ]
CCDS58036.1. [Q92963-2 ]
CCDS58037.1. [Q92963-3 ]
RefSeqi NP_001243749.1. NM_001256820.1. [Q92963-2 ]
NP_001243750.1. NM_001256821.1. [Q92963-3 ]
NP_008843.1. NM_006912.5. [Q92963-1 ]
UniGenei Hs.491234.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KLZ X-ray 2.30 A 19-189 [» ]
ProteinModelPortali Q92963.
SMRi Q92963. Positions 21-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111948. 10 interactions.
IntActi Q92963. 10 interactions.
STRINGi 9606.ENSP00000357306.

PTM databases

PhosphoSitei Q92963.

Polymorphism databases

DMDMi 38258628.

Proteomic databases

MaxQBi Q92963.
PaxDbi Q92963.
PRIDEi Q92963.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368322 ; ENSP00000357305 ; ENSG00000143622 . [Q92963-3 ]
ENST00000368323 ; ENSP00000357306 ; ENSG00000143622 . [Q92963-1 ]
ENST00000539040 ; ENSP00000441950 ; ENSG00000143622 . [Q92963-2 ]
GeneIDi 6016.
KEGGi hsa:6016.
UCSCi uc001fmh.2. human. [Q92963-1 ]

Organism-specific databases

CTDi 6016.
GeneCardsi GC01M155867.
HGNCi HGNC:10023. RIT1.
HPAi HPA053249.
MIMi 609591. gene.
615355. phenotype.
neXtProti NX_Q92963.
Orphaneti 648. Noonan syndrome.
PharmGKBi PA35528.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118778.
HOGENOMi HOG000233973.
HOVERGENi HBG009351.
InParanoidi Q92963.
KOi K07832.
OMAi LKSPFRK.
OrthoDBi EOG7QVM41.
PhylomeDBi Q92963.
TreeFami TF315072.

Enzyme and pathway databases

Reactomei REACT_12077. Signalling to p38 via RIT and RIN.

Miscellaneous databases

GeneWikii RIT1.
GenomeRNAii 6016.
NextBioi 23471.
PROi Q92963.
SOURCEi Search...

Gene expression databases

Bgeei Q92963.
CleanExi HS_RIT1.
ExpressionAtlasi Q92963. baseline and differential.
Genevestigatori Q92963.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins."
    Lee C.H.J., Della N.G., Chew C.E., Zack D.J.
    J. Neurosci. 16:6784-6794(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "RIC, a calmodulin-binding Ras-like GTPase."
    Wes P.D., Yu M., Montell C.
    EMBO J. 15:5839-5848(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Characterization of new small G proteins in the Ras subfamily."
    Kawasaki H., Housman D.E., Graybiel A.M.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Biochemical characterization of the Ras-related GTPases Rit and Rin."
    Shao H., Kadono-Okuda K., Finlin B.S., Andres D.A.
    Arch. Biochem. Biophys. 371:207-219(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, INTERACTION WITH MLLT4; RALGDS AND RLF, MUTAGENESIS OF SER-35; THR-53; GLU-55 AND GLN-79.
    Tissue: Retina.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Esophagus.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  11. "Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades."
    Shi G.-X., Andres D.A.
    Mol. Cell. Biol. 25:830-846(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BRAF AND RAF1.
  12. Cited for: FUNCTION, VARIANTS NS8 GLY-57; GLY-81; LEU-82 AND ALA-95, CHARACTERIZATION OF VARIANTS NS8 GLY-57; GLY-81; LEU-82 AND ALA-95, VARIANTS THR-35; VAL-82; PRO-83 HIS-89 AND ILE-90.

Entry informationi

Entry nameiRIT1_HUMAN
AccessioniPrimary (citable) accession number: Q92963
Secondary accession number(s): B4DQE8
, O00646, O00720, Q5VY89, Q5VY90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation.
Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3