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Q92953 (KCNB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily B member 2
Alternative name(s):
Voltage-gated potassium channel subunit Kv2.2
Gene names
Name:KCNB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length911 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

Subunit structure

Heteromultimer with KCNS1, KCNS2 and KCNS3 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Post-translational modification

Phosphorylated Potential.

Sequence similarities

Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily. [View classification]

Sequence caution

The sequence AAB08433.1 differs from that shown. Reason: Frameshift at position 768.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 911911Potassium voltage-gated channel subfamily B member 2
PRO_0000054048

Regions

Topological domain1 – 190190Cytoplasmic Potential
Transmembrane191 – 21222Helical; Name=Segment S1; Potential
Transmembrane233 – 25321Helical; Name=Segment S2; Potential
Topological domain254 – 26310Cytoplasmic Potential
Transmembrane264 – 28421Helical; Name=Segment S3; Potential
Transmembrane299 – 32022Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain321 – 33414Cytoplasmic Potential
Transmembrane335 – 35521Helical; Name=Segment S5; Potential
Intramembrane369 – 38921Pore-forming; Name=Segment H5; Potential
Transmembrane396 – 41621Helical; Name=Segment S6; Potential
Topological domain417 – 911495Cytoplasmic Potential
Motif381 – 3866Selectivity filter By similarity

Amino acid modifications

Glycosylation2871N-linked (GlcNAc...) Potential

Natural variations

Natural variant4501V → I in a colorectal cancer sample; somatic mutation. Ref.4
VAR_035774
Natural variant6571E → G.
Corresponds to variant rs16938507 [ dbSNP | Ensembl ].
VAR_034050

Experimental info

Sequence conflict161 – 1622ER → DG in AAP46292. Ref.1
Sequence conflict5281S → F in AAP46292. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q92953 [UniParc].

Last modified October 25, 2002. Version 2.
Checksum: 2261D7D6280CF81A

FASTA911102,563
        10         20         30         40         50         60 
MAEKAPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW RTLDRLPRTR 

        70         80         90        100        110        120 
LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL NFYRTGKLHM MEEMCALSFG 

       130        140        150        160        170        180 
QELDYWGIDE IYLESCCQAR YHQKKEQMNE ELRREAETMR EREGEEFDNT CCPDKRKKLW 

       190        200        210        220        230        240 
DLLEKPNSSV AAKILAIVSI LFIVLSTIAL SLNTLPELQE TDEFGQLNDN RQLAHVEAVC 

       250        260        270        280        290        300 
IAWFTMEYLL RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV 

       310        320        330        340        350        360 
QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS SLVFFAEKDE 

       370        380        390        400        410        420 
DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL CCIAGVLVIA LPIPIIVNNF 

       430        440        450        460        470        480 
SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV SMNLKDAFAR SMELIDVAVE KAGESANTKD 

       490        500        510        520        530        540 
SADDNHLSPS RWKWARKALS ETSSNKSFEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL 

       550        560        570        580        590        600 
EMLYNEITKT QPHSHPNPDC QEKPERPSAY EEEIEMEEVV CPQEQLAVAQ TEVIVDMKST 

       610        620        630        640        650        660 
SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPTDLPGT EEHQRARGPP FLTLSREKGP 

       670        680        690        700        710        720 
AARDGTLEYA PVDITVNLDA SGSQCGLHSP LQSDNATDSP KSSLKGSNPL KSRSLKVNFK 

       730        740        750        760        770        780 
ENRGSAPQTP PSTARPLPVT TADFSLTTPQ HISTILLEET PSQGDRPLLG TEVSAPCQGP 

       790        800        810        820        830        840 
SKGLSPRFPK QKLFPFSSRE RRSFTEIDTG DDEDFLELPG AREEKQVDSS PNCFADKPSD 

       850        860        870        880        890        900 
GRDPLREEGS VGSSSPQDTG HNCRQDIYHA VSEVKKDSSQ EGCKMENHLF APEIHSNPGD 

       910 
TGYCPTRETS M 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of two novel gamma Kv subunits."
Preisig-Mueller R., Derst C., Schnitzler M.M., Daut J.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Rae J.L.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles."
Schmalz F., Kinsella J., Koh S.D., Vogalis F., Schneider A., Flynn E.R., Kenyon J.L., Horowitz B.
Am. J. Physiol. 274:G901-G911(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-811.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-450.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF450111 mRNA. Translation: AAP46292.1.
AF338730 mRNA. Translation: AAK16585.1.
U69962 mRNA. Translation: AAB08433.1. Frameshift.
CCDSCCDS6209.1.
RefSeqNP_004761.2. NM_004770.2.
UniGeneHs.661102.

3D structure databases

ProteinModelPortalQ92953.
SMRQ92953. Positions 34-466.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114724. 5 interactions.
IntActQ92953. 1 interaction.
STRING9606.ENSP00000329426.

Chemistry

ChEMBLCHEMBL2362996.
GuidetoPHARMACOLOGY547.

PTM databases

PhosphoSiteQ92953.

Polymorphism databases

DMDM24418855.

Proteomic databases

PaxDbQ92953.
PRIDEQ92953.

Protocols and materials databases

DNASU9312.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000523207; ENSP00000430846; ENSG00000182674.
GeneID9312.
KEGGhsa:9312.
UCSCuc003xzb.3. human.

Organism-specific databases

CTD9312.
GeneCardsGC08P073499.
HGNCHGNC:6232. KCNB2.
MIM607738. gene.
neXtProtNX_Q92953.
PharmGKBPA30025.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000113206.
HOVERGENHBG052225.
InParanoidQ92953.
KOK04886.
OMAIHSNPGD.
OrthoDBEOG7CRTPP.
PhylomeDBQ92953.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ92953.
CleanExHS_KCNB2.
GenevestigatorQ92953.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003973. K_chnl_volt-dep_Kv2.
IPR005826. K_chnl_volt-dep_Kv2.2.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF03521. Kv2channel. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01515. KV22CHANNEL.
PR01491. KVCHANNEL.
PR01495. SHABCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNB2.
GenomeRNAi9312.
NextBio34883.
PROQ92953.
SOURCESearch...

Entry information

Entry nameKCNB2_HUMAN
AccessionPrimary (citable) accession number: Q92953
Secondary accession number(s): Q7Z7D0, Q9BXD3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 25, 2002
Last modified: July 9, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM