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Q92953

- KCNB2_HUMAN

UniProt

Q92953 - KCNB2_HUMAN

Protein

Potassium voltage-gated channel subfamily B member 2

Gene

KCNB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: ProtInc

    GO - Biological processi

    1. potassium ion transport Source: ProtInc
    2. protein homooligomerization Source: InterPro
    3. regulation of smooth muscle contraction Source: ProtInc
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily B member 2
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv2.2
    Gene namesi
    Name:KCNB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:6232. KCNB2.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30025.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 911911Potassium voltage-gated channel subfamily B member 2PRO_0000054048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated.Curated

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ92953.
    PRIDEiQ92953.

    PTM databases

    PhosphoSiteiQ92953.

    Expressioni

    Gene expression databases

    BgeeiQ92953.
    CleanExiHS_KCNB2.
    GenevestigatoriQ92953.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNS1, KCNS2 and KCNS3.By similarity

    Protein-protein interaction databases

    BioGridi114724. 5 interactions.
    IntActiQ92953. 1 interaction.
    STRINGi9606.ENSP00000329426.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92953.
    SMRiQ92953. Positions 34-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 26310CytoplasmicSequence Analysis
    Topological domaini321 – 33414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini417 – 911495CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei369 – 38921Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei191 – 21222Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 32022Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi381 – 3866Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000113206.
    HOVERGENiHBG052225.
    InParanoidiQ92953.
    KOiK04886.
    OMAiIHSNPGD.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiQ92953.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003973. K_chnl_volt-dep_Kv2.
    IPR005826. K_chnl_volt-dep_Kv2.2.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF03521. Kv2channel. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01515. KV22CHANNEL.
    PR01491. KVCHANNEL.
    PR01495. SHABCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92953-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKAPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW    50
    RTLDRLPRTR LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL 100
    NFYRTGKLHM MEEMCALSFG QELDYWGIDE IYLESCCQAR YHQKKEQMNE 150
    ELRREAETMR EREGEEFDNT CCPDKRKKLW DLLEKPNSSV AAKILAIVSI 200
    LFIVLSTIAL SLNTLPELQE TDEFGQLNDN RQLAHVEAVC IAWFTMEYLL 250
    RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV 300
    QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS 350
    SLVFFAEKDE DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL 400
    CCIAGVLVIA LPIPIIVNNF SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV 450
    SMNLKDAFAR SMELIDVAVE KAGESANTKD SADDNHLSPS RWKWARKALS 500
    ETSSNKSFEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL EMLYNEITKT 550
    QPHSHPNPDC QEKPERPSAY EEEIEMEEVV CPQEQLAVAQ TEVIVDMKST 600
    SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPTDLPGT EEHQRARGPP 650
    FLTLSREKGP AARDGTLEYA PVDITVNLDA SGSQCGLHSP LQSDNATDSP 700
    KSSLKGSNPL KSRSLKVNFK ENRGSAPQTP PSTARPLPVT TADFSLTTPQ 750
    HISTILLEET PSQGDRPLLG TEVSAPCQGP SKGLSPRFPK QKLFPFSSRE 800
    RRSFTEIDTG DDEDFLELPG AREEKQVDSS PNCFADKPSD GRDPLREEGS 850
    VGSSSPQDTG HNCRQDIYHA VSEVKKDSSQ EGCKMENHLF APEIHSNPGD 900
    TGYCPTRETS M 911
    Length:911
    Mass (Da):102,563
    Last modified:October 25, 2002 - v2
    Checksum:i2261D7D6280CF81A
    GO

    Sequence cautioni

    The sequence AAB08433.1 differs from that shown. Reason: Frameshift at position 768.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1622ER → DG in AAP46292. 1 PublicationCurated
    Sequence conflicti528 – 5281S → F in AAP46292. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti450 – 4501V → I in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035774
    Natural varianti657 – 6571E → G.
    Corresponds to variant rs16938507 [ dbSNP | Ensembl ].
    VAR_034050

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF450111 mRNA. Translation: AAP46292.1.
    AF338730 mRNA. Translation: AAK16585.1.
    U69962 mRNA. Translation: AAB08433.1. Frameshift.
    CCDSiCCDS6209.1.
    RefSeqiNP_004761.2. NM_004770.2.
    UniGeneiHs.661102.

    Genome annotation databases

    EnsembliENST00000523207; ENSP00000430846; ENSG00000182674.
    GeneIDi9312.
    KEGGihsa:9312.
    UCSCiuc003xzb.3. human.

    Polymorphism databases

    DMDMi24418855.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF450111 mRNA. Translation: AAP46292.1 .
    AF338730 mRNA. Translation: AAK16585.1 .
    U69962 mRNA. Translation: AAB08433.1 . Frameshift.
    CCDSi CCDS6209.1.
    RefSeqi NP_004761.2. NM_004770.2.
    UniGenei Hs.661102.

    3D structure databases

    ProteinModelPortali Q92953.
    SMRi Q92953. Positions 34-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114724. 5 interactions.
    IntActi Q92953. 1 interaction.
    STRINGi 9606.ENSP00000329426.

    Chemistry

    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 547.

    PTM databases

    PhosphoSitei Q92953.

    Polymorphism databases

    DMDMi 24418855.

    Proteomic databases

    PaxDbi Q92953.
    PRIDEi Q92953.

    Protocols and materials databases

    DNASUi 9312.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000523207 ; ENSP00000430846 ; ENSG00000182674 .
    GeneIDi 9312.
    KEGGi hsa:9312.
    UCSCi uc003xzb.3. human.

    Organism-specific databases

    CTDi 9312.
    GeneCardsi GC08P073499.
    HGNCi HGNC:6232. KCNB2.
    MIMi 607738. gene.
    neXtProti NX_Q92953.
    PharmGKBi PA30025.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000113206.
    HOVERGENi HBG052225.
    InParanoidi Q92953.
    KOi K04886.
    OMAi IHSNPGD.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi Q92953.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNB2.
    GenomeRNAii 9312.
    NextBioi 34883.
    PROi Q92953.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92953.
    CleanExi HS_KCNB2.
    Genevestigatori Q92953.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003973. K_chnl_volt-dep_Kv2.
    IPR005826. K_chnl_volt-dep_Kv2.2.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF03521. Kv2channel. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01515. KV22CHANNEL.
    PR01491. KVCHANNEL.
    PR01495. SHABCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two novel gamma Kv subunits."
      Preisig-Mueller R., Derst C., Schnitzler M.M., Daut J.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Rae J.L.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles."
      Schmalz F., Kinsella J., Koh S.D., Vogalis F., Schneider A., Flynn E.R., Kenyon J.L., Horowitz B.
      Am. J. Physiol. 274:G901-G911(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-811.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-450.

    Entry informationi

    Entry nameiKCNB2_HUMAN
    AccessioniPrimary (citable) accession number: Q92953
    Secondary accession number(s): Q7Z7D0, Q9BXD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3