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Protein

G patch domain and KOW motifs-containing protein

Gene

GPKOW

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain and KOW motifs-containing protein
Alternative name(s):
G patch domain-containing protein 5
Protein MOS2 homolog
Protein T54
Gene namesi
Name:GPKOW
Synonyms:GPATC5, GPATCH5, T54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30677. GPKOW.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27238.
OpenTargetsiENSG00000068394.
PharmGKBiPA134956055.

Polymorphism and mutation databases

DMDMi134048659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000875592 – 476G patch domain and KOW motifs-containing proteinAdd BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei216PhosphothreonineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei473PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92917.
MaxQBiQ92917.
PaxDbiQ92917.
PeptideAtlasiQ92917.
PRIDEiQ92917.

PTM databases

iPTMnetiQ92917.
PhosphoSitePlusiQ92917.

Miscellaneous databases

PMAP-CutDBQ92917.

Expressioni

Gene expression databases

BgeeiENSG00000068394.
CleanExiHS_GPKOW.
GenevisibleiQ92917. HS.

Organism-specific databases

HPAiHPA000287.
HPA001894.

Interactioni

Subunit structurei

Interacts with PRKX.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BUD13Q9BRD09EBI-746309,EBI-2561235
CCDC57Q2TAC23EBI-746309,EBI-2808286
DHX16O602312EBI-746309,EBI-311446
DHX38Q926202EBI-746309,EBI-1043041
GOLGA2Q083793EBI-746309,EBI-618309
PRKACBP22694-24EBI-746309,EBI-5258763
PRKXP518172EBI-746309,EBI-4302903
PRPF4O431722EBI-746309,EBI-718395
PRPF8Q6P2Q92EBI-746309,EBI-538479
RBM10P981752EBI-746309,EBI-721525
ROPN1Q9HAT05EBI-746309,EBI-1378139
SH3GL1Q6FGM03EBI-746309,EBI-10173690
SH3GL1Q999613EBI-746309,EBI-697911
TCEA2Q155605EBI-746309,EBI-710310
TERF2IPQ9NYB02EBI-746309,EBI-750109
TRAF2Q129335EBI-746309,EBI-355744
TRIM23P364063EBI-746309,EBI-740098

Protein-protein interaction databases

BioGridi118086. 36 interactors.
IntActiQ92917. 52 interactors.
MINTiMINT-1444323.
STRINGi9606.ENSP00000156109.

Structurei

3D structure databases

ProteinModelPortaliQ92917.
SMRiQ92917.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 210G-patchPROSITE-ProRule annotationAdd BLAST47
Domaini240 – 267KOW 1Add BLAST28
Domaini415 – 442KOW 2Add BLAST28

Sequence similaritiesi

Belongs to the MOS2 family.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 KOW domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4315. Eukaryota.
ENOG410YYBE. LUCA.
GeneTreeiENSGT00390000015154.
HOGENOMiHOG000231362.
HOVERGENiHBG080241.
InParanoidiQ92917.
KOiK13101.
OMAiVEGNRVM.
OrthoDBiEOG091G0DPZ.
PhylomeDBiQ92917.
TreeFamiTF316786.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR005824. KOW.
IPR026822. Spp2/MOS2_G-patch.
[Graphical view]
PfamiPF12656. G-patch_2. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00739. KOW. 2 hits.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK
60 70 80 90 100
TVEGRELQSV KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV
110 120 130 140 150
VSQAVKELIA ESKKSLEERE NAGVDPTLAI PMIQKGCTPS GEGADSEPRA
160 170 180 190 200
ETVPEEANYE AVPVEAYGLA MLRGMGWKPG EGIGRTFNQV VKPRVNSLRP
210 220 230 240 250
KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG LVPGGAVVVL
260 270 280 290 300
SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN
310 320 330 340 350
TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA
360 370 380 390 400
APRSQHWLHR DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR
410 420 430 440 450
VLEGLREDML ETLVPKAEGD RVMVVLGPQT GRVGHLLSRD RARSRALVQL
460 470
PRENQVVELH YDAICQYMGP SDTDDD
Length:476
Mass (Da):52,229
Last modified:March 6, 2007 - v2
Checksum:i36F1C5771969897D
GO

Sequence cautioni

The sequence AAB18640 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317L → F in BAD93043 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66359 mRNA. Translation: AAB18640.1. Sequence problems.
BC000397 mRNA. Translation: AAH00397.1.
BC003148 mRNA. Translation: AAH03148.1.
AB209806 mRNA. Translation: BAD93043.1.
CCDSiCCDS35251.1.
RefSeqiNP_056513.2. NM_015698.5.
UniGeneiHs.503666.

Genome annotation databases

EnsembliENST00000156109; ENSP00000156109; ENSG00000068394.
GeneIDi27238.
KEGGihsa:27238.
UCSCiuc004dmr.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66359 mRNA. Translation: AAB18640.1. Sequence problems.
BC000397 mRNA. Translation: AAH00397.1.
BC003148 mRNA. Translation: AAH03148.1.
AB209806 mRNA. Translation: BAD93043.1.
CCDSiCCDS35251.1.
RefSeqiNP_056513.2. NM_015698.5.
UniGeneiHs.503666.

3D structure databases

ProteinModelPortaliQ92917.
SMRiQ92917.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118086. 36 interactors.
IntActiQ92917. 52 interactors.
MINTiMINT-1444323.
STRINGi9606.ENSP00000156109.

PTM databases

iPTMnetiQ92917.
PhosphoSitePlusiQ92917.

Polymorphism and mutation databases

DMDMi134048659.

Proteomic databases

EPDiQ92917.
MaxQBiQ92917.
PaxDbiQ92917.
PeptideAtlasiQ92917.
PRIDEiQ92917.

Protocols and materials databases

DNASUi27238.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000156109; ENSP00000156109; ENSG00000068394.
GeneIDi27238.
KEGGihsa:27238.
UCSCiuc004dmr.5. human.

Organism-specific databases

CTDi27238.
DisGeNETi27238.
GeneCardsiGPKOW.
HGNCiHGNC:30677. GPKOW.
HPAiHPA000287.
HPA001894.
neXtProtiNX_Q92917.
OpenTargetsiENSG00000068394.
PharmGKBiPA134956055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4315. Eukaryota.
ENOG410YYBE. LUCA.
GeneTreeiENSGT00390000015154.
HOGENOMiHOG000231362.
HOVERGENiHBG080241.
InParanoidiQ92917.
KOiK13101.
OMAiVEGNRVM.
OrthoDBiEOG091G0DPZ.
PhylomeDBiQ92917.
TreeFamiTF316786.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiGPKOW. human.
GenomeRNAii27238.
PMAP-CutDBQ92917.
PROiQ92917.

Gene expression databases

BgeeiENSG00000068394.
CleanExiHS_GPKOW.
GenevisibleiQ92917. HS.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR005824. KOW.
IPR026822. Spp2/MOS2_G-patch.
[Graphical view]
PfamiPF12656. G-patch_2. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00739. KOW. 2 hits.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPKOW_HUMAN
AccessioniPrimary (citable) accession number: Q92917
Secondary accession number(s): Q59EK5, Q9BQA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.