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Q92956

- TNR14_HUMAN

UniProt

Q92956 - TNR14_HUMAN

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Protein

Tumor necrosis factor receptor superfamily member 14

Gene

TNFRSF14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.1 Publication

GO - Molecular functioni

  1. tumor necrosis factor-activated receptor activity Source: ProtInc
  2. ubiquitin protein ligase binding Source: UniProtKB
  3. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. defense response to Gram-negative bacterium Source: Ensembl
  3. defense response to Gram-positive bacterium Source: Ensembl
  4. immune response Source: ProtInc
  5. negative regulation of alpha-beta T cell proliferation Source: Ensembl
  6. positive regulation of cytokine secretion involved in immune response Source: Ensembl
  7. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  8. positive regulation of T cell migration Source: Ensembl
  9. T cell costimulation Source: Reactome
  10. tumor necrosis factor-mediated signaling pathway Source: GOC
  11. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_19344. Costimulation by the CD28 family.
SignaLinkiQ92956.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 14
Alternative name(s):
Herpes virus entry mediator A
Short name:
Herpesvirus entry mediator A
Short name:
HveA
Tumor necrosis factor receptor-like 2
Short name:
TR2
CD_antigen: CD270
Gene namesi
Name:TNFRSF14
Synonyms:HVEA, HVEM
ORF Names:UNQ329/PRO509
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11912. TNFRSF14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 202164ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Topological domaini224 – 28360CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 38381 PublicationAdd
BLAST
Chaini39 – 283245Tumor necrosis factor receptor superfamily member 14PRO_0000034590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 53
Disulfide bondi54 ↔ 67
Disulfide bondi57 ↔ 75
Disulfide bondi78 ↔ 93
Disulfide bondi96 ↔ 111
Disulfide bondi99 ↔ 119
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Disulfide bondi121 ↔ 138
Disulfide bondi127 ↔ 135
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ92956.
PRIDEiQ92956.

Expressioni

Tissue specificityi

Widely expressed, with the highest expression in lung, spleen and thymus.

Gene expression databases

BgeeiQ92956.
CleanExiHS_TNFRSF14.
ExpressionAtlasiQ92956. baseline and differential.
GenevestigatoriQ92956.

Organism-specific databases

HPAiCAB026150.
CAB030007.
HPA006404.

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TNFSF14O435572EBI-1056653,EBI-524131
TRAF2Q12933-24EBI-1056653,EBI-355760
TRAF5O004635EBI-1056653,EBI-523498

Protein-protein interaction databases

BioGridi114298. 30 interactions.
DIPiDIP-34779N.
DIP-6233N.
IntActiQ92956. 29 interactions.
MINTiMINT-208002.
STRINGi9606.ENSP00000347948.

Structurei

Secondary structure

1
283
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 494Combined sources
Beta strandi52 – 554Combined sources
Beta strandi61 – 655Combined sources
Beta strandi69 – 713Combined sources
Beta strandi74 – 774Combined sources
Beta strandi86 – 883Combined sources
Helixi101 – 1033Combined sources
Beta strandi105 – 1095Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi118 – 1214Combined sources
Beta strandi125 – 1317Combined sources
Beta strandi134 – 1407Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JMAX-ray2.65B39-199[»]
2AW2X-ray2.80B/Y39-142[»]
4FHQX-ray2.25A39-162[»]
ProteinModelPortaliQ92956.
SMRiQ92956. Positions 39-200.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92956.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 7534TNFR-Cys 1Add
BLAST
Repeati78 – 11942TNFR-Cys 2Add
BLAST
Repeati121 – 16242TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40150.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000065766.
HOVERGENiHBG072084.
InParanoidiQ92956.
KOiK05152.
OMAiSPGHFCI.
PhylomeDBiQ92956.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022332. TNFR_14.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01965. TNFACTORR14.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92956-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG
60 70 80 90 100
SECCPKCSPG YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD
110 120 130 140 150
PAMGLRASRN CSRTENAVCG CSPGHFCIVQ DGDHCAACRA YATSSPGQRV
160 170 180 190 200
QKGGTESQDT LCQNCPPGTF SPNGTLEECQ HQTKCSWLVT KAGAGTSSSH
210 220 230 240 250
WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS VQRKRQEAEG
260 270 280
EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH
Length:283
Mass (Da):30,392
Last modified:April 27, 2001 - v3
Checksum:i46CE13C2C70242C1
GO
Isoform 2 (identifier: Q92956-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: MEPPGDWGPP...SKCLQCQMCD → MVSRPPRTPLSPSSWT

Show »
Length:199
Mass (Da):21,351
Checksum:iB14A3275B16BBD66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351C → R in AAH29848. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171K → R.3 Publications
Corresponds to variant rs4870 [ dbSNP | Ensembl ].
VAR_013007
Natural varianti117 – 1171A → T.1 Publication
Corresponds to variant rs2234163 [ dbSNP | Ensembl ].
VAR_018955
Natural varianti174 – 1741G → E.1 Publication
Corresponds to variant rs11573986 [ dbSNP | Ensembl ].
VAR_018956
Natural varianti241 – 2411V → I.2 Publications
Corresponds to variant rs2234167 [ dbSNP | Ensembl ].
VAR_013440

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 100100MEPPG…CQMCD → MVSRPPRTPLSPSSWT in isoform 2. 2 PublicationsVSP_054186Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70321 mRNA. Translation: AAB58354.1.
U81232 mRNA. Translation: AAD00505.1.
AF153978 mRNA. Translation: AAF75588.1.
AF373877 mRNA. Translation: AAL47717.1.
AF373878 mRNA. Translation: AAL47718.1.
AY358879 mRNA. Translation: AAQ89238.1.
AK124010 mRNA. Translation: BAG53992.1.
CR456909 mRNA. Translation: CAG33190.1.
AY466111 Genomic DNA. Translation: AAR23264.1.
AL139246 Genomic DNA. Translation: CAX30824.1.
CH471183 Genomic DNA. Translation: EAW56089.1.
CH471183 Genomic DNA. Translation: EAW56090.1.
BC002794 mRNA. Translation: AAH02794.1.
BC029848 mRNA. Translation: AAH29848.1.
CCDSiCCDS44046.1. [Q92956-1]
RefSeqiNP_003811.2. NM_003820.3. [Q92956-1]
UniGeneiHs.512898.
Hs.682060.

Genome annotation databases

EnsembliENST00000355716; ENSP00000347948; ENSG00000157873. [Q92956-1]
ENST00000617968; ENSP00000477642; ENSG00000273936. [Q92956-2]
ENST00000621877; ENSP00000478308; ENSG00000273936. [Q92956-1]
GeneIDi8764.
KEGGihsa:8764.
UCSCiuc001ajr.3. human. [Q92956-1]

Polymorphism databases

DMDMi13878821.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70321 mRNA. Translation: AAB58354.1 .
U81232 mRNA. Translation: AAD00505.1 .
AF153978 mRNA. Translation: AAF75588.1 .
AF373877 mRNA. Translation: AAL47717.1 .
AF373878 mRNA. Translation: AAL47718.1 .
AY358879 mRNA. Translation: AAQ89238.1 .
AK124010 mRNA. Translation: BAG53992.1 .
CR456909 mRNA. Translation: CAG33190.1 .
AY466111 Genomic DNA. Translation: AAR23264.1 .
AL139246 Genomic DNA. Translation: CAX30824.1 .
CH471183 Genomic DNA. Translation: EAW56089.1 .
CH471183 Genomic DNA. Translation: EAW56090.1 .
BC002794 mRNA. Translation: AAH02794.1 .
BC029848 mRNA. Translation: AAH29848.1 .
CCDSi CCDS44046.1. [Q92956-1 ]
RefSeqi NP_003811.2. NM_003820.3. [Q92956-1 ]
UniGenei Hs.512898.
Hs.682060.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JMA X-ray 2.65 B 39-199 [» ]
2AW2 X-ray 2.80 B/Y 39-142 [» ]
4FHQ X-ray 2.25 A 39-162 [» ]
ProteinModelPortali Q92956.
SMRi Q92956. Positions 39-200.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114298. 30 interactions.
DIPi DIP-34779N.
DIP-6233N.
IntActi Q92956. 29 interactions.
MINTi MINT-208002.
STRINGi 9606.ENSP00000347948.

Chemistry

GuidetoPHARMACOLOGYi 1887.

Polymorphism databases

DMDMi 13878821.

Proteomic databases

PaxDbi Q92956.
PRIDEi Q92956.

