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Q92959 (SO2A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name=PGT
Solute carrier family 21 member 2
Gene names
Name:SLCO2A1
Synonyms:OATP2A1, SLC21A2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart. Ref.5

Involvement in disease

Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5 Ref.7 Ref.8 Ref.9

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GRB2P629931EBI-1760532,EBI-401755

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 643643Solute carrier organic anion transporter family member 2A1
PRO_0000191058

Regions

Topological domain1 – 3232Cytoplasmic Potential
Transmembrane33 – 5220Helical; Name=1; Potential
Topological domain53 – 7119Extracellular Potential
Transmembrane72 – 9221Helical; Name=2; Potential
Topological domain93 – 986Cytoplasmic Potential
Transmembrane99 – 12325Helical; Name=3; Potential
Topological domain124 – 16744Extracellular Potential
Transmembrane168 – 19629Helical; Name=4; Potential
Topological domain197 – 21519Cytoplasmic Potential
Transmembrane216 – 23621Helical; Name=5; Potential
Topological domain237 – 25418Extracellular Potential
Transmembrane255 – 27925Helical; Name=6; Potential
Topological domain280 – 32142Cytoplasmic Potential
Transmembrane322 – 34322Helical; Name=7; Potential
Topological domain344 – 36320Extracellular Potential
Transmembrane364 – 38724Helical; Name=8; Potential
Topological domain388 – 3914Cytoplasmic Potential
Transmembrane392 – 41524Helical; Name=9; Potential
Topological domain416 – 518103Extracellular Potential
Transmembrane519 – 54123Helical; Name=10; Potential
Topological domain542 – 5509Cytoplasmic Potential
Transmembrane551 – 57626Helical; Name=11; Potential
Topological domain577 – 61034Extracellular Potential
Transmembrane611 – 62919Helical; Name=12; Potential
Topological domain630 – 64314Cytoplasmic Potential
Domain438 – 49659Kazal-like

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Disulfide bond444 ↔ 470 By similarity
Disulfide bond448 ↔ 459 By similarity
Disulfide bond450 ↔ 474 By similarity

Natural variations

Natural variant851I → F in PHOAR2. Ref.8
VAR_068636
Natural variant971R → H in PHOAR2. Ref.8
VAR_068637
Natural variant1811G → A in PHOAR2. Ref.8
VAR_068638
Natural variant1811G → D in PHOAR2. Ref.8
VAR_068639
Natural variant2041S → L in PHOAR2. Ref.8
VAR_068640
Natural variant2221G → R in PHOAR2. Ref.7 Ref.8
VAR_067598
Natural variant2551G → E in PHOAR2. Ref.7
VAR_067599
Natural variant2551G → R in PHOAR2. Ref.9
VAR_068641
Natural variant3961A → T. Ref.1 Ref.2
Corresponds to variant rs34550074 [ dbSNP | Ensembl ].
VAR_053674
Natural variant4201C → F in PHOAR2; reduced activity. Ref.8
VAR_068642
Natural variant4451R → C. Ref.8
Corresponds to variant rs146970901 [ dbSNP | Ensembl ].
VAR_068643
Natural variant5561Q → H in PHOAR2. Ref.9
VAR_068644
Natural variant5571F → S in PHOAR2. Ref.5
VAR_068352
Natural variant5651W → G in PHOAR2. Ref.8
VAR_068645

Experimental info

Sequence conflict91A → V in AAC09469. Ref.1
Sequence conflict91A → V in AAC62004. Ref.2
Sequence conflict2281V → I in AAC09469. Ref.1
Sequence conflict2281V → I in AAC62004. Ref.2

Secondary structure

... 643
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q92959 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: A1FF933246480984

FASTA64370,044
        10         20         30         40         50         60 
MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA YFKSSLTTIE 

        70         80         90        100        110        120 
KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL IGIGGLFLAA GAFILTLPHF 

       130        140        150        160        170        180 
LSEPYQYTLA STGNNSRLQA ELCQKHWQDL PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA 

       190        200        210        220        230        240 
GIGTVPIQPF GISYVDDFSE PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN 

       250        260        270        280        290        300 
TAAVNLVPGD PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE 

       310        320        330        340        350        360 
EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN KFLEKQYGTS 

       370        380        390        400        410        420 
AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI ATTIITISMI LCVPLFFMGC 

       430        440        450        460        470        480 
STPTVAEVYP PSTSSSIHPQ SPACRRDCSC PDSIFHPVCG DNGIEYLSPC HAGCSNINMS 

       490        500        510        520        530        540 
SATSKQLIYL NCSCVTGGSA SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV 

       550        560        570        580        590        600 
LRVVNQEEKS FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND 

       610        620        630        640 
ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)."
Lu R., Kanai N., Bao Y., Schuster V.L.
J. Clin. Invest. 98:1142-1149(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT THR-396.
[2]"Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization."
Lu R., Schuster V.L.
Biochem. Biophys. Res. Commun. 246:805-812(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-396.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Prostate.
[5]"Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing."
Seifert W., Kuhnisch J., Tuysuz B., Specker C., Brouwers A., Horn D.
Hum. Mutat. 33:660-664(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, VARIANT PHOAR2 SER-557.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy."
Zhang Z., Xia W., He J., Zhang Z., Ke Y., Yue H., Wang C., Zhang H., Gu J., Hu W., Fu W., Hu Y., Li M., Liu Y.
Am. J. Hum. Genet. 90:125-132(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PHOAR2 ARG-222 AND GLU-255.
[8]"Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis."
Diggle C.P., Parry D.A., Logan C.V., Laissue P., Rivera C., Restrepo C.M., Fonseca D.J., Morgan J.E., Allanore Y., Fontenay M., Wipff J., Varret M., Gibault L., Dalantaeva N., Korbonits M., Zhou B., Yuan G., Harifi G. expand/collapse author list , Cefle K., Palanduz S., Akoglu H., Zwijnenburg P.J., Lichtenbelt K.D., Aubry-Rozier B., Superti-Furga A., Dallapiccola B., Accadia M., Brancati F., Sheridan E.G., Taylor G.R., Carr I.M., Johnson C.A., Markham A.F., Bonthron D.T.
Hum. Mutat. 33:1175-1181(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PHOAR2 PHE-85; HIS-97; ALA-181; ASP-181; LEU-204; ARG-222; PHE-420 AND GLY-565, VARIANT CYS-445, CHARACTERIZATION OF VARIANT PHOAR2 PHE-420.
[9]"Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing."
Busch J., Frank V., Bachmann N., Otsuka A., Oji V., Metze D., Shah K., Danda S., Watzer B., Traupe H., Bolz H.J., Kabashima K., Bergmann C.
J. Invest. Dermatol. 132:2473-2476(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PHOAR2 ARG-255 AND HIS-556.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U70867 mRNA. Translation: AAC09469.1.
AF056732 expand/collapse EMBL AC list , AF056719, AF056720, AF056721, AF056722, AF056723, AF056724, AF056725, AF056726, AF056727, AF056728, AF056729, AF056730, AF056731 Genomic DNA. Translation: AAC62004.1.
CH471052 Genomic DNA. Translation: EAW79156.1.
BC041140 mRNA. Translation: AAH41140.2.
BC051347 mRNA. Translation: AAH51347.1.
CCDSCCDS3084.1.
RefSeqNP_005621.2. NM_005630.2.
UniGeneHs.518270.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3MRRX-ray1.60P178-187[»]
ProteinModelPortalQ92959.
SMRQ92959. Positions 448-476.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ92959. 1 interaction.
STRING9606.ENSP00000311291.

Chemistry

BindingDBQ92959.
ChEMBLCHEMBL2073703.
GuidetoPHARMACOLOGY1223.

Protein family/group databases

TCDB2.A.60.1.19. the organo anion transporter (oat) family.

PTM databases

PhosphoSiteQ92959.

Polymorphism databases

DMDM218511799.

Proteomic databases

PaxDbQ92959.
PRIDEQ92959.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310926; ENSP00000311291; ENSG00000174640.
GeneID6578.
KEGGhsa:6578.
UCSCuc003eqa.4. human.

Organism-specific databases

CTD6578.
GeneCardsGC03M133651.
H-InvDBHIX0024333.
HGNCHGNC:10955. SLCO2A1.
HPAHPA013742.
MIM601460. gene.
614441. phenotype.
neXtProtNX_Q92959.
Orphanet2796. Pachydermoperiostosis.
PharmGKBPA35840.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271773.
HOGENOMHOG000231269.
HOVERGENHBG108345.
InParanoidQ92959.
KOK14345.
OMAIYLNCSC.
OrthoDBEOG7QG43R.
PhylomeDBQ92959.
TreeFamTF317540.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ92959.
BgeeQ92959.
CleanExHS_SLCO2A1.
GenevestigatorQ92959.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 4 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLCO2A1. human.
EvolutionaryTraceQ92959.
GeneWikiSLCO2A1.
GenomeRNAi6578.
NextBio25591.
PROQ92959.
SOURCESearch...

Entry information

Entry nameSO2A1_HUMAN
AccessionPrimary (citable) accession number: Q92959
Secondary accession number(s): Q86V98, Q8IUN2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM