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Q92963

- RIT1_HUMAN

UniProt

Q92963 - RIT1_HUMAN

Protein

GTP-binding protein Rit1

Gene

RIT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.2 Publications

    Enzyme regulationi

    Alternates between an inactive form bound to GDP and an active form bound to GTP.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi28 – 358GTPBy similarity
    Nucleotide bindingi75 – 795GTPBy similarity
    Nucleotide bindingi134 – 1374GTPBy similarity

    GO - Molecular functioni

    1. calmodulin binding Source: ProtInc
    2. GTP binding Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. GTP catabolic process Source: InterPro
    2. neurotrophin TRK receptor signaling pathway Source: Reactome
    3. Ras protein signal transduction Source: UniProtKB
    4. signal transduction Source: ProtInc
    5. small GTPase mediated signal transduction Source: Reactome

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_12077. Signalling to p38 via RIT and RIN.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein Rit1
    Alternative name(s):
    Ras-like protein expressed in many tissues
    Ras-like without CAAX protein 1
    Gene namesi
    Name:RIT1
    Synonyms:RIBB, RIT, ROC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10023. RIT1.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Noonan syndrome 8 (NS8) [MIM:615355]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571A → G in NS8; results in increased ELK1 transcriptional activation. 1 Publication
    VAR_070150
    Natural varianti81 – 811E → G in NS8; results in increased ELK1 transcriptional activation. 1 Publication
    VAR_070151
    Natural varianti82 – 821F → L in NS8; results in increased ELK1 transcriptional activation. 1 Publication
    VAR_070152
    Natural varianti95 – 951G → A in NS8; results in increased ELK1 transcriptional activation. 1 Publication
    VAR_070157

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi35 – 351S → N: Dominant negative. Loss of interaction with MLLT4, RLF and RALGDS. 1 Publication
    Mutagenesisi53 – 531T → S: Loss of interaction with MLLT4, RLF and RALGDS; when associated with L-79. 1 Publication
    Mutagenesisi55 – 551E → G: Loss of interaction with MLLT4, but not with RLF and RALGDS; when associated with L-79. 1 Publication
    Mutagenesisi79 – 791Q → L: Constitutively active. Dramatic reduction of the rate of GTP hydrolysis. Loss of interaction with MLLT4, RLF and RALGDS; when associated with S-53. Loss of interaction with MLLT4; when associated with G-55. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi615355. phenotype.
    Orphaneti648. Noonan syndrome.
    PharmGKBiPA35528.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219GTP-binding protein Rit1PRO_0000082725Add
    BLAST

    Proteomic databases

    MaxQBiQ92963.
    PaxDbiQ92963.
    PRIDEiQ92963.

    PTM databases

    PhosphoSiteiQ92963.

    Expressioni

    Tissue specificityi

    Expressed in many tissues.

    Gene expression databases

    ArrayExpressiQ92963.
    BgeeiQ92963.
    CleanExiHS_RIT1.
    GenevestigatoriQ92963.

    Organism-specific databases

    HPAiHPA053249.

    Interactioni

    Subunit structurei

    Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RLFQ131293EBI-365845,EBI-958266

    Protein-protein interaction databases

    BioGridi111948. 10 interactions.
    IntActiQ92963. 10 interactions.
    STRINGi9606.ENSP00000357306.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92963.
    SMRiQ92963. Positions 21-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Ras family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233973.
    HOVERGENiHBG009351.
    InParanoidiQ92963.
    KOiK07832.
    OMAiLKSPFRK.
    OrthoDBiEOG7QVM41.
    PhylomeDBiQ92963.
    TreeFamiTF315072.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92963-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSGTRPVGS CCSSPAGLSR EYKLVMLGAG GVGKSAMTMQ FISHRFPEDH    50
    DPTIEDAYKI RIRIDDEPAN LDILDTAGQA EFTAMRDQYM RAGEGFIICY 100
    SITDRRSFHE VREFKQLIYR VRRTDDTPVV LVGNKSDLKQ LRQVTKEEGL 150
    ALAREFSCPF FETSAAYRYY IDDVFHALVR EIRRKEKEAV LAMEKKSKPK 200
    NSVWKRLKSP FRKKKDSVT 219
    Length:219
    Mass (Da):25,145
    Last modified:February 1, 1997 - v1
    Checksum:i7F957871F836AE92
    GO
    Isoform 2 (identifier: Q92963-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.

    Show »
    Length:183
    Mass (Da):21,633
    Checksum:i61CFC2E07B180267
    GO
    Isoform 3 (identifier: Q92963-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MERWLFLGATEEGPKRTM

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):27,148
    Checksum:iB6B991C6D3668388
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351S → T Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 Publication
    VAR_070149
    Natural varianti57 – 571A → G in NS8; results in increased ELK1 transcriptional activation. 1 Publication
    VAR_070150
    Natural varianti81 – 811E → G in NS8; results in increased ELK1 transcriptional activation. 1 Publication
    VAR_070151
    Natural varianti82 – 821F → L in NS8; results in increased ELK1 transcriptional activation. 1 Publication
    VAR_070152
    Natural varianti82 – 821F → V Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 Publication
    VAR_070153
    Natural varianti83 – 831T → P Probable disease-associated mutation found in patients with features of Noonan syndrome.
    VAR_070154
    Natural varianti89 – 891Y → H Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 Publication
    VAR_070155
    Natural varianti90 – 901M → I Probable disease-associated mutation found in patients with features of Noonan syndrome. 1 Publication
    VAR_070156
    Natural varianti95 – 951G → A in NS8; results in increased ELK1 transcriptional activation. 1 Publication
    VAR_070157

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636Missing in isoform 2. 1 PublicationVSP_045306Add
    BLAST
    Alternative sequencei1 – 11M → MERWLFLGATEEGPKRTM in isoform 3. CuratedVSP_047114

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U71203 mRNA. Translation: AAB42213.1.
    Y07566 mRNA. Translation: CAA68851.1.
    U78165 mRNA. Translation: AAB64246.1.
    AF084462 mRNA. Translation: AAD13021.1.
    AF493923 mRNA. Translation: AAM12637.1.
    AK298768 mRNA. Translation: BAG60910.1.
    AK314239 mRNA. Translation: BAG36908.1.
    CR407639 mRNA. Translation: CAG28567.1.
    AL139128, AL355388 Genomic DNA. Translation: CAH69943.1.
    AL355388, AL139128 Genomic DNA. Translation: CAH72621.1.
    CH471121 Genomic DNA. Translation: EAW53024.1.
    BC104186 mRNA. Translation: AAI04187.1.
    BC104187 mRNA. Translation: AAI04188.1.
    CCDSiCCDS1123.1. [Q92963-1]
    CCDS58036.1. [Q92963-2]
    CCDS58037.1. [Q92963-3]
    RefSeqiNP_001243749.1. NM_001256820.1. [Q92963-2]
    NP_001243750.1. NM_001256821.1. [Q92963-3]
    NP_008843.1. NM_006912.5. [Q92963-1]
    UniGeneiHs.491234.

    Genome annotation databases

    EnsembliENST00000368322; ENSP00000357305; ENSG00000143622. [Q92963-3]
    ENST00000368323; ENSP00000357306; ENSG00000143622. [Q92963-1]
    ENST00000539040; ENSP00000441950; ENSG00000143622. [Q92963-2]
    GeneIDi6016.
    KEGGihsa:6016.
    UCSCiuc001fmh.2. human. [Q92963-1]

    Polymorphism databases

    DMDMi38258628.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U71203 mRNA. Translation: AAB42213.1 .
    Y07566 mRNA. Translation: CAA68851.1 .
    U78165 mRNA. Translation: AAB64246.1 .
    AF084462 mRNA. Translation: AAD13021.1 .
    AF493923 mRNA. Translation: AAM12637.1 .
    AK298768 mRNA. Translation: BAG60910.1 .
    AK314239 mRNA. Translation: BAG36908.1 .
    CR407639 mRNA. Translation: CAG28567.1 .
    AL139128 , AL355388 Genomic DNA. Translation: CAH69943.1 .
    AL355388 , AL139128 Genomic DNA. Translation: CAH72621.1 .
    CH471121 Genomic DNA. Translation: EAW53024.1 .
    BC104186 mRNA. Translation: AAI04187.1 .
    BC104187 mRNA. Translation: AAI04188.1 .
    CCDSi CCDS1123.1. [Q92963-1 ]
    CCDS58036.1. [Q92963-2 ]
    CCDS58037.1. [Q92963-3 ]
    RefSeqi NP_001243749.1. NM_001256820.1. [Q92963-2 ]
    NP_001243750.1. NM_001256821.1. [Q92963-3 ]
    NP_008843.1. NM_006912.5. [Q92963-1 ]
    UniGenei Hs.491234.

    3D structure databases

    ProteinModelPortali Q92963.
    SMRi Q92963. Positions 21-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111948. 10 interactions.
    IntActi Q92963. 10 interactions.
    STRINGi 9606.ENSP00000357306.

    PTM databases

    PhosphoSitei Q92963.

    Polymorphism databases

    DMDMi 38258628.

    Proteomic databases

    MaxQBi Q92963.
    PaxDbi Q92963.
    PRIDEi Q92963.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368322 ; ENSP00000357305 ; ENSG00000143622 . [Q92963-3 ]
    ENST00000368323 ; ENSP00000357306 ; ENSG00000143622 . [Q92963-1 ]
    ENST00000539040 ; ENSP00000441950 ; ENSG00000143622 . [Q92963-2 ]
    GeneIDi 6016.
    KEGGi hsa:6016.
    UCSCi uc001fmh.2. human. [Q92963-1 ]

    Organism-specific databases

    CTDi 6016.
    GeneCardsi GC01M155867.
    HGNCi HGNC:10023. RIT1.
    HPAi HPA053249.
    MIMi 609591. gene.
    615355. phenotype.
    neXtProti NX_Q92963.
    Orphaneti 648. Noonan syndrome.
    PharmGKBi PA35528.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233973.
    HOVERGENi HBG009351.
    InParanoidi Q92963.
    KOi K07832.
    OMAi LKSPFRK.
    OrthoDBi EOG7QVM41.
    PhylomeDBi Q92963.
    TreeFami TF315072.

    Enzyme and pathway databases

    Reactomei REACT_12077. Signalling to p38 via RIT and RIN.

    Miscellaneous databases

    GeneWikii RIT1.
    GenomeRNAii 6016.
    NextBioi 23471.
    PROi Q92963.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92963.
    Bgeei Q92963.
    CleanExi HS_RIT1.
    Genevestigatori Q92963.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins."
      Lee C.H.J., Della N.G., Chew C.E., Zack D.J.
      J. Neurosci. 16:6784-6794(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "RIC, a calmodulin-binding Ras-like GTPase."
      Wes P.D., Yu M., Montell C.
      EMBO J. 15:5839-5848(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Characterization of new small G proteins in the Ras subfamily."
      Kawasaki H., Housman D.E., Graybiel A.M.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Biochemical characterization of the Ras-related GTPases Rit and Rin."
      Shao H., Kadono-Okuda K., Finlin B.S., Andres D.A.
      Arch. Biochem. Biophys. 371:207-219(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, INTERACTION WITH MLLT4; RALGDS AND RLF, MUTAGENESIS OF SER-35; THR-53; GLU-55 AND GLN-79.
      Tissue: Retina.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Esophagus.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    11. "Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades."
      Shi G.-X., Andres D.A.
      Mol. Cell. Biol. 25:830-846(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BRAF AND RAF1.
    12. Cited for: FUNCTION, VARIANTS NS8 GLY-57; GLY-81; LEU-82 AND ALA-95, CHARACTERIZATION OF VARIANTS NS8 GLY-57; GLY-81; LEU-82 AND ALA-95, VARIANTS THR-35; VAL-82; PRO-83 HIS-89 AND ILE-90.

    Entry informationi

    Entry nameiRIT1_HUMAN
    AccessioniPrimary (citable) accession number: Q92963
    Secondary accession number(s): B4DQE8
    , O00646, O00720, Q5VY89, Q5VY90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation.
    Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3