Protocols and materials databases

DNASUi 8764.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355716 ; ENSP00000347948 ; ENSG00000157873 . [Q92956-1 ]
ENST00000617968 ; ENSP00000477642 ; ENSG00000273936 . [Q92956-2 ]
ENST00000621877 ; ENSP00000478308 ; ENSG00000273936 . [Q92956-1 ]
GeneIDi 8764.
KEGGi hsa:8764.
UCSCi uc001ajr.3. human. [Q92956-1 ]

Organism-specific databases

CTDi 8764.
GeneCardsi GC01P002487.
HGNCi HGNC:11912. TNFRSF14.
HPAi CAB026150.
CAB030007.
HPA006404.
MIMi 602746. gene.
neXtProti NX_Q92956.
PharmGKBi PA36605.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40150.
GeneTreei ENSGT00760000119204.
HOGENOMi HOG000065766.
HOVERGENi HBG072084.
InParanoidi Q92956.
KOi K05152.
OMAi SPGHFCI.
PhylomeDBi Q92956.
TreeFami TF331157.

Enzyme and pathway databases

Reactomei REACT_19344. Costimulation by the CD28 family.
SignaLinki Q92956.

Miscellaneous databases

ChiTaRSi TNFRSF14. human.
EvolutionaryTracei Q92956.
GeneWikii TNFRSF14.
GenomeRNAii 8764.
NextBioi 32872.
PROi Q92956.
SOURCEi Search...

Gene expression databases

Bgeei Q92956.
CleanExi HS_TNFRSF14.
ExpressionAtlasi Q92956. baseline and differential.
Genevestigatori Q92956.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022332. TNFR_14.
[Graphical view ]
Pfami PF00020. TNFR_c6. 1 hit.
[Graphical view ]
PRINTSi PR01965. TNFACTORR14.
SMARTi SM00208. TNFR. 3 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family."
    Montgomery R.I., Warner M.S., Lum B.J., Spear P.G.
    Cell 87:427-436(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A RECEPTOR FOR HHV-1.
    Tissue: Cervix adenocarcinoma.
  2. "A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation."
    Kwon B.S., Tan K.B., Ni J., Oh K.-O., Lee Z.H., Kim K.K., Kim Y.-J., Wang S., Gentz R., Yu G.-L., Harrop J., Lyn S.D., Silverman C., Porter T.G., Truneh A., Young P.R.
    J. Biol. Chem. 272:14272-14276(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Zhang W., Wan T., Cao X.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Search for polymorphisms in the genes for herpesvirus entry mediator, Nectin-1, and Nectin-2 in immune seronegative individuals."
    Struyf F., Posavad C.M., Keyaerts E., Van Ranst M., Corey L., Spear P.G.
    J. Infect. Dis. 185:36-44(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-17 AND ILE-241.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-17.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. NIEHS SNPs program
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-17; THR-117; GLU-174 AND ILE-241.
  9. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skin.
  12. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 39-53.
  13. "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5."
    Hsu H., Solovyev I., Colombero A., Elliott R., Kelley M., Boyle W.J.
    J. Biol. Chem. 272:13471-13474(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF2 AND TRAF5.
  14. "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1."
    Marsters S.A., Ayres T.M., Skubatch M., Gray C.L., Rothe M., Ashkenazi A.
    J. Biol. Chem. 272:14029-14032(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF3 AND TRAF5.
  15. "Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry."
    Krummenacher C., Nicola A.V., Whitbeck J.C., Lou H., Hou W., Lambris J.D., Geraghty R.J., Spear P.G., Cohen G.H., Eisenberg R.J.
    J. Virol. 72:7064-7074(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-1 AND HHV-2 GLYCOPROTEIN D.
  16. "Herpes simplex virus glycoprotein D bound to the human receptor HveA."
    Carfi A., Willis S.H., Whitbeck J.C., Krummenacher C., Cohen G.H., Eisenberg R.J., Wiley D.C.
    Mol. Cell 8:169-179(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 39-200 IN COMPLEX WITH HUMAN HERPESVIRUS 1 GLYCOPROTEIN.
  17. "Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex."
    Compaan D.M., Gonzalez L.C., Tom I., Loyet K.M., Eaton D., Hymowitz S.G.
    J. Biol. Chem. 280:39553-39561(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 26-137 IN COMPLEX WITH BTLA, GLYCOSYLATION AT ASN-110.

Entry informationi

Entry nameiTNR14_HUMAN
AccessioniPrimary (citable) accession number: Q92956
Secondary accession number(s): B3KW30
, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q96J31, Q9UM65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 26, 2014
This is version 163 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3