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Protein

Proteoglycan 4

Gene

PRG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.

Miscellaneous

Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: ProtInc
  • immune response Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Proteoglycan 4
Alternative name(s):
Lubricin
Megakaryocyte-stimulating factor
Superficial zone proteoglycan
Cleaved into the following chain:
Gene namesi
Name:PRG4
Synonyms:MSF, SZP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116690.12
HGNCiHGNC:9364 PRG4
MIMi604283 gene
neXtProtiNX_Q92954

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions.
See also OMIM:208250

Organism-specific databases

DisGeNETi10216
MalaCardsiPRG4
MIMi208250 phenotype
OpenTargetsiENSG00000116690
Orphaneti2848 Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome
PharmGKBiPA33736

Polymorphism and mutation databases

BioMutaiPRG4
DMDMi83288393

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004323225 – 1404Proteoglycan 4Add BLAST1380
ChainiPRO_00000432331307 – 1404Proteoglycan 4 C-terminal partAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 46PROSITE-ProRule annotation
Disulfide bondi30 ↔ 34PROSITE-ProRule annotation
Disulfide bondi34 ↔ 64PROSITE-ProRule annotation
Disulfide bondi44 ↔ 57PROSITE-ProRule annotation
Disulfide bondi44 ↔ 46PROSITE-ProRule annotation
Disulfide bondi50 ↔ 56PROSITE-ProRule annotation
Disulfide bondi57 ↔ 64PROSITE-ProRule annotation
Disulfide bondi70 ↔ 86AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 74AlternatePROSITE-ProRule annotation
Disulfide bondi74 ↔ 104AlternatePROSITE-ProRule annotation
Disulfide bondi84 ↔ 97AlternatePROSITE-ProRule annotation
Disulfide bondi84 ↔ 86AlternatePROSITE-ProRule annotation
Disulfide bondi90 ↔ 96PROSITE-ProRule annotation
Disulfide bondi97 ↔ 104AlternatePROSITE-ProRule annotation
Glycosylationi123O-linked (GalNAc...) serine1 Publication1
Glycosylationi136O-linked (GalNAc...) serine1 Publication1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240O-linked (GalNAc...) threonine1 Publication1
Glycosylationi253O-linked (GalNAc...) threonine1 Publication1
Glycosylationi277O-linked (GalNAc...) threonine1 Publication1
Glycosylationi291O-linked (GalNAc...) threonine1 Publication1
Glycosylationi305O-linked (GalNAc...) threonine1 Publication1
Glycosylationi306O-linked (GalNAc...) serine1 Publication1
Glycosylationi310O-linked (GalNAc...) threonine1 Publication1
Glycosylationi317O-linked (GalNAc...) serine1 Publication1
Glycosylationi324O-linked (GalNAc...) threonine1 Publication1
Glycosylationi332O-linked (GalNAc...) threonine1 Publication1
Glycosylationi338O-linked (GalNAc...) threonine1 Publication1
Glycosylationi367O-linked (GalNAc...) threonine1 Publication1
Glycosylationi373O-linked (GalNAc...) serine1 Publication1
Glycosylationi376O-linked (GalNAc...) threonine1 Publication1
Glycosylationi384O-linked (GalNAc...) threonine1 Publication1
Glycosylationi385O-linked (GalNAc...) threonine1 Publication1
Glycosylationi388O-linked (GalNAc...) serine1 Publication1
Glycosylationi391O-linked (GalNAc...) threonine1 Publication1
Glycosylationi399O-linked (GalNAc...) threonine1 Publication1
Glycosylationi400O-linked (GalNAc...) threonine1 Publication1
Glycosylationi407O-linked (GalNAc...) threonine1 Publication1
Glycosylationi408O-linked (GalNAc...) threonine1 Publication1
Glycosylationi415O-linked (GalNAc...) threonine1 Publication1
Glycosylationi423O-linked (GalNAc...) threonine1 Publication1
Glycosylationi427O-linked (GalNAc...) serine1 Publication1
Glycosylationi430O-linked (GalNAc...) threonine1 Publication1
Glycosylationi438O-linked (GalNAc...) threonine1 Publication1
Glycosylationi439O-linked (GalNAc...) threonine1 Publication1
Glycosylationi446O-linked (GalNAc...) threonine1 Publication1
Glycosylationi447O-linked (GalNAc...) threonine1 Publication1
Glycosylationi454O-linked (GalNAc...) threonine1 Publication1
Glycosylationi455O-linked (GalNAc...) threonine1 Publication1
Glycosylationi477O-linked (GalNAc...) threonine1 Publication1
Glycosylationi478O-linked (GalNAc...) threonine1 Publication1
Glycosylationi485O-linked (GalNAc...) threonine1 Publication1
Glycosylationi493O-linked (GalNAc...) threonine1 Publication1
Glycosylationi494O-linked (GalNAc...) threonine1 Publication1
Glycosylationi501O-linked (GalNAc...) threonine1 Publication1
Glycosylationi502O-linked (GalNAc...) threonine1 Publication1
Glycosylationi509O-linked (GalNAc...) threonine1 Publication1
Glycosylationi525O-linked (GalNAc...) threonine1 Publication1
Glycosylationi529O-linked (GalNAc...) serine1 Publication1
Glycosylationi532O-linked (GalNAc...) threonine1 Publication1
Glycosylationi540O-linked (GalNAc...) threonine1 Publication1
Glycosylationi541O-linked (GalNAc...) threonine1 Publication1
Glycosylationi553O-linked (GalNAc...) serine1 Publication1
Glycosylationi555O-linked (GalNAc...) threonine1 Publication1
Glycosylationi563O-linked (GalNAc...) threonine1 Publication1
Glycosylationi564O-linked (GalNAc...) threonine1 Publication1
Glycosylationi571O-linked (GalNAc...) threonine1 Publication1
Glycosylationi572O-linked (GalNAc...) threonine1 Publication1
Glycosylationi579O-linked (GalNAc...) threonine1 Publication1
Glycosylationi580O-linked (GalNAc...) threonine1 Publication1
Glycosylationi587O-linked (GalNAc...) threonine1 Publication1
Glycosylationi588O-linked (GalNAc...) threonine1 Publication1
Glycosylationi595O-linked (GalNAc...) threonine1 Publication1
Glycosylationi603O-linked (GalNAc...) threonine1 Publication1
Glycosylationi604O-linked (GalNAc...) threonine1 Publication1
Glycosylationi611O-linked (GalNAc...) threonine1 Publication1
Glycosylationi612O-linked (GalNAc...) threonine1 Publication1
Glycosylationi616O-linked (GalNAc...) threonine1 Publication1
Glycosylationi619O-linked (GalNAc...) threonine1 Publication1
Glycosylationi627O-linked (GalNAc...) threonine1 Publication1
Glycosylationi676O-linked (GalNAc...) threonine1 Publication1
Glycosylationi683O-linked (GalNAc...) threonine1 Publication1
Glycosylationi684O-linked (GalNAc...) threonine1 Publication1
Glycosylationi691O-linked (GalNAc...) threonine1 Publication1
Glycosylationi692O-linked (GalNAc...) threonine1 Publication1
Glycosylationi699O-linked (GalNAc...) threonine1 Publication1
Glycosylationi700O-linked (GalNAc...) threonine1 Publication1
Glycosylationi704O-linked (GalNAc...) threonine1 Publication1
Glycosylationi707O-linked (GalNAc...) threonine1 Publication1
Glycosylationi723O-linked (GalNAc...) threonine1 Publication1
Glycosylationi724O-linked (GalNAc...) threonine1 Publication1
Glycosylationi736O-linked (GalNAc...) threonine1 Publication1
Glycosylationi768O-linked (GalNAc...) threonine1 Publication1
Glycosylationi769O-linked (GalNAc...) threonine1 Publication1
Glycosylationi776O-linked (GalNAc...) threonine1 Publication1
Glycosylationi777O-linked (GalNAc...) threonine1 Publication1
Glycosylationi792O-linked (GalNAc...) threonine1 Publication1
Glycosylationi793O-linked (GalNAc...) threonine1 Publication1
Glycosylationi805O-linked (GalNAc...) threonine1 Publication1
Glycosylationi812O-linked (GalNAc...) serine1 Publication1
Glycosylationi829O-linked (GalNAc...) threonine1 Publication1
Glycosylationi837O-linked (GalNAc...) threonine1 Publication1
Glycosylationi838O-linked (GalNAc...) threonine1 Publication1
Glycosylationi892O-linked (GalNAc...) serine1 Publication1
Glycosylationi900O-linked (GalNAc...) threonine1 Publication1
Glycosylationi930O-linked (GalNAc...) threonine1 Publication1
Glycosylationi931O-linked (GalNAc...) threonine1 Publication1
Glycosylationi962O-linked (GalNAc...) serine1 Publication1
Glycosylationi963O-linked (GalNAc...) threonine1 Publication1
Glycosylationi968O-linked (GalNAc...) threonine1 Publication1
Glycosylationi975O-linked (GalNAc...) threonine1 Publication1
Glycosylationi978O-linked (GalNAc...) threonine1 Publication1
Glycosylationi979O-linked (GalNAc...) threonine1 Publication1
Glycosylationi980O-linked (GalNAc...) threonine1 Publication1
Glycosylationi1039O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi1146 ↔ 1403PROSITE-ProRule annotation
Glycosylationi1159N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1161O-linked (GalNAc...) threonine1 Publication1

Post-translational modificationi

N-glycosylated (PubMed:16335952).1 Publication
O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans (PubMed:25187573).1 Publication
The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1306 – 1307Cleavage; by subtilisin-like proprotein convertase 4By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

EPDiQ92954
MaxQBiQ92954
PaxDbiQ92954
PeptideAtlasiQ92954
PRIDEiQ92954

PTM databases

CarbonylDBiQ92954
GlyConnecti762
iPTMnetiQ92954
PhosphoSitePlusiQ92954

Expressioni

Tissue specificityi

Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000116690
CleanExiHS_PRG4
ExpressionAtlasiQ92954 baseline and differential
GenevisibleiQ92954 HS

Organism-specific databases

HPAiHPA028523

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

IntActiQ92954, 3 interactors
MINTiQ92954
STRINGi9606.ENSP00000399679

Structurei

3D structure databases

ProteinModelPortaliQ92954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 69SMB 1PROSITE-ProRule annotationAdd BLAST44
Domaini66 – 108SMB 2PROSITE-ProRule annotationAdd BLAST43
Repeati348 – 35518
Repeati356 – 3632; approximate8
Repeati364 – 37138
Repeati372 – 3784; approximate7
Repeati379 – 38658
Repeati387 – 3936; approximate7
Repeati394 – 40178
Repeati402 – 40988
Repeati410 – 41798
Repeati418 – 425108
Repeati426 – 43211; approximate7
Repeati433 – 440128
Repeati441 – 448138
Repeati449 – 456148
Repeati457 – 464158
Repeati465 – 47116; approximate7
Repeati472 – 479178
Repeati480 – 48718; approximate8
Repeati488 – 49519; approximate8
Repeati496 – 503208
Repeati504 – 511218
Repeati512 – 519228
Repeati520 – 527238
Repeati528 – 53424; approximate7
Repeati535 – 542258
Repeati543 – 54926; approximate7
Repeati550 – 557278
Repeati558 – 565288
Repeati566 – 573298
Repeati574 – 581308
Repeati582 – 589318
Repeati590 – 597328
Repeati598 – 60533; approximate8
Repeati606 – 613348
Repeati614 – 62135; approximate8
Repeati622 – 62936; approximate8
Repeati638 – 64537; approximate8
Repeati662 – 66938; approximate8
Repeati678 – 685398
Repeati686 – 693408
Repeati694 – 701418
Repeati702 – 70942; approximate8
Repeati710 – 71743; approximate8
Repeati718 – 725448
Repeati731 – 73845; approximate8
Repeati739 – 74646; approximate8
Repeati747 – 75447; approximate8
Repeati755 – 76248; approximate8
Repeati763 – 770498
Repeati771 – 778508
Repeati779 – 78651; approximate8
Repeati787 – 794528
Repeati800 – 80753; approximate8
Repeati808 – 81554; approximate8
Repeati816 – 82355; approximate8
Repeati824 – 83156; approximate8
Repeati832 – 839578
Repeati840 – 847588
Repeati848 – 85559; approximate8
Repeati1148 – 1191Hemopexin 1Add BLAST44
Repeati1192 – 1239Hemopexin 2Add BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 85559 X 8 AA repeats of K-X-P-X-P-T-T-XAdd BLAST508

