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Q92932 (PTPR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase N2

Short name=R-PTP-N2
EC=3.1.3.48
Alternative name(s):
Islet cell autoantigen-related protein
Short name=IAR
Short name=ICAAR
Phogrin
Gene names
Name:PTPRN2
Synonyms:KIAA0387
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1015 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Implicated in development of nervous system and pancreatic endocrine cells. Ref.1 Ref.3

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasmic vesiclesecretory vesicle membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.

Domain

The cytoplasmic domain appears to contain the autoantigenic epitopes.

Post-translational modification

Appears to undergo multiple proteolytic cleavage at consecutive basic residues.

Miscellaneous

Autoantigen in insulin-dependent diabetes mellitus (IDDM).

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Biophysicochemical properties

pH dependence:

Optimum pH is 4.5.

Sequence caution

The sequence BAA20841.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92932-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92932-2)

The sequence of this isoform differs from the canonical sequence as follows:
     519-547: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q92932-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MGPPLPLLLL...PRGRQLPGRL → MAVESEYSLL...RWQCLVQMWA
Note: No experimental confirmation available.
Isoform 4 (identifier: Q92932-4)

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 1015994Receptor-type tyrosine-protein phosphatase N2
PRO_0000025454

Regions

Topological domain22 – 615594Extracellular Potential
Transmembrane616 – 63621Helical; Potential
Topological domain637 – 1015379Cytoplasmic Potential
Domain745 – 1005261Tyrosine-protein phosphatase
Region945 – 9517Substrate binding By similarity

Sites

Active site9451Phosphocysteine intermediate By similarity
Binding site9131Substrate By similarity
Binding site9901Substrate By similarity
Site427 – 4282Cleavage Potential

Amino acid modifications

Modified residue9701N6-acetyllysine Ref.9
Glycosylation5641N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 3737MGPPL…LPGRL → MAVESEYSLLRTEASFPTMK MFCVSHTLPRVEVMFVSGPQ TRERTEPVDPRWQCLVQMWA in isoform 3.
VSP_035264
Alternative sequence38 – 5417Missing in isoform 4.
VSP_045032
Alternative sequence519 – 54729Missing in isoform 2.
VSP_007779
Natural variant1401S → T. Ref.4
Corresponds to variant rs3800855 [ dbSNP | Ensembl ].
VAR_027955
Natural variant2081S → P. Ref.1 Ref.4 Ref.5 Ref.8
Corresponds to variant rs1130495 [ dbSNP | Ensembl ].
VAR_046301
Natural variant2131R → H. Ref.5
Corresponds to variant rs1130496 [ dbSNP | Ensembl ].
VAR_027956
Natural variant3251S → N. Ref.2 Ref.4
Corresponds to variant rs1130499 [ dbSNP | Ensembl ].
VAR_020302
Natural variant3431V → M.
Corresponds to variant rs3752368 [ dbSNP | Ensembl ].
VAR_022015
Natural variant3881L → H.
Corresponds to variant rs7456452 [ dbSNP | Ensembl ].
VAR_046302
Natural variant7161E → K in a colorectal cancer sample; somatic mutation. Ref.11
VAR_035648

Experimental info

Mutagenesis9451C → S: Loss of activity.
Sequence conflict1601A → D in AAB68603. Ref.4
Sequence conflict2471S → G in CAA69880. Ref.2
Sequence conflict3231G → R in CAA69880. Ref.2

Secondary structure

............................................................... 1015
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 950C15CA89DBC029

FASTA1,015111,271
        10         20         30         40         50         60 
MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE ACVNDGVFGR 

        70         80         90        100        110        120 
CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY TQYVMDQELA DLPKTYLRRP 

       130        140        150        160        170        180 
EASSPARPSK HSVGSERRYS REGGAALANA LRRHLPFLEA LSQAPASDVL ARTHTAQDRP 

       190        200        210        220        230        240 
PAEGDDRFSE SILTYVAHTS ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH 

       250        260        270        280        290        300 
HLMAALSAYA AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS 

       310        320        330        340        350        360 
TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG SPGRAALGES 

       370        380        390        400        410        420 
GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG GLLQDHGSRL LPGALPFARP 

       430        440        450        460        470        480 
LDMERKKSEH PESSLSSEEE TAGVENVKSQ TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP 

       490        500        510        520        530        540 
SKEEQSLPAG AQEALSDGLQ LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP 

       550        560        570        580        590        600 
SSAFADVEVL GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL 

       610        620        630        640        650        660 
KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK LSGLGGDPGA 

       670        680        690        700        710        720 
DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG PIPSPSARSS ASSWSEEPVQ 

       730        740        750        760        770        780 
SNMDISTGHM ILSYMEDHLK NKNRLEKEWE ALCAYQAEPN SSFVAQREEN VPKNRSLAVL 

       790        800        810        820        830        840 
TYDHSRVLLK AENSHSHSDY INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV 

       850        860        870        880        890        900 
VIVMLTPLAE NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET 

       910        920        930        940        950        960 
RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG RSGTYVLIDM 

       970        980        990       1000       1010 
VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT AVAEEVNAIL KALPQ 

« Hide

Isoform 2 [UniParc].

Checksum: 6AECE2238F5E1DAE
Show »

FASTA986108,054
Isoform 3 [UniParc].

Checksum: DB2F9170755B08A6
Show »

FASTA1,038114,360
Isoform 4 [UniParc].

Checksum: DD03BB2583397566
Show »

FASTA998109,622

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes."
Kawasaki E., Hutton J.C., Eisenbarth G.S.
Biochem. Biophys. Res. Commun. 227:440-447(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS, VARIANT PRO-208.
Tissue: Pancreas.
[2]"ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins."
Smith P.D., Barker K.T., Wang J., Lu Y.-J., Shipley J., Crompton M.R.
Biochem. Biophys. Res. Commun. 229:402-411(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ASN-325.
Tissue: Fetal brain.
[3]"Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes."
Cui L., Yu W.-P., de Aizpurua H.J., Schmidli R.S., Pallen C.J.
J. Biol. Chem. 271:24817-24823(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS.
Tissue: Brain and Pancreas.
[4]"Characterization and chromosomal localization of PTPRP, a receptor protein tyrosine phosphatase predominantly expressed in brain and pancreas."
Jiang S., Tulloch G., Fu Y., London R., Hummel G.S., White R.A., Avraham H., Avraham S.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS THR-140; PRO-208 AND ASN-325.
Tissue: Brain.
[5]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS PRO-208 AND HIS-213.
Tissue: Brain.
[6]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[7]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-208.
Tissue: Brain.
[9]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-970, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Large-scale structural analysis of the classical human protein tyrosine phosphatome."
Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 715-1010.
[11]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-716.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66702 mRNA. Translation: AAC50742.1.
Y08569 Genomic DNA. Translation: CAA69880.1.
AF007555 mRNA. Translation: AAB63600.1.
U81561 mRNA. Translation: AAB68603.1.
AB002385 mRNA. Translation: BAA20841.2. Different initiation.
AC005481 Genomic DNA. No translation available.
AC006003 Genomic DNA. No translation available.
AC006372 Genomic DNA. No translation available.
AC011899 Genomic DNA. No translation available.
AC019043 Genomic DNA. No translation available.
AC078942 Genomic DNA. No translation available.
AC093662 Genomic DNA. No translation available.
AC093856 Genomic DNA. No translation available.
AC125243 Genomic DNA. No translation available.
BC034040 mRNA. Translation: AAH34040.1.
PIRJC5062.
JC5263.
RefSeqNP_002838.2. NM_002847.3.
NP_570857.2. NM_130842.2.
NP_570858.2. NM_130843.2.
UniGeneHs.490789.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2QEPX-ray2.50A/B715-1010[»]
4HTIX-ray1.95A502-599[»]
4HTJX-ray2.01A502-599[»]
ProteinModelPortalQ92932.
SMRQ92932. Positions 510-597, 724-1010.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111763. 3 interactions.
IntActQ92932. 6 interactions.
MINTMINT-1349716.
STRING9606.ENSP00000374069.

PTM databases

PhosphoSiteQ92932.

Polymorphism databases

DMDM116242738.

Proteomic databases

PaxDbQ92932.
PRIDEQ92932.

Protocols and materials databases

DNASU5799.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000389413; ENSP00000374064; ENSG00000155093. [Q92932-2]
ENST00000389416; ENSP00000374067; ENSG00000155093. [Q92932-4]
ENST00000389418; ENSP00000374069; ENSG00000155093. [Q92932-1]
ENST00000404321; ENSP00000385464; ENSG00000155093. [Q92932-3]
GeneID5799.
KEGGhsa:5799.
UCSCuc003wno.3. human. [Q92932-1]
uc003wnq.3. human. [Q92932-2]
uc011kwa.2. human. [Q92932-3]

Organism-specific databases

CTD5799.
GeneCardsGC07M157331.
H-InvDBHIX0019047.
HGNCHGNC:9677. PTPRN2.
HPAHPA006900.
HPA026656.
MIM601698. gene.
neXtProtNX_Q92932.
PharmGKBPA34022.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000243992.
HOVERGENHBG105788.
KOK07817.
OMAYRYEVSP.
OrthoDBEOG7K9K30.
PhylomeDBQ92932.
TreeFamTF351976.

Gene expression databases

ArrayExpressQ92932.
BgeeQ92932.
CleanExHS_PTPRN2.
GenevestigatorQ92932.

Family and domain databases

InterProIPR021613. Receptor_IA-2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPTPRN2. human.
EvolutionaryTraceQ92932.
GeneWikiPTPRN2.
GenomeRNAi5799.
NextBio22584.
PROQ92932.
SOURCESearch...

Entry information

Entry namePTPR2_HUMAN
AccessionPrimary (citable) accession number: Q92932
Secondary accession number(s): E9PC57 expand/collapse secondary AC list , Q8N4I5, Q92662, Q9Y4F8, Q9Y4I6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM