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Q92917

- GPKOW_HUMAN

UniProt

Q92917 - GPKOW_HUMAN

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Protein

G patch domain and KOW motifs-containing protein

Gene

GPKOW

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain and KOW motifs-containing protein
Alternative name(s):
G patch domain-containing protein 5
Protein MOS2 homolog
Protein T54
Gene namesi
Name:GPKOW
Synonyms:GPATC5, GPATCH5, T54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:30677. GPKOW.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 476475G patch domain and KOW motifs-containing proteinPRO_0000087559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei42 – 421Phosphoserine2 Publications
Modified residuei216 – 2161Phosphothreonine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ92917.
PaxDbiQ92917.
PRIDEiQ92917.

PTM databases

PhosphoSiteiQ92917.

Miscellaneous databases

PMAP-CutDBQ92917.

Expressioni

Gene expression databases

BgeeiQ92917.
CleanExiHS_GPKOW.
GenevestigatoriQ92917.

Organism-specific databases

HPAiHPA000287.
HPA001894.

Interactioni

Subunit structurei

Interacts with PRKX.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BUD13Q9BRD02EBI-746309,EBI-2561235
DHX16O602312EBI-746309,EBI-311446
DHX38Q926202EBI-746309,EBI-1043041
PRKACBP22694-24EBI-746309,EBI-5258763
PRKXP518172EBI-746309,EBI-4302903
PRPF4O431722EBI-746309,EBI-718395
PRPF8Q6P2Q92EBI-746309,EBI-538479
RBM10P981752EBI-746309,EBI-721525

Protein-protein interaction databases

BioGridi118086. 19 interactions.
IntActiQ92917. 16 interactions.
MINTiMINT-1444323.
STRINGi9606.ENSP00000156109.

Structurei

3D structure databases

ProteinModelPortaliQ92917.
SMRiQ92917. Positions 240-278, 352-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 21047G-patchPROSITE-ProRule annotationAdd
BLAST
Domaini240 – 26728KOW 1Add
BLAST
Domaini415 – 44228KOW 2Add
BLAST

Sequence similaritiesi

Belongs to the MOS2 family.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 KOW domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG81508.
GeneTreeiENSGT00390000015154.
HOGENOMiHOG000231362.
HOVERGENiHBG080241.
InParanoidiQ92917.
KOiK13101.
OMAiMVTVSEY.
OrthoDBiEOG7FV3Q7.
PhylomeDBiQ92917.
TreeFamiTF316786.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR005824. KOW.
IPR026822. Spp2/MOS2_G-patch.
[Graphical view]
PfamiPF12656. G-patch_2. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00739. KOW. 2 hits.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92917-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK
60 70 80 90 100
TVEGRELQSV KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV
110 120 130 140 150
VSQAVKELIA ESKKSLEERE NAGVDPTLAI PMIQKGCTPS GEGADSEPRA
160 170 180 190 200
ETVPEEANYE AVPVEAYGLA MLRGMGWKPG EGIGRTFNQV VKPRVNSLRP
210 220 230 240 250
KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG LVPGGAVVVL
260 270 280 290 300
SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN
310 320 330 340 350
TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA
360 370 380 390 400
APRSQHWLHR DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR
410 420 430 440 450
VLEGLREDML ETLVPKAEGD RVMVVLGPQT GRVGHLLSRD RARSRALVQL
460 470
PRENQVVELH YDAICQYMGP SDTDDD
Length:476
Mass (Da):52,229
Last modified:March 6, 2007 - v2
Checksum:i36F1C5771969897D
GO

Sequence cautioni

The sequence AAB18640.1 differs from that shown. Reason: Frameshift at several positions.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti317 – 3171L → F in BAD93043. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66359 mRNA. Translation: AAB18640.1. Sequence problems.
BC000397 mRNA. Translation: AAH00397.1.
BC003148 mRNA. Translation: AAH03148.1.
AB209806 mRNA. Translation: BAD93043.1.
CCDSiCCDS35251.1.
RefSeqiNP_056513.2. NM_015698.5.
UniGeneiHs.503666.

Genome annotation databases

EnsembliENST00000156109; ENSP00000156109; ENSG00000068394.
GeneIDi27238.
KEGGihsa:27238.
UCSCiuc004dmr.3. human.

Polymorphism databases

DMDMi134048659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66359 mRNA. Translation: AAB18640.1 . Sequence problems.
BC000397 mRNA. Translation: AAH00397.1 .
BC003148 mRNA. Translation: AAH03148.1 .
AB209806 mRNA. Translation: BAD93043.1 .
CCDSi CCDS35251.1.
RefSeqi NP_056513.2. NM_015698.5.
UniGenei Hs.503666.

3D structure databases

ProteinModelPortali Q92917.
SMRi Q92917. Positions 240-278, 352-467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118086. 19 interactions.
IntActi Q92917. 16 interactions.
MINTi MINT-1444323.
STRINGi 9606.ENSP00000156109.

PTM databases

PhosphoSitei Q92917.

Polymorphism databases

DMDMi 134048659.

Proteomic databases

MaxQBi Q92917.
PaxDbi Q92917.
PRIDEi Q92917.

Protocols and materials databases

DNASUi 27238.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000156109 ; ENSP00000156109 ; ENSG00000068394 .
GeneIDi 27238.
KEGGi hsa:27238.
UCSCi uc004dmr.3. human.

Organism-specific databases

CTDi 27238.
GeneCardsi GC0XM048970.
HGNCi HGNC:30677. GPKOW.
HPAi HPA000287.
HPA001894.
neXtProti NX_Q92917.
PharmGKBi PA134956055.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81508.
GeneTreei ENSGT00390000015154.
HOGENOMi HOG000231362.
HOVERGENi HBG080241.
InParanoidi Q92917.
KOi K13101.
OMAi MVTVSEY.
OrthoDBi EOG7FV3Q7.
PhylomeDBi Q92917.
TreeFami TF316786.

Miscellaneous databases

GenomeRNAii 27238.
NextBioi 50115.
PMAP-CutDB Q92917.
PROi Q92917.

Gene expression databases

Bgeei Q92917.
CleanExi HS_GPKOW.
Genevestigatori Q92917.

Family and domain databases

InterProi IPR000467. G_patch_dom.
IPR005824. KOW.
IPR026822. Spp2/MOS2_G-patch.
[Graphical view ]
Pfami PF12656. G-patch_2. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
SM00739. KOW. 2 hits.
[Graphical view ]
PROSITEi PS50174. G_PATCH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval."
    Schindelhauer D., Hellebrand H., Grimm L., Bader I., Meitinger T., Wehnert M., Ross M., Meindl A.
    Genome Res. 6:1056-1069(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-476.
    Tissue: Brain.
  4. "MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana."
    Zhang Y., Cheng Y.T., Bi D., Palma K., Li X.
    Curr. Biol. 15:1936-1942(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation."
    Glesne D., Huberman E.
    Oncogene 25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRKX.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPKOW_HUMAN
AccessioniPrimary (citable) accession number: Q92917
Secondary accession number(s): Q59EK5, Q9BQA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3