Q92953 (KCNB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily B member 2

Alternative name(s):
Voltage-gated potassium channel subunit Kv2.2

Gene names

Name:

KCNB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	911 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
Subunit structure	Heteromultimer with KCNS1, KCNS2 and KCNS3 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Post-translational modification	Phosphorylated Potential.
Sequence similarities	Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily. [View classification]
Sequence caution	The sequence AAB08433.1 differs from that shown. Reason: Frameshift at position 768.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro regulation of smooth muscle contraction Traceable author statement Ref.3. Source: ProtInc synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Traceable author statement Ref.3. Source: ProtInc
Molecular_function	delayed rectifier potassium channel activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 911	911	Potassium voltage-gated channel subfamily B member 2		PRO_0000054048
Regions
	Topological domain	1 – 190	190	Cytoplasmic Potential
	Transmembrane	191 – 212	22	Helical; Name=Segment S1; Potential
	Transmembrane	233 – 253	21	Helical; Name=Segment S2; Potential
	Topological domain	254 – 263	10	Cytoplasmic Potential
	Transmembrane	264 – 284	21	Helical; Name=Segment S3; Potential
	Transmembrane	299 – 320	22	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	321 – 334	14	Cytoplasmic Potential
	Transmembrane	335 – 355	21	Helical; Name=Segment S5; Potential
	Intramembrane	369 – 389	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	396 – 416	21	Helical; Name=Segment S6; Potential
	Topological domain	417 – 911	495	Cytoplasmic Potential
	Motif	381 – 386	6	Selectivity filter By similarity
Amino acid modifications
	Glycosylation	287	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	450	1	V → I in a colorectal cancer sample; somatic mutation. Ref.4		VAR_035774
	Natural variant	657	1	E → G. Corresponds to variant rs16938507 [ dbSNP | Ensembl ].		VAR_034050
Experimental info
	Sequence conflict	161 – 162	2	ER → DG in AAP46292. Ref.1
	Sequence conflict	528	1	S → F in AAP46292. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q92953 [UniParc]. Last modified October 25, 2002. Version 2. Checksum: 2261D7D6280CF81A	FASTA	911	102,563
	10 20 30 40 50 60 MAEKAPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW RTLDRLPRTR 70 80 90 100 110 120 LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL NFYRTGKLHM MEEMCALSFG 130 140 150 160 170 180 QELDYWGIDE IYLESCCQAR YHQKKEQMNE ELRREAETMR EREGEEFDNT CCPDKRKKLW 190 200 210 220 230 240 DLLEKPNSSV AAKILAIVSI LFIVLSTIAL SLNTLPELQE TDEFGQLNDN RQLAHVEAVC 250 260 270 280 290 300 IAWFTMEYLL RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV 310 320 330 340 350 360 QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS SLVFFAEKDE 370 380 390 400 410 420 DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL CCIAGVLVIA LPIPIIVNNF 430 440 450 460 470 480 SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV SMNLKDAFAR SMELIDVAVE KAGESANTKD 490 500 510 520 530 540 SADDNHLSPS RWKWARKALS ETSSNKSFEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL 550 560 570 580 590 600 EMLYNEITKT QPHSHPNPDC QEKPERPSAY EEEIEMEEVV CPQEQLAVAQ TEVIVDMKST 610 620 630 640 650 660 SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPTDLPGT EEHQRARGPP FLTLSREKGP 670 680 690 700 710 720 AARDGTLEYA PVDITVNLDA SGSQCGLHSP LQSDNATDSP KSSLKGSNPL KSRSLKVNFK 730 740 750 760 770 780 ENRGSAPQTP PSTARPLPVT TADFSLTTPQ HISTILLEET PSQGDRPLLG TEVSAPCQGP 790 800 810 820 830 840 SKGLSPRFPK QKLFPFSSRE RRSFTEIDTG DDEDFLELPG AREEKQVDSS PNCFADKPSD 850 860 870 880 890 900 GRDPLREEGS VGSSSPQDTG HNCRQDIYHA VSEVKKDSSQ EGCKMENHLF APEIHSNPGD 910 TGYCPTRETS M

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of two novel gamma Kv subunits." Preisig-Mueller R., Derst C., Schnitzler M.M., Daut J. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	Rae J.L. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles." Schmalz F., Kinsella J., Koh S.D., Vogalis F., Schneider A., Flynn E.R., Kenyon J.L., Horowitz B. Am. J. Physiol. 274:G901-G911(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-811.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-450.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF450111 mRNA. Translation: AAP46292.1. AF338730 mRNA. Translation: AAK16585.1. U69962 mRNA. Translation: AAB08433.1. Frameshift.
IPI	IPI00024330.
RefSeq	NP_004761.2. NM_004770.2.
UniGene	Hs.661102.
3D structure databases
ProteinModelPortal	Q92953.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92953. 1 interaction.
STRING	9606.ENSP00000329426.
PTM databases
PhosphoSite	Q92953.
Polymorphism databases
DMDM	24418855.
Proteomic databases
PaxDb	Q92953.
PRIDE	Q92953.
Protocols and materials databases
DNASU	9312.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000523207; ENSP00000430846; ENSG00000182674.
GeneID	9312.
KEGG	hsa:9312.
UCSC	uc003xzb.3. human.
Organism-specific databases
CTD	9312.
GeneCards	GC08P073499.
HGNC	HGNC:6232. KCNB2.
MIM	607738. gene.
neXtProt	NX_Q92953.
PharmGKB	PA30025.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000113206.
HOVERGEN	HBG052225.
InParanoid	Q92953.
KO	K04886.
OMA	FAPEIHS.
OrthoDB	EOG4X6C7Q.
PhylomeDB	Q92953.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q92953.
CleanEx	HS_KCNB2.
Genevestigator	Q92953.
GermOnline	ENSG00000182674. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003973. K_chnl_volt-dep_Kv2. IPR005826. K_chnl_volt-dep_Kv2.2. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. PF03521. Kv2channel. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01515. KV22CHANNEL. PR01491. KVCHANNEL. PR01495. SHABCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	9312.
NextBio	34883.
SOURCE	Search...

Entry information

Entry name

KCNB2_HUMAN

Accession

Primary (citable) accession number: Q92953
Secondary accession number(s): Q7Z7D0, Q9BXD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	October 25, 2002
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.