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Protein

Proteoglycan 4

Gene

PRG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: ProtInc
  • immune response Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116690-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteoglycan 4
Alternative name(s):
Lubricin
Megakaryocyte-stimulating factor
Superficial zone proteoglycan
Cleaved into the following chain:
Gene namesi
Name:PRG4
Synonyms:MSF, SZP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9364. PRG4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions.
See also OMIM:208250

Organism-specific databases

DisGeNETi10216.
MalaCardsiPRG4.
MIMi208250. phenotype.
Orphaneti2848. Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome.
PharmGKBiPA33736.

Polymorphism and mutation databases

BioMutaiPRG4.
DMDMi83288393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004323225 – 1404Proteoglycan 4Add BLAST1380
ChainiPRO_00000432331307 – 1404Proteoglycan 4 C-terminal partAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 46PROSITE-ProRule annotation
Disulfide bondi30 ↔ 34PROSITE-ProRule annotation
Disulfide bondi34 ↔ 64PROSITE-ProRule annotation
Disulfide bondi44 ↔ 57PROSITE-ProRule annotation
Disulfide bondi44 ↔ 46PROSITE-ProRule annotation
Disulfide bondi50 ↔ 56PROSITE-ProRule annotation
Disulfide bondi57 ↔ 64PROSITE-ProRule annotation
Disulfide bondi70 ↔ 86AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 74AlternatePROSITE-ProRule annotation
Disulfide bondi74 ↔ 104AlternatePROSITE-ProRule annotation
Disulfide bondi84 ↔ 97AlternatePROSITE-ProRule annotation
Disulfide bondi84 ↔ 86AlternatePROSITE-ProRule annotation
Disulfide bondi90 ↔ 96PROSITE-ProRule annotation
Disulfide bondi97 ↔ 104AlternatePROSITE-ProRule annotation
Glycosylationi123O-linked (GalNAc...)1 Publication1
Glycosylationi136O-linked (GalNAc...)1 Publication1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi240O-linked (GalNAc...)1 Publication1
Glycosylationi253O-linked (GalNAc...)1 Publication1
Glycosylationi277O-linked (GalNAc...)1 Publication1
Glycosylationi291O-linked (GalNAc...)1 Publication1
Glycosylationi305O-linked (GalNAc...)1 Publication1
Glycosylationi306O-linked (GalNAc...)1 Publication1
Glycosylationi310O-linked (GalNAc...)1 Publication1
Glycosylationi317O-linked (GalNAc...)1 Publication1
Glycosylationi324O-linked (GalNAc...)1 Publication1
Glycosylationi332O-linked (GalNAc...)1 Publication1
Glycosylationi338O-linked (GalNAc...)1 Publication1
Glycosylationi367O-linked (GalNAc...)1 Publication1
Glycosylationi376O-linked (GalNAc...)1 Publication1
Glycosylationi384O-linked (GalNAc...)1 Publication1
Glycosylationi385O-linked (GalNAc...)1 Publication1
Glycosylationi388O-linked (GalNAc...)1 Publication1
Glycosylationi391O-linked (GalNAc...)1 Publication1
Glycosylationi399O-linked (GalNAc...)1 Publication1
Glycosylationi407O-linked (GalNAc...)1 Publication1
Glycosylationi408O-linked (GalNAc...)1 Publication1
Glycosylationi415O-linked (GalNAc...)1 Publication1
Glycosylationi423O-linked (GalNAc...)1 Publication1
Glycosylationi427O-linked (GalNAc...)1 Publication1
Glycosylationi430O-linked (GalNAc...)1 Publication1
Glycosylationi438O-linked (GalNAc...)1 Publication1
Glycosylationi439O-linked (GalNAc...)1 Publication1
Glycosylationi446O-linked (GalNAc...)1 Publication1
Glycosylationi447O-linked (GalNAc...)1 Publication1
Glycosylationi454O-linked (GalNAc...)1 Publication1
Glycosylationi455O-linked (GalNAc...)1 Publication1
Glycosylationi477O-linked (GalNAc...)1 Publication1
Glycosylationi478O-linked (GalNAc...)1 Publication1
Glycosylationi485O-linked (GalNAc...)1 Publication1
Glycosylationi493O-linked (GalNAc...)1 Publication1
Glycosylationi494O-linked (GalNAc...)1 Publication1
Glycosylationi501O-linked (GalNAc...)1 Publication1
Glycosylationi502O-linked (GalNAc...)1 Publication1
Glycosylationi509O-linked (GalNAc...)1 Publication1
Glycosylationi525O-linked (GalNAc...)1 Publication1
Glycosylationi529O-linked (GalNAc...)1 Publication1
Glycosylationi532O-linked (GalNAc...)1 Publication1
Glycosylationi540O-linked (GalNAc...)1 Publication1
Glycosylationi541O-linked (GalNAc...)1 Publication1
Glycosylationi553O-linked (GalNAc...)1 Publication1
Glycosylationi555O-linked (GalNAc...)1 Publication1
Glycosylationi563O-linked (GalNAc...)1 Publication1
Glycosylationi564O-linked (GalNAc...)1 Publication1
Glycosylationi571O-linked (GalNAc...)1 Publication1
Glycosylationi572O-linked (GalNAc...)1 Publication1
Glycosylationi579O-linked (GalNAc...)1 Publication1
Glycosylationi580O-linked (GalNAc...)1 Publication1
Glycosylationi587O-linked (GalNAc...)1 Publication1
Glycosylationi588O-linked (GalNAc...)1 Publication1
Glycosylationi595O-linked (GalNAc...)1 Publication1
Glycosylationi603O-linked (GalNAc...)1 Publication1
Glycosylationi604O-linked (GalNAc...)1 Publication1
Glycosylationi611O-linked (GalNAc...)1 Publication1
Glycosylationi612O-linked (GalNAc...)1 Publication1
Glycosylationi616O-linked (GalNAc...)1 Publication1
Glycosylationi619O-linked (GalNAc...)1 Publication1
Glycosylationi627O-linked (GalNAc...)1 Publication1
Glycosylationi676O-linked (GalNAc...)1 Publication1
Glycosylationi683O-linked (GalNAc...)1 Publication1
Glycosylationi684O-linked (GalNAc...)1 Publication1
Glycosylationi691O-linked (GalNAc...)1 Publication1
Glycosylationi692O-linked (GalNAc...)1 Publication1
Glycosylationi699O-linked (GalNAc...)1 Publication1
Glycosylationi700O-linked (GalNAc...)1 Publication1
Glycosylationi704O-linked (GalNAc...)1 Publication1
Glycosylationi707O-linked (GalNAc...)1 Publication1
Glycosylationi723O-linked (GalNAc...)1 Publication1
Glycosylationi724O-linked (GalNAc...)1 Publication1
Glycosylationi736O-linked (GalNAc...)1 Publication1
Glycosylationi768O-linked (GalNAc...)1 Publication1
Glycosylationi769O-linked (GalNAc...)1 Publication1
Glycosylationi776O-linked (GalNAc...)1 Publication1
Glycosylationi777O-linked (GalNAc...)1 Publication1
Glycosylationi792O-linked (GalNAc...)1 Publication1
Glycosylationi793O-linked (GalNAc...)1 Publication1
Glycosylationi805O-linked (GalNAc...)1 Publication1
Glycosylationi812O-linked (GalNAc...)1 Publication1
Glycosylationi829O-linked (GalNAc...)1 Publication1
Glycosylationi837O-linked (GalNAc...)1 Publication1
Glycosylationi838O-linked (GalNAc...)1 Publication1
Glycosylationi892O-linked (GalNAc...)1 Publication1
Glycosylationi900O-linked (GalNAc...)1 Publication1
Glycosylationi930O-linked (GalNAc...)1 Publication1
Glycosylationi931O-linked (GalNAc...)1 Publication1
Glycosylationi962O-linked (GalNAc...)1 Publication1
Glycosylationi963O-linked (GalNAc...)1 Publication1
Glycosylationi968O-linked (GalNAc...)1 Publication1
Glycosylationi975O-linked (GalNAc...)1 Publication1
Glycosylationi978O-linked (GalNAc...)1 Publication1
Glycosylationi979O-linked (GalNAc...)1 Publication1
Glycosylationi980O-linked (GalNAc...)1 Publication1
Glycosylationi1039O-linked (GalNAc...)1 Publication1
Disulfide bondi1146 ↔ 1403PROSITE-ProRule annotation
Glycosylationi1159N-linked (GlcNAc...)1 Publication1
Glycosylationi1161O-linked (GalNAc...)1 Publication1

Post-translational modificationi

N-glycosylated (PubMed:16335952).1 Publication
O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans (PubMed:25187573).1 Publication
The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1306 – 1307Cleavage; by subtilisin-like proprotein convertase 4By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

EPDiQ92954.
MaxQBiQ92954.
PaxDbiQ92954.
PeptideAtlasiQ92954.
PRIDEiQ92954.

PTM databases

iPTMnetiQ92954.
PhosphoSitePlusiQ92954.

Expressioni

Tissue specificityi

Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000116690.
CleanExiHS_PRG4.
ExpressionAtlasiQ92954. baseline and differential.
GenevisibleiQ92954. HS.

Organism-specific databases

HPAiHPA028523.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi115511. 1 interactor.
IntActiQ92954. 3 interactors.
MINTiMINT-7970782.
STRINGi9606.ENSP00000399679.

Structurei

3D structure databases

ProteinModelPortaliQ92954.
SMRiQ92954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 69SMB 1PROSITE-ProRule annotationAdd BLAST44
Domaini66 – 108SMB 2PROSITE-ProRule annotationAdd BLAST43
Repeati348 – 35518
Repeati356 – 3632; approximate8
Repeati364 – 37138
Repeati372 – 3784; approximate7
Repeati379 – 38658
Repeati387 – 3936; approximate7
Repeati394 – 40178
Repeati402 – 40988
Repeati410 – 41798
Repeati418 – 425108
Repeati426 – 43211; approximate7
Repeati433 – 440128
Repeati441 – 448138
Repeati449 – 456148
Repeati457 – 464158
Repeati465 – 47116; approximate7
Repeati472 – 479178
Repeati480 – 48718; approximate8
Repeati488 – 49519; approximate8
Repeati496 – 503208
Repeati504 – 511218
Repeati512 – 519228
Repeati520 – 527238
Repeati528 – 53424; approximate7
Repeati535 – 542258
Repeati543 – 54926; approximate7
Repeati550 – 557278
Repeati558 – 565288
Repeati566 – 573298
Repeati574 – 581308
Repeati582 – 589318
Repeati590 – 597328
Repeati598 – 60533; approximate8
Repeati606 – 613348
Repeati614 – 62135; approximate8
Repeati622 – 62936; approximate8
Repeati638 – 64537; approximate8
Repeati662 – 66938; approximate8
Repeati678 – 685398
Repeati686 – 693408
Repeati694 – 701418
Repeati702 – 70942; approximate8
Repeati710 – 71743; approximate8
Repeati718 – 725448
Repeati731 – 73845; approximate8
Repeati739 – 74646; approximate8
Repeati747 – 75447; approximate8
Repeati755 – 76248; approximate8
Repeati763 – 770498
Repeati771 – 778508
Repeati779 – 78651; approximate8
Repeati787 – 794528
Repeati800 – 80753; approximate8
Repeati808 – 81554; approximate8
Repeati816 – 82355; approximate8
Repeati824 – 83156; approximate8
Repeati832 – 839578
Repeati840 – 847588
Repeati848 – 85559; approximate8
Repeati1148 – 1191Hemopexin 1Add BLAST44
Repeati1192 – 1239Hemopexin 2Add BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 85559 X 8 AA repeats of K-X-P-X-P-T-T-XAdd BLAST508

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 188Ser-richAdd BLAST30

Sequence similaritiesi

Contains 2 hemopexin repeats.Curated
Contains 2 SMB (somatomedin-B) domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOGENOMiHOG000115691.
InParanoidiQ92954.
OrthoDBiEOG091G0D8U.
PhylomeDBiQ92954.
TreeFamiTF332780.

Family and domain databases

CDDicd00094. HX. 1 hit.
Gene3Di2.110.10.10. 2 hits.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PfamiPF00045. Hemopexin. 1 hit.
PF01033. Somatomedin_B. 2 hits.
[Graphical view]
PRINTSiPR00022. SOMATOMEDINB.
SMARTiSM00120. HX. 2 hits.
SM00201. SO. 2 hits.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 2 hits.
SSF90188. SSF90188. 2 hits.
PROSITEiPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 2 hits.
PS00524. SMB_1. 2 hits.
PS50958. SMB_2. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q92954-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC
60 70 80 90 100
QHYMECCPDF KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY
110 120 130 140 150
ESFCAEVHNP TSPPSSKKAP PPSGASQTIK STTKRSPKPP NKKKTKKVIE
160 170 180 190 200
SEEITEEHSV SENQESSSSS SSSSSSSTIR KIKSSKNSAA NRELQKKLKV
210 220 230 240 250
KDNKKNRTKK KPTPKPPVVD EAGSGLDNGD FKVTTPDTST TQHNKVSTSP
260 270 280 290 300
KITTAKPINP RPSLPPNSDT SKETSLTVNK ETTVETKETT TTNKQTSTDG
310 320 330 340 350
KEKTTSAKET QSIEKTSAKD LAPTSKVLAK PTPKAETTTK GPALTTPKEP
360 370 380 390 400
TPTTPKEPAS TTPKEPTPTT IKSAPTTPKE PAPTTTKSAP TTPKEPAPTT
410 420 430 440 450
TKEPAPTTPK EPAPTTTKEP APTTTKSAPT TPKEPAPTTP KKPAPTTPKE
460 470 480 490 500
PAPTTPKEPT PTTPKEPAPT TKEPAPTTPK EPAPTAPKKP APTTPKEPAP
510 520 530 540 550
TTPKEPAPTT TKEPSPTTPK EPAPTTTKSA PTTTKEPAPT TTKSAPTTPK
560 570 580 590 600
EPSPTTTKEP APTTPKEPAP TTPKKPAPTT PKEPAPTTPK EPAPTTTKKP
610 620 630 640 650
APTTPKEPAP TTPKETAPTT PKKLTPTTPE KLAPTTPEKP APTTPEELAP
660 670 680 690 700
TTPEEPTPTT PEEPAPTTPK AAAPNTPKEP APTTPKEPAP TTPKEPAPTT
710 720 730 740 750
PKETAPTTPK GTAPTTLKEP APTTPKKPAP KELAPTTTKE PTSTTCDKPA
760 770 780 790 800
PTTPKGTAPT TPKEPAPTTP KEPAPTTPKG TAPTTLKEPA PTTPKKPAPK
810 820 830 840 850
ELAPTTTKGP TSTTSDKPAP TTPKETAPTT PKEPAPTTPK KPAPTTPETP
860 870 880 890 900
PPTTSEVSTP TTTKEPTTIH KSPDESTPEL SAEPTPKALE NSPKEPGVPT
910 920 930 940 950
TKTPAATKPE MTTTAKDKTT ERDLRTTPET TTAAPKMTKE TATTTEKTTE
960 970 980 990 1000
SKITATTTQV TSTTTQDTTP FKITTLKTTT LAPKVTTTKK TITTTEIMNK
1010 1020 1030 1040 1050
PEETAKPKDR ATNSKATTPK PQKPTKAPKK PTSTKKPKTM PRVRKPKTTP
1060 1070 1080 1090 1100
TPRKMTSTMP ELNPTSRIAE AMLQTTTRPN QTPNSKLVEV NPKSEDAGGA
1110 1120 1130 1140 1150
EGETPHMLLR PHVFMPEVTP DMDYLPRVPN QGIIINPMLS DETNICNGKP
1160 1170 1180 1190 1200
VDGLTTLRNG TLVAFRGHYF WMLSPFSPPS PARRITEVWG IPSPIDTVFT
1210 1220 1230 1240 1250
RCNCEGKTFF FKDSQYWRFT NDIKDAGYPK PIFKGFGGLT GQIVAALSTA
1260 1270 1280 1290 1300
KYKNWPESVY FFKRGGSIQQ YIYKQEPVQK CPGRRPALNY PVYGETTQVR
1310 1320 1330 1340 1350
RRRFERAIGP SQTHTIRIQY SPARLAYQDK GVLHNEVKVS ILWRGLPNVV
1360 1370 1380 1390 1400
TSAISLPNIR KPDGYDYYAF SKDQYYNIDV PSRTARAITT RSGQTLSKVW

