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Protein

Solute carrier organic anion transporter family member 2A1

Gene

SLCO2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

GO - Biological processi

  • lipid transport Source: ProtInc
  • sodium-independent organic anion transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174640-MONOMER.
ReactomeiR-HSA-879518. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.19. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:SLCO2A1
Synonyms:OATP2A1, SLC21A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:10955. SLCO2A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini53 – 71ExtracellularSequence analysisAdd BLAST19
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 98CytoplasmicSequence analysis6
Transmembranei99 – 123Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini124 – 167ExtracellularSequence analysisAdd BLAST44
Transmembranei168 – 196Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini197 – 215CytoplasmicSequence analysisAdd BLAST19
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 254ExtracellularSequence analysisAdd BLAST18
Transmembranei255 – 279Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini280 – 321CytoplasmicSequence analysisAdd BLAST42
Transmembranei322 – 343Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini344 – 363ExtracellularSequence analysisAdd BLAST20
Transmembranei364 – 387Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini388 – 391CytoplasmicSequence analysis4
Transmembranei392 – 415Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini416 – 518ExtracellularSequence analysisAdd BLAST103
Transmembranei519 – 541Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini542 – 550CytoplasmicSequence analysis9
Transmembranei551 – 576Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini577 – 610ExtracellularSequence analysisAdd BLAST34
Transmembranei611 – 629Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini630 – 643CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease.
See also OMIM:614441
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06863685I → F in PHOAR2. 1 PublicationCorresponds to variant rs387907296dbSNPEnsembl.1
Natural variantiVAR_06863797R → H in PHOAR2. 1 Publication1
Natural variantiVAR_068638181G → A in PHOAR2. 1 Publication1
Natural variantiVAR_068639181G → D in PHOAR2. 1 Publication1
Natural variantiVAR_068640204S → L in PHOAR2. 1 PublicationCorresponds to variant rs555934769dbSNPEnsembl.1
Natural variantiVAR_067598222G → R in PHOAR2. 2 PublicationsCorresponds to variant rs774795340dbSNPEnsembl.1
Natural variantiVAR_067599255G → E in PHOAR2. 1 PublicationCorresponds to variant rs387906806dbSNPEnsembl.1
Natural variantiVAR_068641255G → R in PHOAR2. 1 Publication1
Natural variantiVAR_068642420C → F in PHOAR2; reduced activity. 1 PublicationCorresponds to variant rs387907295dbSNPEnsembl.1
Natural variantiVAR_068644556Q → H in PHOAR2. 1 Publication1
Natural variantiVAR_068352557F → S in PHOAR2. 1 Publication1
Natural variantiVAR_068645565W → G in PHOAR2. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6578.
MalaCardsiSLCO2A1.
MIMi614441. phenotype.
OpenTargetsiENSG00000174640.
Orphaneti2796. Pachydermoperiostosis.
PharmGKBiPA35840.

Chemistry databases

ChEMBLiCHEMBL2073703.
DrugBankiDB00770. Alprostadil.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB00695. Furosemide.
DB01088. Iloprost.
DB04398. Lactic Acid.
DB01174. Phenobarbital.
DB00119. Pyruvic acid.

Polymorphism and mutation databases

BioMutaiSLCO2A1.
DMDMi218511799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910581 – 643Solute carrier organic anion transporter family member 2A1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi444 ↔ 470PROSITE-ProRule annotation
Disulfide bondi448 ↔ 459PROSITE-ProRule annotation
Disulfide bondi450 ↔ 474PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ92959.
PaxDbiQ92959.
PeptideAtlasiQ92959.
PRIDEiQ92959.

PTM databases

PhosphoSitePlusiQ92959.

Expressioni

Tissue specificityi

Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.1 Publication

Gene expression databases

BgeeiENSG00000174640.
CleanExiHS_SLCO2A1.
ExpressionAtlasiQ92959. baseline and differential.
GenevisibleiQ92959. HS.

Organism-specific databases

HPAiHPA013742.

Interactioni

Protein-protein interaction databases

IntActiQ92959. 1 interactor.
STRINGi9606.ENSP00000311291.

Chemistry databases

BindingDBiQ92959.

Structurei

Secondary structure

1643
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi181 – 183Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MRRX-ray1.60P178-187[»]
ProteinModelPortaliQ92959.
SMRiQ92959.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92959.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini438 – 496Kazal-likePROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ92959.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG091G08QD.
PhylomeDBiQ92959.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL
110 120 130 140 150
IGIGGLFLAA GAFILTLPHF LSEPYQYTLA STGNNSRLQA ELCQKHWQDL
160 170 180 190 200
PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA GIGTVPIQPF GISYVDDFSE
210 220 230 240 250
PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN TAAVNLVPGD
260 270 280 290 300
PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE
310 320 330 340 350
EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN
360 370 380 390 400
KFLEKQYGTS AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI
410 420 430 440 450
ATTIITISMI LCVPLFFMGC STPTVAEVYP PSTSSSIHPQ SPACRRDCSC
460 470 480 490 500
PDSIFHPVCG DNGIEYLSPC HAGCSNINMS SATSKQLIYL NCSCVTGGSA
510 520 530 540 550
SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV LRVVNQEEKS
560 570 580 590 600
FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND
610 620 630 640
ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI
Length:643
Mass (Da):70,044
Last modified:December 16, 2008 - v2
Checksum:iA1FF933246480984
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → V in AAC09469 (PubMed:8787677).Curated1
Sequence conflicti9A → V in AAC62004 (PubMed:9618293).Curated1
Sequence conflicti228V → I in AAC09469 (PubMed:8787677).Curated1
Sequence conflicti228V → I in AAC62004 (PubMed:9618293).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06863685I → F in PHOAR2. 1 PublicationCorresponds to variant rs387907296dbSNPEnsembl.1
Natural variantiVAR_06863797R → H in PHOAR2. 1 Publication1
Natural variantiVAR_068638181G → A in PHOAR2. 1 Publication1
Natural variantiVAR_068639181G → D in PHOAR2. 1 Publication1
Natural variantiVAR_068640204S → L in PHOAR2. 1 PublicationCorresponds to variant rs555934769dbSNPEnsembl.1
Natural variantiVAR_067598222G → R in PHOAR2. 2 PublicationsCorresponds to variant rs774795340dbSNPEnsembl.1
Natural variantiVAR_067599255G → E in PHOAR2. 1 PublicationCorresponds to variant rs387906806dbSNPEnsembl.1
Natural variantiVAR_068641255G → R in PHOAR2. 1 Publication1
Natural variantiVAR_053674396A → T.2 PublicationsCorresponds to variant rs34550074dbSNPEnsembl.1
Natural variantiVAR_068642420C → F in PHOAR2; reduced activity. 1 PublicationCorresponds to variant rs387907295dbSNPEnsembl.1
Natural variantiVAR_068643445R → C.1 PublicationCorresponds to variant rs146970901dbSNPEnsembl.1
Natural variantiVAR_068644556Q → H in PHOAR2. 1 Publication1
Natural variantiVAR_068352557F → S in PHOAR2. 1 Publication1
Natural variantiVAR_068645565W → G in PHOAR2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70867 mRNA. Translation: AAC09469.1.
AF056732
, AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA. Translation: AAC62004.1.
CH471052 Genomic DNA. Translation: EAW79156.1.
BC041140 mRNA. Translation: AAH41140.2.
BC051347 mRNA. Translation: AAH51347.1.
CCDSiCCDS3084.1.
RefSeqiNP_005621.2. NM_005630.2.
UniGeneiHs.518270.

Genome annotation databases

EnsembliENST00000310926; ENSP00000311291; ENSG00000174640.
GeneIDi6578.
KEGGihsa:6578.
UCSCiuc003eqa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Solute carrier organic anion transporter family, member 2A1 (SLCO2A1)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70867 mRNA. Translation: AAC09469.1.
AF056732
, AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA. Translation: AAC62004.1.
CH471052 Genomic DNA. Translation: EAW79156.1.
BC041140 mRNA. Translation: AAH41140.2.
BC051347 mRNA. Translation: AAH51347.1.
CCDSiCCDS3084.1.
RefSeqiNP_005621.2. NM_005630.2.
UniGeneiHs.518270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MRRX-ray1.60P178-187[»]
ProteinModelPortaliQ92959.
SMRiQ92959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ92959. 1 interactor.
STRINGi9606.ENSP00000311291.

Chemistry databases

BindingDBiQ92959.
ChEMBLiCHEMBL2073703.
DrugBankiDB00770. Alprostadil.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB00695. Furosemide.
DB01088. Iloprost.
DB04398. Lactic Acid.
DB01174. Phenobarbital.
DB00119. Pyruvic acid.

Protein family/group databases

TCDBi2.A.60.1.19. the organo anion transporter (oat) family.

PTM databases

PhosphoSitePlusiQ92959.

Polymorphism and mutation databases

BioMutaiSLCO2A1.
DMDMi218511799.

Proteomic databases

EPDiQ92959.
PaxDbiQ92959.
PeptideAtlasiQ92959.
PRIDEiQ92959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310926; ENSP00000311291; ENSG00000174640.
GeneIDi6578.
KEGGihsa:6578.
UCSCiuc003eqa.4. human.

Organism-specific databases

CTDi6578.
DisGeNETi6578.
GeneCardsiSLCO2A1.
H-InvDBHIX0024333.
HGNCiHGNC:10955. SLCO2A1.
HPAiHPA013742.
MalaCardsiSLCO2A1.
MIMi601460. gene.
614441. phenotype.
neXtProtiNX_Q92959.
OpenTargetsiENSG00000174640.
Orphaneti2796. Pachydermoperiostosis.
PharmGKBiPA35840.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ92959.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG091G08QD.
PhylomeDBiQ92959.
TreeFamiTF317540.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174640-MONOMER.
ReactomeiR-HSA-879518. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSLCO2A1. human.
EvolutionaryTraceiQ92959.
GeneWikiiSLCO2A1.
GenomeRNAii6578.
PROiQ92959.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174640.
CleanExiHS_SLCO2A1.
ExpressionAtlasiQ92959. baseline and differential.
GenevisibleiQ92959. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO2A1_HUMAN
AccessioniPrimary (citable) accession number: Q92959
Secondary accession number(s): Q86V98, Q8IUN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.