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Q92959

- SO2A1_HUMAN

UniProt

Q92959 - SO2A1_HUMAN

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Protein

Solute carrier organic anion transporter family member 2A1

Gene

SLCO2A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

  1. lipid transporter activity Source: ProtInc
  2. prostaglandin transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. lipid transport Source: ProtInc
  2. sodium-independent organic anion transport Source: Reactome
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_23988. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.19. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:SLCO2A1
Synonyms:OATP2A1, SLC21A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10955. SLCO2A1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease.4 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851I → F in PHOAR2. 1 Publication
VAR_068636
Natural varianti97 – 971R → H in PHOAR2. 1 Publication
VAR_068637
Natural varianti181 – 1811G → A in PHOAR2. 1 Publication
VAR_068638
Natural varianti181 – 1811G → D in PHOAR2. 1 Publication
VAR_068639
Natural varianti204 – 2041S → L in PHOAR2. 1 Publication
VAR_068640
Natural varianti222 – 2221G → R in PHOAR2. 2 Publications
VAR_067598
Natural varianti255 – 2551G → E in PHOAR2. 1 Publication
VAR_067599
Natural varianti255 – 2551G → R in PHOAR2. 1 Publication
VAR_068641
Natural varianti420 – 4201C → F in PHOAR2; reduced activity. 1 Publication
VAR_068642
Natural varianti556 – 5561Q → H in PHOAR2. 1 Publication
VAR_068644
Natural varianti557 – 5571F → S in PHOAR2. 1 Publication
VAR_068352
Natural varianti565 – 5651W → G in PHOAR2. 1 Publication
VAR_068645

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614441. phenotype.
Orphaneti2796. Pachydermoperiostosis.
PharmGKBiPA35840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Solute carrier organic anion transporter family member 2A1PRO_0000191058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi444 ↔ 470PROSITE-ProRule annotation
Disulfide bondi448 ↔ 459PROSITE-ProRule annotation
Disulfide bondi450 ↔ 474PROSITE-ProRule annotation
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ92959.
PRIDEiQ92959.

PTM databases

PhosphoSiteiQ92959.

Expressioni

Tissue specificityi

Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.1 Publication

Gene expression databases

BgeeiQ92959.
CleanExiHS_SLCO2A1.
ExpressionAtlasiQ92959. baseline and differential.
GenevestigatoriQ92959.

Organism-specific databases

HPAiHPA013742.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629931EBI-1760532,EBI-401755

Protein-protein interaction databases

IntActiQ92959. 1 interaction.
STRINGi9606.ENSP00000311291.

Structurei

Secondary structure

1
643
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi181 – 1833

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MRRX-ray1.60P178-187[»]
ProteinModelPortaliQ92959.
SMRiQ92959. Positions 448-476.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92959.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini53 – 7119ExtracellularSequence AnalysisAdd
BLAST
Topological domaini93 – 986CytoplasmicSequence Analysis
Topological domaini124 – 16744ExtracellularSequence AnalysisAdd
BLAST
Topological domaini197 – 21519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini237 – 25418ExtracellularSequence AnalysisAdd
BLAST
Topological domaini280 – 32142CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini344 – 36320ExtracellularSequence AnalysisAdd
BLAST
Topological domaini388 – 3914CytoplasmicSequence Analysis
Topological domaini416 – 518103ExtracellularSequence AnalysisAdd
BLAST
Topological domaini542 – 5509CytoplasmicSequence Analysis
Topological domaini577 – 61034ExtracellularSequence AnalysisAdd
BLAST
Topological domaini630 – 64314CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5220Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei99 – 12325Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei168 – 19629Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei255 – 27925Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei322 – 34322Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei364 – 38724Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei392 – 41524Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei519 – 54123Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei551 – 57626Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei611 – 62919Helical; Name=12Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini438 – 49659Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271773.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ92959.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG7QG43R.
PhylomeDBiQ92959.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92959-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL
110 120 130 140 150
IGIGGLFLAA GAFILTLPHF LSEPYQYTLA STGNNSRLQA ELCQKHWQDL
160 170 180 190 200
PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA GIGTVPIQPF GISYVDDFSE
210 220 230 240 250
PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN TAAVNLVPGD
260 270 280 290 300
PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE
310 320 330 340 350
EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN
360 370 380 390 400
KFLEKQYGTS AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI
410 420 430 440 450
ATTIITISMI LCVPLFFMGC STPTVAEVYP PSTSSSIHPQ SPACRRDCSC
460 470 480 490 500
PDSIFHPVCG DNGIEYLSPC HAGCSNINMS SATSKQLIYL NCSCVTGGSA
510 520 530 540 550
SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV LRVVNQEEKS
560 570 580 590 600
FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND
610 620 630 640
ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI
Length:643
Mass (Da):70,044
Last modified:December 16, 2008 - v2
Checksum:iA1FF933246480984
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → V in AAC09469. (PubMed:8787677)Curated
Sequence conflicti9 – 91A → V in AAC62004. (PubMed:9618293)Curated
Sequence conflicti228 – 2281V → I in AAC09469. (PubMed:8787677)Curated
Sequence conflicti228 – 2281V → I in AAC62004. (PubMed:9618293)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851I → F in PHOAR2. 1 Publication
VAR_068636
Natural varianti97 – 971R → H in PHOAR2. 1 Publication
VAR_068637
Natural varianti181 – 1811G → A in PHOAR2. 1 Publication
VAR_068638
Natural varianti181 – 1811G → D in PHOAR2. 1 Publication
VAR_068639
Natural varianti204 – 2041S → L in PHOAR2. 1 Publication
VAR_068640
Natural varianti222 – 2221G → R in PHOAR2. 2 Publications
VAR_067598
Natural varianti255 – 2551G → E in PHOAR2. 1 Publication
VAR_067599
Natural varianti255 – 2551G → R in PHOAR2. 1 Publication
VAR_068641
Natural varianti396 – 3961A → T.2 Publications
Corresponds to variant rs34550074 [ dbSNP | Ensembl ].
VAR_053674
Natural varianti420 – 4201C → F in PHOAR2; reduced activity. 1 Publication
VAR_068642
Natural varianti445 – 4451R → C.1 Publication
Corresponds to variant rs146970901 [ dbSNP | Ensembl ].
VAR_068643
Natural varianti556 – 5561Q → H in PHOAR2. 1 Publication
VAR_068644
Natural varianti557 – 5571F → S in PHOAR2. 1 Publication
VAR_068352
Natural varianti565 – 5651W → G in PHOAR2. 1 Publication
VAR_068645

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70867 mRNA. Translation: AAC09469.1.
AF056732
, AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA. Translation: AAC62004.1.
CH471052 Genomic DNA. Translation: EAW79156.1.
BC041140 mRNA. Translation: AAH41140.2.
BC051347 mRNA. Translation: AAH51347.1.
CCDSiCCDS3084.1.
RefSeqiNP_005621.2. NM_005630.2.
UniGeneiHs.518270.

Genome annotation databases

EnsembliENST00000310926; ENSP00000311291; ENSG00000174640.
GeneIDi6578.
KEGGihsa:6578.
UCSCiuc003eqa.4. human.

Polymorphism databases

DMDMi218511799.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Solute carrier organic anion transporter family, member 2A1 (SLCO2A1)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70867 mRNA. Translation: AAC09469.1 .
AF056732
, AF056719 , AF056720 , AF056721 , AF056722 , AF056723 , AF056724 , AF056725 , AF056726 , AF056727 , AF056728 , AF056729 , AF056730 , AF056731 Genomic DNA. Translation: AAC62004.1 .
CH471052 Genomic DNA. Translation: EAW79156.1 .
BC041140 mRNA. Translation: AAH41140.2 .
BC051347 mRNA. Translation: AAH51347.1 .
CCDSi CCDS3084.1.
RefSeqi NP_005621.2. NM_005630.2.
UniGenei Hs.518270.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3MRR X-ray 1.60 P 178-187 [» ]
ProteinModelPortali Q92959.
SMRi Q92959. Positions 448-476.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q92959. 1 interaction.
STRINGi 9606.ENSP00000311291.

