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Protein

Potassium voltage-gated channel subfamily B member 2

Gene

KCNB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: GO_Central

GO - Biological processi

  1. potassium ion transmembrane transport Source: GO_Central
  2. potassium ion transport Source: ProtInc
  3. protein homooligomerization Source: InterPro
  4. regulation of smooth muscle contraction Source: ProtInc
  5. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily B member 2
Alternative name(s):
Voltage-gated potassium channel subunit Kv2.2
Gene namesi
Name:KCNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:6232. KCNB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei191 – 21222Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini254 – 26310CytoplasmicSequence Analysis
Transmembranei264 – 28421Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei299 – 32022Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini321 – 33414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei335 – 35521Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Intramembranei369 – 38921Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Transmembranei396 – 41621Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini417 – 911495CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
  3. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 911911Potassium voltage-gated channel subfamily B member 2PRO_0000054048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ92953.
PRIDEiQ92953.

PTM databases

PhosphoSiteiQ92953.

Expressioni

Gene expression databases

BgeeiQ92953.
CleanExiHS_KCNB2.
GenevestigatoriQ92953.

Interactioni

Subunit structurei

Heteromultimer with KCNS1, KCNS2 and KCNS3.By similarity

Protein-protein interaction databases

BioGridi114724. 5 interactions.
IntActiQ92953. 1 interaction.
STRINGi9606.ENSP00000329426.

Structurei

3D structure databases

ProteinModelPortaliQ92953.
SMRiQ92953. Positions 34-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi381 – 3866Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000113206.
HOVERGENiHBG052225.
InParanoidiQ92953.
KOiK04886.
OMAiIHSNPGD.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ92953.
TreeFamiTF313103.

Family and domain databases

InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003973. K_chnl_volt-dep_Kv2.
IPR005826. K_chnl_volt-dep_Kv2.2.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF03521. Kv2channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01515. KV22CHANNEL.
PR01491. KVCHANNEL.
PR01495. SHABCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKAPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW
60 70 80 90 100
RTLDRLPRTR LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL
110 120 130 140 150
NFYRTGKLHM MEEMCALSFG QELDYWGIDE IYLESCCQAR YHQKKEQMNE
160 170 180 190 200
ELRREAETMR EREGEEFDNT CCPDKRKKLW DLLEKPNSSV AAKILAIVSI
210 220 230 240 250
LFIVLSTIAL SLNTLPELQE TDEFGQLNDN RQLAHVEAVC IAWFTMEYLL
260 270 280 290 300
RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV
310 320 330 340 350
QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS
360 370 380 390 400
SLVFFAEKDE DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL
410 420 430 440 450
CCIAGVLVIA LPIPIIVNNF SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV
460 470 480 490 500
SMNLKDAFAR SMELIDVAVE KAGESANTKD SADDNHLSPS RWKWARKALS
510 520 530 540 550
ETSSNKSFEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL EMLYNEITKT
560 570 580 590 600
QPHSHPNPDC QEKPERPSAY EEEIEMEEVV CPQEQLAVAQ TEVIVDMKST
610 620 630 640 650
SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPTDLPGT EEHQRARGPP
660 670 680 690 700
FLTLSREKGP AARDGTLEYA PVDITVNLDA SGSQCGLHSP LQSDNATDSP
710 720 730 740 750
KSSLKGSNPL KSRSLKVNFK ENRGSAPQTP PSTARPLPVT TADFSLTTPQ
760 770 780 790 800
HISTILLEET PSQGDRPLLG TEVSAPCQGP SKGLSPRFPK QKLFPFSSRE
810 820 830 840 850
RRSFTEIDTG DDEDFLELPG AREEKQVDSS PNCFADKPSD GRDPLREEGS
860 870 880 890 900
VGSSSPQDTG HNCRQDIYHA VSEVKKDSSQ EGCKMENHLF APEIHSNPGD
910
TGYCPTRETS M
Length:911
Mass (Da):102,563
Last modified:October 24, 2002 - v2
Checksum:i2261D7D6280CF81A
GO

Sequence cautioni

The sequence AAB08433.1 differs from that shown. Reason: Frameshift at position 768. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1622ER → DG in AAP46292 (Ref. 1) Curated
Sequence conflicti528 – 5281S → F in AAP46292 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti450 – 4501V → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035774
Natural varianti657 – 6571E → G.
Corresponds to variant rs16938507 [ dbSNP | Ensembl ].
VAR_034050

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450111 mRNA. Translation: AAP46292.1.
AF338730 mRNA. Translation: AAK16585.1.
U69962 mRNA. Translation: AAB08433.1. Frameshift.
CCDSiCCDS6209.1.
RefSeqiNP_004761.2. NM_004770.2.
UniGeneiHs.661102.

Genome annotation databases

EnsembliENST00000523207; ENSP00000430846; ENSG00000182674.
GeneIDi9312.
KEGGihsa:9312.
UCSCiuc003xzb.3. human.

Polymorphism databases

DMDMi24418855.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450111 mRNA. Translation: AAP46292.1.
AF338730 mRNA. Translation: AAK16585.1.
U69962 mRNA. Translation: AAB08433.1. Frameshift.
CCDSiCCDS6209.1.
RefSeqiNP_004761.2. NM_004770.2.
UniGeneiHs.661102.

3D structure databases

ProteinModelPortaliQ92953.
SMRiQ92953. Positions 34-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114724. 5 interactions.
IntActiQ92953. 1 interaction.
STRINGi9606.ENSP00000329426.

Chemistry

ChEMBLiCHEMBL2321618.
DrugBankiDB06637. Dalfampridine.
GuidetoPHARMACOLOGYi547.

PTM databases

PhosphoSiteiQ92953.

Polymorphism databases

DMDMi24418855.

Proteomic databases

PaxDbiQ92953.
PRIDEiQ92953.

Protocols and materials databases

DNASUi9312.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000523207; ENSP00000430846; ENSG00000182674.
GeneIDi9312.
KEGGihsa:9312.
UCSCiuc003xzb.3. human.

Organism-specific databases

CTDi9312.
GeneCardsiGC08P073499.
HGNCiHGNC:6232. KCNB2.
MIMi607738. gene.
neXtProtiNX_Q92953.
PharmGKBiPA30025.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000113206.
HOVERGENiHBG052225.
InParanoidiQ92953.
KOiK04886.
OMAiIHSNPGD.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ92953.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNB2.
GenomeRNAii9312.
NextBioi34883.
PROiQ92953.
SOURCEiSearch...

Gene expression databases

BgeeiQ92953.
CleanExiHS_KCNB2.
GenevestigatoriQ92953.

Family and domain databases

InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003973. K_chnl_volt-dep_Kv2.
IPR005826. K_chnl_volt-dep_Kv2.2.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF03521. Kv2channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01515. KV22CHANNEL.
PR01491. KVCHANNEL.
PR01495. SHABCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two novel gamma Kv subunits."
    Preisig-Mueller R., Derst C., Schnitzler M.M., Daut J.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Rae J.L.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles."
    Schmalz F., Kinsella J., Koh S.D., Vogalis F., Schneider A., Flynn E.R., Kenyon J.L., Horowitz B.
    Am. J. Physiol. 274:G901-G911(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-811.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-450.

Entry informationi

Entry nameiKCNB2_HUMAN
AccessioniPrimary (citable) accession number: Q92953
Secondary accession number(s): Q7Z7D0, Q9BXD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: October 24, 2002
Last modified: February 3, 2015
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.