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Q92954 (PRG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteoglycan 4
Alternative name(s):
Lubricin
Megakaryocyte-stimulating factor
Superficial zone proteoglycan

Cleaved into the following chain:

  1. Proteoglycan 4 C-terminal part
Gene names
Name:PRG4
Synonyms:MSF, SZP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1404 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Ref.6 Ref.12

Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. Ref.6 Ref.12

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted Ref.6.

Tissue specificity

Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed. Ref.10 Ref.11

Post-translational modification

N-glycosylated. Ref.9 Ref.12

O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. Ref.9 Ref.12

The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage By similarity.

Involvement in disease

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) [MIM:208250]: Autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10

Miscellaneous

Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage By similarity.

Sequence similarities

Contains 2 hemopexin repeats.

Contains 2 SMB (somatomedin-B) domains.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q92954-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q92954-2)

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
Isoform C (identifier: Q92954-3)

The sequence of this isoform differs from the canonical sequence as follows:
     107-199: Missing.
Isoform D (identifier: Q92954-4)

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     107-199: Missing.
Isoform E (identifier: Q92954-5)

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     412-841: Missing.
Note: No experimental confirmation available.
Isoform F (identifier: Q92954-6)

Also known as: Hemangiopoietin; HAPO;

The sequence of this isoform differs from the canonical sequence as follows:
     157-199: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 14041380Proteoglycan 4
PRO_0000043232
Chain1307 – 140498Proteoglycan 4 C-terminal part
PRO_0000043233

Regions

Domain26 – 6944SMB 1
Domain66 – 10843SMB 2
Repeat348 – 35581
Repeat356 – 36382; approximate
Repeat364 – 37183
Repeat372 – 37874; approximate
Repeat379 – 38685
Repeat387 – 39376; approximate
Repeat394 – 40187
Repeat402 – 40988
Repeat410 – 41789
Repeat418 – 425810
Repeat426 – 432711; approximate
Repeat433 – 440812
Repeat441 – 448813
Repeat449 – 456814
Repeat457 – 464815
Repeat465 – 471716; approximate
Repeat472 – 479817
Repeat480 – 487818; approximate
Repeat488 – 495819; approximate
Repeat496 – 503820
Repeat504 – 511821
Repeat512 – 519822
Repeat520 – 527823
Repeat528 – 534724; approximate
Repeat535 – 542825
Repeat543 – 549726; approximate
Repeat550 – 557827
Repeat558 – 565828
Repeat566 – 573829
Repeat574 – 581830
Repeat582 – 589831
Repeat590 – 597832
Repeat598 – 605833; approximate
Repeat606 – 613834
Repeat614 – 621835; approximate
Repeat622 – 629836; approximate
Repeat638 – 645837; approximate
Repeat662 – 669838; approximate
Repeat678 – 685839
Repeat686 – 693840
Repeat694 – 701841
Repeat702 – 709842; approximate
Repeat710 – 717843; approximate
Repeat718 – 725844
Repeat731 – 738845; approximate
Repeat739 – 746846; approximate
Repeat747 – 754847; approximate
Repeat755 – 762848; approximate
Repeat763 – 770849
Repeat771 – 778850
Repeat779 – 786851; approximate
Repeat787 – 794852
Repeat800 – 807853; approximate
Repeat808 – 815854; approximate
Repeat816 – 823855; approximate
Repeat824 – 831856; approximate
Repeat832 – 839857
Repeat840 – 847858
Repeat848 – 855859; approximate
Repeat1148 – 119144Hemopexin 1
Repeat1192 – 123948Hemopexin 2
Region348 – 85550859 X 8 AA repeats of K-X-P-X-P-T-T-X
Compositional bias159 – 18830Ser-rich

Sites

Site1306 – 13072Cleavage; by subtilisin-like proprotein convertase 4 By similarity

Amino acid modifications

Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation11591N-linked (GlcNAc...) Ref.13
Disulfide bond30 ↔ 46Alternate By similarity
Disulfide bond30 ↔ 34Alternate By similarity
Disulfide bond34 ↔ 64Alternate By similarity
Disulfide bond44 ↔ 57Alternate By similarity
Disulfide bond44 ↔ 46Alternate By similarity
Disulfide bond50 ↔ 56 By similarity
Disulfide bond57 ↔ 64Alternate By similarity
Disulfide bond70 ↔ 86Alternate By similarity
Disulfide bond70 ↔ 74Alternate By similarity
Disulfide bond74 ↔ 104Alternate By similarity
Disulfide bond84 ↔ 97Alternate By similarity
Disulfide bond84 ↔ 86Alternate By similarity
Disulfide bond90 ↔ 96 By similarity
Disulfide bond97 ↔ 104Alternate By similarity
Disulfide bond1146 ↔ 1403 By similarity

Natural variations

Alternative sequence26 – 6641Missing in isoform B, isoform D and isoform E.
VSP_016467
Alternative sequence107 – 19993Missing in isoform C and isoform D.
VSP_016468
Alternative sequence157 – 19943Missing in isoform F.
VSP_016469
Alternative sequence412 – 841430Missing in isoform E.
VSP_016470
Natural variant1801R → W. Ref.1
Corresponds to variant rs2273779 [ dbSNP | Ensembl ].
VAR_024023
Natural variant11301N → S.
Corresponds to variant rs10158395 [ dbSNP | Ensembl ].
VAR_051559
Natural variant12721I → T.
Corresponds to variant rs1293985 [ dbSNP | Ensembl ].
VAR_051560
Natural variant12961T → M. Ref.1
Corresponds to variant rs12134934 [ dbSNP | Ensembl ].
VAR_051561

Experimental info

Sequence conflict6041T → A in AAB09089. Ref.1
Sequence conflict7461C → S in AAB09089. Ref.1
Sequence conflict13401S → G in AAT74746. Ref.4
Sequence conflict13801V → G in AAT74746. Ref.4
Sequence conflict13971S → F in AAT74746. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 782A11746B3FDEE5

FASTA1,404151,077
        10         20         30         40         50         60 
MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC QHYMECCPDF 

        70         80         90        100        110        120 
KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY ESFCAEVHNP TSPPSSKKAP 

       130        140        150        160        170        180 
PPSGASQTIK STTKRSPKPP NKKKTKKVIE SEEITEEHSV SENQESSSSS SSSSSSSTIR 

       190        200        210        220        230        240 
KIKSSKNSAA NRELQKKLKV KDNKKNRTKK KPTPKPPVVD EAGSGLDNGD FKVTTPDTST 

       250        260        270        280        290        300 
TQHNKVSTSP KITTAKPINP RPSLPPNSDT SKETSLTVNK ETTVETKETT TTNKQTSTDG 

       310        320        330        340        350        360 
KEKTTSAKET QSIEKTSAKD LAPTSKVLAK PTPKAETTTK GPALTTPKEP TPTTPKEPAS 

       370        380        390        400        410        420 
TTPKEPTPTT IKSAPTTPKE PAPTTTKSAP TTPKEPAPTT TKEPAPTTPK EPAPTTTKEP 

       430        440        450        460        470        480 
APTTTKSAPT TPKEPAPTTP KKPAPTTPKE PAPTTPKEPT PTTPKEPAPT TKEPAPTTPK 

       490        500        510        520        530        540 
EPAPTAPKKP APTTPKEPAP TTPKEPAPTT TKEPSPTTPK EPAPTTTKSA PTTTKEPAPT 

       550        560        570        580        590        600 
TTKSAPTTPK EPSPTTTKEP APTTPKEPAP TTPKKPAPTT PKEPAPTTPK EPAPTTTKKP 

       610        620        630        640        650        660 
APTTPKEPAP TTPKETAPTT PKKLTPTTPE KLAPTTPEKP APTTPEELAP TTPEEPTPTT 

       670        680        690        700        710        720 
PEEPAPTTPK AAAPNTPKEP APTTPKEPAP TTPKEPAPTT PKETAPTTPK GTAPTTLKEP 

       730        740        750        760        770        780 
APTTPKKPAP KELAPTTTKE PTSTTCDKPA PTTPKGTAPT TPKEPAPTTP KEPAPTTPKG 

       790        800        810        820        830        840 
TAPTTLKEPA PTTPKKPAPK ELAPTTTKGP TSTTSDKPAP TTPKETAPTT PKEPAPTTPK 

       850        860        870        880        890        900 
KPAPTTPETP PPTTSEVSTP TTTKEPTTIH KSPDESTPEL SAEPTPKALE NSPKEPGVPT 

       910        920        930        940        950        960 
TKTPAATKPE MTTTAKDKTT ERDLRTTPET TTAAPKMTKE TATTTEKTTE SKITATTTQV 

       970        980        990       1000       1010       1020 
TSTTTQDTTP FKITTLKTTT LAPKVTTTKK TITTTEIMNK PEETAKPKDR ATNSKATTPK 

