Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-8B

Gene

RAB8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166128-MONOMER.
ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-8B
Gene namesi
Name:RAB8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:30273. RAB8B.

Subcellular locationi

GO - Cellular componenti

  • cell tip Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
  • peroxisomal membrane Source: UniProtKB
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51762.
OpenTargetsiENSG00000166128.
PharmGKBiPA134944620.

Polymorphism and mutation databases

BioMutaiRAB8B.
DMDMi13638434.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211341 – 204Ras-related protein Rab-8BAdd BLAST204
PropeptideiPRO_0000370800205 – 207Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei180PhosphoserineBy similarity1
Modified residuei204Cysteine methyl esterSequence analysis1
Lipidationi204S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ92930.
MaxQBiQ92930.
PaxDbiQ92930.
PeptideAtlasiQ92930.
PRIDEiQ92930.

PTM databases

iPTMnetiQ92930.
PhosphoSitePlusiQ92930.
SwissPalmiQ92930.

Expressioni

Gene expression databases

BgeeiENSG00000166128.
CleanExiHS_RAB8B.
ExpressionAtlasiQ92930. baseline and differential.
GenevisibleiQ92930. HS.

Interactioni

Subunit structurei

Associated with actin, delta-catenin and alpha and beta tubulins (By similarity). Interacts with OTOF (By similarity). Interacts with PEX5R (By similarity). Interacts with RAB3IP. Interacts with VIM (By similarity). Interacts with CDH1 (By similarity). Interacts with MICALL2 (By similarity).By similarity

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119719. 44 interactors.
IntActiQ92930. 4 interactors.
MINTiMINT-3049578.
STRINGi9606.ENSP00000312734.

Structurei

3D structure databases

ProteinModelPortaliQ92930.
SMRiQ92930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
GeneTreeiENSGT00860000133675.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ92930.
KOiK07902.
OMAiFDNIKTW.
OrthoDBiEOG091G0LA6.
PhylomeDBiQ92930.
TreeFamiTF314097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTYDYLFK LLLIGDSGVG KTCLLFRFSE DAFNTTFIST IGIDFKIRTI
60 70 80 90 100
ELDGKKIKLQ IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIK
110 120 130 140 150
NWIRNIEEHA SSDVERMILG NKCDMNDKRQ VSKERGEKLA IDYGIKFLET
160 170 180 190 200
SAKSSANVEE AFFTLARDIM TKLNRKMNDS NSAGAGGPVK ITENRSKKTS

FFRCSLL
Length:207
Mass (Da):23,584
Last modified:April 27, 2001 - v2
Checksum:i5960993C0F87F944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038995 mRNA. Translation: BAA92249.1.
AK001111 mRNA. Translation: BAG50856.1.
AL833365 mRNA. Translation: CAI46143.1.
AC016207 Genomic DNA. No translation available.
BC020654 mRNA. Translation: AAH20654.1.
U66624 mRNA. Translation: AAC51199.1.
CCDSiCCDS10183.1.
RefSeqiNP_057614.1. NM_016530.2.
UniGeneiHs.389733.

Genome annotation databases

EnsembliENST00000321437; ENSP00000312734; ENSG00000166128.
GeneIDi51762.
KEGGihsa:51762.
UCSCiuc002alz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038995 mRNA. Translation: BAA92249.1.
AK001111 mRNA. Translation: BAG50856.1.
AL833365 mRNA. Translation: CAI46143.1.
AC016207 Genomic DNA. No translation available.
BC020654 mRNA. Translation: AAH20654.1.
U66624 mRNA. Translation: AAC51199.1.
CCDSiCCDS10183.1.
RefSeqiNP_057614.1. NM_016530.2.
UniGeneiHs.389733.

3D structure databases

ProteinModelPortaliQ92930.
SMRiQ92930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119719. 44 interactors.
IntActiQ92930. 4 interactors.
MINTiMINT-3049578.
STRINGi9606.ENSP00000312734.

PTM databases

iPTMnetiQ92930.
PhosphoSitePlusiQ92930.
SwissPalmiQ92930.

Polymorphism and mutation databases

BioMutaiRAB8B.
DMDMi13638434.

Proteomic databases

EPDiQ92930.
MaxQBiQ92930.
PaxDbiQ92930.
PeptideAtlasiQ92930.
PRIDEiQ92930.

Protocols and materials databases

DNASUi51762.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321437; ENSP00000312734; ENSG00000166128.
GeneIDi51762.
KEGGihsa:51762.
UCSCiuc002alz.4. human.

Organism-specific databases

CTDi51762.
DisGeNETi51762.
GeneCardsiRAB8B.
HGNCiHGNC:30273. RAB8B.
MIMi613532. gene.
neXtProtiNX_Q92930.
OpenTargetsiENSG00000166128.
PharmGKBiPA134944620.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
GeneTreeiENSGT00860000133675.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ92930.
KOiK07902.
OMAiFDNIKTW.
OrthoDBiEOG091G0LA6.
PhylomeDBiQ92930.
TreeFamiTF314097.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166128-MONOMER.
ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiRAB8B. human.
GeneWikiiRAB8B.
GenomeRNAii51762.
PROiQ92930.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166128.
CleanExiHS_RAB8B.
ExpressionAtlasiQ92930. baseline and differential.
GenevisibleiQ92930. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB8B_HUMAN
AccessioniPrimary (citable) accession number: Q92930
Secondary accession number(s): Q5JPC4, Q9P293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.