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Q92932

- PTPR2_HUMAN

UniProt

Q92932 - PTPR2_HUMAN

Protein

Receptor-type tyrosine-protein phosphatase N2

Gene

PTPRN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Implicated in development of nervous system and pancreatic endocrine cells.2 Publications

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    pH dependencei

    Optimum pH is 4.5.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei427 – 4282CleavageSequence Analysis
    Binding sitei913 – 9131SubstrateBy similarity
    Active sitei945 – 9451Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei990 – 9901SubstrateBy similarity

    GO - Molecular functioni

    1. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of GTPase activity Source: Ensembl
    2. peptidyl-tyrosine dephosphorylation Source: GOC
    3. protein dephosphorylation Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase N2 (EC:3.1.3.48)
    Short name:
    R-PTP-N2
    Alternative name(s):
    Islet cell autoantigen-related protein
    Short name:
    IAR
    Short name:
    ICAAR
    Phogrin
    Gene namesi
    Name:PTPRN2
    Synonyms:KIAA0387
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:9677. PTPRN2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. receptor complex Source: MGI
    4. secretory granule Source: Ensembl
    5. terminal bouton Source: Ensembl
    6. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi945 – 9451C → S: Loss of activity.

    Organism-specific databases

    PharmGKBiPA34022.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 1015994Receptor-type tyrosine-protein phosphatase N2PRO_0000025454Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis
    Modified residuei970 – 9701N6-acetyllysine1 Publication

    Post-translational modificationi

    Appears to undergo multiple proteolytic cleavage at consecutive basic residues.

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    PaxDbiQ92932.
    PRIDEiQ92932.

    PTM databases

    PhosphoSiteiQ92932.

    Expressioni

    Tissue specificityi

    Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.

    Gene expression databases

    ArrayExpressiQ92932.
    BgeeiQ92932.
    CleanExiHS_PTPRN2.
    GenevestigatoriQ92932.

    Organism-specific databases

    HPAiHPA006900.
    HPA026656.

    Interactioni

    Protein-protein interaction databases

    BioGridi111763. 3 interactions.
    IntActiQ92932. 6 interactions.
    MINTiMINT-1349716.
    STRINGi9606.ENSP00000374069.

    Structurei

    Secondary structure

    1
    1015
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi512 – 5176
    Helixi523 – 53614
    Helixi541 – 5433
    Beta strandi544 – 5507
    Beta strandi553 – 5586
    Helixi567 – 57610
    Helixi578 – 5858
    Beta strandi589 – 5946
    Helixi725 – 73814
    Helixi742 – 75413
    Turni763 – 7664
    Turni768 – 7703
    Helixi771 – 7733
    Helixi783 – 7853
    Turni791 – 7933
    Beta strandi795 – 7973
    Beta strandi802 – 8065
    Beta strandi811 – 8133
    Beta strandi815 – 8195
    Helixi824 – 8263
    Helixi827 – 83610
    Beta strandi841 – 8444
    Beta strandi848 – 8503
    Beta strandi862 – 8687
    Beta strandi871 – 88212
    Beta strandi885 – 89410
    Turni895 – 8984
    Beta strandi899 – 90810
    Helixi920 – 93415
    Beta strandi941 – 9444
    Beta strandi946 – 9494
    Helixi950 – 96617
    Helixi974 – 9829
    Helixi992 – 101019

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QEPX-ray2.50A/B715-1010[»]
    4HTIX-ray1.95A502-599[»]
    4HTJX-ray2.01A502-599[»]
    ProteinModelPortaliQ92932.
    SMRiQ92932. Positions 510-597, 724-1010.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92932.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 615594ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini637 – 1015379CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei616 – 63621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini745 – 1005261Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni945 – 9517Substrate bindingBy similarity

    Domaini

    The cytoplasmic domain appears to contain the autoantigenic epitopes.

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000243992.
    HOVERGENiHBG105788.
    KOiK07817.
    OMAiYRYEVSP.
    OrthoDBiEOG7K9K30.
    PhylomeDBiQ92932.
    TreeFamiTF351976.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR021613. Receptor_IA-2_dom.
    IPR029403. RESP18_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF11548. Receptor_IA-2. 1 hit.
    PF14948. RESP18. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92932-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE     50
    ACVNDGVFGR CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY 100
    TQYVMDQELA DLPKTYLRRP EASSPARPSK HSVGSERRYS REGGAALANA 150
    LRRHLPFLEA LSQAPASDVL ARTHTAQDRP PAEGDDRFSE SILTYVAHTS 200
    ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH HLMAALSAYA 250
    AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS 300
    TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG 350
    SPGRAALGES GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG 400
    GLLQDHGSRL LPGALPFARP LDMERKKSEH PESSLSSEEE TAGVENVKSQ 450
    TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP SKEEQSLPAG AQEALSDGLQ 500
    LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP SSAFADVEVL 550
    GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL 600
    KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK 650
    LSGLGGDPGA DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG 700
    PIPSPSARSS ASSWSEEPVQ SNMDISTGHM ILSYMEDHLK NKNRLEKEWE 750
    ALCAYQAEPN SSFVAQREEN VPKNRSLAVL TYDHSRVLLK AENSHSHSDY 800
    INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV VIVMLTPLAE 850
    NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET 900
    RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG 950
    RSGTYVLIDM VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT 1000
    AVAEEVNAIL KALPQ 1015
    Length:1,015
    Mass (Da):111,271
    Last modified:October 17, 2006 - v2
    Checksum:i950C15CA89DBC029
    GO
    Isoform 2 (identifier: Q92932-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         519-547: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:986
    Mass (Da):108,054
    Checksum:i6AECE2238F5E1DAE
    GO
    Isoform 3 (identifier: Q92932-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-37: MGPPLPLLLL...PRGRQLPGRL → MAVESEYSLL...RWQCLVQMWA

    Note: No experimental confirmation available.

    Show »
    Length:1,038
    Mass (Da):114,360
    Checksum:iDB2F9170755B08A6
    GO
    Isoform 4 (identifier: Q92932-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-54: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:998
    Mass (Da):109,622
    Checksum:iDD03BB2583397566
    GO

    Sequence cautioni

    The sequence BAA20841.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601A → D in AAB68603. 1 PublicationCurated
    Sequence conflicti247 – 2471S → G in CAA69880. (PubMed:8954911)Curated
    Sequence conflicti323 – 3231G → R in CAA69880. (PubMed:8954911)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401S → T.1 Publication
    Corresponds to variant rs3800855 [ dbSNP | Ensembl ].
    VAR_027955
    Natural varianti208 – 2081S → P.4 Publications
    Corresponds to variant rs1130495 [ dbSNP | Ensembl ].
    VAR_046301
    Natural varianti213 – 2131R → H.1 Publication
    Corresponds to variant rs1130496 [ dbSNP | Ensembl ].
    VAR_027956
    Natural varianti325 – 3251S → N.2 Publications
    Corresponds to variant rs1130499 [ dbSNP | Ensembl ].
    VAR_020302
    Natural varianti343 – 3431V → M.
    Corresponds to variant rs3752368 [ dbSNP | Ensembl ].
    VAR_022015
    Natural varianti388 – 3881L → H.
    Corresponds to variant rs7456452 [ dbSNP | Ensembl ].
    VAR_046302
    Natural varianti716 – 7161E → K in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035648

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3737MGPPL…LPGRL → MAVESEYSLLRTEASFPTMK MFCVSHTLPRVEVMFVSGPQ TRERTEPVDPRWQCLVQMWA in isoform 3. 1 PublicationVSP_035264Add
    BLAST
    Alternative sequencei38 – 5417Missing in isoform 4. 1 PublicationVSP_045032Add
    BLAST
    Alternative sequencei519 – 54729Missing in isoform 2. 1 PublicationVSP_007779Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66702 mRNA. Translation: AAC50742.1.
    Y08569 Genomic DNA. Translation: CAA69880.1.
    AF007555 mRNA. Translation: AAB63600.1.
    U81561 mRNA. Translation: AAB68603.1.
    AB002385 mRNA. Translation: BAA20841.2. Different initiation.
    AC005481 Genomic DNA. No translation available.
    AC006003 Genomic DNA. No translation available.
    AC006372 Genomic DNA. No translation available.
    AC011899 Genomic DNA. No translation available.
    AC019043 Genomic DNA. No translation available.
    AC078942 Genomic DNA. No translation available.
    AC093662 Genomic DNA. No translation available.
    AC093856 Genomic DNA. No translation available.
    AC125243 Genomic DNA. No translation available.
    BC034040 mRNA. Translation: AAH34040.1.
    CCDSiCCDS5947.1. [Q92932-1]
    CCDS5948.1. [Q92932-4]
    CCDS5949.1. [Q92932-2]
    PIRiJC5062.
    JC5263.
    RefSeqiNP_002838.2. NM_002847.3. [Q92932-1]
    NP_570857.2. NM_130842.2. [Q92932-4]
    NP_570858.2. NM_130843.2. [Q92932-2]
    UniGeneiHs.490789.

    Genome annotation databases

    EnsembliENST00000389413; ENSP00000374064; ENSG00000155093. [Q92932-2]
    ENST00000389416; ENSP00000374067; ENSG00000155093. [Q92932-4]
    ENST00000389418; ENSP00000374069; ENSG00000155093. [Q92932-1]
    ENST00000404321; ENSP00000385464; ENSG00000155093. [Q92932-3]
    GeneIDi5799.
    KEGGihsa:5799.
    UCSCiuc003wno.3. human. [Q92932-1]
    uc003wnq.3. human. [Q92932-2]
    uc011kwa.2. human. [Q92932-3]

    Polymorphism databases

    DMDMi116242738.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66702 mRNA. Translation: AAC50742.1 .
    Y08569 Genomic DNA. Translation: CAA69880.1 .
    AF007555 mRNA. Translation: AAB63600.1 .
    U81561 mRNA. Translation: AAB68603.1 .
    AB002385 mRNA. Translation: BAA20841.2 . Different initiation.
    AC005481 Genomic DNA. No translation available.
    AC006003 Genomic DNA. No translation available.
    AC006372 Genomic DNA. No translation available.
    AC011899 Genomic DNA. No translation available.
    AC019043 Genomic DNA. No translation available.
    AC078942 Genomic DNA. No translation available.
    AC093662 Genomic DNA. No translation available.
    AC093856 Genomic DNA. No translation available.
    AC125243 Genomic DNA. No translation available.
    BC034040 mRNA. Translation: AAH34040.1 .
    CCDSi CCDS5947.1. [Q92932-1 ]
    CCDS5948.1. [Q92932-4 ]
    CCDS5949.1. [Q92932-2 ]
    PIRi JC5062.
    JC5263.
    RefSeqi NP_002838.2. NM_002847.3. [Q92932-1 ]
    NP_570857.2. NM_130842.2. [Q92932-4 ]
    NP_570858.2. NM_130843.2. [Q92932-2 ]
    UniGenei Hs.490789.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QEP X-ray 2.50 A/B 715-1010 [» ]
    4HTI X-ray 1.95 A 502-599 [» ]
    4HTJ X-ray 2.01 A 502-599 [» ]
    ProteinModelPortali Q92932.
    SMRi Q92932. Positions 510-597, 724-1010.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111763. 3 interactions.
    IntActi Q92932. 6 interactions.
    MINTi MINT-1349716.
    STRINGi 9606.ENSP00000374069.

    PTM databases

    PhosphoSitei Q92932.

    Polymorphism databases

    DMDMi 116242738.

    Proteomic databases

    PaxDbi Q92932.
    PRIDEi Q92932.

    Protocols and materials databases

    DNASUi 5799.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000389413 ; ENSP00000374064 ; ENSG00000155093 . [Q92932-2 ]
    ENST00000389416 ; ENSP00000374067 ; ENSG00000155093 . [Q92932-4 ]
    ENST00000389418 ; ENSP00000374069 ; ENSG00000155093 . [Q92932-1 ]
    ENST00000404321 ; ENSP00000385464 ; ENSG00000155093 . [Q92932-3 ]
    GeneIDi 5799.
    KEGGi hsa:5799.
    UCSCi uc003wno.3. human. [Q92932-1 ]
    uc003wnq.3. human. [Q92932-2 ]
    uc011kwa.2. human. [Q92932-3 ]

    Organism-specific databases

    CTDi 5799.
    GeneCardsi GC07M157331.
    H-InvDB HIX0019047.
    HGNCi HGNC:9677. PTPRN2.
    HPAi HPA006900.
    HPA026656.
    MIMi 601698. gene.
    neXtProti NX_Q92932.
    PharmGKBi PA34022.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000243992.
    HOVERGENi HBG105788.
    KOi K07817.
    OMAi YRYEVSP.
    OrthoDBi EOG7K9K30.
    PhylomeDBi Q92932.
    TreeFami TF351976.

    Miscellaneous databases

    ChiTaRSi PTPRN2. human.
    EvolutionaryTracei Q92932.
    GeneWikii PTPRN2.
    GenomeRNAii 5799.
    NextBioi 22584.
    PROi Q92932.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92932.
    Bgeei Q92932.
    CleanExi HS_PTPRN2.
    Genevestigatori Q92932.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR021613. Receptor_IA-2_dom.
    IPR029403. RESP18_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF11548. Receptor_IA-2. 1 hit.
    PF14948. RESP18. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes."
      Kawasaki E., Hutton J.C., Eisenbarth G.S.
      Biochem. Biophys. Res. Commun. 227:440-447(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS, VARIANT PRO-208.
      Tissue: Pancreas.
    2. "ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins."
      Smith P.D., Barker K.T., Wang J., Lu Y.-J., Shipley J., Crompton M.R.
      Biochem. Biophys. Res. Commun. 229:402-411(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ASN-325.
      Tissue: Fetal brain.
    3. "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes."
      Cui L., Yu W.-P., de Aizpurua H.J., Schmidli R.S., Pallen C.J.
      J. Biol. Chem. 271:24817-24823(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS.
      Tissue: Brain and Pancreas.
    4. "Characterization and chromosomal localization of PTPRP, a receptor protein tyrosine phosphatase predominantly expressed in brain and pancreas."
      Jiang S., Tulloch G., Fu Y., London R., Hummel G.S., White R.A., Avraham H., Avraham S.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS THR-140; PRO-208 AND ASN-325.
      Tissue: Brain.
    5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS PRO-208 AND HIS-213.
      Tissue: Brain.
    6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-208.
      Tissue: Brain.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-970, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
      Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
      Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 715-1010.
    11. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-716.

    Entry informationi

    Entry nameiPTPR2_HUMAN
    AccessioniPrimary (citable) accession number: Q92932
    Secondary accession number(s): E9PC57
    , Q8N4I5, Q92662, Q9Y4F8, Q9Y4I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Autoantigen in insulin-dependent diabetes mellitus (IDDM).

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3