      1030       1040       1050       1060       1070       1080 
PQKPTKAPKK PTSTKKPKTM PRVRKPKTTP TPRKMTSTMP ELNPTSRIAE AMLQTTTRPN 

      1090       1100       1110       1120       1130       1140 
QTPNSKLVEV NPKSEDAGGA EGETPHMLLR PHVFMPEVTP DMDYLPRVPN QGIIINPMLS 

      1150       1160       1170       1180       1190       1200 
DETNICNGKP VDGLTTLRNG TLVAFRGHYF WMLSPFSPPS PARRITEVWG IPSPIDTVFT 

      1210       1220       1230       1240       1250       1260 
RCNCEGKTFF FKDSQYWRFT NDIKDAGYPK PIFKGFGGLT GQIVAALSTA KYKNWPESVY 

      1270       1280       1290       1300       1310       1320 
FFKRGGSIQQ YIYKQEPVQK CPGRRPALNY PVYGETTQVR RRRFERAIGP SQTHTIRIQY 

      1330       1340       1350       1360       1370       1380 
SPARLAYQDK GVLHNEVKVS ILWRGLPNVV TSAISLPNIR KPDGYDYYAF SKDQYYNIDV 

      1390       1400 
PSRTARAITT RSGQTLSKVW YNCP 

« Hide

Isoform B [UniParc].

Checksum: 50E8651CE1EE09A7
Show »

FASTA1,363146,518
Isoform C [UniParc].

Checksum: D01B2F4A548A6625
Show »

FASTA1,311141,106
Isoform D [UniParc].

Checksum: 3218D3229FA74D85
Show »

FASTA1,270136,547
Isoform E [UniParc].

Checksum: B883773C5BC21A23
Show »

FASTA933102,513
Isoform F (Hemangiopoietin) (HAPO) [UniParc].

Checksum: 72DD98ED1A613593
Show »

FASTA1,361146,468

References

« Hide 'large scale' references
[1]Turner K.J., Fitz L.J., Temple P., Jacobs K., Larson D., Leary A.C., Kelleher K., Giannotti J., Calvetti J., Fitzgerald M., Kriz M.J., Ferenz C., Grobholz J., Fraser H., Bean K., Norton C.R., Gesner T., Bhatia S. expand/collapse author list , Kriz R., Hewick R., Clark S.C.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS TRP-180 AND MET-1296.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM E).
Tissue: Synovial cell.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Cloning and production of recombinant PRG4/cartilage superficial zone proteoglycan (SZP) N- and C-terminal domains."
Jones A.R., Hughes C.E., Flannery C.R., Caterson B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-193 AND 1148-1398.
[5]"Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism."
Flannery C.R., Hughes C.E., Schumacher B.L., Tudor D., Aydelotte M.B., Kuettner K.E., Caterson B.
Biochem. Biophys. Res. Commun. 254:535-541(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-90; 158-258 AND 1209-1295, IDENTIFICATION (ISOFORM C).
[6]"Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages."
Liu Y.J., Lu S.H., Xu B., Yang R.C., Ren Q., Liu B., Li B., Lu M., Yan F.Y., Han Z.B., Han Z.C.
Blood 103:4449-4456(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-376 (ISOFORM F), FUNCTION, SUBCELLULAR LOCATION.
Tissue: Fetal liver.
[7]"Purification, biochemical characterization, and cloning of a novel megakaryocyte stimulating factor that has megakaryocyte colony stimulating activity."
Turner K.J., Fitz L.J., Temple P., Jacobs K., Larson D., Leary A.C., Kelleher K., Giannotti J., Calvetti J., Fitzgerald M., Kriz M.-J., Ferenz C., Grobholz J., Fraser H., Bean K., Norton C.R., Gesner T., Bhatia S. expand/collapse author list , Kriz R., Hewick R., Clark S.C.
Blood 78:279A-279A(1991)
Cited for: PURIFICATION.
Tissue: Urine.
[8]"A comparison of vitronectin and megakaryocyte stimulating factor."
Merberg D.M., Fitz L.J., Temple P., Giannotti J., Murtha P., Fitzgerald M., Scaltreto H., Kelleher K., Preissner K., Kriz R., Jacobs K., Turner K.
(In) Preissner K.T., Rosenblatt S., Kost C., Wegerhoff J., Mosher D.F. (eds.); Biology of vitronectins and their receptors, pp.45-52, Elsevier Science Publishers B.V., Amsterdam (1993)
Cited for: GENE STRUCTURE.
[9]"A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage."
Schumacher B.L., Block J.A., Schmid T.M., Aydelotte M.B., Kuettner K.E.
Arch. Biochem. Biophys. 311:144-152(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION.
[10]"CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome."
Marcelino J., Carpten J.D., Suwairi W.M., Gutierrez O.M., Schwartz S., Robbins C., Sood R., Makalowska I., Baxevanis A., Johnstone B., Laxer R.M., Zemel L., Kim C.A., Herd J.K., Ihle J., Williams C., Johnson M., Raman V. expand/collapse author list , Alonso L.G., Brunoni D., Gerstein A., Papadopoulos N., Bahabri S.A., Trent J.M., Warman M.L.
Nat. Genet. 23:319-322(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN CACP.
[11]"Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes."
Ikegawa S., Sano M., Koshizuka Y., Nakamura Y.
Cytogenet. Cell Genet. 90:291-297(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, IDENTIFICATION (ISOFORMS B; C AND D).
[12]"Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts."
Jay G.D., Britt D.E., Cha C.-J.
J. Rheumatol. 27:594-600(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, GLYCOSYLATION.
[13]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1159.
Tissue: Plasma.
[14]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[15]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U70136 mRNA. Translation: AAB09089.1.
AK131434 mRNA. Translation: BAD18580.1.
AL133553 Genomic DNA. Translation: CAC36090.1.
AY653037 mRNA. Translation: AAT74745.1.
AY653038 mRNA. Translation: AAT74746.1.
CCDSCCDS1369.1. [Q92954-1]
CCDS44287.1. [Q92954-3]
CCDS44288.1. [Q92954-2]
RefSeqNP_001121180.1. NM_001127708.1. [Q92954-2]
NP_001121181.1. NM_001127709.1. [Q92954-3]
NP_001121182.1. NM_001127710.1. [Q92954-4]
NP_005798.2. NM_005807.3. [Q92954-1]
UniGeneHs.647723.

3D structure databases

ProteinModelPortalQ92954.
SMRQ92954. Positions 26-106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115511. 1 interaction.
IntActQ92954. 3 interactions.
MINTMINT-7970782.

PTM databases

PhosphoSiteQ92954.

Polymorphism databases

DMDM83288393.

Proteomic databases

MaxQBQ92954.
PaxDbQ92954.
PRIDEQ92954.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367483; ENSP00000356453; ENSG00000116690. [Q92954-2]
ENST00000367485; ENSP00000356455; ENSG00000116690. [Q92954-3]
ENST00000367486; ENSP00000356456; ENSG00000116690. [Q92954-6]
ENST00000445192; ENSP00000399679; ENSG00000116690. [Q92954-1]
GeneID10216.
KEGGhsa:10216.
UCSCuc001grt.4. human. [Q92954-2]
uc001gru.4. human. [Q92954-1]
uc009wyl.3. human. [Q92954-3]
uc009wym.3. human. [Q92954-4]

Organism-specific databases

CTD10216.
GeneCardsGC01P186265.
HGNCHGNC:9364. PRG4.
HPAHPA028523.
MIM208250. phenotype.
604283. gene.
neXtProtNX_Q92954.
Orphanet2848. Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome.
PharmGKBPA33736.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000115691.
InParanoidQ92954.
OMAPTTTKGP.
PhylomeDBQ92954.
TreeFamTF332780.

Gene expression databases

ArrayExpressQ92954.
BgeeQ92954.
CleanExHS_PRG4.
GenevestigatorQ92954.

Family and domain databases

Gene3D2.110.10.10. 2 hits.
InterProIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PfamPF00045. Hemopexin. 1 hit.
PF01033. Somatomedin_B. 2 hits.
[Graphical view]
PRINTSPR00022. SOMATOMEDINB.
SMARTSM00120. HX. 2 hits.
SM00201. SO. 2 hits.
[Graphical view]
SUPFAMSSF50923. SSF50923. 2 hits.
PROSITEPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 2 hits.
PS00524. SMB_1. 2 hits.
PS50958. SMB_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPRG4.
GenomeRNAi10216.
NextBio38682.
PROQ92954.
SOURCESearch...

Entry information

Entry namePRG4_HUMAN
AccessionPrimary (citable) accession number: Q92954
Secondary accession number(s): Q6DNC4 expand/collapse secondary AC list , Q6DNC5, Q6ZMZ5, Q9BX49
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM