Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92917 (GPKOW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G patch domain and KOW motifs-containing protein
Alternative name(s):
G patch domain-containing protein 5
Protein MOS2 homolog
Protein T54
Gene names
Name:GPKOW
Synonyms:GPATC5, GPATCH5, T54
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with PRKX. Ref.6

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the MOS2 family.

Contains 1 G-patch domain.

Contains 2 KOW domains.

Sequence caution

The sequence AAB18640.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from direct assay. Source: HPA

   Molecular_functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.13
Chain2 – 476475G patch domain and KOW motifs-containing protein
PRO_0000087559

Regions

Domain164 – 21047G-patch
Domain240 – 26728KOW 1
Domain415 – 44228KOW 2

Amino acid modifications

Modified residue21N-acetylalanine Ref.13
Modified residue421Phosphoserine Ref.8 Ref.11
Modified residue2161Phosphothreonine Ref.8 Ref.10 Ref.11

Experimental info

Sequence conflict3171L → F in BAD93043. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q92917 [UniParc].

Last modified March 6, 2007. Version 2.
Checksum: 36F1C5771969897D

FASTA47652,229
        10         20         30         40         50         60 
MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK TVEGRELQSV 

        70         80         90        100        110        120 
KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV VSQAVKELIA ESKKSLEERE 

       130        140        150        160        170        180 
NAGVDPTLAI PMIQKGCTPS GEGADSEPRA ETVPEEANYE AVPVEAYGLA MLRGMGWKPG 

       190        200        210        220        230        240 
EGIGRTFNQV VKPRVNSLRP KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG 

       250        260        270        280        290        300 
LVPGGAVVVL SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN 

       310        320        330        340        350        360 
TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA APRSQHWLHR 

       370        380        390        400        410        420 
DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR VLEGLREDML ETLVPKAEGD 

       430        440        450        460        470 
RVMVVLGPQT GRVGHLLSRD RARSRALVQL PRENQVVELH YDAICQYMGP SDTDDD 

« Hide

References

« Hide 'large scale' references
[1]"Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval."
Schindelhauer D., Hellebrand H., Grimm L., Bader I., Meitinger T., Wehnert M., Ross M., Meindl A.
Genome Res. 6:1056-1069(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-476.
Tissue: Brain.
[4]"MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana."
Zhang Y., Cheng Y.T., Bi D., Palma K., Li X.
Curr. Biol. 15:1936-1942(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation."
Glesne D., Huberman E.
Oncogene 25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PRKX.
[7]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66359 mRNA. Translation: AAB18640.1. Sequence problems.
BC000397 mRNA. Translation: AAH00397.1.
BC003148 mRNA. Translation: AAH03148.1.
AB209806 mRNA. Translation: BAD93043.1.
RefSeqNP_056513.2. NM_015698.5.
UniGeneHs.503666.

3D structure databases

ProteinModelPortalQ92917.
SMRQ92917. Positions 240-278, 352-467.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118086. 18 interactions.
IntActQ92917. 16 interactions.
MINTMINT-1444323.
STRING9606.ENSP00000156109.

PTM databases

PhosphoSiteQ92917.

Polymorphism databases

DMDM134048659.

Proteomic databases

PaxDbQ92917.
PRIDEQ92917.

Protocols and materials databases

DNASU27238.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000156109; ENSP00000156109; ENSG00000068394.
ENST00000598064; ENSP00000471681; ENSG00000268675.
GeneID27238.
KEGGhsa:27238.
UCSCuc004dmr.3. human.

Organism-specific databases

CTD27238.
GeneCardsGC0XM048970.
HGNCHGNC:30677. GPKOW.
HPAHPA000287.
HPA001894.
neXtProtNX_Q92917.
PharmGKBPA134956055.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81508.
HOGENOMHOG000231362.
HOVERGENHBG080241.
InParanoidQ92917.
KOK13101.
OMAMVTVSEY.
OrthoDBEOG7FV3Q7.
PhylomeDBQ92917.
TreeFamTF316786.

Gene expression databases

BgeeQ92917.
CleanExHS_GPKOW.
GenevestigatorQ92917.

Family and domain databases

InterProIPR000467. G_patch_dom.
IPR005824. KOW.
[Graphical view]
PfamPF00467. KOW. 1 hit.
[Graphical view]
SMARTSM00443. G_patch. 1 hit.
SM00739. KOW. 2 hits.
[Graphical view]
PROSITEPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi27238.
NextBio50115.
PMAP-CutDBQ92917.
PROQ92917.

Entry information

Entry nameGPKOW_HUMAN
AccessionPrimary (citable) accession number: Q92917
Secondary accession number(s): Q59EK5, Q9BQA8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: March 19, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM