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Protein

Forkhead box protein J1

Gene

FOXJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi120 – 210Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCilium biogenesis/degradation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J1Curated
Alternative name(s):
Forkhead-related protein FKHL131 Publication
Hepatocyte nuclear factor 3 forkhead homolog 41 Publication
Short name:
HFH-41 Publication
Gene namesi
Name:FOXJ1Imported
Synonyms:FKHL131 Publication, HFH41 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000129654.7
HGNCiHGNC:3816 FOXJ1
MIMi602291 gene
neXtProtiNX_Q92949

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Allergic rhinitis (ALRH)
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
See also OMIM:607154

Organism-specific databases

DisGeNETi2302
MIMi607154 phenotype
OpenTargetsiENSG00000129654
PharmGKBiPA28233

Polymorphism and mutation databases

BioMutaiFOXJ1
DMDMi12644465

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918501 – 421Forkhead box protein J1Add BLAST421

Proteomic databases

MaxQBiQ92949
PaxDbiQ92949
PeptideAtlasiQ92949
PRIDEiQ92949
ProteomicsDBi75620

PTM databases

iPTMnetiQ92949
PhosphoSitePlusiQ92949

Expressioni

Tissue specificityi

Testis, oviduct, lung and brain cortex.

Developmental stagei

Expressed in developing lung, kidney and central nervous system.

Gene expression databases

BgeeiENSG00000129654
CleanExiHS_FOXJ1
ExpressionAtlasiQ92949 baseline and differential
GenevisibleiQ92949 HS

Organism-specific databases

HPAiHPA005714

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RFX2P483783EBI-1760377,EBI-746731

Protein-protein interaction databases

BioGridi108591, 22 interactors
IntActiQ92949, 20 interactors
MINTiQ92949
STRINGi9606.ENSP00000323880

Structurei

3D structure databases

ProteinModelPortaliQ92949
SMRiQ92949
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FOXJ1 family.Curated

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00920000148974
HOGENOMiHOG000112631
HOVERGENiHBG056832
InParanoidiQ92949
KOiK09402
OMAiTSFLQHP
OrthoDBiEOG091G06N9
PhylomeDBiQ92949
TreeFamiTF333250

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q92949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESWLRLSG AGPAEEAGPE GGLEEPDALD DSLTSLQWLQ EFSILNAKAP
60 70 80 90 100
ALPPGGTDPH GYHQVPGSAA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA
110 120 130 140 150
PPGLQAPPPD DVDYATNPHV KPPYSYATLI CMAMQASKAT KITLSAIYKW
160 170 180 190 200
ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI KVPREKDEPG KGGFWRIDPQ
210 220 230 240 250
YAERLLSGAF KKRRLPPVHI HPAFARQAAQ EPSAVPRAGP LTVNTEAQQL
260 270 280 290 300
LREFEEATGE AGWGAGEGRL GHKRKQPLPK RVAKVPRPPS TLLPTPEEQG
310 320 330 340 350
ELEPLKGNFD WEAIFDAGTL GGELGALEAL ELSPPLSPAS HVDVDLTIHG
360 370 380 390 400
RHIDCPATWG PSVEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPLF
410 420
EAGDATLASD LQDWASVGAF L
Length:421
Mass (Da):45,247
Last modified:December 1, 2000 - v3
Checksum:iA8BB0020CB67F97F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5W → C in CAA67729 (PubMed:9073514).Curated1
Sequence conflicti5W → C in CAA67730 (PubMed:9073514).Curated1
Sequence conflicti11A → T in CAA67729 (PubMed:9073514).Curated1
Sequence conflicti11A → T in CAA67730 (PubMed:9073514).Curated1
Sequence conflicti17 – 22AGPEGG → PAGGR in CAA67729 (PubMed:9073514).Curated6
Sequence conflicti56G → A in AAB09039 (PubMed:9530170).Curated1
Sequence conflicti257A → P in CAA67729 (PubMed:9073514).Curated1
Sequence conflicti257A → P in CAA67730 (PubMed:9073514).Curated1
Sequence conflicti262 – 287GWGAG…AKVPR → VWVQARAGWDISPNTLCPRG GQGPA in CAA67729 (PubMed:9073514).CuratedAdd BLAST26
Sequence conflicti311W → L in AAB09039 (PubMed:9530170).Curated1
Sequence conflicti330L → V in AAB09039 (PubMed:9530170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69537 mRNA Translation: AAB09039.1
X99349 mRNA Translation: CAA67729.1
X99350, X99351 Genomic DNA Translation: CAA67730.1
AJ272064 Genomic DNA Translation: CAB76562.1
BC046460 mRNA Translation: AAH46460.1
CCDSiCCDS32739.1
RefSeqiNP_001445.2, NM_001454.3
UniGeneiHs.651204

Genome annotation databases

EnsembliENST00000322957; ENSP00000323880; ENSG00000129654
GeneIDi2302
KEGGihsa:2302
UCSCiuc002jqx.4 human

Similar proteinsi

Entry informationi

Entry nameiFOXJ1_HUMAN
AccessioniPrimary (citable) accession number: Q92949
Secondary accession number(s): O00630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: June 20, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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