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Q92932

- PTPR2_HUMAN

UniProt

Q92932 - PTPR2_HUMAN

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Protein
Receptor-type tyrosine-protein phosphatase N2
Gene
PTPRN2, KIAA0387
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in development of nervous system and pancreatic endocrine cells.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

pH dependencei

Optimum pH is 4.5.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei427 – 4282Cleavage Reviewed prediction
Binding sitei913 – 9131Substrate By similarity
Active sitei945 – 9451Phosphocysteine intermediate By similarity
Binding sitei990 – 9901Substrate By similarity

GO - Molecular functioni

  1. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. negative regulation of GTPase activity Source: Ensembl
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase N2 (EC:3.1.3.48)
Short name:
R-PTP-N2
Alternative name(s):
Islet cell autoantigen-related protein
Short name:
IAR
Short name:
ICAAR
Phogrin
Gene namesi
Name:PTPRN2
Synonyms:KIAA0387
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:9677. PTPRN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 615594Extracellular Reviewed prediction
Add
BLAST
Transmembranei616 – 63621Helical; Reviewed prediction
Add
BLAST
Topological domaini637 – 1015379Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. receptor complex Source: MGI
  4. secretory granule Source: Ensembl
  5. terminal bouton Source: Ensembl
  6. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi945 – 9451C → S: Loss of activity.

Organism-specific databases

PharmGKBiPA34022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 1015994Receptor-type tyrosine-protein phosphatase N2
PRO_0000025454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi564 – 5641N-linked (GlcNAc...) Reviewed prediction
Modified residuei970 – 9701N6-acetyllysine1 Publication

Post-translational modificationi

Appears to undergo multiple proteolytic cleavage at consecutive basic residues.

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ92932.
PRIDEiQ92932.

PTM databases

PhosphoSiteiQ92932.

Expressioni

Tissue specificityi

Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.

Gene expression databases

ArrayExpressiQ92932.
BgeeiQ92932.
CleanExiHS_PTPRN2.
GenevestigatoriQ92932.

Organism-specific databases

HPAiHPA006900.
HPA026656.

Interactioni

Protein-protein interaction databases

BioGridi111763. 3 interactions.
IntActiQ92932. 6 interactions.
MINTiMINT-1349716.
STRINGi9606.ENSP00000374069.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi512 – 5176
Helixi523 – 53614
Helixi541 – 5433
Beta strandi544 – 5507
Beta strandi553 – 5586
Helixi567 – 57610
Helixi578 – 5858
Beta strandi589 – 5946
Helixi725 – 73814
Helixi742 – 75413
Turni763 – 7664
Turni768 – 7703
Helixi771 – 7733
Helixi783 – 7853
Turni791 – 7933
Beta strandi795 – 7973
Beta strandi802 – 8065
Beta strandi811 – 8133
Beta strandi815 – 8195
Helixi824 – 8263
Helixi827 – 83610
Beta strandi841 – 8444
Beta strandi848 – 8503
Beta strandi862 – 8687
Beta strandi871 – 88212
Beta strandi885 – 89410
Turni895 – 8984
Beta strandi899 – 90810
Helixi920 – 93415
Beta strandi941 – 9444
Beta strandi946 – 9494
Helixi950 – 96617
Helixi974 – 9829
Helixi992 – 101019

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QEPX-ray2.50A/B715-1010[»]
4HTIX-ray1.95A502-599[»]
4HTJX-ray2.01A502-599[»]
ProteinModelPortaliQ92932.
SMRiQ92932. Positions 510-597, 724-1010.

Miscellaneous databases

EvolutionaryTraceiQ92932.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini745 – 1005261Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni945 – 9517Substrate binding By similarity

Domaini

The cytoplasmic domain appears to contain the autoantigenic epitopes.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000243992.
HOVERGENiHBG105788.
KOiK07817.
OMAiYRYEVSP.
OrthoDBiEOG7K9K30.
PhylomeDBiQ92932.
TreeFamiTF351976.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR029403. RESP18_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF14948. RESP18. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92932-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE     50
ACVNDGVFGR CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY 100
TQYVMDQELA DLPKTYLRRP EASSPARPSK HSVGSERRYS REGGAALANA 150
LRRHLPFLEA LSQAPASDVL ARTHTAQDRP PAEGDDRFSE SILTYVAHTS 200
ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH HLMAALSAYA 250
AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS 300
TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG 350
SPGRAALGES GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG 400
GLLQDHGSRL LPGALPFARP LDMERKKSEH PESSLSSEEE TAGVENVKSQ 450
TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP SKEEQSLPAG AQEALSDGLQ 500
LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP SSAFADVEVL 550
GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL 600
KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK 650
LSGLGGDPGA DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG 700
PIPSPSARSS ASSWSEEPVQ SNMDISTGHM ILSYMEDHLK NKNRLEKEWE 750
ALCAYQAEPN SSFVAQREEN VPKNRSLAVL TYDHSRVLLK AENSHSHSDY 800
INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV VIVMLTPLAE 850
NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET 900
RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG 950
RSGTYVLIDM VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT 1000
AVAEEVNAIL KALPQ 1015
Length:1,015
Mass (Da):111,271
Last modified:October 17, 2006 - v2
Checksum:i950C15CA89DBC029
GO
Isoform 2 (identifier: Q92932-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     519-547: Missing.

Note: No experimental confirmation available.

Show »
Length:986
Mass (Da):108,054
Checksum:i6AECE2238F5E1DAE
GO
Isoform 3 (identifier: Q92932-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MGPPLPLLLL...PRGRQLPGRL → MAVESEYSLL...RWQCLVQMWA

Note: No experimental confirmation available.

Show »
Length:1,038
Mass (Da):114,360
Checksum:iDB2F9170755B08A6
GO
Isoform 4 (identifier: Q92932-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: Missing.

Note: No experimental confirmation available.

Show »
Length:998
Mass (Da):109,622
Checksum:iDD03BB2583397566
GO

Sequence cautioni

The sequence BAA20841.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401S → T.1 Publication
Corresponds to variant rs3800855 [ dbSNP | Ensembl ].
VAR_027955
Natural varianti208 – 2081S → P.4 Publications
Corresponds to variant rs1130495 [ dbSNP | Ensembl ].
VAR_046301
Natural varianti213 – 2131R → H.1 Publication
Corresponds to variant rs1130496 [ dbSNP | Ensembl ].
VAR_027956
Natural varianti325 – 3251S → N.2 Publications
Corresponds to variant rs1130499 [ dbSNP | Ensembl ].
VAR_020302
Natural varianti343 – 3431V → M.
Corresponds to variant rs3752368 [ dbSNP | Ensembl ].
VAR_022015
Natural varianti388 – 3881L → H.
Corresponds to variant rs7456452 [ dbSNP | Ensembl ].
VAR_046302
Natural varianti716 – 7161E → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035648

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737MGPPL…LPGRL → MAVESEYSLLRTEASFPTMK MFCVSHTLPRVEVMFVSGPQ TRERTEPVDPRWQCLVQMWA in isoform 3.
VSP_035264Add
BLAST
Alternative sequencei38 – 5417Missing in isoform 4.
VSP_045032Add
BLAST
Alternative sequencei519 – 54729Missing in isoform 2.
VSP_007779Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601A → D in AAB68603. 1 Publication
Sequence conflicti247 – 2471S → G in CAA69880. 1 Publication
Sequence conflicti323 – 3231G → R in CAA69880. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66702 mRNA. Translation: AAC50742.1.
Y08569 Genomic DNA. Translation: CAA69880.1.
AF007555 mRNA. Translation: AAB63600.1.
U81561 mRNA. Translation: AAB68603.1.
AB002385 mRNA. Translation: BAA20841.2. Different initiation.
AC005481 Genomic DNA. No translation available.
AC006003 Genomic DNA. No translation available.
AC006372 Genomic DNA. No translation available.
AC011899 Genomic DNA. No translation available.
AC019043 Genomic DNA. No translation available.
AC078942 Genomic DNA. No translation available.
AC093662 Genomic DNA. No translation available.
AC093856 Genomic DNA. No translation available.
AC125243 Genomic DNA. No translation available.
BC034040 mRNA. Translation: AAH34040.1.
CCDSiCCDS5947.1. [Q92932-1]
CCDS5948.1. [Q92932-4]
CCDS5949.1. [Q92932-2]
PIRiJC5062.
JC5263.
RefSeqiNP_002838.2. NM_002847.3. [Q92932-1]
NP_570857.2. NM_130842.2. [Q92932-4]
NP_570858.2. NM_130843.2. [Q92932-2]
UniGeneiHs.490789.

Genome annotation databases

EnsembliENST00000389413; ENSP00000374064; ENSG00000155093. [Q92932-2]
ENST00000389416; ENSP00000374067; ENSG00000155093. [Q92932-4]
ENST00000389418; ENSP00000374069; ENSG00000155093. [Q92932-1]
ENST00000404321; ENSP00000385464; ENSG00000155093. [Q92932-3]
GeneIDi5799.
KEGGihsa:5799.
UCSCiuc003wno.3. human. [Q92932-1]
uc003wnq.3. human. [Q92932-2]
uc011kwa.2. human. [Q92932-3]

Polymorphism databases

DMDMi116242738.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66702 mRNA. Translation: AAC50742.1 .
Y08569 Genomic DNA. Translation: CAA69880.1 .
AF007555 mRNA. Translation: AAB63600.1 .
U81561 mRNA. Translation: AAB68603.1 .
AB002385 mRNA. Translation: BAA20841.2 . Different initiation.
AC005481 Genomic DNA. No translation available.
AC006003 Genomic DNA. No translation available.
AC006372 Genomic DNA. No translation available.
AC011899 Genomic DNA. No translation available.
AC019043 Genomic DNA. No translation available.
AC078942 Genomic DNA. No translation available.
AC093662 Genomic DNA. No translation available.
AC093856 Genomic DNA. No translation available.
AC125243 Genomic DNA. No translation available.
BC034040 mRNA. Translation: AAH34040.1 .
CCDSi CCDS5947.1. [Q92932-1 ]
CCDS5948.1. [Q92932-4 ]
CCDS5949.1. [Q92932-2 ]
PIRi JC5062.
JC5263.
RefSeqi NP_002838.2. NM_002847.3. [Q92932-1 ]
NP_570857.2. NM_130842.2. [Q92932-4 ]
NP_570858.2. NM_130843.2. [Q92932-2 ]
UniGenei Hs.490789.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2QEP X-ray 2.50 A/B 715-1010 [» ]
4HTI X-ray 1.95 A 502-599 [» ]
4HTJ X-ray 2.01 A 502-599 [» ]
ProteinModelPortali Q92932.
SMRi Q92932. Positions 510-597, 724-1010.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111763. 3 interactions.
IntActi Q92932. 6 interactions.
MINTi MINT-1349716.
STRINGi 9606.ENSP00000374069.

PTM databases

PhosphoSitei Q92932.

Polymorphism databases

DMDMi 116242738.

Proteomic databases

PaxDbi Q92932.
PRIDEi Q92932.

Protocols and materials databases

DNASUi 5799.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389413 ; ENSP00000374064 ; ENSG00000155093 . [Q92932-2 ]
ENST00000389416 ; ENSP00000374067 ; ENSG00000155093 . [Q92932-4 ]
ENST00000389418 ; ENSP00000374069 ; ENSG00000155093 . [Q92932-1 ]
ENST00000404321 ; ENSP00000385464 ; ENSG00000155093 . [Q92932-3 ]
GeneIDi 5799.
KEGGi hsa:5799.
UCSCi uc003wno.3. human. [Q92932-1 ]
uc003wnq.3. human. [Q92932-2 ]
uc011kwa.2. human. [Q92932-3 ]

Organism-specific databases

CTDi 5799.
GeneCardsi GC07M157331.
H-InvDB HIX0019047.
HGNCi HGNC:9677. PTPRN2.
HPAi HPA006900.
HPA026656.
MIMi 601698. gene.
neXtProti NX_Q92932.
PharmGKBi PA34022.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000243992.
HOVERGENi HBG105788.
KOi K07817.
OMAi YRYEVSP.
OrthoDBi EOG7K9K30.
PhylomeDBi Q92932.
TreeFami TF351976.

Miscellaneous databases

ChiTaRSi PTPRN2. human.
EvolutionaryTracei Q92932.
GeneWikii PTPRN2.
GenomeRNAii 5799.
NextBioi 22584.
PROi Q92932.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92932.
Bgeei Q92932.
CleanExi HS_PTPRN2.
Genevestigatori Q92932.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR029403. RESP18_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF11548. Receptor_IA-2. 1 hit.
PF14948. RESP18. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes."
    Kawasaki E., Hutton J.C., Eisenbarth G.S.
    Biochem. Biophys. Res. Commun. 227:440-447(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS, VARIANT PRO-208.
    Tissue: Pancreas.
  2. "ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins."
    Smith P.D., Barker K.T., Wang J., Lu Y.-J., Shipley J., Crompton M.R.
    Biochem. Biophys. Res. Commun. 229:402-411(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ASN-325.
    Tissue: Fetal brain.
  3. "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes."
    Cui L., Yu W.-P., de Aizpurua H.J., Schmidli R.S., Pallen C.J.
    J. Biol. Chem. 271:24817-24823(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ROLE IN DIABETES MELLITUS.
    Tissue: Brain and Pancreas.
  4. "Characterization and chromosomal localization of PTPRP, a receptor protein tyrosine phosphatase predominantly expressed in brain and pancreas."
    Jiang S., Tulloch G., Fu Y., London R., Hummel G.S., White R.A., Avraham H., Avraham S.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANTS THR-140; PRO-208 AND ASN-325.
    Tissue: Brain.
  5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS PRO-208 AND HIS-213.
    Tissue: Brain.
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-208.
    Tissue: Brain.
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-970, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
    Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
    Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 715-1010.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-716.

Entry informationi

Entry nameiPTPR2_HUMAN
AccessioniPrimary (citable) accession number: Q92932
Secondary accession number(s): E9PC57
, Q8N4I5, Q92662, Q9Y4F8, Q9Y4I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Autoantigen in insulin-dependent diabetes mellitus (IDDM).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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