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Protein

Receptor-type tyrosine-protein phosphatase N2

Gene

PTPRN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in development of nervous system and pancreatic endocrine cells.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

pH dependencei

Optimum pH is 4.5.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei427 – 4282CleavageSequence Analysis
Binding sitei913 – 9131SubstrateBy similarity
Active sitei945 – 9451Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei990 – 9901SubstrateBy similarity

GO - Molecular functioni

  1. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. negative regulation of GTPase activity Source: Ensembl
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDAi3.1.3.48. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase N2 (EC:3.1.3.48)
Short name:
R-PTP-N2
Alternative name(s):
Islet cell autoantigen-related protein
Short name:
IAR
Short name:
ICAAR
Phogrin
Gene namesi
Name:PTPRN2
Synonyms:KIAA0387
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9677. PTPRN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 615594ExtracellularSequence AnalysisAdd
BLAST
Transmembranei616 – 63621HelicalSequence AnalysisAdd
BLAST
Topological domaini637 – 1015379CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. receptor complex Source: MGI
  4. secretory granule Source: Ensembl
  5. terminal bouton Source: Ensembl
  6. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi945 – 9451C → S: Loss of activity.

Organism-specific databases

PharmGKBiPA34022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 1015994Receptor-type tyrosine-protein phosphatase N2PRO_0000025454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis
Modified residuei970 – 9701N6-acetyllysine1 Publication

Post-translational modificationi

Appears to undergo multiple proteolytic cleavage at consecutive basic residues.

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ92932.
PRIDEiQ92932.

PTM databases

DEPODiQ92932.
PhosphoSiteiQ92932.

Expressioni

Tissue specificityi

Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.

Gene expression databases

BgeeiQ92932.
CleanExiHS_PTPRN2.
ExpressionAtlasiQ92932. baseline and differential.
GenevestigatoriQ92932.

Organism-specific databases

HPAiHPA006900.
HPA026656.

Interactioni

Protein-protein interaction databases

BioGridi111763. 3 interactions.
IntActiQ92932. 6 interactions.
MINTiMINT-1349716.
STRINGi9606.ENSP00000374069.

Structurei

Secondary structure

1
1015
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi512 – 5176Combined sources
Helixi523 – 53614Combined sources
Helixi541 – 5433Combined sources
Beta strandi544 – 5507Combined sources
Beta strandi553 – 5586Combined sources
Helixi567 – 57610Combined sources
Helixi578 – 5858Combined sources
Beta strandi589 – 5946Combined sources
Helixi725 – 73814Combined sources
Helixi742 – 75413Combined sources
Turni763 – 7664Combined sources
Turni768 – 7703Combined sources
Helixi771 – 7733Combined sources
Helixi783 – 7853Combined sources
Turni791 – 7933Combined sources
Beta strandi795 – 7973Combined sources
Beta strandi802 – 8065Combined sources
Beta strandi811 – 8133Combined sources
Beta strandi815 – 8195Combined sources
Helixi824 – 8263Combined sources
Helixi827 – 83610Combined sources
Beta strandi841 – 8444Combined sources
Beta strandi848 – 8503Combined sources
Beta strandi862 – 8687Combined sources
Beta strandi871 – 88212Combined sources
Beta strandi885 – 89410Combined sources
Turni895 – 8984Combined sources
Beta strandi899 – 90810Combined sources
Helixi920 – 93415Combined sources
Beta strandi941 – 9444Combined sources
Beta strandi946 – 9494Combined sources
Helixi950 – 96617Combined sources
Helixi974 – 9829Combined sources
Helixi992 – 101019Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QEPX-ray2.50A/B715-1010[»]
4HTIX-ray1.95A502-599[»]
4HTJX-ray2.01A502-599[»]
ProteinModelPortaliQ92932.
SMRiQ92932. Positions 510-597, 724-1010.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92932.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini745 – 1005261Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni945 – 9517Substrate bindingBy similarity

Domaini

The cytoplasmic domain appears to contain the autoantigenic epitopes.

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121961.
HOGENOMiHOG000243992.
HOVERGENiHBG105788.
InParanoidiQ92932.
KOiK07817.
OMAiHTSALTY.
OrthoDBiEOG7K9K30.
PhylomeDBiQ92932.
TreeFamiTF351976.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR029403. RESP18_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF14948. RESP18. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92932-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE
60 70 80 90 100
ACVNDGVFGR CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY
110 120 130 140 150
TQYVMDQELA DLPKTYLRRP EASSPARPSK HSVGSERRYS REGGAALANA
160 170 180 190 200
LRRHLPFLEA LSQAPASDVL ARTHTAQDRP PAEGDDRFSE SILTYVAHTS
210 220 230 240 250
ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH HLMAALSAYA
260 270 280 290 300
AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS
310 320 330 340 350
TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG
360 370 380 390 400
SPGRAALGES GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG
410 420 430 440 450
GLLQDHGSRL LPGALPFARP LDMERKKSEH PESSLSSEEE TAGVENVKSQ
460 470 480 490 500
TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP SKEEQSLPAG AQEALSDGLQ
510 520 530 540 550
LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP SSAFADVEVL
560 570 580 590 600
GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL
610 620 630 640 650
KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK
660 670 680 690 700
LSGLGGDPGA DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG
710 720 730 740 750
PIPSPSARSS ASSWSEEPVQ SNMDISTGHM ILSYMEDHLK NKNRLEKEWE
760 770 780 790 800
ALCAYQAEPN SSFVAQREEN VPKNRSLAVL TYDHSRVLLK AENSHSHSDY
810 820 830 840 850
INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV VIVMLTPLAE
860 870 880 890 900
NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET
910 920 930 940 950
RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG
960 970 980 990 1000
RSGTYVLIDM VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT
1010
AVAEEVNAIL KALPQ
Length:1,015
Mass (Da):111,271
Last modified:October 17, 2006 - v2
Checksum:i950C15CA89DBC029
GO
Isoform 2 (identifier: Q92932-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     519-547: Missing.

Note: No experimental confirmation available.

Show »
Length:986
Mass (Da):108,054
Checksum:i6AECE2238F5E1DAE
GO
Isoform 3 (identifier: Q92932-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MGPPLPLLLL...PRGRQLPGRL → MAVESEYSLL...RWQCLVQMWA

Note: No experimental confirmation available.

Show »
Length:1,038
Mass (Da):114,360
Checksum:iDB2F9170755B08A6
GO
Isoform 4 (identifier: Q92932-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: Missing.

Note: No experimental confirmation available.

Show »
Length:998
Mass (Da):109,622
Checksum:iDD03BB2583397566
GO

Sequence cautioni

The sequence BAA20841.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601A → D in AAB68603 (Ref. 4) Curated
Sequence conflicti247 – 2471S → G in CAA69880 (PubMed:8954911).Curated
Sequence conflicti323 – 3231G → R in CAA69880 (PubMed:8954911).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401S → T.1 Publication
Corresponds to variant rs3800855 [ dbSNP | Ensembl ].
VAR_027955
Natural varianti208 – 2081S → P.4 Publications
Corresponds to variant rs1130495 [ dbSNP | Ensembl ].
VAR_046301
Natural varianti213 – 2131R → H.1 Publication
Corresponds to variant rs1130496 [ dbSNP | Ensembl ].
VAR_027956
Natural varianti325 – 3251S → N.2 Publications
Corresponds to variant rs1130499 [ dbSNP | Ensembl ].
VAR_020302
Natural varianti343 – 3431V → M.
Corresponds to variant rs3752368 [ dbSNP | Ensembl ].
VAR_022015
Natural varianti388 – 3881L → H.
Corresponds to variant rs7456452 [ dbSNP | Ensembl ].
VAR_046302
Natural varianti716 – 7161E → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035648

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737MGPPL…LPGRL → MAVESEYSLLRTEASFPTMK MFCVSHTLPRVEVMFVSGPQ TRERTEPVDPRWQCLVQMWA in isoform 3. 1 PublicationVSP_035264Add
BLAST
Alternative sequencei38 – 5417Missing in isoform 4. 1 PublicationVSP_045032Add
BLAST
Alternative sequencei519 – 54729Missing in isoform 2. 1 PublicationVSP_007779Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66702 mRNA. Translation: AAC50742.1.
Y08569 Genomic DNA. Translation: CAA69880.1.
AF007555 mRNA. Translation: AAB63600.1.
U81561 mRNA. Translation: AAB68603.1.
AB002385 mRNA. Translation: BAA20841.2. Different initiation.
AC005481 Genomic DNA. No translation available.
AC006003 Genomic DNA. No translation available.
AC006372 Genomic DNA. No translation available.
AC011899 Genomic DNA. No translation available.
AC019043 Genomic DNA. No translation available.
AC078942 Genomic DNA. No translation available.
AC093662 Genomic DNA. No translation available.
AC093856 Genomic DNA. No translation available.
AC125243 Genomic DNA. No translation available.
BC034040 mRNA. Translation: AAH34040.1.
CCDSiCCDS5947.1. [Q92932-1]
CCDS5948.1. [Q92932-4]
CCDS5949.1. [Q92932-2]
PIRiJC5062.
JC5263.
RefSeqiNP_002838.2. NM_002847.3. [Q92932-1]
NP_570857.2. NM_130842.2. [Q92932-4]
NP_570858.2. NM_130843.2. [Q92932-2]
UniGeneiHs.490789.

