Q92954 (PRG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proteoglycan 4

Alternative name(s):
Lubricin
Megakaryocyte-stimulating factor
Superficial zone proteoglycan

Cleaved into the following chain:

1. Proteoglycan 4 C-terminal part

Gene names

Name:	PRG4
Synonyms:	MSF, SZP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Ref.6 Ref.12 Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. Ref.6 Ref.12
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Secreted Ref.6.
Tissue specificity	Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed. Ref.10 Ref.11
Post-translational modification	N-glycosylated. Ref.9 Ref.12 O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. Ref.9 Ref.12 The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage By similarity.
Involvement in disease	Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) [MIM:208250]: Autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10
Miscellaneous	Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage By similarity.
Sequence similarities	Contains 2 hemopexin-like domains. Contains 2 SMB (somatomedin-B) domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
PTM	Disulfide bond Glycoprotein Proteoglycan
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.10. Source: ProtInc immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	polysaccharide binding Inferred from electronic annotation. Source: InterPro scavenger receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q92954-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q92954-2)

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.

Isoform C (identifier: Q92954-3)

The sequence of this isoform differs from the canonical sequence as follows:
     107-199: Missing.

Isoform D (identifier: Q92954-4)

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     107-199: Missing.

Isoform E (identifier: Q92954-5)

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     412-841: Missing.

Note: No experimental confirmation available.

Isoform F (identifier: Q92954-6)

Also known as: Hemangiopoietin; HAPO;

The sequence of this isoform differs from the canonical sequence as follows:
     157-199: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 1404	1380	Proteoglycan 4		PRO_0000043232
	Chain	1307 – 1404	98	Proteoglycan 4 C-terminal part		PRO_0000043233
Regions
	Domain	26 – 69	44	SMB 1
	Domain	66 – 108	43	SMB 2
	Repeat	348 – 355	8	1
	Repeat	356 – 363	8	2; approximate
	Repeat	364 – 371	8	3
	Repeat	372 – 378	7	4; approximate
	Repeat	379 – 386	8	5
	Repeat	387 – 393	7	6; approximate
	Repeat	394 – 401	8	7
	Repeat	402 – 409	8	8
	Repeat	410 – 417	8	9
	Repeat	418 – 425	8	10
	Repeat	426 – 432	7	11; approximate
	Repeat	433 – 440	8	12
	Repeat	441 – 448	8	13
	Repeat	449 – 456	8	14
	Repeat	457 – 464	8	15
	Repeat	465 – 471	7	16; approximate
	Repeat	472 – 479	8	17
	Repeat	480 – 487	8	18; approximate
	Repeat	488 – 495	8	19; approximate
	Repeat	496 – 503	8	20
	Repeat	504 – 511	8	21
	Repeat	512 – 519	8	22
	Repeat	520 – 527	8	23
	Repeat	528 – 534	7	24; approximate
	Repeat	535 – 542	8	25
	Repeat	543 – 549	7	26; approximate
	Repeat	550 – 557	8	27
	Repeat	558 – 565	8	28
	Repeat	566 – 573	8	29
	Repeat	574 – 581	8	30
	Repeat	582 – 589	8	31
	Repeat	590 – 597	8	32
	Repeat	598 – 605	8	33; approximate
	Repeat	606 – 613	8	34
	Repeat	614 – 621	8	35; approximate
	Repeat	622 – 629	8	36; approximate
	Repeat	638 – 645	8	37; approximate
	Repeat	662 – 669	8	38; approximate
	Repeat	678 – 685	8	39
	Repeat	686 – 693	8	40
	Repeat	694 – 701	8	41
	Repeat	702 – 709	8	42; approximate
	Repeat	710 – 717	8	43; approximate
	Repeat	718 – 725	8	44
	Repeat	731 – 738	8	45; approximate
	Repeat	739 – 746	8	46; approximate
	Repeat	747 – 754	8	47; approximate
	Repeat	755 – 762	8	48; approximate
	Repeat	763 – 770	8	49
	Repeat	771 – 778	8	50
	Repeat	779 – 786	8	51; approximate
	Repeat	787 – 794	8	52
	Repeat	800 – 807	8	53; approximate
	Repeat	808 – 815	8	54; approximate
	Repeat	816 – 823	8	55; approximate
	Repeat	824 – 831	8	56; approximate
	Repeat	832 – 839	8	57
	Repeat	840 – 847	8	58
	Repeat	848 – 855	8	59; approximate
	Domain	1151 – 1193	43	Hemopexin-like 1
	Domain	1195 – 1241	47	Hemopexin-like 2
	Region	348 – 855	508	59 X 8 AA repeats of K-X-P-X-P-T-T-X
	Compositional bias	159 – 188	30	Ser-rich
Sites
	Site	1306 – 1307	2	Cleavage; by subtilisin-like proprotein convertase 4 By similarity
Amino acid modifications
	Glycosylation	206	1	N-linked (GlcNAc...) Potential
	Glycosylation	1159	1	N-linked (GlcNAc...) Ref.13
	Disulfide bond	30 ↔ 46		Alternate By similarity
	Disulfide bond	30 ↔ 34		By similarity
	Disulfide bond	34 ↔ 64		Alternate By similarity
	Disulfide bond	44 ↔ 57		Alternate By similarity
	Disulfide bond	44 ↔ 46		By similarity
	Disulfide bond	50 ↔ 56		By similarity
	Disulfide bond	57 ↔ 64		By similarity
	Disulfide bond	70 ↔ 86		Alternate By similarity
	Disulfide bond	70 ↔ 74		By similarity
	Disulfide bond	74 ↔ 104		Alternate By similarity
	Disulfide bond	84 ↔ 97		Alternate By similarity
	Disulfide bond	84 ↔ 86		By similarity
	Disulfide bond	90 ↔ 96		By similarity
	Disulfide bond	97 ↔ 104		By similarity
	Disulfide bond	1146 ↔ 1403		By similarity
Natural variations
	Alternative sequence	26 – 66	41	Missing in isoform B, isoform D and isoform E.		VSP_016467
