Q92932 (PTPR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase N2
Short name=R-PTP-N2
EC=3.1.3.48

Alternative name(s):
Islet cell autoantigen-related protein
Short name=IAR
Short name=ICAAR
Phogrin

Gene names

Name:	PTPRN2
Synonyms:	KIAA0387

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1015 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Implicated in development of nervous system and pancreatic endocrine cells. Ref.1 Ref.3
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasmic vesicle › secretory vesicle membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.
Domain	The cytoplasmic domain appears to contain the autoantigenic epitopes.
Post-translational modification	Appears to undergo multiple proteolytic cleavage at consecutive basic residues.
Miscellaneous	Autoantigen in insulin-dependent diabetes mellitus (IDDM).
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain.
Biophysicochemical properties	pH dependence: Optimum pH is 4.5.
Sequence caution	The sequence BAA20841.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Acetylation Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of GTPase activity Inferred from electronic annotation. Source: Compara
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.3. Source: ProtInc secretory granule Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara transport vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transmembrane receptor protein tyrosine phosphatase activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92932-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92932-2)

The sequence of this isoform differs from the canonical sequence as follows:
     519-547: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q92932-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MGPPLPLLLL...PRGRQLPGRL → MAVESEYSLL...RWQCLVQMWA

Note: No experimental confirmation available.

Isoform 4 (identifier: Q92932-4)

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Potential

Chain

22 – 1015

994

Receptor-type tyrosine-protein phosphatase N2

PRO_0000025454

Regions

Topological domain

22 – 615

594

Extracellular Potential

Transmembrane

616 – 636

21

Helical; Potential

Topological domain

637 – 1015

379

Cytoplasmic Potential

Domain

745 – 1005

261

Tyrosine-protein phosphatase

Region

945 – 951

7

Substrate binding By similarity

Sites

Active site

945

1

Phosphocysteine intermediate By similarity

Binding site

913

1

Substrate By similarity

Binding site

990

1

Substrate By similarity

Site

427 – 428

2

Cleavage Potential

Amino acid modifications

Modified residue

692

1

Phosphoserine By similarity

Modified residue

970

1

N6-acetyllysine Ref.9

Glycosylation

564

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

1 – 37

37

MGPPL…LPGRL → MAVESEYSLLRTEASFPTMK MFCVSHTLPRVEVMFVSGPQ TRERTEPVDPRWQCLVQMWA in isoform 3.

VSP_035264

Alternative sequence

38 – 54

17

Missing in isoform 4.

VSP_045032

Alternative sequence

519 – 547

29

Missing in isoform 2.

VSP_007779

Natural variant

140

1

S → T. Ref.4
Corresponds to variant rs3800855 [ dbSNP | Ensembl ].

VAR_027955

Natural variant

208

1

S → P. Ref.1 Ref.4 Ref.5 Ref.8
Corresponds to variant rs1130495 [ dbSNP | Ensembl ].

VAR_046301

Natural variant

213

1

R → H. Ref.5
Corresponds to variant rs1130496 [ dbSNP | Ensembl ].

VAR_027956

Natural variant

325

1

S → N. Ref.2 Ref.4
Corresponds to variant rs1130499 [ dbSNP | Ensembl ].

VAR_020302

Natural variant

343

1

V → M.
Corresponds to variant rs3752368 [ dbSNP | Ensembl ].

VAR_022015

Natural variant

388

1

L → H.
Corresponds to variant rs7456452 [ dbSNP | Ensembl ].

VAR_046302

Natural variant

716

1

E → K in a colorectal cancer sample; somatic mutation. Ref.11

VAR_035648

Experimental info

Mutagenesis

945

1

C → S: Loss of activity.

Sequence conflict

160

1

A → D in AAB68603. Ref.4

Sequence conflict

247

1

S → G in CAA69880. Ref.2

Sequence conflict

323

1

G → R in CAA69880. Ref.2

Secondary structure

1

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1015

Helix Strand Turn

Details...

Beta strand

512 – 517

6

Helix

523 – 536

14

Helix

541 – 543

3

Beta strand

544 – 550

7

Beta strand

553 – 558

6

Helix

567 – 576

10

Helix

578 – 585

8

Beta strand

589 – 594

6

Helix

725 – 738

14

Helix

742 – 754

13

Turn

763 – 766

4

Turn

768 – 770

3

Helix

771 – 773

3

Helix

783 – 785

3

Turn

791 – 793

3

Beta strand

795 – 797

3

Beta strand

802 – 806

5

Beta strand

811 – 813

3

Beta strand

815 – 819

5

Helix

824 – 826

3

Helix

827 – 836

10

Beta strand

841 – 844

4

Beta strand

848 – 850

3

Beta strand

862 – 868

7

Beta strand

871 – 882

12

Beta strand

885 – 894

10

Turn

895 – 898

4

Beta strand

899 – 908

10

Helix

920 – 934

15

Beta strand

941 – 944

4

Beta strand

946 – 949

4

Helix

950 – 966

17

Helix

974 – 982

9

Helix

992 – 1010

19

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 950C15CA89DBC029	FASTA	1,015	111,271
	10 20 30 40 50 60 MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE ACVNDGVFGR 70 80 90 100 110 120 CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY TQYVMDQELA DLPKTYLRRP 130 140 150 160 170 180 EASSPARPSK HSVGSERRYS REGGAALANA LRRHLPFLEA LSQAPASDVL ARTHTAQDRP 190 200 210 220 230 240 PAEGDDRFSE SILTYVAHTS ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH 250 260 270 280 290 300 HLMAALSAYA AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS 310 320 330 340 350 360 TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG SPGRAALGES 370 380 390 400 410 420 GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG GLLQDHGSRL LPGALPFARP 430 440 450 460 470 480 LDMERKKSEH PESSLSSEEE TAGVENVKSQ TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP 490 500 510 520 530 540 SKEEQSLPAG AQEALSDGLQ LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP 550 560 570 580 590 600 SSAFADVEVL GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL 610 620 630 640 650 660 KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK LSGLGGDPGA 670 680 690 700 710 720 DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG PIPSPSARSS ASSWSEEPVQ 730 740 750 760 770 780 SNMDISTGHM ILSYMEDHLK NKNRLEKEWE ALCAYQAEPN SSFVAQREEN VPKNRSLAVL 790 800 810 820 830 840 TYDHSRVLLK AENSHSHSDY INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV 850 860 870 880 890 900 VIVMLTPLAE NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET 910 920 930 940 950 960 RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG RSGTYVLIDM 970 980 990 1000 1010 VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT AVAEEVNAIL KALPQ
	Isoform 2 [UniParc]. Checksum: 6AECE2238F5E1DAE	FASTA	986	108,054
	10 20 30 40 50 60 MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE ACVNDGVFGR 70 80 90 100 110 120 CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY TQYVMDQELA DLPKTYLRRP 130 140 150 160 170 180 EASSPARPSK HSVGSERRYS REGGAALANA LRRHLPFLEA LSQAPASDVL ARTHTAQDRP 190 200 210 220 230 240 PAEGDDRFSE SILTYVAHTS ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH 250 260 270 280 290 300 HLMAALSAYA AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS 310 320 330 340 350 360 TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG SPGRAALGES 370 380 390 400 410 420 GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG GLLQDHGSRL LPGALPFARP 430 440 450 460 470 480 LDMERKKSEH PESSLSSEEE TAGVENVKSQ TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP 490 500 510 520 530 540 SKEEQSLPAG AQEALSDGLQ LEVQPSEEEA RGYIVTDREV LGPAVTFKVS ANVQNVTTED 550 560 570 580 590 600 VEKATVDNKD KLEETSGLKI LQTGVGSKSK LKFLPPQAEQ EDSTKFIALT LVSLACILGV 610 620 630 640 650 660 LLASGLIYCL RHSSQHRLKE KLSGLGGDPG ADATAAYQEL CRQRMATRPP DRPEGPHTSR 670 680 690 700 710 720 ISSVSSQFSD GPIPSPSARS SASSWSEEPV QSNMDISTGH MILSYMEDHL KNKNRLEKEW 730 740 750 760 770 780 EALCAYQAEP NSSFVAQREE NVPKNRSLAV LTYDHSRVLL KAENSHSHSD YINASPIMDH 790 800 810 820 830 840 DPRNPAYIAT QGPLPATVAD FWQMVWESGC VVIVMLTPLA ENGVRQCYHY WPDEGSNLYH 850 860 870 880 890 900 IYEVNLVSEH IWCEDFLVRS FYLKNLQTNE TRTVTQFHFL SWYDRGVPSS SRSLLDFRRK 910 920 930 940 950 960 VNKCYRGRSC PIIVHCSDGA GRSGTYVLID MVLNKMAKGA KEIDIAATLE HLRDQRPGMV 970 980 QTKEQFEFAL TAVAEEVNAI LKALPQ
	Isoform 3 [UniParc]. Checksum: DB2F9170755B08A6	FASTA	1,038	114,360
	10 20 30 40 50 60 MAVESEYSLL RTEASFPTMK MFCVSHTLPR VEVMFVSGPQ TRERTEPVDP RWQCLVQMWA 70 80 90 100 110 120 GCLLEEGLCG ASEACVNDGV FGRCQKVPAM DFYRYEVSPV ALQRLRVALQ KLSGTGFTWQ 130 140 150 160 170 180 DDYTQYVMDQ ELADLPKTYL RRPEASSPAR PSKHSVGSER RYSREGGAAL ANALRRHLPF 190 200 210 220 230 240 LEALSQAPAS DVLARTHTAQ DRPPAEGDDR FSESILTYVA HTSALTYPPG SRTQLREDLL 250 260 270 280 290 300 PRTLGQLQPD ELSPKVDSGV DRHHLMAALS AYAAQRPPAP PGEGSLEPQY LLRAPSRMPR 310 320 330 340 350 360 PLLAPAAPQK WPSPLGDSED PSSTGDGARI HTLLKDLQRQ PAEVRGLSGL ELDGMAELMA 370 380 390 400 410 420 GLMQGVDHGV ARGSPGRAAL GESGEQADGP KATLRGDSFP DDGVQDDDDR LYQEVHRLSA 430 440 450 460 470 480 TLGGLLQDHG SRLLPGALPF ARPLDMERKK SEHPESSLSS EEETAGVENV KSQTYSKDLL 490 500 510 520 530 540 GQQPHSEPGA AAFGELQNQM PGPSKEEQSL PAGAQEALSD GLQLEVQPSE EEARGYIVTD 550 560 570 580 590 600 RDPLRPEEGR RLVEDVARLL QVPSSAFADV EVLGPAVTFK VSANVQNVTT EDVEKATVDN 610 620 630 640 650 660 KDKLEETSGL KILQTGVGSK SKLKFLPPQA EQEDSTKFIA LTLVSLACIL GVLLASGLIY 670 680 690 700 710 720 CLRHSSQHRL KEKLSGLGGD PGADATAAYQ ELCRQRMATR PPDRPEGPHT SRISSVSSQF 730 740 750 760 770 780 SDGPIPSPSA RSSASSWSEE PVQSNMDIST GHMILSYMED HLKNKNRLEK EWEALCAYQA 790 800 810 820 830 840 EPNSSFVAQR EENVPKNRSL AVLTYDHSRV LLKAENSHSH SDYINASPIM DHDPRNPAYI 850 860 870 880 890 900 ATQGPLPATV ADFWQMVWES GCVVIVMLTP LAENGVRQCY HYWPDEGSNL YHIYEVNLVS 910 920 930 940 950 960 EHIWCEDFLV RSFYLKNLQT NETRTVTQFH FLSWYDRGVP SSSRSLLDFR RKVNKCYRGR 970 980 990 1000 1010 1020 SCPIIVHCSD GAGRSGTYVL IDMVLNKMAK GAKEIDIAAT LEHLRDQRPG MVQTKEQFEF 1030 ALTAVAEEVN AILKALPQ
	Isoform 4 [UniParc]. Checksum: DD03BB2583397566	FASTA	998	109,622
	10 20 30 40 50 60 MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLDGV FGRCQKVPAM DFYRYEVSPV 70 80 90 100 110 120 ALQRLRVALQ KLSGTGFTWQ DDYTQYVMDQ ELADLPKTYL RRPEASSPAR PSKHSVGSER 130 140 150 160 170 180 RYSREGGAAL ANALRRHLPF LEALSQAPAS DVLARTHTAQ DRPPAEGDDR FSESILTYVA 190 200 210 220 230 240 HTSALTYPPG SRTQLREDLL PRTLGQLQPD ELSPKVDSGV DRHHLMAALS AYAAQRPPAP 250 260 270 280 290 300 PGEGSLEPQY LLRAPSRMPR PLLAPAAPQK WPSPLGDSED PSSTGDGARI HTLLKDLQRQ 310 320 330 340 350 360 PAEVRGLSGL ELDGMAELMA GLMQGVDHGV ARGSPGRAAL GESGEQADGP KATLRGDSFP 370 380 390 400 410 420 DDGVQDDDDR LYQEVHRLSA TLGGLLQDHG SRLLPGALPF ARPLDMERKK SEHPESSLSS 430 440 450 460 470 480 EEETAGVENV KSQTYSKDLL GQQPHSEPGA AAFGELQNQM PGPSKEEQSL PAGAQEALSD 490 500 510 520 530 540 GLQLEVQPSE EEARGYIVTD RDPLRPEEGR RLVEDVARLL QVPSSAFADV EVLGPAVTFK 550 560 570 580 590 600 VSANVQNVTT EDVEKATVDN KDKLEETSGL KILQTGVGSK SKLKFLPPQA EQEDSTKFIA 610 620 630 640 650 660 LTLVSLACIL GVLLASGLIY CLRHSSQHRL KEKLSGLGGD PGADATAAYQ ELCRQRMATR 670 680 690 700 710 720 PPDRPEGPHT SRISSVSSQF SDGPIPSPSA RSSASSWSEE PVQSNMDIST GHMILSYMED 730 740 750 760 770 780 HLKNKNRLEK EWEALCAYQA EPNSSFVAQR EENVPKNRSL AVLTYDHSRV LLKAENSHSH 790 800 810 820 830 840 SDYINASPIM DHDPRNPAYI ATQGPLPATV ADFWQMVWES GCVVIVMLTP LAENGVRQCY 850 860 870 880 890 900 HYWPDEGSNL YHIYEVNLVS EHIWCEDFLV RSFYLKNLQT NETRTVTQFH FLSWYDRGVP 910 920 930 940 950 960 SSSRSLLDFR RKVNKCYRGR SCPIIVHCSD GAGRSGTYVL IDMVLNKMAK GAKEIDIAAT 970 980 990 LEHLRDQRPG MVQTKEQFEF ALTAVAEEVN AILKALPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes." Kawasaki E., Hutton J.C., Eisenbarth G.S. Biochem. Biophys. Res. Commun. 227:440-447(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS, VARIANT PRO-208. Tissue: Pancreas.
[2]	"ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins." Smith P.D., Barker K.T., Wang J., Lu Y.-J., Shipley J., Crompton M.R. Biochem. Biophys. Res. Commun. 229:402-411(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ASN-325. Tissue: Fetal brain.
[3]	"Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes." Cui L., Yu W.-P., de Aizpurua H.J., Schmidli R.S., Pallen C.J. J. Biol. Chem. 271:24817-24823(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS. Tissue: Brain and Pancreas.
[4]	"Characterization and chromosomal localization of PTPRP, a receptor protein tyrosine phosphatase predominantly expressed in brain and pancreas." Jiang S., Tulloch G., Fu Y., London R., Hummel G.S., White R.A., Avraham H., Avraham S. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS THR-140; PRO-208 AND ASN-325. Tissue: Brain.
[5]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS PRO-208 AND HIS-213. Tissue: Brain.
[6]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[7]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-208. Tissue: Brain.
[9]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-970, MASS SPECTROMETRY.
[10]	"Large-scale structural analysis of the classical human protein tyrosine phosphatome." Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S. Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 715-1010.
[11]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-716.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U66702 mRNA. Translation: AAC50742.1.
Y08569 Genomic DNA. Translation: CAA69880.1.
AF007555 mRNA. Translation: AAB63600.1.
U81561 mRNA. Translation: AAB68603.1.
AB002385 mRNA. Translation: BAA20841.2. Different initiation.
AC005481 Genomic DNA. No translation available.
AC006003 Genomic DNA. No translation available.
AC006372 Genomic DNA. No translation available.
AC011899 Genomic DNA. No translation available.
AC019043 Genomic DNA. No translation available.
AC078942 Genomic DNA. No translation available.
AC093662 Genomic DNA. No translation available.
AC093856 Genomic DNA. No translation available.
AC125243 Genomic DNA. No translation available.
BC034040 mRNA. Translation: AAH34040.1.

IPI

IPI00334666.
IPI00334667.
IPI00472249.
IPI00902906.

PIR

JC5062.
JC5263.

RefSeq

NP_002838.2. NM_002847.3.
NP_570857.2. NM_130842.2.
NP_570858.2. NM_130843.2.

UniGene

Hs.490789.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2QEP	X-ray	2.50	A/B	715-1010	[»]
4HTI	X-ray	1.95	A	502-599	[»]
4HTJ	X-ray	2.01	A	502-599	[»]

ProteinModelPortal

Q92932.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q92932. 4 interactions.

MINT

MINT-1349716.

STRING

9606.ENSP00000374069.

PTM databases

PhosphoSite

Q92932.

Polymorphism databases

DMDM

116242738.

Proteomic databases

PaxDb

Q92932.

PRIDE

Q92932.

Protocols and materials databases

DNASU

5799.

StructuralBiologyKnowledgebase

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Genome annotation databases

Ensembl

ENST00000389413; ENSP00000374064; ENSG00000155093.
ENST00000389416; ENSP00000374067; ENSG00000155093.
ENST00000389418; ENSP00000374069; ENSG00000155093.
ENST00000404321; ENSP00000385464; ENSG00000155093.

GeneID

5799.

KEGG

hsa:5799.

UCSC

uc003wno.3. human.
uc003wnq.3. human.
uc011kwa.2. human.

Organism-specific databases

CTD

5799.

GeneCards

GC07M157331.

H-InvDB

HIX0019047.

HGNC

HGNC:9677. PTPRN2.

HPA

HPA006900.
HPA026656.

MIM

601698. gene.

neXtProt

NX_Q92932.

PharmGKB

PA34022.

HUGE

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GenAtlas

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Phylogenomic databases

eggNOG

COG5599.

HOGENOM

HOG000243992.

HOVERGEN

HBG105788.

KO

K07817.

OMA

YVAHTSA.

Gene expression databases

ArrayExpress

Q92932.

Bgee

Q92932.

CleanEx

HS_PTPRN2.

Genevestigator

Q92932.

GermOnline

ENSG00000155093. Homo sapiens.

Family and domain databases

InterPro

IPR021613. Receptor_IA-2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Pfam

PF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]

PRINTS

PR00700. PRTYPHPHTASE.

SMART

SM00194. PTPc. 1 hit.
[Graphical view]

PROSITE

PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PTPRN2. human.

EvolutionaryTrace

Q92932.

GenomeRNAi

5799.

NextBio

22584.

SOURCE

Search...

Entry information

Entry name

PTPR2_HUMAN

Accession

Primary (citable) accession number: Q92932
Secondary accession number(s): E9PC57 , Q8N4I5, Q92662, Q9Y4F8, Q9Y4I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.