Genome annotation databases

EnsembliENST00000389413; ENSP00000374064; ENSG00000155093. [Q92932-2]
ENST00000389416; ENSP00000374067; ENSG00000155093. [Q92932-4]
ENST00000389418; ENSP00000374069; ENSG00000155093. [Q92932-1]
GeneIDi5799.
KEGGihsa:5799.
UCSCiuc003wno.3. human. [Q92932-1]
uc003wnq.3. human. [Q92932-2]
uc011kwa.2. human. [Q92932-3]

Polymorphism databases

DMDMi116242738.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66702 mRNA. Translation: AAC50742.1.
Y08569 Genomic DNA. Translation: CAA69880.1.
AF007555 mRNA. Translation: AAB63600.1.
U81561 mRNA. Translation: AAB68603.1.
AB002385 mRNA. Translation: BAA20841.2. Different initiation.
AC005481 Genomic DNA. No translation available.
AC006003 Genomic DNA. No translation available.
AC006372 Genomic DNA. No translation available.
AC011899 Genomic DNA. No translation available.
AC019043 Genomic DNA. No translation available.
AC078942 Genomic DNA. No translation available.
AC093662 Genomic DNA. No translation available.
AC093856 Genomic DNA. No translation available.
AC125243 Genomic DNA. No translation available.
BC034040 mRNA. Translation: AAH34040.1.
CCDSiCCDS5947.1. [Q92932-1]
CCDS5948.1. [Q92932-4]
CCDS5949.1. [Q92932-2]
PIRiJC5062.
JC5263.
RefSeqiNP_002838.2. NM_002847.3. [Q92932-1]
NP_570857.2. NM_130842.2. [Q92932-4]
NP_570858.2. NM_130843.2. [Q92932-2]
UniGeneiHs.490789.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QEPX-ray2.50A/B715-1010[»]
4HTIX-ray1.95A502-599[»]
4HTJX-ray2.01A502-599[»]
ProteinModelPortaliQ92932.
SMRiQ92932. Positions 510-597, 724-1010.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111763. 3 interactions.
IntActiQ92932. 6 interactions.
MINTiMINT-1349716.
STRINGi9606.ENSP00000374069.

PTM databases

DEPODiQ92932.
PhosphoSiteiQ92932.

Polymorphism databases

DMDMi116242738.

Proteomic databases

PaxDbiQ92932.
PRIDEiQ92932.

Protocols and materials databases

DNASUi5799.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389413; ENSP00000374064; ENSG00000155093. [Q92932-2]
ENST00000389416; ENSP00000374067; ENSG00000155093. [Q92932-4]
ENST00000389418; ENSP00000374069; ENSG00000155093. [Q92932-1]
GeneIDi5799.
KEGGihsa:5799.
UCSCiuc003wno.3. human. [Q92932-1]
uc003wnq.3. human. [Q92932-2]
uc011kwa.2. human. [Q92932-3]

Organism-specific databases

CTDi5799.
GeneCardsiGC07M157331.
H-InvDBHIX0019047.
HGNCiHGNC:9677. PTPRN2.
HPAiHPA006900.
HPA026656.
MIMi601698. gene.
neXtProtiNX_Q92932.
PharmGKBiPA34022.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121961.
HOGENOMiHOG000243992.
HOVERGENiHBG105788.
InParanoidiQ92932.
KOiK07817.
OMAiHTSALTY.
OrthoDBiEOG7K9K30.
PhylomeDBiQ92932.
TreeFamiTF351976.

Enzyme and pathway databases

BRENDAi3.1.3.48. 2681.

Miscellaneous databases

ChiTaRSiPTPRN2. human.
EvolutionaryTraceiQ92932.
GeneWikiiPTPRN2.
GenomeRNAii5799.
NextBioi22584.
PROiQ92932.
SOURCEiSearch...

Gene expression databases

BgeeiQ92932.
CleanExiHS_PTPRN2.
ExpressionAtlasiQ92932. baseline and differential.
GenevestigatoriQ92932.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR029403. RESP18_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF14948. RESP18. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes."
    Kawasaki E., Hutton J.C., Eisenbarth G.S.
    Biochem. Biophys. Res. Commun. 227:440-447(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS, VARIANT PRO-208.
    Tissue: Pancreas.
  2. "ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins."
    Smith P.D., Barker K.T., Wang J., Lu Y.-J., Shipley J., Crompton M.R.
    Biochem. Biophys. Res. Commun. 229:402-411(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ASN-325.
    Tissue: Fetal brain.
  3. "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes."
    Cui L., Yu W.-P., de Aizpurua H.J., Schmidli R.S., Pallen C.J.
    J. Biol. Chem. 271:24817-24823(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS.
    Tissue: Brain and Pancreas.
  4. "Characterization and chromosomal localization of PTPRP, a receptor protein tyrosine phosphatase predominantly expressed in brain and pancreas."
    Jiang S., Tulloch G., Fu Y., London R., Hummel G.S., White R.A., Avraham H., Avraham S.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS THR-140; PRO-208 AND ASN-325.
    Tissue: Brain.
  5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS PRO-208 AND HIS-213.
    Tissue: Brain.
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-208.
    Tissue: Brain.
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-970, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
    Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
    Cell 136:352-363(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 715-1010.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-716.

Entry informationi

Entry nameiPTPR2_HUMAN
AccessioniPrimary (citable) accession number: Q92932
Secondary accession number(s): E9PC57
, Q8N4I5, Q92662, Q9Y4F8, Q9Y4I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: April 1, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Autoantigen in insulin-dependent diabetes mellitus (IDDM).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.