Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small conductance calcium-activated potassium channel protein 1

Gene

KCNN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).By similarity

GO - Molecular functioni

  1. calcium-activated potassium channel activity Source: ProtInc
  2. calmodulin binding Source: GO_Central
  3. small conductance calcium-activated potassium channel activity Source: GO_Central

GO - Biological processi

  1. potassium ion transmembrane transport Source: GO_Central
  2. potassium ion transport Source: ProtInc
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_75896. Ca2+ activated K+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 1
Short name:
SK1
Short name:
SKCa 1
Short name:
SKCa1
Alternative name(s):
KCa2.1
Gene namesi
Name:KCNN1
Synonyms:SK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6290. KCNN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei111 – 13121Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei228 – 24821Helical; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Intramembranei317 – 33721Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Transmembranei346 – 36621Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. neuronal cell body Source: GO_Central
  3. plasma membrane Source: GO_Central
  4. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30070.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Small conductance calcium-activated potassium channel protein 1PRO_0000155007Add
BLAST

Proteomic databases

PaxDbiQ92952.
PRIDEiQ92952.

PTM databases

PhosphoSiteiQ92952.

Expressioni

Gene expression databases

BgeeiQ92952.
CleanExiHS_KCNN1.
ExpressionAtlasiQ92952. baseline and differential.
GenevestigatoriQ92952.

Interactioni

Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).By similarity

Protein-protein interaction databases

BioGridi109981. 1 interaction.
IntActiQ92952. 1 interaction.
STRINGi9606.ENSP00000222249.

Structurei

3D structure databases

ProteinModelPortaliQ92952.
SMRiQ92952. Positions 295-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni384 – 46380Calmodulin-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi509 – 51810Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320393.
GeneTreeiENSGT00500000044784.
HOGENOMiHOG000276908.
HOVERGENiHBG052241.
InParanoidiQ92952.
KOiK04942.
OMAiGQYYFLW.
PhylomeDBiQ92952.
TreeFamiTF315015.

Family and domain databases

InterProiIPR013099. 2pore_dom_K_chnl_dom.
IPR004178. CaM-bd_dom.
IPR015449. K_chnl_Ca-activ_SK.
[Graphical view]
PANTHERiPTHR10153. PTHR10153. 1 hit.
PfamiPF02888. CaMBD. 1 hit.
PF07885. Ion_trans_2. 1 hit.
PF03530. SK_channel. 1 hit.
[Graphical view]
PRINTSiPR01451. SKCHANNEL.
SMARTiSM01053. CaMBD. 1 hit.
[Graphical view]
SUPFAMiSSF81327. SSF81327. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE
60 70 80 90 100
PARPSPGSPR GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF
110 120 130 140 150
EKRKRLSDYA LIFGMFGIVV MVTETELSWG VYTKESLYSF ALKCLISLST
160 170 180 190 200
AILLGLVVLY HAREIQLFMV DNGADDWRIA MTCERVFLIS LELAVCAIHP
210 220 230 240 250
VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL LGRVMLLHSK
260 270 280 290 300
IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT
310 320 330 340 350
VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT
360 370 380 390 400
GIMGAGCTAL VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR
410 420 430 440 450
ETWLIYKHTR LVKKPDQARV RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ
460 470 480 490 500
ANTLTDLAKT QTVMYDLVSE LHAQHEELEA RLATLESRLD ALGASLQALP
510 520 530 540
GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS DCG
Length:543
Mass (Da):59,987
Last modified:January 23, 2007 - v2
Checksum:i13EFF47C263BCB11
GO
Isoform 2 (identifier: Q92952-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPRAACSEPNPCTQVVM

Show »
Length:561
Mass (Da):61,827
Checksum:i66CA9A21C5FFDE74
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti513 – 54230PLPPR…APSDC → RLPRQRAGLDH in BAD86831 (Ref. 3) CuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPGPRAACSEPNPCTQVVM in isoform 2. 2 PublicationsVSP_022501

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69883 mRNA. Translation: AAB09562.1.
AF131948
, AF131940, AF131941, AF131942, AF131943, AF131944, AF131945, AF131946, AF131947 Genomic DNA. Translation: AAD37507.1.
AB198191 mRNA. Translation: BAD86831.1.
BC075037 mRNA. Translation: AAH75037.3.
CCDSiCCDS67611.1. [Q92952-1]
RefSeqiNP_002239.2. NM_002248.4. [Q92952-1]
UniGeneiHs.158173.

Genome annotation databases

EnsembliENST00000222249; ENSP00000476519; ENSG00000105642. [Q92952-1]
GeneIDi3780.
KEGGihsa:3780.
UCSCiuc002nht.3. human. [Q92952-1]

Polymorphism databases

DMDMi124056468.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69883 mRNA. Translation: AAB09562.1.
AF131948
, AF131940, AF131941, AF131942, AF131943, AF131944, AF131945, AF131946, AF131947 Genomic DNA. Translation: AAD37507.1.
AB198191 mRNA. Translation: BAD86831.1.
BC075037 mRNA. Translation: AAH75037.3.
CCDSiCCDS67611.1. [Q92952-1]
RefSeqiNP_002239.2. NM_002248.4. [Q92952-1]
UniGeneiHs.158173.

3D structure databases

ProteinModelPortaliQ92952.
SMRiQ92952. Positions 295-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109981. 1 interaction.
IntActiQ92952. 1 interaction.
STRINGi9606.ENSP00000222249.

Chemistry

BindingDBiQ92952.
ChEMBLiCHEMBL2369.
DrugBankiDB01110. Miconazole.
DB00721. Procaine.
GuidetoPHARMACOLOGYi381.

PTM databases

PhosphoSiteiQ92952.

Polymorphism databases

DMDMi124056468.

Proteomic databases

PaxDbiQ92952.
PRIDEiQ92952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222249; ENSP00000476519; ENSG00000105642. [Q92952-1]
GeneIDi3780.
KEGGihsa:3780.
UCSCiuc002nht.3. human. [Q92952-1]

Organism-specific databases

CTDi3780.
GeneCardsiGC19P018062.
HGNCiHGNC:6290. KCNN1.
MIMi602982. gene.
neXtProtiNX_Q92952.
PharmGKBiPA30070.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320393.
GeneTreeiENSGT00500000044784.
HOGENOMiHOG000276908.
HOVERGENiHBG052241.
InParanoidiQ92952.
KOiK04942.
OMAiGQYYFLW.
PhylomeDBiQ92952.
TreeFamiTF315015.

Enzyme and pathway databases

ReactomeiREACT_75896. Ca2+ activated K+ channels.

Miscellaneous databases

GeneWikiiKCNN1.
GenomeRNAii3780.
NextBioi14833.
PROiQ92952.
SOURCEiSearch...

Gene expression databases

BgeeiQ92952.
CleanExiHS_KCNN1.
ExpressionAtlasiQ92952. baseline and differential.
GenevestigatoriQ92952.

Family and domain databases

InterProiIPR013099. 2pore_dom_K_chnl_dom.
IPR004178. CaM-bd_dom.
IPR015449. K_chnl_Ca-activ_SK.
[Graphical view]
PANTHERiPTHR10153. PTHR10153. 1 hit.
PfamiPF02888. CaMBD. 1 hit.
PF07885. Ion_trans_2. 1 hit.
PF03530. SK_channel. 1 hit.
[Graphical view]
PRINTSiPR01451. SKCHANNEL.
SMARTiSM01053. CaMBD. 1 hit.
[Graphical view]
SUPFAMiSSF81327. SSF81327. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Small-conductance, calcium-activated potassium channels from mammalian brain."
    Koehler M., Hirschberg B., Bond C.T., Kinzie J.M., Marrion N.V., Maylie J., Adelman J.P.
    Science 273:1709-1714(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  2. "Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)."
    Litt M., LaMorticella D., Bond C.T., Adelman J.P.
    Cytogenet. Cell Genet. 86:70-73(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Molecular cloning of a small-conductance calcium-activated potassium channel from human fetal brain."
    Tagaya M., Higashioka M., Takagaki K., Ohgi T.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal brain.

Entry informationi

Entry nameiKCNN1_HUMAN
AccessioniPrimary (citable) accession number: Q92952
Secondary accession number(s): Q5KR10, Q6DJU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.