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Q92952

- KCNN1_HUMAN

UniProt

Q92952 - KCNN1_HUMAN

Protein

Small conductance calcium-activated potassium channel protein 1

Gene

KCNN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin By similarity.By similarity

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: ProtInc
    2. calmodulin binding Source: RefGenome
    3. small conductance calcium-activated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. potassium ion transport Source: ProtInc
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calmodulin-binding

    Enzyme and pathway databases

    ReactomeiREACT_75896. Ca2+ activated K+ channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small conductance calcium-activated potassium channel protein 1
    Short name:
    SK1
    Short name:
    SKCa 1
    Short name:
    SKCa1
    Alternative name(s):
    KCa2.1
    Gene namesi
    Name:KCNN1
    Synonyms:SK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6290. KCNN1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. neuronal cell body Source: RefGenome
    3. plasma membrane Source: RefGenome
    4. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30070.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Small conductance calcium-activated potassium channel protein 1PRO_0000155007Add
    BLAST

    Proteomic databases

    PaxDbiQ92952.
    PRIDEiQ92952.

    PTM databases

    PhosphoSiteiQ92952.

    Expressioni

    Gene expression databases

    BgeeiQ92952.
    CleanExiHS_KCNN1.
    GenevestigatoriQ92952.

    Interactioni

    Subunit structurei

    Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109981. 2 interactions.
    IntActiQ92952. 1 interaction.
    STRINGi9606.ENSP00000222249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92952.
    SMRiQ92952. Positions 296-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei317 – 33721Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 13121Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni384 – 46380Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi509 – 51810Poly-Pro

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320393.
    HOGENOMiHOG000276908.
    HOVERGENiHBG052241.
    InParanoidiQ92952.
    KOiK04942.
    PhylomeDBiQ92952.
    TreeFamiTF315015.

    Family and domain databases

    InterProiIPR013099. 2pore_dom_K_chnl_dom.
    IPR004178. CaM-bd_dom.
    IPR015449. K_chnl_Ca-activ_SK.
    [Graphical view]
    PANTHERiPTHR10153. PTHR10153. 1 hit.
    PfamiPF02888. CaMBD. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    PF03530. SK_channel. 1 hit.
    [Graphical view]
    PRINTSiPR01451. SKCHANNEL.
    SMARTiSM01053. CaMBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF81327. SSF81327. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92952-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE    50
    PARPSPGSPR GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF 100
    EKRKRLSDYA LIFGMFGIVV MVTETELSWG VYTKESLYSF ALKCLISLST 150
    AILLGLVVLY HAREIQLFMV DNGADDWRIA MTCERVFLIS LELAVCAIHP 200
    VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL LGRVMLLHSK 250
    IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT 300
    VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT 350
    GIMGAGCTAL VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR 400
    ETWLIYKHTR LVKKPDQARV RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ 450
    ANTLTDLAKT QTVMYDLVSE LHAQHEELEA RLATLESRLD ALGASLQALP 500
    GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS DCG 543
    Length:543
    Mass (Da):59,987
    Last modified:January 23, 2007 - v2
    Checksum:i13EFF47C263BCB11
    GO
    Isoform 2 (identifier: Q92952-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPGPRAACSEPNPCTQVVM

    Show »
    Length:561
    Mass (Da):61,827
    Checksum:i66CA9A21C5FFDE74
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti513 – 54230PLPPR…APSDC → RLPRQRAGLDH in BAD86831. 1 PublicationCuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MPGPRAACSEPNPCTQVVM in isoform 2. 2 PublicationsVSP_022501

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69883 mRNA. Translation: AAB09562.1.
    AF131948
    , AF131940, AF131941, AF131942, AF131943, AF131944, AF131945, AF131946, AF131947 Genomic DNA. Translation: AAD37507.1.
    AB198191 mRNA. Translation: BAD86831.1.
    BC075037 mRNA. Translation: AAH75037.3.
    CCDSiCCDS67611.1. [Q92952-1]
    RefSeqiNP_002239.2. NM_002248.4. [Q92952-1]
    UniGeneiHs.158173.

    Genome annotation databases

    EnsembliENST00000222249; ENSP00000476519; ENSG00000105642. [Q92952-1]
    GeneIDi3780.
    KEGGihsa:3780.
    UCSCiuc002nht.3. human. [Q92952-1]

    Polymorphism databases

    DMDMi124056468.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69883 mRNA. Translation: AAB09562.1 .
    AF131948
    , AF131940 , AF131941 , AF131942 , AF131943 , AF131944 , AF131945 , AF131946 , AF131947 Genomic DNA. Translation: AAD37507.1 .
    AB198191 mRNA. Translation: BAD86831.1 .
    BC075037 mRNA. Translation: AAH75037.3 .
    CCDSi CCDS67611.1. [Q92952-1 ]
    RefSeqi NP_002239.2. NM_002248.4. [Q92952-1 ]
    UniGenei Hs.158173.

    3D structure databases

    ProteinModelPortali Q92952.
    SMRi Q92952. Positions 296-461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109981. 2 interactions.
    IntActi Q92952. 1 interaction.
    STRINGi 9606.ENSP00000222249.

    Chemistry

    BindingDBi Q92952.
    ChEMBLi CHEMBL2369.
    GuidetoPHARMACOLOGYi 381.

    PTM databases

    PhosphoSitei Q92952.

    Polymorphism databases

    DMDMi 124056468.

    Proteomic databases

    PaxDbi Q92952.
    PRIDEi Q92952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222249 ; ENSP00000476519 ; ENSG00000105642 . [Q92952-1 ]
    GeneIDi 3780.
    KEGGi hsa:3780.
    UCSCi uc002nht.3. human. [Q92952-1 ]

    Organism-specific databases

    CTDi 3780.
    GeneCardsi GC19P018062.
    HGNCi HGNC:6290. KCNN1.
    MIMi 602982. gene.
    neXtProti NX_Q92952.
    PharmGKBi PA30070.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320393.
    HOGENOMi HOG000276908.
    HOVERGENi HBG052241.
    InParanoidi Q92952.
    KOi K04942.
    PhylomeDBi Q92952.
    TreeFami TF315015.

    Enzyme and pathway databases

    Reactomei REACT_75896. Ca2+ activated K+ channels.

    Miscellaneous databases

    GeneWikii KCNN1.
    GenomeRNAii 3780.
    NextBioi 14833.
    PROi Q92952.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92952.
    CleanExi HS_KCNN1.
    Genevestigatori Q92952.

    Family and domain databases

    InterProi IPR013099. 2pore_dom_K_chnl_dom.
    IPR004178. CaM-bd_dom.
    IPR015449. K_chnl_Ca-activ_SK.
    [Graphical view ]
    PANTHERi PTHR10153. PTHR10153. 1 hit.
    Pfami PF02888. CaMBD. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    PF03530. SK_channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01451. SKCHANNEL.
    SMARTi SM01053. CaMBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81327. SSF81327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Small-conductance, calcium-activated potassium channels from mammalian brain."
      Koehler M., Hirschberg B., Bond C.T., Kinzie J.M., Marrion N.V., Maylie J., Adelman J.P.
      Science 273:1709-1714(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Hippocampus.
    2. "Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)."
      Litt M., LaMorticella D., Bond C.T., Adelman J.P.
      Cytogenet. Cell Genet. 86:70-73(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Molecular cloning of a small-conductance calcium-activated potassium channel from human fetal brain."
      Tagaya M., Higashioka M., Takagaki K., Ohgi T.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Fetal brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiKCNN1_HUMAN
    AccessioniPrimary (citable) accession number: Q92952
    Secondary accession number(s): Q5KR10, Q6DJU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3