Q92917 (GPKOW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G patch domain and KOW motifs-containing protein

Alternative name(s):
G patch domain-containing protein 5
Protein MOS2 homolog
Protein T54

Gene names

Name:	GPKOW
Synonyms:	GPATC5, GPATCH5, T54

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with PRKX. Ref.6
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the MOS2 family. Contains 1 G-patch domain. Contains 2 KOW domains.
Sequence caution	The sequence AAB18640.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRKACB	P22694-2	4	EBI-746309,EBI-5258763
PRKX	P51817	2	EBI-746309,EBI-4302903

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	G patch domain and KOW motifs-containing protein		PRO_0000087559
Regions
	Domain	164 – 210	47	G-patch
	Domain	240 – 267	28	KOW 1
	Domain	415 – 442	28	KOW 2
Amino acid modifications
	Modified residue	42	1	Phosphoserine Ref.8 Ref.10
	Modified residue	216	1	Phosphothreonine Ref.8 Ref.9 Ref.10
Experimental info
	Sequence conflict	317	1	L → F in BAD93043. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q92917 [UniParc]. Last modified March 6, 2007. Version 2. Checksum: 36F1C5771969897D	FASTA	476	52,229
	10 20 30 40 50 60 MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK TVEGRELQSV 70 80 90 100 110 120 KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV VSQAVKELIA ESKKSLEERE 130 140 150 160 170 180 NAGVDPTLAI PMIQKGCTPS GEGADSEPRA ETVPEEANYE AVPVEAYGLA MLRGMGWKPG 190 200 210 220 230 240 EGIGRTFNQV VKPRVNSLRP KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG 250 260 270 280 290 300 LVPGGAVVVL SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN 310 320 330 340 350 360 TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA APRSQHWLHR 370 380 390 400 410 420 DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR VLEGLREDML ETLVPKAEGD 430 440 450 460 470 RVMVVLGPQT GRVGHLLSRD RARSRALVQL PRENQVVELH YDAICQYMGP SDTDDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval." Schindelhauer D., Hellebrand H., Grimm L., Bader I., Meitinger T., Wehnert M., Ross M., Meindl A. Genome Res. 6:1056-1069(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-476. Tissue: Brain.
[4]	"MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana." Zhang Y., Cheng Y.T., Bi D., Palma K., Li X. Curr. Biol. 15:1936-1942(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation." Glesne D., Huberman E. Oncogene 25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PRKX.
[7]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-216, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-216, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-216, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66359 mRNA. Translation: AAB18640.1. Sequence problems. BC000397 mRNA. Translation: AAH00397.1. BC003148 mRNA. Translation: AAH03148.1. AB209806 mRNA. Translation: BAD93043.1.
IPI	IPI00024255.
RefSeq	NP_056513.2. NM_015698.4.
UniGene	Hs.503666.
3D structure databases
ProteinModelPortal	Q92917.
SMR	Q92917. Positions 236-278, 351-467.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92917. 6 interactions.
MINT	MINT-1444323.
STRING	9606.ENSP00000156109.
PTM databases
PhosphoSite	Q92917.
Polymorphism databases
DMDM	134048659.
Proteomic databases
PaxDb	Q92917.
PRIDE	Q92917.
Protocols and materials databases
DNASU	27238.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000156109; ENSP00000156109; ENSG00000068394. ENST00000598064; ENSP00000471681; ENSG00000268675.
GeneID	27238.
KEGG	hsa:27238.
UCSC	uc004dmr.3. human.
Organism-specific databases
CTD	27238.
GeneCards	GC0XM048970.
HGNC	HGNC:30677. GPKOW.
HPA	HPA000287. HPA001894.
neXtProt	NX_Q92917.
PharmGKB	PA134956055.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81508.
HOGENOM	HOG000231362.
HOVERGEN	HBG080241.
InParanoid	Q92917.
KO	K13101.
OMA	DPTLAIP.
OrthoDB	EOG4RXZ02.
PhylomeDB	Q92917.
Gene expression databases
Bgee	Q92917.
CleanEx	HS_GPKOW.
Genevestigator	Q92917.
GermOnline	ENSG00000068394. Homo sapiens.
Family and domain databases
InterPro	IPR000467. G_patch_dom. IPR005824. KOW. [Graphical view]
Pfam	PF00467. KOW. 1 hit. [Graphical view]
SMART	SM00443. G_patch. 1 hit. SM00739. KOW. 2 hits. [Graphical view]
PROSITE	PS50174. G_PATCH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27238.
NextBio	50115.
PMAP-CutDB	Q92917.

Entry information

Entry name

GPKOW_HUMAN

Accession

Primary (citable) accession number: Q92917
Secondary accession number(s): Q59EK5, Q9BQA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.