	Alternative sequence	107 – 199	93	Missing in isoform C and isoform D.		VSP_016468
	Alternative sequence	157 – 199	43	Missing in isoform F.		VSP_016469
	Alternative sequence	412 – 841	430	Missing in isoform E.		VSP_016470
	Natural variant	180	1	R → W. Ref.1 Corresponds to variant rs2273779 [ dbSNP | Ensembl ].		VAR_024023
	Natural variant	1130	1	N → S. Corresponds to variant rs10158395 [ dbSNP | Ensembl ].		VAR_051559
	Natural variant	1272	1	I → T. Corresponds to variant rs1293985 [ dbSNP | Ensembl ].		VAR_051560
	Natural variant	1296	1	T → M. Ref.1 Corresponds to variant rs12134934 [ dbSNP | Ensembl ].		VAR_051561
Experimental info
	Sequence conflict	604	1	T → A in AAB09089. Ref.1
	Sequence conflict	746	1	C → S in AAB09089. Ref.1
	Sequence conflict	1340	1	S → G in AAT74746. Ref.4
	Sequence conflict	1380	1	V → G in AAT74746. Ref.4
	Sequence conflict	1397	1	S → F in AAT74746. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 782A11746B3FDEE5	FASTA	1,404	151,077
	10 20 30 40 50 60 MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC QHYMECCPDF 70 80 90 100 110 120 KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY ESFCAEVHNP TSPPSSKKAP 130 140 150 160 170 180 PPSGASQTIK STTKRSPKPP NKKKTKKVIE SEEITEEHSV SENQESSSSS SSSSSSSTIR 190 200 210 220 230 240 KIKSSKNSAA NRELQKKLKV KDNKKNRTKK KPTPKPPVVD EAGSGLDNGD FKVTTPDTST 250 260 270 280 290 300 TQHNKVSTSP KITTAKPINP RPSLPPNSDT SKETSLTVNK ETTVETKETT TTNKQTSTDG 310 320 330 340 350 360 KEKTTSAKET QSIEKTSAKD LAPTSKVLAK PTPKAETTTK GPALTTPKEP TPTTPKEPAS 370 380 390 400 410 420 TTPKEPTPTT IKSAPTTPKE PAPTTTKSAP TTPKEPAPTT TKEPAPTTPK EPAPTTTKEP 430 440 450 460 470 480 APTTTKSAPT TPKEPAPTTP KKPAPTTPKE PAPTTPKEPT PTTPKEPAPT TKEPAPTTPK 490 500 510 520 530 540 EPAPTAPKKP APTTPKEPAP TTPKEPAPTT TKEPSPTTPK EPAPTTTKSA PTTTKEPAPT 550 560 570 580 590 600 TTKSAPTTPK EPSPTTTKEP APTTPKEPAP TTPKKPAPTT PKEPAPTTPK EPAPTTTKKP 610 620 630 640 650 660 APTTPKEPAP TTPKETAPTT PKKLTPTTPE KLAPTTPEKP APTTPEELAP TTPEEPTPTT 670 680 690 700 710 720 PEEPAPTTPK AAAPNTPKEP APTTPKEPAP TTPKEPAPTT PKETAPTTPK GTAPTTLKEP 730 740 750 760 770 780 APTTPKKPAP KELAPTTTKE PTSTTCDKPA PTTPKGTAPT TPKEPAPTTP KEPAPTTPKG 790 800 810 820 830 840 TAPTTLKEPA PTTPKKPAPK ELAPTTTKGP TSTTSDKPAP TTPKETAPTT PKEPAPTTPK 850 860 870 880 890 900 KPAPTTPETP PPTTSEVSTP TTTKEPTTIH KSPDESTPEL SAEPTPKALE NSPKEPGVPT 910 920 930 940 950 960 TKTPAATKPE MTTTAKDKTT ERDLRTTPET TTAAPKMTKE TATTTEKTTE SKITATTTQV 970 980 990 1000 1010 1020 TSTTTQDTTP FKITTLKTTT LAPKVTTTKK TITTTEIMNK PEETAKPKDR ATNSKATTPK 1030 1040 1050 1060 1070 1080 PQKPTKAPKK PTSTKKPKTM PRVRKPKTTP TPRKMTSTMP ELNPTSRIAE AMLQTTTRPN 1090 1100 1110 1120 1130 1140 QTPNSKLVEV NPKSEDAGGA EGETPHMLLR PHVFMPEVTP DMDYLPRVPN QGIIINPMLS 1150 1160 1170 1180 1190 1200 DETNICNGKP VDGLTTLRNG TLVAFRGHYF WMLSPFSPPS PARRITEVWG IPSPIDTVFT 1210 1220 1230 1240 1250 1260 RCNCEGKTFF FKDSQYWRFT NDIKDAGYPK PIFKGFGGLT GQIVAALSTA KYKNWPESVY 1270 1280 1290 1300 1310 1320 FFKRGGSIQQ YIYKQEPVQK CPGRRPALNY PVYGETTQVR RRRFERAIGP SQTHTIRIQY 1330 1340 1350 1360 1370 1380 SPARLAYQDK GVLHNEVKVS ILWRGLPNVV TSAISLPNIR KPDGYDYYAF SKDQYYNIDV 1390 1400 PSRTARAITT RSGQTLSKVW YNCP
	Isoform B [UniParc]. Checksum: 50E8651CE1EE09A7	FASTA	1,363	146,518
	10 20 30 40 50 60 MAWKTLPIYL LLLLSVFVIQ QVSSQELSCK GRCFESFERG RECDCDAQCK KYDKCCPDYE 70 80 90 100 110 120 SFCAEVHNPT SPPSSKKAPP PSGASQTIKS TTKRSPKPPN KKKTKKVIES EEITEEHSVS 130 140 150 160 170 180 ENQESSSSSS SSSSSSTIRK IKSSKNSAAN RELQKKLKVK DNKKNRTKKK PTPKPPVVDE 190 200 210 220 230 240 AGSGLDNGDF KVTTPDTSTT QHNKVSTSPK ITTAKPINPR PSLPPNSDTS KETSLTVNKE 250 260 270 280 290 300 TTVETKETTT TNKQTSTDGK EKTTSAKETQ SIEKTSAKDL APTSKVLAKP TPKAETTTKG 310 320 330 340 350 360 PALTTPKEPT PTTPKEPAST TPKEPTPTTI KSAPTTPKEP APTTTKSAPT TPKEPAPTTT 370 380 390 400 410 420 KEPAPTTPKE PAPTTTKEPA PTTTKSAPTT PKEPAPTTPK KPAPTTPKEP APTTPKEPTP 430 440 450 460 470 480 TTPKEPAPTT KEPAPTTPKE PAPTAPKKPA PTTPKEPAPT TPKEPAPTTT KEPSPTTPKE 490 500 510 520 530 540 PAPTTTKSAP TTTKEPAPTT TKSAPTTPKE PSPTTTKEPA PTTPKEPAPT TPKKPAPTTP 550 560 570 580 590 600 KEPAPTTPKE PAPTTTKKPA PTTPKEPAPT TPKETAPTTP KKLTPTTPEK LAPTTPEKPA 610 620 630 640 650 660 PTTPEELAPT TPEEPTPTTP EEPAPTTPKA AAPNTPKEPA PTTPKEPAPT TPKEPAPTTP 670 680 690 700 710 720 KETAPTTPKG TAPTTLKEPA PTTPKKPAPK ELAPTTTKEP TSTTCDKPAP TTPKGTAPTT 730 740 750 760 770 780 PKEPAPTTPK EPAPTTPKGT APTTLKEPAP TTPKKPAPKE LAPTTTKGPT STTSDKPAPT 790 800 810 820 830 840 TPKETAPTTP KEPAPTTPKK PAPTTPETPP PTTSEVSTPT TTKEPTTIHK SPDESTPELS 850 860 870 880 890 900 AEPTPKALEN SPKEPGVPTT KTPAATKPEM TTTAKDKTTE RDLRTTPETT TAAPKMTKET 910 920 930 940 950 960 ATTTEKTTES KITATTTQVT STTTQDTTPF KITTLKTTTL APKVTTTKKT ITTTEIMNKP 970 980 990 1000 1010 1020 EETAKPKDRA TNSKATTPKP QKPTKAPKKP TSTKKPKTMP RVRKPKTTPT PRKMTSTMPE 1030 1040 1050 1060 1070 1080 LNPTSRIAEA MLQTTTRPNQ TPNSKLVEVN PKSEDAGGAE GETPHMLLRP HVFMPEVTPD 1090 1100 1110 1120 1130 1140 MDYLPRVPNQ GIIINPMLSD ETNICNGKPV DGLTTLRNGT LVAFRGHYFW MLSPFSPPSP 1150 1160 1170 1180 1190 1200 ARRITEVWGI PSPIDTVFTR CNCEGKTFFF KDSQYWRFTN DIKDAGYPKP IFKGFGGLTG 1210 1220 1230 1240 1250 1260 QIVAALSTAK YKNWPESVYF FKRGGSIQQY IYKQEPVQKC PGRRPALNYP VYGETTQVRR 1270 1280 1290 1300 1310 1320 RRFERAIGPS QTHTIRIQYS PARLAYQDKG VLHNEVKVSI LWRGLPNVVT SAISLPNIRK 1330 1340 1350 1360 PDGYDYYAFS KDQYYNIDVP SRTARAITTR SGQTLSKVWY NCP
	Isoform C [UniParc]. Checksum: D01B2F4A548A6625	FASTA	1,311	141,106
	10 20 30 40 50 60 MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC QHYMECCPDF 70 80 90 100 110 120 KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY ESFCAEVKDN KKNRTKKKPT 130 140 150 160 170 180 PKPPVVDEAG SGLDNGDFKV TTPDTSTTQH NKVSTSPKIT TAKPINPRPS LPPNSDTSKE 190 200 210 220 230 240 TSLTVNKETT VETKETTTTN KQTSTDGKEK TTSAKETQSI EKTSAKDLAP TSKVLAKPTP 250 260 270 280 290 300 KAETTTKGPA LTTPKEPTPT TPKEPASTTP KEPTPTTIKS APTTPKEPAP TTTKSAPTTP 310 320 330 340 350 360 KEPAPTTTKE PAPTTPKEPA PTTTKEPAPT TTKSAPTTPK EPAPTTPKKP APTTPKEPAP 370 380 390 400 410 420 TTPKEPTPTT PKEPAPTTKE PAPTTPKEPA PTAPKKPAPT TPKEPAPTTP KEPAPTTTKE 430 440 450 460 470 480 PSPTTPKEPA PTTTKSAPTT TKEPAPTTTK SAPTTPKEPS PTTTKEPAPT TPKEPAPTTP 490 500 510 520 530 540 KKPAPTTPKE PAPTTPKEPA PTTTKKPAPT TPKEPAPTTP KETAPTTPKK LTPTTPEKLA 550 560 570 580 590 600 PTTPEKPAPT TPEELAPTTP EEPTPTTPEE PAPTTPKAAA PNTPKEPAPT TPKEPAPTTP 610 620 630 640 650 660 KEPAPTTPKE TAPTTPKGTA PTTLKEPAPT TPKKPAPKEL APTTTKEPTS TTCDKPAPTT 670 680 690 700 710 720 PKGTAPTTPK EPAPTTPKEP APTTPKGTAP TTLKEPAPTT PKKPAPKELA PTTTKGPTST 730 740 750 760 770 780 TSDKPAPTTP KETAPTTPKE PAPTTPKKPA PTTPETPPPT TSEVSTPTTT KEPTTIHKSP 790 800 810 820 830 840 DESTPELSAE PTPKALENSP KEPGVPTTKT PAATKPEMTT TAKDKTTERD LRTTPETTTA 850 860 870 880 890 900 APKMTKETAT TTEKTTESKI TATTTQVTST TTQDTTPFKI TTLKTTTLAP KVTTTKKTIT 910 920 930 940 950 960 TTEIMNKPEE TAKPKDRATN SKATTPKPQK PTKAPKKPTS TKKPKTMPRV RKPKTTPTPR 970 980 990 1000 1010 1020 KMTSTMPELN PTSRIAEAML QTTTRPNQTP NSKLVEVNPK SEDAGGAEGE TPHMLLRPHV 1030 1040 1050 1060 1070 1080 FMPEVTPDMD YLPRVPNQGI IINPMLSDET NICNGKPVDG LTTLRNGTLV AFRGHYFWML 1090 1100 1110 1120 1130 1140 SPFSPPSPAR RITEVWGIPS PIDTVFTRCN CEGKTFFFKD SQYWRFTNDI KDAGYPKPIF 1150 1160 1170 1180 1190 1200 KGFGGLTGQI VAALSTAKYK NWPESVYFFK RGGSIQQYIY KQEPVQKCPG RRPALNYPVY 1210 1220 1230 1240 1250 1260 GETTQVRRRR FERAIGPSQT HTIRIQYSPA RLAYQDKGVL HNEVKVSILW RGLPNVVTSA 1270 1280 1290 1300 1310 ISLPNIRKPD GYDYYAFSKD QYYNIDVPSR TARAITTRSG QTLSKVWYNC P
	Isoform D [UniParc]. Checksum: 3218D3229FA74D85	FASTA	1,270	136,547
	10 20 30 40 50 60 MAWKTLPIYL LLLLSVFVIQ QVSSQELSCK GRCFESFERG RECDCDAQCK KYDKCCPDYE 70 80 90 100 110 120 SFCAEVKDNK KNRTKKKPTP KPPVVDEAGS GLDNGDFKVT TPDTSTTQHN KVSTSPKITT 130 140 150 160 170 180 AKPINPRPSL PPNSDTSKET SLTVNKETTV ETKETTTTNK QTSTDGKEKT TSAKETQSIE 190 200 210 220 230 240 KTSAKDLAPT SKVLAKPTPK AETTTKGPAL TTPKEPTPTT PKEPASTTPK EPTPTTIKSA 250 260 270 280 290 300 PTTPKEPAPT TTKSAPTTPK EPAPTTTKEP APTTPKEPAP TTTKEPAPTT TKSAPTTPKE 310 320 330 340 350 360 PAPTTPKKPA PTTPKEPAPT TPKEPTPTTP KEPAPTTKEP APTTPKEPAP TAPKKPAPTT 370 380 390 400 410 420 PKEPAPTTPK EPAPTTTKEP SPTTPKEPAP TTTKSAPTTT KEPAPTTTKS APTTPKEPSP 430 440 450 460 470 480 TTTKEPAPTT PKEPAPTTPK KPAPTTPKEP APTTPKEPAP TTTKKPAPTT PKEPAPTTPK 490 500 510 520 530 540 ETAPTTPKKL TPTTPEKLAP TTPEKPAPTT PEELAPTTPE EPTPTTPEEP APTTPKAAAP 550 560 570 580 590 600 NTPKEPAPTT PKEPAPTTPK EPAPTTPKET APTTPKGTAP TTLKEPAPTT PKKPAPKELA 610 620 630 640 650 660 PTTTKEPTST TCDKPAPTTP KGTAPTTPKE PAPTTPKEPA PTTPKGTAPT TLKEPAPTTP 670 680 690 700 710 720 KKPAPKELAP TTTKGPTSTT SDKPAPTTPK ETAPTTPKEP APTTPKKPAP TTPETPPPTT 730 740 750 760 770 780 SEVSTPTTTK EPTTIHKSPD ESTPELSAEP TPKALENSPK EPGVPTTKTP AATKPEMTTT 790 800 810 820 830 840 AKDKTTERDL RTTPETTTAA PKMTKETATT TEKTTESKIT ATTTQVTSTT TQDTTPFKIT 850 860 870 880 890 900 TLKTTTLAPK VTTTKKTITT TEIMNKPEET AKPKDRATNS KATTPKPQKP TKAPKKPTST 910 920 930 940 950 960 KKPKTMPRVR KPKTTPTPRK MTSTMPELNP TSRIAEAMLQ TTTRPNQTPN SKLVEVNPKS 970 980 990 1000 1010 1020 EDAGGAEGET PHMLLRPHVF MPEVTPDMDY LPRVPNQGII INPMLSDETN ICNGKPVDGL 1030 1040 1050 1060 1070 1080 TTLRNGTLVA FRGHYFWMLS PFSPPSPARR ITEVWGIPSP IDTVFTRCNC EGKTFFFKDS 1090 1100 1110 1120 1130 1140 QYWRFTNDIK DAGYPKPIFK GFGGLTGQIV AALSTAKYKN WPESVYFFKR GGSIQQYIYK 1150 1160 1170 1180 1190 1200 QEPVQKCPGR RPALNYPVYG ETTQVRRRRF ERAIGPSQTH TIRIQYSPAR LAYQDKGVLH 1210 1220 1230 1240 1250 1260 NEVKVSILWR GLPNVVTSAI SLPNIRKPDG YDYYAFSKDQ YYNIDVPSRT ARAITTRSGQ 1270 TLSKVWYNCP
	Isoform E [UniParc]. Checksum: B883773C5BC21A23	FASTA	933	102,513
	10 20 30 40 50 60 MAWKTLPIYL LLLLSVFVIQ QVSSQELSCK GRCFESFERG RECDCDAQCK KYDKCCPDYE 70 80 90 100 110 120 SFCAEVHNPT SPPSSKKAPP PSGASQTIKS TTKRSPKPPN KKKTKKVIES EEITEEHSVS 130 140 150 160 170 180 ENQESSSSSS SSSSSSTIRK IKSSKNSAAN RELQKKLKVK DNKKNRTKKK PTPKPPVVDE 190 200 210 220 230 240 AGSGLDNGDF KVTTPDTSTT QHNKVSTSPK ITTAKPINPR PSLPPNSDTS KETSLTVNKE 250 260 270 280 290 300 TTVETKETTT TNKQTSTDGK EKTTSAKETQ SIEKTSAKDL APTSKVLAKP TPKAETTTKG 310 320 330 340 350 360 PALTTPKEPT PTTPKEPAST TPKEPTPTTI KSAPTTPKEP APTTTKSAPT TPKEPAPTTT 370 380 390 400 410 420 KEPAPTTPKE PAPTTPETPP PTTSEVSTPT TTKEPTTIHK SPDESTPELS AEPTPKALEN 430 440 450 460 470 480 SPKEPGVPTT KTPAATKPEM TTTAKDKTTE RDLRTTPETT TAAPKMTKET ATTTEKTTES 490 500 510 520 530 540 KITATTTQVT STTTQDTTPF KITTLKTTTL APKVTTTKKT ITTTEIMNKP EETAKPKDRA 550 560 570 580 590 600 TNSKATTPKP QKPTKAPKKP TSTKKPKTMP RVRKPKTTPT PRKMTSTMPE LNPTSRIAEA 610 620 630 640 650 660 MLQTTTRPNQ TPNSKLVEVN PKSEDAGGAE GETPHMLLRP HVFMPEVTPD MDYLPRVPNQ 670 680 690 700 710 720 GIIINPMLSD ETNICNGKPV DGLTTLRNGT LVAFRGHYFW MLSPFSPPSP ARRITEVWGI 730 740 750 760 770 780 PSPIDTVFTR CNCEGKTFFF KDSQYWRFTN DIKDAGYPKP IFKGFGGLTG QIVAALSTAK 790 800 810 820 830 840 YKNWPESVYF FKRGGSIQQY IYKQEPVQKC PGRRPALNYP VYGETTQVRR RRFERAIGPS 850 860 870 880 890 900 QTHTIRIQYS PARLAYQDKG VLHNEVKVSI LWRGLPNVVT SAISLPNIRK PDGYDYYAFS 910 920 930 KDQYYNIDVP SRTARAITTR SGQTLSKVWY NCP
	Isoform F (Hemangiopoietin) (HAPO) [UniParc]. Checksum: 72DD98ED1A613593	FASTA	1,361	146,468
	10 20 30 40 50 60 MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC QHYMECCPDF 70 80 90 100 110 120 KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY ESFCAEVHNP TSPPSSKKAP 130 140 150 160 170 180 PPSGASQTIK STTKRSPKPP NKKKTKKVIE SEEITEVKDN KKNRTKKKPT PKPPVVDEAG 190 200 210 220 230 240 SGLDNGDFKV TTPDTSTTQH NKVSTSPKIT TAKPINPRPS LPPNSDTSKE TSLTVNKETT 250 260 270 280 290 300 VETKETTTTN KQTSTDGKEK TTSAKETQSI EKTSAKDLAP TSKVLAKPTP KAETTTKGPA 310 320 330 340 350 360 LTTPKEPTPT TPKEPASTTP KEPTPTTIKS APTTPKEPAP TTTKSAPTTP KEPAPTTTKE 370 380 390 400 410 420 PAPTTPKEPA PTTTKEPAPT TTKSAPTTPK EPAPTTPKKP APTTPKEPAP TTPKEPTPTT 430 440 450 460 470 480 PKEPAPTTKE PAPTTPKEPA PTAPKKPAPT TPKEPAPTTP KEPAPTTTKE PSPTTPKEPA 490 500 510 520 530 540 PTTTKSAPTT TKEPAPTTTK SAPTTPKEPS PTTTKEPAPT TPKEPAPTTP KKPAPTTPKE 550 560 570 580 590 600 PAPTTPKEPA PTTTKKPAPT TPKEPAPTTP KETAPTTPKK LTPTTPEKLA PTTPEKPAPT 610 620 630 640 650 660 TPEELAPTTP EEPTPTTPEE PAPTTPKAAA PNTPKEPAPT TPKEPAPTTP KEPAPTTPKE 670 680 690 700 710 720 TAPTTPKGTA PTTLKEPAPT TPKKPAPKEL APTTTKEPTS TTCDKPAPTT PKGTAPTTPK 730 740 750 760 770 780 EPAPTTPKEP APTTPKGTAP TTLKEPAPTT PKKPAPKELA PTTTKGPTST TSDKPAPTTP 790 800 810 820 830 840 KETAPTTPKE PAPTTPKKPA PTTPETPPPT TSEVSTPTTT KEPTTIHKSP DESTPELSAE 850 860 870 880 890 900 PTPKALENSP KEPGVPTTKT PAATKPEMTT TAKDKTTERD LRTTPETTTA APKMTKETAT 910 920 930 940 950 960 TTEKTTESKI TATTTQVTST TTQDTTPFKI TTLKTTTLAP KVTTTKKTIT TTEIMNKPEE 970 980 990 1000 1010 1020 TAKPKDRATN SKATTPKPQK PTKAPKKPTS TKKPKTMPRV RKPKTTPTPR KMTSTMPELN 1030 1040 1050 1060 1070 1080 PTSRIAEAML QTTTRPNQTP NSKLVEVNPK SEDAGGAEGE TPHMLLRPHV FMPEVTPDMD 1090 1100 1110 1120 1130 1140 YLPRVPNQGI IINPMLSDET NICNGKPVDG LTTLRNGTLV AFRGHYFWML SPFSPPSPAR 1150 1160 1170 1180 1190 1200 RITEVWGIPS PIDTVFTRCN CEGKTFFFKD SQYWRFTNDI KDAGYPKPIF KGFGGLTGQI 1210 1220 1230 1240 1250 1260 VAALSTAKYK NWPESVYFFK RGGSIQQYIY KQEPVQKCPG RRPALNYPVY GETTQVRRRR 1270 1280 1290 1300 1310 1320 FERAIGPSQT HTIRIQYSPA RLAYQDKGVL HNEVKVSILW RGLPNVVTSA ISLPNIRKPD 1330 1340 1350 1360 GYDYYAFSKD QYYNIDVPSR TARAITTRSG QTLSKVWYNC P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Turner K.J., Fitz L.J., Temple P., Jacobs K., Larson D., Leary A.C., Kelleher K., Giannotti J., Calvetti J., Fitzgerald M., Kriz M.J., Ferenz C., Grobholz J., Fraser H., Bean K., Norton C.R., Gesner T., Bhatia S. , Kriz R., Hewick R., Clark S.C. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS TRP-180 AND MET-1296.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM E). Tissue: Synovial cell.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Cloning and production of recombinant PRG4/cartilage superficial zone proteoglycan (SZP) N- and C-terminal domains." Jones A.R., Hughes C.E., Flannery C.R., Caterson B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-193 AND 1148-1398.
[5]	"Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism." Flannery C.R., Hughes C.E., Schumacher B.L., Tudor D., Aydelotte M.B., Kuettner K.E., Caterson B. Biochem. Biophys. Res. Commun. 254:535-541(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-90; 158-258 AND 1209-1295, IDENTIFICATION (ISOFORM C).
[6]	"Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages." Liu Y.J., Lu S.H., Xu B., Yang R.C., Ren Q., Liu B., Li B., Lu M., Yan F.Y., Han Z.B., Han Z.C. Blood 103:4449-4456(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-376 (ISOFORM F), FUNCTION, SUBCELLULAR LOCATION. Tissue: Fetal liver.
[7]	"Purification, biochemical characterization, and cloning of a novel megakaryocyte stimulating factor that has megakaryocyte colony stimulating activity." Turner K.J., Fitz L.J., Temple P., Jacobs K., Larson D., Leary A.C., Kelleher K., Giannotti J., Calvetti J., Fitzgerald M., Kriz M.-J., Ferenz C., Grobholz J., Fraser H., Bean K., Norton C.R., Gesner T., Bhatia S. , Kriz R., Hewick R., Clark S.C. Blood 78:279A-279A(1991) Cited for: PURIFICATION. Tissue: Urine.
[8]	"A comparison of vitronectin and megakaryocyte stimulating factor." Merberg D.M., Fitz L.J., Temple P., Giannotti J., Murtha P., Fitzgerald M., Scaltreto H., Kelleher K., Preissner K., Kriz R., Jacobs K., Turner K. (In) Preissner K.T., Rosenblatt S., Kost C., Wegerhoff J., Mosher D.F. (eds.); Biology of vitronectins and their receptors, pp.45-52, Elsevier Science Publishers B.V., Amsterdam (1993) Cited for: GENE STRUCTURE.
[9]	"A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage." Schumacher B.L., Block J.A., Schmid T.M., Aydelotte M.B., Kuettner K.E. Arch. Biochem. Biophys. 311:144-152(1994) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION.
[10]	"CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome." Marcelino J., Carpten J.D., Suwairi W.M., Gutierrez O.M., Schwartz S., Robbins C., Sood R., Makalowska I., Baxevanis A., Johnstone B., Laxer R.M., Zemel L., Kim C.A., Herd J.K., Ihle J., Williams C., Johnson M., Raman V. , Alonso L.G., Brunoni D., Gerstein A., Papadopoulos N., Bahabri S.A., Trent J.M., Warman M.L. Nat. Genet. 23:319-322(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN CACP.
[11]	"Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes." Ikegawa S., Sano M., Koshizuka Y., Nakamura Y. Cytogenet. Cell Genet. 90:291-297(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, IDENTIFICATION (ISOFORMS B; C AND D).
[12]	"Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts." Jay G.D., Britt D.E., Cha C.-J. J. Rheumatol. 27:594-600(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, GLYCOSYLATION.
[13]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1159, MASS SPECTROMETRY. Tissue: Plasma.
[14]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	U70136 mRNA. Translation: AAB09089.1. AK131434 mRNA. Translation: BAD18580.1. AL133553 Genomic DNA. Translation: CAC36090.1. AY653037 mRNA. Translation: AAT74745.1. AY653038 mRNA. Translation: AAT74746.1.
IPI	IPI00024825. IPI00655676. IPI00655927. IPI00655976. IPI00656092. IPI00656111.
RefSeq	NP_001121180.1. NM_001127708.1. NP_001121181.1. NM_001127709.1. NP_001121182.1. NM_001127710.1. NP_005798.2. NM_005807.3.
UniGene	Hs.647723.
3D structure databases
ProteinModelPortal	Q92954.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92954. 2 interactions.
PTM databases
PhosphoSite	Q92954.
Polymorphism databases
DMDM	83288393.
Proteomic databases
PaxDb	Q92954.
PRIDE	Q92954.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367483; ENSP00000356453; ENSG00000116690. ENST00000367485; ENSP00000356455; ENSG00000116690. ENST00000367486; ENSP00000356456; ENSG00000116690. ENST00000445192; ENSP00000399679; ENSG00000116690.
GeneID	10216.
KEGG	hsa:10216.
UCSC	uc001grt.4. human. uc001gru.4. human. uc009wyl.3. human. uc009wym.3. human.
Organism-specific databases
CTD	10216.
GeneCards	GC01P186265.
HGNC	HGNC:9364. PRG4.
HPA	HPA028523.
MIM	208250. phenotype. 604283. gene.
neXtProt	NX_Q92954.
Orphanet	2848. Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome.
PharmGKB	PA33736.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000115691.
InParanoid	Q92954.
OMA	EDPKPTP.
OrthoDB	EOG4JM7QM.
Gene expression databases
ArrayExpress	Q92954.
Bgee	Q92954.
CleanEx	HS_PRG4.
Genevestigator	Q92954.
GermOnline	ENSG00000116690. Homo sapiens.
Family and domain databases
Gene3D	2.110.10.10. 2 hits.
InterPro	IPR000585. Hemopexin-like_dom. IPR018487. Hemopexin-like_repeat. IPR018486. Hemopexin_CS. IPR020436. Somatomedin_B_chordata. IPR001212. Somatomedin_B_dom. [Graphical view]
Pfam	PF00045. Hemopexin. 1 hit. PF01033. Somatomedin_B. 2 hits. [Graphical view]
PRINTS	PR00022. SOMATOMEDINB.
SMART	SM00120. HX. 2 hits. SM00201. SO. 2 hits. [Graphical view]
SUPFAM	SSF50923. Hemopexin. 1 hit.
PROSITE	PS00024. HEMOPEXIN. 1 hit. PS00524. SMB_1. 2 hits. PS50958. SMB_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10216.
NextBio	38682.
SOURCE	Search...

Entry information

Entry name

PRG4_HUMAN

Accession

Primary (citable) accession number: Q92954
Secondary accession number(s): Q6DNC4 , Q6DNC5, Q6ZMZ5, Q9BX49

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.