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Q92917

- GPKOW_HUMAN

UniProt

Q92917 - GPKOW_HUMAN

Protein

G patch domain and KOW motifs-containing protein

Gene

GPKOW

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G patch domain and KOW motifs-containing protein
    Alternative name(s):
    G patch domain-containing protein 5
    Protein MOS2 homolog
    Protein T54
    Gene namesi
    Name:GPKOW
    Synonyms:GPATC5, GPATCH5, T54
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:30677. GPKOW.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134956055.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 476475G patch domain and KOW motifs-containing proteinPRO_0000087559Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei42 – 421Phosphoserine2 Publications
    Modified residuei216 – 2161Phosphothreonine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ92917.
    PaxDbiQ92917.
    PRIDEiQ92917.

    PTM databases

    PhosphoSiteiQ92917.

    Miscellaneous databases

    PMAP-CutDBQ92917.

    Expressioni

    Gene expression databases

    BgeeiQ92917.
    CleanExiHS_GPKOW.
    GenevestigatoriQ92917.

    Organism-specific databases

    HPAiHPA000287.
    HPA001894.

    Interactioni

    Subunit structurei

    Interacts with PRKX.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BUD13Q9BRD02EBI-746309,EBI-2561235
    DHX16O602312EBI-746309,EBI-311446
    DHX38Q926202EBI-746309,EBI-1043041
    PRKACBP22694-24EBI-746309,EBI-5258763
    PRKXP518172EBI-746309,EBI-4302903
    PRPF4O431722EBI-746309,EBI-718395
    PRPF8Q6P2Q92EBI-746309,EBI-538479
    RBM10P981752EBI-746309,EBI-721525

    Protein-protein interaction databases

    BioGridi118086. 18 interactions.
    IntActiQ92917. 16 interactions.
    MINTiMINT-1444323.
    STRINGi9606.ENSP00000156109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92917.
    SMRiQ92917. Positions 240-278, 352-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini164 – 21047G-patchPROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 26728KOW 1Add
    BLAST
    Domaini415 – 44228KOW 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the MOS2 family.Curated
    Contains 1 G-patch domain.PROSITE-ProRule annotation
    Contains 2 KOW domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG81508.
    HOGENOMiHOG000231362.
    HOVERGENiHBG080241.
    InParanoidiQ92917.
    KOiK13101.
    OMAiMVTVSEY.
    OrthoDBiEOG7FV3Q7.
    PhylomeDBiQ92917.
    TreeFamiTF316786.

    Family and domain databases

    InterProiIPR000467. G_patch_dom.
    IPR005824. KOW.
    IPR026822. Spp2/MOS2_G-patch.
    [Graphical view]
    PfamiPF12656. G-patch_2. 1 hit.
    PF00467. KOW. 1 hit.
    [Graphical view]
    SMARTiSM00443. G_patch. 1 hit.
    SM00739. KOW. 2 hits.
    [Graphical view]
    PROSITEiPS50174. G_PATCH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK    50
    TVEGRELQSV KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV 100
    VSQAVKELIA ESKKSLEERE NAGVDPTLAI PMIQKGCTPS GEGADSEPRA 150
    ETVPEEANYE AVPVEAYGLA MLRGMGWKPG EGIGRTFNQV VKPRVNSLRP 200
    KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG LVPGGAVVVL 250
    SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN 300
    TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA 350
    APRSQHWLHR DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR 400
    VLEGLREDML ETLVPKAEGD RVMVVLGPQT GRVGHLLSRD RARSRALVQL 450
    PRENQVVELH YDAICQYMGP SDTDDD 476
    Length:476
    Mass (Da):52,229
    Last modified:March 6, 2007 - v2
    Checksum:i36F1C5771969897D
    GO

    Sequence cautioni

    The sequence AAB18640.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti317 – 3171L → F in BAD93043. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66359 mRNA. Translation: AAB18640.1. Sequence problems.
    BC000397 mRNA. Translation: AAH00397.1.
    BC003148 mRNA. Translation: AAH03148.1.
    AB209806 mRNA. Translation: BAD93043.1.
    CCDSiCCDS35251.1.
    RefSeqiNP_056513.2. NM_015698.5.
    UniGeneiHs.503666.

    Genome annotation databases

    EnsembliENST00000156109; ENSP00000156109; ENSG00000068394.
    GeneIDi27238.
    KEGGihsa:27238.
    UCSCiuc004dmr.3. human.

    Polymorphism databases

    DMDMi134048659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66359 mRNA. Translation: AAB18640.1 . Sequence problems.
    BC000397 mRNA. Translation: AAH00397.1 .
    BC003148 mRNA. Translation: AAH03148.1 .
    AB209806 mRNA. Translation: BAD93043.1 .
    CCDSi CCDS35251.1.
    RefSeqi NP_056513.2. NM_015698.5.
    UniGenei Hs.503666.

    3D structure databases

    ProteinModelPortali Q92917.
    SMRi Q92917. Positions 240-278, 352-467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118086. 18 interactions.
    IntActi Q92917. 16 interactions.
    MINTi MINT-1444323.
    STRINGi 9606.ENSP00000156109.

    PTM databases

    PhosphoSitei Q92917.

    Polymorphism databases

    DMDMi 134048659.

    Proteomic databases

    MaxQBi Q92917.
    PaxDbi Q92917.
    PRIDEi Q92917.

    Protocols and materials databases

    DNASUi 27238.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000156109 ; ENSP00000156109 ; ENSG00000068394 .
    GeneIDi 27238.
    KEGGi hsa:27238.
    UCSCi uc004dmr.3. human.

    Organism-specific databases

    CTDi 27238.
    GeneCardsi GC0XM048970.
    HGNCi HGNC:30677. GPKOW.
    HPAi HPA000287.
    HPA001894.
    neXtProti NX_Q92917.
    PharmGKBi PA134956055.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81508.
    HOGENOMi HOG000231362.
    HOVERGENi HBG080241.
    InParanoidi Q92917.
    KOi K13101.
    OMAi MVTVSEY.
    OrthoDBi EOG7FV3Q7.
    PhylomeDBi Q92917.
    TreeFami TF316786.

    Miscellaneous databases

    GenomeRNAii 27238.
    NextBioi 50115.
    PMAP-CutDB Q92917.
    PROi Q92917.

    Gene expression databases

    Bgeei Q92917.
    CleanExi HS_GPKOW.
    Genevestigatori Q92917.

    Family and domain databases

    InterProi IPR000467. G_patch_dom.
    IPR005824. KOW.
    IPR026822. Spp2/MOS2_G-patch.
    [Graphical view ]
    Pfami PF12656. G-patch_2. 1 hit.
    PF00467. KOW. 1 hit.
    [Graphical view ]
    SMARTi SM00443. G_patch. 1 hit.
    SM00739. KOW. 2 hits.
    [Graphical view ]
    PROSITEi PS50174. G_PATCH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval."
      Schindelhauer D., Hellebrand H., Grimm L., Bader I., Meitinger T., Wehnert M., Ross M., Meindl A.
      Genome Res. 6:1056-1069(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-476.
      Tissue: Brain.
    4. "MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana."
      Zhang Y., Cheng Y.T., Bi D., Palma K., Li X.
      Curr. Biol. 15:1936-1942(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation."
      Glesne D., Huberman E.
      Oncogene 25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRKX.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGPKOW_HUMAN
    AccessioniPrimary (citable) accession number: Q92917
    Secondary accession number(s): Q59EK5, Q9BQA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3