Chemistry

BindingDBi Q92959.
ChEMBLi CHEMBL2073703.
DrugBanki DB00770. Alprostadil.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB00695. Furosemide.
DB01088. Iloprost.
DB01174. Phenobarbital.
DB00119. Pyruvic acid.
GuidetoPHARMACOLOGYi 1223.

Protein family/group databases

TCDBi 2.A.60.1.19. the organo anion transporter (oat) family.

PTM databases

PhosphoSitei Q92959.

Polymorphism databases

DMDMi 218511799.

Proteomic databases

PaxDbi Q92959.
PRIDEi Q92959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310926 ; ENSP00000311291 ; ENSG00000174640 .
GeneIDi 6578.
KEGGi hsa:6578.
UCSCi uc003eqa.4. human.

Organism-specific databases

CTDi 6578.
GeneCardsi GC03M133651.
H-InvDB HIX0024333.
HGNCi HGNC:10955. SLCO2A1.
HPAi HPA013742.
MIMi 601460. gene.
614441. phenotype.
neXtProti NX_Q92959.
Orphaneti 2796. Pachydermoperiostosis.
PharmGKBi PA35840.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271773.
GeneTreei ENSGT00760000119014.
HOGENOMi HOG000231269.
HOVERGENi HBG108345.
InParanoidi Q92959.
KOi K14345.
OMAi IYLNCSC.
OrthoDBi EOG7QG43R.
PhylomeDBi Q92959.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_23988. Transport of organic anions.

Miscellaneous databases

ChiTaRSi SLCO2A1. human.
EvolutionaryTracei Q92959.
GeneWikii SLCO2A1.
GenomeRNAii 6578.
NextBioi 25591.
PROi Q92959.
SOURCEi Search...

Gene expression databases

Bgeei Q92959.
CleanExi HS_SLCO2A1.
ExpressionAtlasi Q92959. baseline and differential.
Genevestigatori Q92959.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 4 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)."
    Lu R., Kanai N., Bao Y., Schuster V.L.
    J. Clin. Invest. 98:1142-1149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT THR-396.
  2. "Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization."
    Lu R., Schuster V.L.
    Biochem. Biophys. Res. Commun. 246:805-812(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-396.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Prostate.
  5. "Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing."
    Seifert W., Kuhnisch J., Tuysuz B., Specker C., Brouwers A., Horn D.
    Hum. Mutat. 33:660-664(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, VARIANT PHOAR2 SER-557.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy."
    Zhang Z., Xia W., He J., Zhang Z., Ke Y., Yue H., Wang C., Zhang H., Gu J., Hu W., Fu W., Hu Y., Li M., Liu Y.
    Am. J. Hum. Genet. 90:125-132(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PHOAR2 ARG-222 AND GLU-255.
  8. Cited for: VARIANTS PHOAR2 PHE-85; HIS-97; ALA-181; ASP-181; LEU-204; ARG-222; PHE-420 AND GLY-565, VARIANT CYS-445, CHARACTERIZATION OF VARIANT PHOAR2 PHE-420.
  9. "Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing."
    Busch J., Frank V., Bachmann N., Otsuka A., Oji V., Metze D., Shah K., Danda S., Watzer B., Traupe H., Bolz H.J., Kabashima K., Bergmann C.
    J. Invest. Dermatol. 132:2473-2476(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PHOAR2 ARG-255 AND HIS-556.

Entry informationi

Entry nameiSO2A1_HUMAN
AccessioniPrimary (citable) accession number: Q92959
Secondary accession number(s): Q86V98, Q8IUN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3