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Q92959

- SO2A1_HUMAN

UniProt

Q92959 - SO2A1_HUMAN

Protein

Solute carrier organic anion transporter family member 2A1

Gene

SLCO2A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

    GO - Molecular functioni

    1. lipid transporter activity Source: ProtInc
    2. prostaglandin transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. lipid transport Source: ProtInc
    2. sodium-independent organic anion transport Source: Reactome
    3. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_23988. Transport of organic anions.

    Protein family/group databases

    TCDBi2.A.60.1.19. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 2A1
    Alternative name(s):
    Prostaglandin transporter
    Short name:
    PGT
    Solute carrier family 21 member 2
    Gene namesi
    Name:SLCO2A1
    Synonyms:OATP2A1, SLC21A2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:10955. SLCO2A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease.4 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851I → F in PHOAR2. 1 Publication
    VAR_068636
    Natural varianti97 – 971R → H in PHOAR2. 1 Publication
    VAR_068637
    Natural varianti181 – 1811G → A in PHOAR2. 1 Publication
    VAR_068638
    Natural varianti181 – 1811G → D in PHOAR2. 1 Publication
    VAR_068639
    Natural varianti204 – 2041S → L in PHOAR2. 1 Publication
    VAR_068640
    Natural varianti222 – 2221G → R in PHOAR2. 2 Publications
    VAR_067598
    Natural varianti255 – 2551G → E in PHOAR2. 1 Publication
    VAR_067599
    Natural varianti255 – 2551G → R in PHOAR2. 1 Publication
    VAR_068641
    Natural varianti420 – 4201C → F in PHOAR2; reduced activity. 1 Publication
    VAR_068642
    Natural varianti556 – 5561Q → H in PHOAR2. 1 Publication
    VAR_068644
    Natural varianti557 – 5571F → S in PHOAR2. 1 Publication
    VAR_068352
    Natural varianti565 – 5651W → G in PHOAR2. 1 Publication
    VAR_068645

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614441. phenotype.
    Orphaneti2796. Pachydermoperiostosis.
    PharmGKBiPA35840.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 643643Solute carrier organic anion transporter family member 2A1PRO_0000191058Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi444 ↔ 470PROSITE-ProRule annotation
    Disulfide bondi448 ↔ 459PROSITE-ProRule annotation
    Disulfide bondi450 ↔ 474PROSITE-ProRule annotation
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ92959.
    PRIDEiQ92959.

    PTM databases

    PhosphoSiteiQ92959.

    Expressioni

    Tissue specificityi

    Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.1 Publication

    Gene expression databases

    ArrayExpressiQ92959.
    BgeeiQ92959.
    CleanExiHS_SLCO2A1.
    GenevestigatoriQ92959.

    Organism-specific databases

    HPAiHPA013742.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GRB2P629931EBI-1760532,EBI-401755

    Protein-protein interaction databases

    IntActiQ92959. 1 interaction.
    STRINGi9606.ENSP00000311291.

    Structurei

    Secondary structure

    1
    643
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi181 – 1833

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3MRRX-ray1.60P178-187[»]
    ProteinModelPortaliQ92959.
    SMRiQ92959. Positions 448-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92959.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini53 – 7119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini93 – 986CytoplasmicSequence Analysis
    Topological domaini124 – 16744ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini237 – 25418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 32142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini344 – 36320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini388 – 3914CytoplasmicSequence Analysis
    Topological domaini416 – 518103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini542 – 5509CytoplasmicSequence Analysis
    Topological domaini577 – 61034ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini630 – 64314CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5220Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 12325Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 19629Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27925Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei322 – 34322Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei364 – 38724Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei392 – 41524Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei519 – 54123Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei551 – 57626Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei611 – 62919Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini438 – 49659Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271773.
    HOGENOMiHOG000231269.
    HOVERGENiHBG108345.
    InParanoidiQ92959.
    KOiK14345.
    OMAiIYLNCSC.
    OrthoDBiEOG7QG43R.
    PhylomeDBiQ92959.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 4 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92959-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA    50
    YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL 100
    IGIGGLFLAA GAFILTLPHF LSEPYQYTLA STGNNSRLQA ELCQKHWQDL 150
    PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA GIGTVPIQPF GISYVDDFSE 200
    PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN TAAVNLVPGD 250
    PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE 300
    EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN 350
    KFLEKQYGTS AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI 400
    ATTIITISMI LCVPLFFMGC STPTVAEVYP PSTSSSIHPQ SPACRRDCSC 450
    PDSIFHPVCG DNGIEYLSPC HAGCSNINMS SATSKQLIYL NCSCVTGGSA 500
    SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV LRVVNQEEKS 550
    FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND 600
    ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI 643
    Length:643
    Mass (Da):70,044
    Last modified:December 16, 2008 - v2
    Checksum:iA1FF933246480984
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91A → V in AAC09469. (PubMed:8787677)Curated
    Sequence conflicti9 – 91A → V in AAC62004. (PubMed:9618293)Curated
    Sequence conflicti228 – 2281V → I in AAC09469. (PubMed:8787677)Curated
    Sequence conflicti228 – 2281V → I in AAC62004. (PubMed:9618293)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851I → F in PHOAR2. 1 Publication
    VAR_068636
    Natural varianti97 – 971R → H in PHOAR2. 1 Publication
    VAR_068637
    Natural varianti181 – 1811G → A in PHOAR2. 1 Publication
    VAR_068638
    Natural varianti181 – 1811G → D in PHOAR2. 1 Publication
    VAR_068639
    Natural varianti204 – 2041S → L in PHOAR2. 1 Publication
    VAR_068640
    Natural varianti222 – 2221G → R in PHOAR2. 2 Publications
    VAR_067598
    Natural varianti255 – 2551G → E in PHOAR2. 1 Publication
    VAR_067599
    Natural varianti255 – 2551G → R in PHOAR2. 1 Publication
    VAR_068641
    Natural varianti396 – 3961A → T.2 Publications
    Corresponds to variant rs34550074 [ dbSNP | Ensembl ].
    VAR_053674
    Natural varianti420 – 4201C → F in PHOAR2; reduced activity. 1 Publication
    VAR_068642
    Natural varianti445 – 4451R → C.1 Publication
    Corresponds to variant rs146970901 [ dbSNP | Ensembl ].
    VAR_068643
    Natural varianti556 – 5561Q → H in PHOAR2. 1 Publication
    VAR_068644
    Natural varianti557 – 5571F → S in PHOAR2. 1 Publication
    VAR_068352
    Natural varianti565 – 5651W → G in PHOAR2. 1 Publication
    VAR_068645

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70867 mRNA. Translation: AAC09469.1.
    AF056732
    , AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA. Translation: AAC62004.1.
    CH471052 Genomic DNA. Translation: EAW79156.1.
    BC041140 mRNA. Translation: AAH41140.2.
    BC051347 mRNA. Translation: AAH51347.1.
    CCDSiCCDS3084.1.
    RefSeqiNP_005621.2. NM_005630.2.
    UniGeneiHs.518270.

    Genome annotation databases

    EnsembliENST00000310926; ENSP00000311291; ENSG00000174640.
    GeneIDi6578.
    KEGGihsa:6578.
    UCSCiuc003eqa.4. human.

    Polymorphism databases

    DMDMi218511799.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Solute carrier organic anion transporter family, member 2A1 (SLCO2A1)

    Leiden Open Variation Database (LOVD)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70867 mRNA. Translation: AAC09469.1 .
    AF056732
    , AF056719 , AF056720 , AF056721 , AF056722 , AF056723 , AF056724 , AF056725 , AF056726 , AF056727 , AF056728 , AF056729 , AF056730 , AF056731 Genomic DNA. Translation: AAC62004.1 .
    CH471052 Genomic DNA. Translation: EAW79156.1 .
    BC041140 mRNA. Translation: AAH41140.2 .
    BC051347 mRNA. Translation: AAH51347.1 .
    CCDSi CCDS3084.1.
    RefSeqi NP_005621.2. NM_005630.2.
    UniGenei Hs.518270.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3MRR X-ray 1.60 P 178-187 [» ]
    ProteinModelPortali Q92959.
    SMRi Q92959. Positions 448-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q92959. 1 interaction.
    STRINGi 9606.ENSP00000311291.

    Chemistry

    BindingDBi Q92959.
    ChEMBLi CHEMBL2073703.
    GuidetoPHARMACOLOGYi 1223.

    Protein family/group databases

    TCDBi 2.A.60.1.19. the organo anion transporter (oat) family.

    PTM databases

    PhosphoSitei Q92959.

    Polymorphism databases

    DMDMi 218511799.

    Proteomic databases

    PaxDbi Q92959.
    PRIDEi Q92959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310926 ; ENSP00000311291 ; ENSG00000174640 .
    GeneIDi 6578.
    KEGGi hsa:6578.
    UCSCi uc003eqa.4. human.

    Organism-specific databases

    CTDi 6578.
    GeneCardsi GC03M133651.
    H-InvDB HIX0024333.
    HGNCi HGNC:10955. SLCO2A1.
    HPAi HPA013742.
    MIMi 601460. gene.
    614441. phenotype.
    neXtProti NX_Q92959.
    Orphaneti 2796. Pachydermoperiostosis.
    PharmGKBi PA35840.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271773.
    HOGENOMi HOG000231269.
    HOVERGENi HBG108345.
    InParanoidi Q92959.
    KOi K14345.
    OMAi IYLNCSC.
    OrthoDBi EOG7QG43R.
    PhylomeDBi Q92959.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_23988. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSi SLCO2A1. human.
    EvolutionaryTracei Q92959.
    GeneWikii SLCO2A1.
    GenomeRNAii 6578.
    NextBioi 25591.
    PROi Q92959.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92959.
    Bgeei Q92959.
    CleanExi HS_SLCO2A1.
    Genevestigatori Q92959.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 4 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)."
      Lu R., Kanai N., Bao Y., Schuster V.L.
      J. Clin. Invest. 98:1142-1149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT THR-396.
    2. "Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization."
      Lu R., Schuster V.L.
      Biochem. Biophys. Res. Commun. 246:805-812(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-396.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Prostate.
    5. "Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing."
      Seifert W., Kuhnisch J., Tuysuz B., Specker C., Brouwers A., Horn D.
      Hum. Mutat. 33:660-664(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, VARIANT PHOAR2 SER-557.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy."
      Zhang Z., Xia W., He J., Zhang Z., Ke Y., Yue H., Wang C., Zhang H., Gu J., Hu W., Fu W., Hu Y., Li M., Liu Y.
      Am. J. Hum. Genet. 90:125-132(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PHOAR2 ARG-222 AND GLU-255.
    8. Cited for: VARIANTS PHOAR2 PHE-85; HIS-97; ALA-181; ASP-181; LEU-204; ARG-222; PHE-420 AND GLY-565, VARIANT CYS-445, CHARACTERIZATION OF VARIANT PHOAR2 PHE-420.
    9. "Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing."
      Busch J., Frank V., Bachmann N., Otsuka A., Oji V., Metze D., Shah K., Danda S., Watzer B., Traupe H., Bolz H.J., Kabashima K., Bergmann C.
      J. Invest. Dermatol. 132:2473-2476(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PHOAR2 ARG-255 AND HIS-556.

    Entry informationi

    Entry nameiSO2A1_HUMAN
    AccessioniPrimary (citable) accession number: Q92959
    Secondary accession number(s): Q86V98, Q8IUN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3