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Q92914 (FGF11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 11

Short name=FGF-11
Alternative name(s):
Fibroblast growth factor homologous factor 3
Short name=FHF-3
Gene names
Name:FGF11
Synonyms:FHF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably involved in nervous system development and function.

Tissue specificity

Nervous system.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionGrowth factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell-cell signaling

Traceable author statement Ref.1. Source: ProtInc

nervous system development

Traceable author statement Ref.1. Source: ProtInc

signal transduction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular_functiongrowth factor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Fibroblast growth factor 11
PRO_0000147602

Natural variations

Natural variant1631R → G. Ref.3
VAR_018886

Sequences

Sequence LengthMass (Da)Tools
Q92914 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 3176FF22053072DC

FASTA22525,005
        10         20         30         40         50         60 
MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV RLCGGRPARP 

        70         80         90        100        110        120 
DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS FTHFNLIPVG LRVVTIQSAK 

       130        140        150        160        170        180 
LGHYMAMNAE GLLYSSPHFT AECRFKECVF ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ 

       190        200        210        220 
VMKGNRVKKT KAAAHFLPKL LEVAMYQEPS LHSVPEASPS SPPAP 

« Hide

References

« Hide 'large scale' references
[1]"Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]Han C., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]NIEHS SNPs program
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-163.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Skin.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66199 mRNA. Translation: AAB18915.1.
AY049782 mRNA. Translation: AAL15439.1.
AY094623 Genomic DNA. Translation: AAM11871.1.
BC032502 mRNA. Translation: AAH32502.1.
BC108265 mRNA. Translation: AAI08266.1.
RefSeqNP_004103.1. NM_004112.2.
UniGeneHs.655193.

3D structure databases

ProteinModelPortalQ92914.
SMRQ92914. Positions 66-203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000293829.

PTM databases

PhosphoSiteQ92914.

Polymorphism databases

DMDM2494457.

Proteomic databases

PaxDbQ92914.
PRIDEQ92914.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293829; ENSP00000293829; ENSG00000161958.
GeneID2256.
KEGGhsa:2256.
UCSCuc002ggz.3. human.

Organism-specific databases

CTD2256.
GeneCardsGC17P007342.
H-InvDBHIX0079953.
HGNCHGNC:3667. FGF11.
MIM601514. gene.
neXtProtNX_Q92914.
PharmGKBPA28107.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG257340.
HOGENOMHOG000290676.
HOVERGENHBG007580.
InParanoidQ92914.
KOK04358.
OMACRSGRAW.
OrthoDBEOG7J447D.
PhylomeDBQ92914.
TreeFamTF317805.

Gene expression databases

BgeeQ92914.
CleanExHS_FGF11.
GenevestigatorQ92914.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028253. FGF11.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF15. PTHR11486:SF15. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2256.
NextBio9139.
PROQ92914.
SOURCESearch...

Entry information

Entry nameFGF11_HUMAN
AccessionPrimary (citable) accession number: Q92914
Secondary accession number(s): Q2YDX8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM