Q92952 (KCNN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small conductance calcium-activated potassium channel protein 1
Short name=SK1
Short name=SKCa 1
Short name=SKCa1

Alternative name(s):
KCa2.1

Gene names

Name:	KCNN1
Synonyms:	SK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin By similarity.
Subunit structure	Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Calmodulin-binding
Molecular function	Ion channel
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	calcium-activated potassium channel activity Traceable author statement Ref.1. Source: ProtInc small conductance calcium-activated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92952-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92952-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPRAACSEPNPCTQVVM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 543	543	Small conductance calcium-activated potassium channel protein 1		PRO_0000155007
Regions
	Transmembrane	111 – 131	21	Helical; Name=Segment S1; Potential
	Transmembrane	140 – 160	21	Helical; Name=Segment S2; Potential
	Transmembrane	179 – 199	21	Helical; Name=Segment S3; Potential
	Transmembrane	228 – 248	21	Helical; Name=Segment S4; Potential
	Transmembrane	277 – 297	21	Helical; Name=Segment S5; Potential
	Intramembrane	317 – 337	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	346 – 366	21	Helical; Name=Segment S6; Potential
	Region	384 – 463	80	Calmodulin-binding By similarity
	Compositional bias	509 – 518	10	Poly-Pro
Amino acid modifications
	Modified residue	107	1	Phosphoserine By similarity
	Modified residue	109	1	Phosphotyrosine By similarity
	Modified residue	123	1	Phosphothreonine By similarity
	Modified residue	128	1	Phosphoserine By similarity
	Modified residue	133	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1	1	M → MPGPRAACSEPNPCTQVVM in isoform 2.		VSP_022501
Experimental info
	Sequence conflict	513 – 542	30	PLPPR…APSDC → RLPRQRAGLDH in BAD86831. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 13EFF47C263BCB11	FASTA	543	59,987
	10 20 30 40 50 60 MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE PARPSPGSPR 70 80 90 100 110 120 GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF EKRKRLSDYA LIFGMFGIVV 130 140 150 160 170 180 MVTETELSWG VYTKESLYSF ALKCLISLST AILLGLVVLY HAREIQLFMV DNGADDWRIA 190 200 210 220 230 240 MTCERVFLIS LELAVCAIHP VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL 250 260 270 280 290 300 LGRVMLLHSK IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT 310 320 330 340 350 360 VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT GIMGAGCTAL 370 380 390 400 410 420 VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR ETWLIYKHTR LVKKPDQARV 430 440 450 460 470 480 RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ ANTLTDLAKT QTVMYDLVSE LHAQHEELEA 490 500 510 520 530 540 RLATLESRLD ALGASLQALP GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS DCG
	Isoform 2 [UniParc]. Checksum: 66CA9A21C5FFDE74	FASTA	561	61,827
	10 20 30 40 50 60 MPGPRAACSE PNPCTQVVMN SHSYNGSVGR PLGSGPGALG RDPPDPEAGH PPQPPHSPGL 70 80 90 100 110 120 QVVVAKSEPA RPSPGSPRGQ PQDQDDDEDD EEDEAGRQRA SGKPSNVGHR LGHRRALFEK 130 140 150 160 170 180 RKRLSDYALI FGMFGIVVMV TETELSWGVY TKESLYSFAL KCLISLSTAI LLGLVVLYHA 190 200 210 220 230 240 REIQLFMVDN GADDWRIAMT CERVFLISLE LAVCAIHPVP GHYRFTWTAR LAFTYAPSVA 250 260 270 280 290 300 EADVDVLLSI PMFLRLYLLG RVMLLHSKIF TDASSRSIGA LNKITFNTRF VMKTLMTICP 310 320 330 340 350 360 GTVLLVFSIS SWIIAAWTVR VCERYHDKQE VTSNFLGAMW LISITFLSIG YGDMVPHTYC 370 380 390 400 410 420 GKGVCLLTGI MGAGCTALVV AVVARKLELT KAEKHVHNFM MDTQLTKRVK NAAANVLRET 430 440 450 460 470 480 WLIYKHTRLV KKPDQARVRK HQRKFLQAIH QAQKLRSVKI EQGKLNDQAN TLTDLAKTQT 490 500 510 520 530 540 VMYDLVSELH AQHEELEARL ATLESRLDAL GASLQALPGL IAQAIRPPPP PLPPRPGPGP 550 560 QDQAARSSPC RWTPVAPSDC G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Small-conductance, calcium-activated potassium channels from mammalian brain." Koehler M., Hirschberg B., Bond C.T., Kinzie J.M., Marrion N.V., Maylie J., Adelman J.P. Science 273:1709-1714(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Hippocampus.
[2]	"Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)." Litt M., LaMorticella D., Bond C.T., Adelman J.P. Cytogenet. Cell Genet. 86:70-73(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Molecular cloning of a small-conductance calcium-activated potassium channel from human fetal brain." Tagaya M., Higashioka M., Takagaki K., Ohgi T. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Fetal brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Fetal brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U69883 mRNA. Translation: AAB09562.1. AF131948 , AF131940, AF131941, AF131942, AF131943, AF131944, AF131945, AF131946, AF131947 Genomic DNA. Translation: AAD37507.1. AB198191 mRNA. Translation: BAD86831.1. BC075037 mRNA. Translation: AAH75037.3.
IPI	IPI00218812. IPI00827551.
RefSeq	NP_002239.2. NM_002248.4.
UniGene	Hs.158173.
3D structure databases
ProteinModelPortal	Q92952.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92952. 1 interaction.
STRING	9606.ENSP00000222249.
PTM databases
PhosphoSite	Q92952.
Polymorphism databases
DMDM	124056468.
Proteomic databases
PaxDb	Q92952.
PRIDE	Q92952.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3780.
KEGG	hsa:3780.
UCSC	uc002nht.3. human.
Organism-specific databases
CTD	3780.
GeneCards	GC19P018062.
HGNC	HGNC:6290. KCNN1.
MIM	602982. gene.
neXtProt	NX_Q92952.
PharmGKB	PA30070.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320393.
HOGENOM	HOG000276908.
HOVERGEN	HBG052241.
InParanoid	Q92952.
KO	K04942.
OrthoDB	EOG49CQ7G.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q92952.
Bgee	Q92952.
CleanEx	HS_KCNN1.
Genevestigator	Q92952.
GermOnline	ENSG00000105642. Homo sapiens.
Family and domain databases
InterPro	IPR004178. CaM-bd_dom. IPR013099. Ion_trans_2. IPR015449. K_chnl_Ca-activ_SK. [Graphical view]
PANTHER	PTHR10153. PTHR10153. 1 hit.
Pfam	PF02888. CaMBD. 1 hit. PF07885. Ion_trans_2. 1 hit. PF03530. SK_channel. 1 hit. [Graphical view]
PRINTS	PR01451. SKCHANNEL.
SMART	SM01053. CaMBD. 1 hit. [Graphical view]
SUPFAM	SSF81327. CaM_bd. 1 hit.
ProtoNet	Search...
Other
BindingDB	Q92952.
ChEMBL	CHEMBL2369.
GenomeRNAi	3780.
NextBio	14833.
SOURCE	Search...

Entry information

Entry name

KCNN1_HUMAN

Accession

Primary (citable) accession number: Q92952
Secondary accession number(s): Q5KR10, Q6DJU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.