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Q92954

- PRG4_HUMAN

UniProt

Q92954 - PRG4_HUMAN

Protein

Proteoglycan 4

Gene

PRG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
    Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei1306 – 13072Cleavage; by subtilisin-like proprotein convertase 4By similarity

    GO - Molecular functioni

    1. polysaccharide binding Source: InterPro
    2. scavenger receptor activity Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. hematopoietic stem cell proliferation Source: Ensembl
    3. immune response Source: InterPro
    4. negative regulation of interleukin-6 biosynthetic process Source: Ensembl
    5. regulation of cell proliferation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteoglycan 4
    Alternative name(s):
    Lubricin
    Megakaryocyte-stimulating factor
    Superficial zone proteoglycan
    Cleaved into the following chain:
    Gene namesi
    Name:PRG4
    Synonyms:MSF, SZP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:9364. PRG4.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) [MIM:208250]: Autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi208250. phenotype.
    Orphaneti2848. Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome.
    PharmGKBiPA33736.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 14041380Proteoglycan 4PRO_0000043232Add
    BLAST
    Chaini1307 – 140498Proteoglycan 4 C-terminal partPRO_0000043233Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 46AlternatePROSITE-ProRule annotation
    Disulfide bondi30 ↔ 34AlternatePROSITE-ProRule annotation
    Disulfide bondi34 ↔ 64AlternatePROSITE-ProRule annotation
    Disulfide bondi44 ↔ 57AlternatePROSITE-ProRule annotation
    Disulfide bondi44 ↔ 46AlternatePROSITE-ProRule annotation
    Disulfide bondi50 ↔ 56PROSITE-ProRule annotation
    Disulfide bondi57 ↔ 64AlternatePROSITE-ProRule annotation
    Disulfide bondi70 ↔ 86AlternatePROSITE-ProRule annotation
    Disulfide bondi70 ↔ 74AlternatePROSITE-ProRule annotation
    Disulfide bondi74 ↔ 104AlternatePROSITE-ProRule annotation
    Disulfide bondi84 ↔ 97AlternatePROSITE-ProRule annotation
    Disulfide bondi84 ↔ 86AlternatePROSITE-ProRule annotation
    Disulfide bondi90 ↔ 96PROSITE-ProRule annotation
    Disulfide bondi97 ↔ 104AlternatePROSITE-ProRule annotation
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1146 ↔ 1403PROSITE-ProRule annotation
    Glycosylationi1159 – 11591N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    N-glycosylated.
    O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate.
    The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Proteomic databases

    MaxQBiQ92954.
    PaxDbiQ92954.
    PRIDEiQ92954.

    PTM databases

    PhosphoSiteiQ92954.

    Expressioni

    Tissue specificityi

    Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed.2 Publications

    Gene expression databases

    ArrayExpressiQ92954.
    BgeeiQ92954.
    CleanExiHS_PRG4.
    GenevestigatoriQ92954.

    Organism-specific databases

    HPAiHPA028523.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    BioGridi115511. 1 interaction.
    IntActiQ92954. 3 interactions.
    MINTiMINT-7970782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92954.
    SMRiQ92954. Positions 26-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 6944SMB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini66 – 10843SMB 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati348 – 35581
    Repeati356 – 36382; approximate
    Repeati364 – 37183
    Repeati372 – 37874; approximate
    Repeati379 – 38685
    Repeati387 – 39376; approximate
    Repeati394 – 40187
    Repeati402 – 40988
    Repeati410 – 41789
    Repeati418 – 425810
    Repeati426 – 432711; approximate
    Repeati433 – 440812
    Repeati441 – 448813
    Repeati449 – 456814
    Repeati457 – 464815
    Repeati465 – 471716; approximate
    Repeati472 – 479817
    Repeati480 – 487818; approximate
    Repeati488 – 495819; approximate
    Repeati496 – 503820
    Repeati504 – 511821
    Repeati512 – 519822
    Repeati520 – 527823
    Repeati528 – 534724; approximate
    Repeati535 – 542825
    Repeati543 – 549726; approximate
    Repeati550 – 557827
    Repeati558 – 565828
    Repeati566 – 573829
    Repeati574 – 581830
    Repeati582 – 589831
    Repeati590 – 597832
    Repeati598 – 605833; approximate
    Repeati606 – 613834
    Repeati614 – 621835; approximate
    Repeati622 – 629836; approximate
    Repeati638 – 645837; approximate
    Repeati662 – 669838; approximate
    Repeati678 – 685839
    Repeati686 – 693840
    Repeati694 – 701841
    Repeati702 – 709842; approximate
    Repeati710 – 717843; approximate
    Repeati718 – 725844
    Repeati731 – 738845; approximate
    Repeati739 – 746846; approximate
    Repeati747 – 754847; approximate
    Repeati755 – 762848; approximate
    Repeati763 – 770849
    Repeati771 – 778850
    Repeati779 – 786851; approximate
    Repeati787 – 794852
    Repeati800 – 807853; approximate
    Repeati808 – 815854; approximate
    Repeati816 – 823855; approximate
    Repeati824 – 831856; approximate
    Repeati832 – 839857
    Repeati840 – 847858
    Repeati848 – 855859; approximate
    Repeati1148 – 119144Hemopexin 1Add
    BLAST
    Repeati1192 – 123948Hemopexin 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni348 – 85550859 X 8 AA repeats of K-X-P-X-P-T-T-XAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi159 – 18830Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 hemopexin repeats.Curated
    Contains 2 SMB (somatomedin-B) domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000115691.
    InParanoidiQ92954.
    OMAiPTTTKGP.
    PhylomeDBiQ92954.
    TreeFamiTF332780.

    Family and domain databases

    Gene3Di2.110.10.10. 2 hits.
    InterProiIPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR018486. Hemopexin_CS.
    IPR020436. Somatomedin_B_chordata.
    IPR001212. Somatomedin_B_dom.
    [Graphical view]
    PfamiPF00045. Hemopexin. 1 hit.
    PF01033. Somatomedin_B. 2 hits.
    [Graphical view]
    PRINTSiPR00022. SOMATOMEDINB.
    SMARTiSM00120. HX. 2 hits.
    SM00201. SO. 2 hits.
    [Graphical view]
    SUPFAMiSSF50923. SSF50923. 2 hits.
    PROSITEiPS00024. HEMOPEXIN. 1 hit.
    PS51642. HEMOPEXIN_2. 2 hits.
    PS00524. SMB_1. 2 hits.
    PS50958. SMB_2. 2 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q92954-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC     50
    QHYMECCPDF KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY 100
    ESFCAEVHNP TSPPSSKKAP PPSGASQTIK STTKRSPKPP NKKKTKKVIE 150
    SEEITEEHSV SENQESSSSS SSSSSSSTIR KIKSSKNSAA NRELQKKLKV 200
    KDNKKNRTKK KPTPKPPVVD EAGSGLDNGD FKVTTPDTST TQHNKVSTSP 250
    KITTAKPINP RPSLPPNSDT SKETSLTVNK ETTVETKETT TTNKQTSTDG 300
    KEKTTSAKET QSIEKTSAKD LAPTSKVLAK PTPKAETTTK GPALTTPKEP 350
    TPTTPKEPAS TTPKEPTPTT IKSAPTTPKE PAPTTTKSAP TTPKEPAPTT 400
    TKEPAPTTPK EPAPTTTKEP APTTTKSAPT TPKEPAPTTP KKPAPTTPKE 450
    PAPTTPKEPT PTTPKEPAPT TKEPAPTTPK EPAPTAPKKP APTTPKEPAP 500
    TTPKEPAPTT TKEPSPTTPK EPAPTTTKSA PTTTKEPAPT TTKSAPTTPK 550
    EPSPTTTKEP APTTPKEPAP TTPKKPAPTT PKEPAPTTPK EPAPTTTKKP 600
    APTTPKEPAP TTPKETAPTT PKKLTPTTPE KLAPTTPEKP APTTPEELAP 650
    TTPEEPTPTT PEEPAPTTPK AAAPNTPKEP APTTPKEPAP TTPKEPAPTT 700
    PKETAPTTPK GTAPTTLKEP APTTPKKPAP KELAPTTTKE PTSTTCDKPA 750
    PTTPKGTAPT TPKEPAPTTP KEPAPTTPKG TAPTTLKEPA PTTPKKPAPK 800
    ELAPTTTKGP TSTTSDKPAP TTPKETAPTT PKEPAPTTPK KPAPTTPETP 850
    PPTTSEVSTP TTTKEPTTIH KSPDESTPEL SAEPTPKALE NSPKEPGVPT 900
    TKTPAATKPE MTTTAKDKTT ERDLRTTPET TTAAPKMTKE TATTTEKTTE 950
    SKITATTTQV TSTTTQDTTP FKITTLKTTT LAPKVTTTKK TITTTEIMNK 1000
    PEETAKPKDR ATNSKATTPK PQKPTKAPKK PTSTKKPKTM PRVRKPKTTP 1050
    TPRKMTSTMP ELNPTSRIAE AMLQTTTRPN QTPNSKLVEV NPKSEDAGGA 1100
    EGETPHMLLR PHVFMPEVTP DMDYLPRVPN QGIIINPMLS DETNICNGKP 1150
    VDGLTTLRNG TLVAFRGHYF WMLSPFSPPS PARRITEVWG IPSPIDTVFT 1200
    RCNCEGKTFF FKDSQYWRFT NDIKDAGYPK PIFKGFGGLT GQIVAALSTA 1250
    KYKNWPESVY FFKRGGSIQQ YIYKQEPVQK CPGRRPALNY PVYGETTQVR 1300
    RRRFERAIGP SQTHTIRIQY SPARLAYQDK GVLHNEVKVS ILWRGLPNVV 1350
    TSAISLPNIR KPDGYDYYAF SKDQYYNIDV PSRTARAITT RSGQTLSKVW 1400
    YNCP 1404
    Length:1,404
    Mass (Da):151,077
    Last modified:December 6, 2005 - v2
    Checksum:i782A11746B3FDEE5
    GO
    Isoform B (identifier: Q92954-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-66: Missing.

    Show »
    Length:1,363
    Mass (Da):146,518
    Checksum:i50E8651CE1EE09A7
    GO
    Isoform C (identifier: Q92954-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         107-199: Missing.

    Show »
    Length:1,311
    Mass (Da):141,106
    Checksum:iD01B2F4A548A6625
    GO
    Isoform D (identifier: Q92954-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-66: Missing.
         107-199: Missing.

    Show »
    Length:1,270
    Mass (Da):136,547
    Checksum:i3218D3229FA74D85
    GO
    Isoform E (identifier: Q92954-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-66: Missing.
         412-841: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:933
    Mass (Da):102,513
    Checksum:iB883773C5BC21A23
    GO
    Isoform F (identifier: Q92954-6) [UniParc]FASTAAdd to Basket

    Also known as: Hemangiopoietin, HAPO

    The sequence of this isoform differs from the canonical sequence as follows:
         157-199: Missing.

    Show »
    Length:1,361
    Mass (Da):146,468
    Checksum:i72DD98ED1A613593
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti604 – 6041T → A in AAB09089. 1 PublicationCurated
    Sequence conflicti746 – 7461C → S in AAB09089. 1 PublicationCurated
    Sequence conflicti1340 – 13401S → G in AAT74746. 1 PublicationCurated
    Sequence conflicti1380 – 13801V → G in AAT74746. 1 PublicationCurated
    Sequence conflicti1397 – 13971S → F in AAT74746. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti180 – 1801R → W.1 Publication
    Corresponds to variant rs2273779 [ dbSNP | Ensembl ].
    VAR_024023
    Natural varianti1130 – 11301N → S.
    Corresponds to variant rs10158395 [ dbSNP | Ensembl ].
    VAR_051559
    Natural varianti1272 – 12721I → T.
    Corresponds to variant rs1293985 [ dbSNP | Ensembl ].
    VAR_051560
    Natural varianti1296 – 12961T → M.1 Publication
    Corresponds to variant rs12134934 [ dbSNP | Ensembl ].
    VAR_051561

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei26 – 6641Missing in isoform B, isoform D and isoform E. 1 PublicationVSP_016467Add
    BLAST
    Alternative sequencei107 – 19993Missing in isoform C and isoform D. CuratedVSP_016468Add
    BLAST
    Alternative sequencei157 – 19943Missing in isoform F. 1 PublicationVSP_016469Add
    BLAST
    Alternative sequencei412 – 841430Missing in isoform E. 1 PublicationVSP_016470Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70136 mRNA. Translation: AAB09089.1.
    AK131434 mRNA. Translation: BAD18580.1.
    AL133553 Genomic DNA. Translation: CAC36090.1.
    AY653037 mRNA. Translation: AAT74745.1.
    AY653038 mRNA. Translation: AAT74746.1.
    CCDSiCCDS1369.1. [Q92954-1]
    CCDS44287.1. [Q92954-3]
    CCDS44288.1. [Q92954-2]
    RefSeqiNP_001121180.1. NM_001127708.1. [Q92954-2]
    NP_001121181.1. NM_001127709.1. [Q92954-3]
    NP_001121182.1. NM_001127710.1. [Q92954-4]
    NP_005798.2. NM_005807.3. [Q92954-1]
    UniGeneiHs.647723.

    Genome annotation databases

    EnsembliENST00000367483; ENSP00000356453; ENSG00000116690. [Q92954-2]
    ENST00000367485; ENSP00000356455; ENSG00000116690. [Q92954-3]
    ENST00000445192; ENSP00000399679; ENSG00000116690. [Q92954-1]
    GeneIDi10216.
    KEGGihsa:10216.
    UCSCiuc001grt.4. human. [Q92954-2]
    uc001gru.4. human. [Q92954-1]
    uc009wyl.3. human. [Q92954-3]
    uc009wym.3. human. [Q92954-4]

    Polymorphism databases

    DMDMi83288393.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70136 mRNA. Translation: AAB09089.1 .
    AK131434 mRNA. Translation: BAD18580.1 .
    AL133553 Genomic DNA. Translation: CAC36090.1 .
    AY653037 mRNA. Translation: AAT74745.1 .
    AY653038 mRNA. Translation: AAT74746.1 .
    CCDSi CCDS1369.1. [Q92954-1 ]
    CCDS44287.1. [Q92954-3 ]
    CCDS44288.1. [Q92954-2 ]
    RefSeqi NP_001121180.1. NM_001127708.1. [Q92954-2 ]
    NP_001121181.1. NM_001127709.1. [Q92954-3 ]
    NP_001121182.1. NM_001127710.1. [Q92954-4 ]
    NP_005798.2. NM_005807.3. [Q92954-1 ]
    UniGenei Hs.647723.

    3D structure databases

    ProteinModelPortali Q92954.
    SMRi Q92954. Positions 26-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115511. 1 interaction.
    IntActi Q92954. 3 interactions.
    MINTi MINT-7970782.

    PTM databases

    PhosphoSitei Q92954.

    Polymorphism databases

    DMDMi 83288393.

    Proteomic databases

    MaxQBi Q92954.
    PaxDbi Q92954.
    PRIDEi Q92954.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367483 ; ENSP00000356453 ; ENSG00000116690 . [Q92954-2 ]
    ENST00000367485 ; ENSP00000356455 ; ENSG00000116690 . [Q92954-3 ]
    ENST00000445192 ; ENSP00000399679 ; ENSG00000116690 . [Q92954-1 ]
    GeneIDi 10216.
    KEGGi hsa:10216.
    UCSCi uc001grt.4. human. [Q92954-2 ]
    uc001gru.4. human. [Q92954-1 ]
    uc009wyl.3. human. [Q92954-3 ]
    uc009wym.3. human. [Q92954-4 ]

    Organism-specific databases

    CTDi 10216.
    GeneCardsi GC01P186265.
    HGNCi HGNC:9364. PRG4.
    HPAi HPA028523.
    MIMi 208250. phenotype.
    604283. gene.
    neXtProti NX_Q92954.
    Orphaneti 2848. Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome.
    PharmGKBi PA33736.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000115691.
    InParanoidi Q92954.
    OMAi PTTTKGP.
    PhylomeDBi Q92954.
    TreeFami TF332780.

    Miscellaneous databases

    GeneWikii PRG4.
    GenomeRNAii 10216.
    NextBioi 38682.
    PROi Q92954.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92954.
    Bgeei Q92954.
    CleanExi HS_PRG4.
    Genevestigatori Q92954.

    Family and domain databases

    Gene3Di 2.110.10.10. 2 hits.
    InterProi IPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR018486. Hemopexin_CS.
    IPR020436. Somatomedin_B_chordata.
    IPR001212. Somatomedin_B_dom.
    [Graphical view ]
    Pfami PF00045. Hemopexin. 1 hit.
    PF01033. Somatomedin_B. 2 hits.
    [Graphical view ]
    PRINTSi PR00022. SOMATOMEDINB.
    SMARTi SM00120. HX. 2 hits.
    SM00201. SO. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50923. SSF50923. 2 hits.
    PROSITEi PS00024. HEMOPEXIN. 1 hit.
    PS51642. HEMOPEXIN_2. 2 hits.
    PS00524. SMB_1. 2 hits.
    PS50958. SMB_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS TRP-180 AND MET-1296.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM E).
      Tissue: Synovial cell.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Cloning and production of recombinant PRG4/cartilage superficial zone proteoglycan (SZP) N- and C-terminal domains."
      Jones A.R., Hughes C.E., Flannery C.R., Caterson B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-193 AND 1148-1398.
    5. "Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism."
      Flannery C.R., Hughes C.E., Schumacher B.L., Tudor D., Aydelotte M.B., Kuettner K.E., Caterson B.
      Biochem. Biophys. Res. Commun. 254:535-541(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-90; 158-258 AND 1209-1295, IDENTIFICATION (ISOFORM C).
    6. "Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages."
      Liu Y.J., Lu S.H., Xu B., Yang R.C., Ren Q., Liu B., Li B., Lu M., Yan F.Y., Han Z.B., Han Z.C.
      Blood 103:4449-4456(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-376 (ISOFORM F), FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Fetal liver.
    7. "Purification, biochemical characterization, and cloning of a novel megakaryocyte stimulating factor that has megakaryocyte colony stimulating activity."
      Turner K.J., Fitz L.J., Temple P., Jacobs K., Larson D., Leary A.C., Kelleher K., Giannotti J., Calvetti J., Fitzgerald M., Kriz M.-J., Ferenz C., Grobholz J., Fraser H., Bean K., Norton C.R., Gesner T., Bhatia S.
      , Kriz R., Hewick R., Clark S.C.
      Blood 78:279A-279A(1991)
      Cited for: PURIFICATION.
      Tissue: Urine.
    8. "A comparison of vitronectin and megakaryocyte stimulating factor."
      Merberg D.M., Fitz L.J., Temple P., Giannotti J., Murtha P., Fitzgerald M., Scaltreto H., Kelleher K., Preissner K., Kriz R., Jacobs K., Turner K.
      (In) Preissner K.T., Rosenblatt S., Kost C., Wegerhoff J., Mosher D.F. (eds.); Biology of vitronectins and their receptors, pp.45-52, Elsevier Science Publishers B.V., Amsterdam (1993)
      Cited for: GENE STRUCTURE.
    9. "A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage."
      Schumacher B.L., Block J.A., Schmid T.M., Aydelotte M.B., Kuettner K.E.
      Arch. Biochem. Biophys. 311:144-152(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION.
    10. Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN CACP.
    11. "Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes."
      Ikegawa S., Sano M., Koshizuka Y., Nakamura Y.
      Cytogenet. Cell Genet. 90:291-297(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, IDENTIFICATION (ISOFORMS B; C AND D).
    12. "Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts."
      Jay G.D., Britt D.E., Cha C.-J.
      J. Rheumatol. 27:594-600(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, GLYCOSYLATION.
    13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1159.
      Tissue: Plasma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPRG4_HUMAN
    AccessioniPrimary (citable) accession number: Q92954
    Secondary accession number(s): Q6DNC4
    , Q6DNC5, Q6ZMZ5, Q9BX49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3