YNCP
Length:1,404
Mass (Da):151,077
Last modified:December 6, 2005 - v2
Checksum:i782A11746B3FDEE5
GO
Isoform B (identifier: Q92954-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.

Show »
Length:1,363
Mass (Da):146,518
Checksum:i50E8651CE1EE09A7
GO
Isoform C (identifier: Q92954-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-199: Missing.

Show »
Length:1,311
Mass (Da):141,106
Checksum:iD01B2F4A548A6625
GO
Isoform D (identifier: Q92954-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     107-199: Missing.

Show »
Length:1,270
Mass (Da):136,547
Checksum:i3218D3229FA74D85
GO
Isoform E (identifier: Q92954-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-66: Missing.
     412-841: Missing.

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):102,513
Checksum:iB883773C5BC21A23
GO
Isoform F (identifier: Q92954-6) [UniParc]FASTAAdd to basket
Also known as: Hemangiopoietin, HAPO

The sequence of this isoform differs from the canonical sequence as follows:
     157-199: Missing.

Show »
Length:1,361
Mass (Da):146,468
Checksum:i72DD98ED1A613593
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti604T → A in AAB09089 (Ref. 1) Curated1
Sequence conflicti746C → S in AAB09089 (Ref. 1) Curated1
Sequence conflicti1340S → G in AAT74746 (Ref. 4) Curated1
Sequence conflicti1380V → G in AAT74746 (Ref. 4) Curated1
Sequence conflicti1397S → F in AAT74746 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024023180R → W.1 PublicationCorresponds to variant rs2273779dbSNPEnsembl.1
Natural variantiVAR_0515591130N → S.Corresponds to variant rs10158395dbSNPEnsembl.1
Natural variantiVAR_0515601272I → T.Corresponds to variant rs1293985dbSNPEnsembl.1
Natural variantiVAR_0515611296T → M.1 PublicationCorresponds to variant rs12134934dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01646726 – 66Missing in isoform B, isoform D and isoform E. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_016468107 – 199Missing in isoform C and isoform D. CuratedAdd BLAST93
Alternative sequenceiVSP_016469157 – 199Missing in isoform F. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_016470412 – 841Missing in isoform E. 1 PublicationAdd BLAST430

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70136 mRNA. Translation: AAB09089.1.
AK131434 mRNA. Translation: BAD18580.1.
AL133553 Genomic DNA. Translation: CAC36090.1.
AY653037 mRNA. Translation: AAT74745.1.
AY653038 mRNA. Translation: AAT74746.1.
CCDSiCCDS1369.1. [Q92954-1]
CCDS44287.1. [Q92954-3]
CCDS44288.1. [Q92954-2]
CCDS81411.1. [Q92954-6]
RefSeqiNP_001121180.2. NM_001127708.2.
NP_001121181.2. NM_001127709.2.
NP_001121182.2. NM_001127710.2.
NP_001290161.1. NM_001303232.1.
NP_005798.3. NM_005807.4.
UniGeneiHs.647723.

Genome annotation databases

EnsembliENST00000367483; ENSP00000356453; ENSG00000116690.
ENST00000367485; ENSP00000356455; ENSG00000116690.
ENST00000445192; ENSP00000399679; ENSG00000116690.
GeneIDi10216.
KEGGihsa:10216.
UCSCiuc001grt.5. human. [Q92954-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70136 mRNA. Translation: AAB09089.1.
AK131434 mRNA. Translation: BAD18580.1.
AL133553 Genomic DNA. Translation: CAC36090.1.
AY653037 mRNA. Translation: AAT74745.1.
AY653038 mRNA. Translation: AAT74746.1.
CCDSiCCDS1369.1. [Q92954-1]
CCDS44287.1. [Q92954-3]
CCDS44288.1. [Q92954-2]
CCDS81411.1. [Q92954-6]
RefSeqiNP_001121180.2. NM_001127708.2.
NP_001121181.2. NM_001127709.2.
NP_001121182.2. NM_001127710.2.
NP_001290161.1. NM_001303232.1.
NP_005798.3. NM_005807.4.
UniGeneiHs.647723.

3D structure databases

ProteinModelPortaliQ92954.
SMRiQ92954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115511. 1 interactor.
IntActiQ92954. 3 interactors.
MINTiMINT-7970782.
STRINGi9606.ENSP00000399679.

PTM databases

iPTMnetiQ92954.
PhosphoSitePlusiQ92954.

Polymorphism and mutation databases

BioMutaiPRG4.
DMDMi83288393.

Proteomic databases

EPDiQ92954.
MaxQBiQ92954.
PaxDbiQ92954.
PeptideAtlasiQ92954.
PRIDEiQ92954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367483; ENSP00000356453; ENSG00000116690.
ENST00000367485; ENSP00000356455; ENSG00000116690.
ENST00000445192; ENSP00000399679; ENSG00000116690.
GeneIDi10216.
KEGGihsa:10216.
UCSCiuc001grt.5. human. [Q92954-1]

Organism-specific databases

CTDi10216.
DisGeNETi10216.
GeneCardsiPRG4.
HGNCiHGNC:9364. PRG4.
HPAiHPA028523.
MalaCardsiPRG4.
MIMi208250. phenotype.
604283. gene.
neXtProtiNX_Q92954.
Orphaneti2848. Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome.
PharmGKBiPA33736.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOGENOMiHOG000115691.
InParanoidiQ92954.
OrthoDBiEOG091G0D8U.
PhylomeDBiQ92954.
TreeFamiTF332780.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116690-MONOMER.

Miscellaneous databases

GeneWikiiPRG4.
GenomeRNAii10216.
PROiQ92954.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116690.
CleanExiHS_PRG4.
ExpressionAtlasiQ92954. baseline and differential.
GenevisibleiQ92954. HS.

Family and domain databases

CDDicd00094. HX. 1 hit.
Gene3Di2.110.10.10. 2 hits.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PfamiPF00045. Hemopexin. 1 hit.
PF01033. Somatomedin_B. 2 hits.
[Graphical view]
PRINTSiPR00022. SOMATOMEDINB.
SMARTiSM00120. HX. 2 hits.
SM00201. SO. 2 hits.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 2 hits.
SSF90188. SSF90188. 2 hits.
PROSITEiPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 2 hits.
PS00524. SMB_1. 2 hits.
PS50958. SMB_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRG4_HUMAN
AccessioniPrimary (citable) accession number: Q92954
Secondary accession number(s): Q6DNC4
, Q6DNC5, Q6ZMZ5, Q9BX49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Different forms varying in molecular weight have been observed. Such forms are possibly due to different levels of glycosylation and protein cleavage (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.