ID   FGF11_HUMAN             Reviewed;         225 AA.
AC   Q92914; Q2YDX8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-JAN-2012, entry version 92.
DE   RecName: Full=Fibroblast growth factor 11;
DE            Short=FGF-11;
DE   AltName: Full=Fibroblast growth factor homologous factor 3;
DE            Short=FHF-3;
GN   Name=FGF11; Synonyms=FHF3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   MEDLINE=96382556; PubMed=8790420; DOI=10.1073/pnas.93.18.9850;
RA   Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H.,
RA   Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.;
RT   "Fibroblast growth factor (FGF) homologous factors: new members of the
RT   FGF family implicated in nervous system development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Han C., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.;
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLY-163.
RG   NIEHS SNPs program;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably involved in nervous system development and
CC       function.
CC   -!- TISSUE SPECIFICITY: Nervous system.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/fgf11/";
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DR   EMBL; U66199; AAB18915.1; -; mRNA.
DR   EMBL; AY049782; AAL15439.1; -; mRNA.
DR   EMBL; AY094623; AAM11871.1; -; Genomic_DNA.
DR   EMBL; BC032502; AAH32502.1; -; mRNA.
DR   EMBL; BC108265; AAI08266.1; -; mRNA.
DR   IPI; IPI00024252; -.
DR   RefSeq; NP_004103.1; NM_004112.2.
DR   UniGene; Hs.655193; -.
DR   ProteinModelPortal; Q92914; -.
DR   SMR; Q92914; 66-203.
DR   STRING; Q92914; -.
DR   PhosphoSite; Q92914; -.
DR   DMDM; 2494457; -.
DR   PRIDE; Q92914; -.
DR   Ensembl; ENST00000293829; ENSP00000293829; ENSG00000161958.
DR   GeneID; 2256; -.
DR   KEGG; hsa:2256; -.
DR   UCSC; uc002ggz.1; human.
DR   CTD; 2256; -.
DR   GeneCards; GC17P007342; -.
DR   H-InvDB; HIX0079953; -.
DR   HGNC; HGNC:3667; FGF11.
DR   MIM; 601514; gene.
DR   neXtProt; NX_Q92914; -.
DR   PharmGKB; PA28107; -.
DR   eggNOG; prNOG17863; -.
DR   GeneTree; ENSGT00590000082822; -.
DR   HOGENOM; HBG715432; -.
DR   HOVERGEN; HBG007580; -.
DR   InParanoid; Q92914; -.
DR   OMA; SINGTRE; -.
DR   OrthoDB; EOG4H464M; -.
DR   PhylomeDB; Q92914; -.
DR   NextBio; 9139; -.
DR   ArrayExpress; Q92914; -.
DR   Bgee; Q92914; -.
DR   CleanEx; HS_FGF11; -.
DR   Genevestigator; Q92914; -.
DR   GermOnline; ENSG00000161958; Homo sapiens.
DR   GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR002209; GF_heparin-bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   KO; K04358; -.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Growth factor; Polymorphism; Reference proteome.
FT   CHAIN         1    225       Fibroblast growth factor 11.
FT                                /FTId=PRO_0000147602.
FT   VARIANT     163    163       R -> G.
FT                                /FTId=VAR_018886.
SQ   SEQUENCE   225 AA;  25005 MW;  3176FF22053072DC CRC64;
     MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV RLCGGRPARP
     DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS FTHFNLIPVG LRVVTIQSAK
     LGHYMAMNAE GLLYSSPHFT AECRFKECVF ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ
     VMKGNRVKKT KAAAHFLPKL LEVAMYQEPS LHSVPEASPS SPPAP
//