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Q92930

- RAB8B_HUMAN

UniProt

Q92930 - RAB8B_HUMAN

Protein

Ras-related protein Rab-8B

Gene

RAB8B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi121 – 1244GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: UniProtKB
    3. GTP binding Source: UniProtKB-KW
    4. receptor binding Source: UniProtKB

    GO - Biological processi

    1. adherens junction organization Source: UniProtKB
    2. antigen processing and presentation Source: UniProt
    3. GTP catabolic process Source: GOC
    4. positive regulation of cell projection organization Source: Ensembl
    5. positive regulation of corticotropin secretion Source: Ensembl
    6. protein import into peroxisome membrane Source: UniProtKB
    7. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-8B
    Gene namesi
    Name:RAB8B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:30273. RAB8B.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasmic vesiclephagosome 1 Publication. Cytoplasmic vesiclephagosome membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication
    Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.

    GO - Cellular componenti

    1. cell tip Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. mitochondrion Source: Ensembl
    4. perinuclear region of cytoplasm Source: Ensembl
    5. peroxisomal membrane Source: UniProtKB
    6. phagocytic vesicle Source: UniProtKB
    7. phagocytic vesicle membrane Source: UniProtKB-SubCell
    8. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134944620.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Ras-related protein Rab-8BPRO_0000121134Add
    BLAST
    Propeptidei205 – 2073Removed in mature formSequence AnalysisPRO_0000370800

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei180 – 1801PhosphoserineBy similarity
    Modified residuei204 – 2041Cysteine methyl esterSequence Analysis
    Lipidationi204 – 2041S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiQ92930.
    PaxDbiQ92930.
    PeptideAtlasiQ92930.
    PRIDEiQ92930.

    PTM databases

    PhosphoSiteiQ92930.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92930.
    BgeeiQ92930.
    CleanExiHS_RAB8B.
    GenevestigatoriQ92930.

    Interactioni

    Subunit structurei

    Associated with actin, delta-catenin and alpha and beta tubulins By similarity. Interacts with OTOF By similarity. Interacts with PEX5R By similarity. Interacts with RAB3IP. Interacts with VIM By similarity. Interacts with CDH1 By similarity. Interacts with MICALL2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi119719. 17 interactions.
    IntActiQ92930. 2 interactions.
    MINTiMINT-3049578.
    STRINGi9606.ENSP00000312734.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92930.
    SMRiQ92930. Positions 6-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ92930.
    KOiK07902.
    OMAiTWHANID.
    OrthoDBiEOG7VB2H4.
    PhylomeDBiQ92930.
    TreeFamiTF314097.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92930-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKTYDYLFK LLLIGDSGVG KTCLLFRFSE DAFNTTFIST IGIDFKIRTI    50
    ELDGKKIKLQ IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIK 100
    NWIRNIEEHA SSDVERMILG NKCDMNDKRQ VSKERGEKLA IDYGIKFLET 150
    SAKSSANVEE AFFTLARDIM TKLNRKMNDS NSAGAGGPVK ITENRSKKTS 200
    FFRCSLL 207
    Length:207
    Mass (Da):23,584
    Last modified:April 27, 2001 - v2
    Checksum:i5960993C0F87F944
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038995 mRNA. Translation: BAA92249.1.
    AK001111 mRNA. Translation: BAG50856.1.
    AL833365 mRNA. Translation: CAI46143.1.
    AC016207 Genomic DNA. No translation available.
    BC020654 mRNA. Translation: AAH20654.1.
    U66624 mRNA. Translation: AAC51199.1.
    CCDSiCCDS10183.1.
    RefSeqiNP_057614.1. NM_016530.2.
    UniGeneiHs.389733.

    Genome annotation databases

    EnsembliENST00000321437; ENSP00000312734; ENSG00000166128.
    GeneIDi51762.
    KEGGihsa:51762.
    UCSCiuc002alz.3. human.

    Polymorphism databases

    DMDMi13638434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038995 mRNA. Translation: BAA92249.1 .
    AK001111 mRNA. Translation: BAG50856.1 .
    AL833365 mRNA. Translation: CAI46143.1 .
    AC016207 Genomic DNA. No translation available.
    BC020654 mRNA. Translation: AAH20654.1 .
    U66624 mRNA. Translation: AAC51199.1 .
    CCDSi CCDS10183.1.
    RefSeqi NP_057614.1. NM_016530.2.
    UniGenei Hs.389733.

    3D structure databases

    ProteinModelPortali Q92930.
    SMRi Q92930. Positions 6-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119719. 17 interactions.
    IntActi Q92930. 2 interactions.
    MINTi MINT-3049578.
    STRINGi 9606.ENSP00000312734.

    PTM databases

    PhosphoSitei Q92930.

    Polymorphism databases

    DMDMi 13638434.

    Proteomic databases

    MaxQBi Q92930.
    PaxDbi Q92930.
    PeptideAtlasi Q92930.
    PRIDEi Q92930.

    Protocols and materials databases

    DNASUi 51762.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321437 ; ENSP00000312734 ; ENSG00000166128 .
    GeneIDi 51762.
    KEGGi hsa:51762.
    UCSCi uc002alz.3. human.

    Organism-specific databases

    CTDi 51762.
    GeneCardsi GC15P063481.
    HGNCi HGNC:30273. RAB8B.
    MIMi 613532. gene.
    neXtProti NX_Q92930.
    PharmGKBi PA134944620.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q92930.
    KOi K07902.
    OMAi TWHANID.
    OrthoDBi EOG7VB2H4.
    PhylomeDBi Q92930.
    TreeFami TF314097.

    Miscellaneous databases

    ChiTaRSi RAB8B. human.
    GeneWikii RAB8B.
    GenomeRNAii 51762.
    NextBioi 55874.
    PROi Q92930.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92930.
    Bgeei Q92930.
    CleanExi HS_RAB8B.
    Genevestigatori Q92930.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Seki N., Saito T.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph node.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "RAB GTPases expressed in human melanoma cells."
      Chen D., Guo J., Gahl W.A.
      Biochim. Biophys. Acta 1355:1-6(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-119.
      Tissue: Melanoma.
    7. "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport."
      Hattula K., Furuhjelm J., Arffman A., Peranen J.
      Mol. Biol. Cell 13:3268-3280(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAB3IP.
      Tissue: Brain.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
      Seto S., Tsujimura K., Koide Y.
      Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRAB8B_HUMAN
    AccessioniPrimary (citable) accession number: Q92930
    Secondary accession number(s): Q5JPC4, Q9P293
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3