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 188Ser-richAdd BLAST30

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00530000063751
HOGENOMiHOG000115691
InParanoidiQ92954
OrthoDBiEOG091G0D8U
PhylomeDBiQ92954
TreeFamiTF332780

Family and domain databases

CDDicd00094 HX, 1 hit
Gene3Di2.110.10.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF00045 Hemopexin, 1 hit
PF01033 Somatomedin_B, 2 hits
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00120 HX, 2 hits
SM00201 SO, 2 hits
SUPFAMiSSF50923 SSF50923, 2 hits
SSF90188 SSF90188, 2 hits
PROSITEiView protein in PROSITE
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 2 hits
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q92954-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC
60 70 80 90 100
QHYMECCPDF KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY
110 120 130 140 150
ESFCAEVHNP TSPPSSKKAP PPSGASQTIK STTKRSPKPP NKKKTKKVIE
160 170 180 190 200
SEEITEEHSV SENQESSSSS SSSSSSSTIR KIKSSKNSAA NRELQKKLKV
210 220 230 240 250
KDNKKNRTKK KPTPKPPVVD EAGSGLDNGD FKVTTPDTST TQHNKVSTSP
260 270 280 290 300
KITTAKPINP RPSLPPNSDT SKETSLTVNK ETTVETKETT TTNKQTSTDG
310 320 330 340 350
KEKTTSAKET QSIEKTSAKD LAPTSKVLAK PTPKAETTTK GPALTTPKEP
360 370 380 390 400
TPTTPKEPAS TTPKEPTPTT IKSAPTTPKE PAPTTTKSAP TTPKEPAPTT
410 420 430 440 450
TKEPAPTTPK EPAPTTTKEP APTTTKSAPT TPKEPAPTTP KKPAPTTPKE
460 470 480 490 500
PAPTTPKEPT PTTPKEPAPT TKEPAPTTPK EPAPTAPKKP APTTPKEPAP
510 520 530 540 550
TTPKEPAPTT TKEPSPTTPK EPAPTTTKSA PTTTKEPAPT TTKSAPTTPK
560 570 580 590 600
EPSPTTTKEP APTTPKEPAP TTPKKPAPTT PKEPAPTTPK EPAPTTTKKP
610 620 630 640 650
APTTPKEPAP TTPKETAPTT PKKLTPTTPE KLAPTTPEKP APTTPEELAP
660 670 680 690 700
TTPEEPTPTT PEEPAPTTPK AAAPNTPKEP APTTPKEPAP TTPKEPAPTT
710 720 730 740 750
PKETAPTTPK GTAPTTLKEP APTTPKKPAP KELAPTTTKE PTSTTSDKPA
760 770 780 790 800
PTTPKGTAPT TPKEPAPTTP KEPAPTTPKG TAPTTLKEPA PTTPKKPAPK
810 820 830 840 850
ELAPTTTKGP TSTTSDKPAP TTPKETAPTT PKEPAPTTPK KPAPTTPETP
860 870 880 890 900
PPTTSEVSTP TTTKEPTTIH KSPDESTPEL SAEPTPKALE NSPKEPGVPT
910 920 930 940 950
TKTPAATKPE MTTTAKDKTT ERDLRTTPET TTAAPKMTKE TATTTEKTTE
960 970 980 990 1000
SKITATTTQV TSTTTQDTTP FKITTLKTTT LAPKVTTTKK TITTTEIMNK
1010 1020 1030 1040 1050
PEETAKPKDR ATNSKATTPK PQKPTKAPKK PTSTKKPKTM PRVRKPKTTP
1060 1070 1080 1090 1100
TPRKMTSTMP ELNPTSRIAE AMLQTTTRPN QTPNSKLVEV NPKSEDAGGA
1110 1120 1130 1140 1150
EGETPHMLLR PHVFMPEVTP DMDYLPRVPN QGIIINPMLS DETNICNGKP
1160 1170 1180 1190 1200
VDGLTTLRNG TLVAFRGHYF WMLSPFSPPS PARRITEVWG IPSPIDTVFT
1210 1220 1230 1240 1250
RCNCEGKTFF FKDSQYWRFT NDIKDAGYPK PIFKGFGGLT GQIVAALSTA
1260 1270 1280 1290 1300
KYKNWPESVY FFKRGGSIQQ YIYKQEPVQK CPGRRPALNY PVYGETTQVR
1310 1320 1330 1340 1350
RRRFERAIGP SQTHTIRIQY SPARLAYQDK GVLHNEVKVS ILWRGLPNVV
1360 1370 1380 1390 1400
TSAISLPNIR KPDGYDYYAF SKDQYYNIDV PSRTARAITT RSGQTLSKVW

YNCP
Length:1,404
Mass (Da):151,061
Last modified:March 28, 2018 - v3
Checksum:i7FE71EA184B03972
GO
Isoform B (identifier: Q92954-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.

Show »
Length:1,363
Mass (Da):146,502
Checksum:i57256AC90E61EE30
GO
Isoform C (identifier: Q92954-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-199: Missing.

Show »
Length:1,311
Mass (Da):141,090
Checksum:iD7D6209FBB0581B2
GO
Isoform D (identifier: Q92954-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     107-199: Missing.

Show »
Length:1,270
Mass (Da):136,531
Checksum:i35D5DCF77028AA12
GO
Isoform E (identifier: Q92954-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     412-841: Missing.

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):102,513
Checksum:iB883773C5BC21A23
GO
Isoform F (identifier: Q92954-6) [UniParc]FASTAAdd to basket
Also known as: Hemangiopoietin, HAPO

The sequence of this isoform differs from the canonical sequence as follows:
     157-199: Missing.

Show »
Length:1,361
Mass (Da):146,452
Checksum:i75109738F5EED204
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti604T → A in AAB09089 (Ref. 1) Curated1
Sequence conflicti1340S → G in AAT74746 (Ref. 4) Curated1
Sequence conflicti1380V → G in AAT74746 (Ref. 4) Curated1
Sequence conflicti1397 – 1404SKVWYNCP → FK in AAT74746 (Ref. 4) Curated8

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024023180R → W1 PublicationCorresponds to variant dbSNP:rs2273779EnsemblClinVar.1
Natural variantiVAR_0515591130N → S. Corresponds to variant dbSNP:rs10158395Ensembl.1
Natural variantiVAR_0515601272I → T. Corresponds to variant dbSNP:rs1293985Ensembl.1
Natural variantiVAR_0515611296T → M1 PublicationCorresponds to variant dbSNP:rs12134934Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01646726 – 66Missing in isoform B, isoform D and isoform E. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_016468107 – 199Missing in isoform C and isoform D. CuratedAdd BLAST93
Alternative sequenceiVSP_016469157 – 199Missing in isoform F. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_016470412 – 841Missing in isoform E. 1 PublicationAdd BLAST430

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70136 mRNA Translation: AAB09089.1
AK131434 mRNA Translation: BAD18580.1
AL133553 Genomic DNA No translation available.
KF455089 Genomic DNA No translation available.
AY653037 mRNA Translation: AAT74745.1
AY653038 mRNA Translation: AAT74746.1
CCDSiCCDS1369.1 [Q92954-1]
CCDS44287.1 [Q92954-3]
CCDS44288.1 [Q92954-2]
CCDS81411.1 [Q92954-6]
RefSeqiNP_001121180.2, NM_001127708.2 [Q92954-2]
NP_001121181.2, NM_001127709.2 [Q92954-3]
NP_001121182.2, NM_001127710.2 [Q92954-4]
NP_001290161.1, NM_001303232.1 [Q92954-6]
NP_005798.3, NM_005807.4 [Q92954-1]
XP_016855491.1, XM_017000002.1 [Q92954-3]
XP_016855492.1, XM_017000003.1 [Q92954-4]
UniGeneiHs.647723

Genome annotation databases

EnsembliENST00000367483; ENSP00000356453; ENSG00000116690 [Q92954-2]
ENST00000367485; ENSP00000356455; ENSG00000116690 [Q92954-3]
ENST00000445192; ENSP00000399679; ENSG00000116690 [Q92954-1]
ENST00000635041; ENSP00000489292; ENSG00000116690 [Q92954-6]
GeneIDi10216
KEGGihsa:10216
UCSCiuc001grt.5 human [Q92954-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRG4_HUMAN
AccessioniPrimary (citable) accession number: Q92954
Secondary accession number(s): Q6DNC4
, Q6DNC5, Q6ZMZ5, Q9BX49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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