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Q92952 (KCNN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small conductance calcium-activated potassium channel protein 1

Short name=SK1
Short name=SKCa 1
Short name=SKCa1
Alternative name(s):
KCa2.1
Gene names
Name:KCNN1
Synonyms:SK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin By similarity.

Subunit structure

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92952-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92952-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPRAACSEPNPCTQVVM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Small conductance calcium-activated potassium channel protein 1
PRO_0000155007

Regions

Transmembrane111 – 13121Helical; Name=Segment S1; Potential
Transmembrane140 – 16021Helical; Name=Segment S2; Potential
Transmembrane179 – 19921Helical; Name=Segment S3; Potential
Transmembrane228 – 24821Helical; Name=Segment S4; Potential
Transmembrane277 – 29721Helical; Name=Segment S5; Potential
Intramembrane317 – 33721Pore-forming; Name=Segment H5; Potential
Transmembrane346 – 36621Helical; Name=Segment S6; Potential
Region384 – 46380Calmodulin-binding By similarity
Compositional bias509 – 51810Poly-Pro

Natural variations

Alternative sequence11M → MPGPRAACSEPNPCTQVVM in isoform 2.
VSP_022501

Experimental info

Sequence conflict513 – 54230PLPPR…APSDC → RLPRQRAGLDH in BAD86831. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 13EFF47C263BCB11

FASTA54359,987
        10         20         30         40         50         60 
MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE PARPSPGSPR 

        70         80         90        100        110        120 
GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF EKRKRLSDYA LIFGMFGIVV 

       130        140        150        160        170        180 
MVTETELSWG VYTKESLYSF ALKCLISLST AILLGLVVLY HAREIQLFMV DNGADDWRIA 

       190        200        210        220        230        240 
MTCERVFLIS LELAVCAIHP VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL 

       250        260        270        280        290        300 
LGRVMLLHSK IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT 

       310        320        330        340        350        360 
VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT GIMGAGCTAL 

       370        380        390        400        410        420 
VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR ETWLIYKHTR LVKKPDQARV 

       430        440        450        460        470        480 
RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ ANTLTDLAKT QTVMYDLVSE LHAQHEELEA 

       490        500        510        520        530        540 
RLATLESRLD ALGASLQALP GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS 


DCG 

« Hide

Isoform 2 [UniParc].

Checksum: 66CA9A21C5FFDE74
Show »

FASTA56161,827

References

« Hide 'large scale' references
[1]"Small-conductance, calcium-activated potassium channels from mammalian brain."
Koehler M., Hirschberg B., Bond C.T., Kinzie J.M., Marrion N.V., Maylie J., Adelman J.P.
Science 273:1709-1714(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Hippocampus.
[2]"Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)."
Litt M., LaMorticella D., Bond C.T., Adelman J.P.
Cytogenet. Cell Genet. 86:70-73(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Molecular cloning of a small-conductance calcium-activated potassium channel from human fetal brain."
Tagaya M., Higashioka M., Takagaki K., Ohgi T.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Fetal brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U69883 mRNA. Translation: AAB09562.1.
AF131948 expand/collapse EMBL AC list , AF131940, AF131941, AF131942, AF131943, AF131944, AF131945, AF131946, AF131947 Genomic DNA. Translation: AAD37507.1.
AB198191 mRNA. Translation: BAD86831.1.
BC075037 mRNA. Translation: AAH75037.3.
RefSeqNP_002239.2. NM_002248.4.
UniGeneHs.158173.

3D structure databases

ProteinModelPortalQ92952.
SMRQ92952. Positions 284-365, 367-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109981. 2 interactions.
IntActQ92952. 1 interaction.
STRING9606.ENSP00000222249.

Chemistry

BindingDBQ92952.
ChEMBLCHEMBL2369.
GuidetoPHARMACOLOGY381.

PTM databases

PhosphoSiteQ92952.

Polymorphism databases

DMDM124056468.

Proteomic databases

PaxDbQ92952.
PRIDEQ92952.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222249; ENSP00000476519; ENSG00000105642. [Q92952-1]
GeneID3780.
KEGGhsa:3780.
UCSCuc002nht.3. human. [Q92952-1]

Organism-specific databases

CTD3780.
GeneCardsGC19P018062.
HGNCHGNC:6290. KCNN1.
MIM602982. gene.
neXtProtNX_Q92952.
PharmGKBPA30070.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320393.
HOGENOMHOG000276908.
HOVERGENHBG052241.
InParanoidQ92952.
KOK04942.
PhylomeDBQ92952.
TreeFamTF315015.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ92952.
CleanExHS_KCNN1.
GenevestigatorQ92952.

Family and domain databases

InterProIPR013099. 2pore_dom_K_chnl_dom.
IPR004178. CaM-bd_dom.
IPR015449. K_chnl_Ca-activ_SK.
[Graphical view]
PANTHERPTHR10153. PTHR10153. 1 hit.
PfamPF02888. CaMBD. 1 hit.
PF07885. Ion_trans_2. 1 hit.
PF03530. SK_channel. 1 hit.
[Graphical view]
PRINTSPR01451. SKCHANNEL.
SMARTSM01053. CaMBD. 1 hit.
[Graphical view]
SUPFAMSSF81327. SSF81327. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNN1.
GenomeRNAi3780.
NextBio14833.
PROQ92952.
SOURCESearch...

Entry information

Entry nameKCNN1_HUMAN
AccessionPrimary (citable) accession number: Q92952
Secondary accession number(s): Q5KR10, Q6DJU4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM