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Protein

Fibroblast growth factor 11

Gene

FGF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.

GO - Molecular functioni

  • growth factor activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • nervous system development Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 11
Short name:
FGF-11
Alternative name(s):
Fibroblast growth factor homologous factor 3
Short name:
FHF-3
Gene namesi
Name:FGF11
Synonyms:FHF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:3667. FGF11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28107.

Polymorphism and mutation databases

BioMutaiFGF11.
DMDMi2494457.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Fibroblast growth factor 11PRO_0000147602Add
BLAST

Proteomic databases

PaxDbiQ92914.
PRIDEiQ92914.

PTM databases

PhosphoSiteiQ92914.

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiQ92914.
CleanExiHS_FGF11.
ExpressionAtlasiQ92914. baseline.
GenevisibleiQ92914. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000293829.

Structurei

3D structure databases

ProteinModelPortaliQ92914.
SMRiQ92914. Positions 66-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG257340.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiQ92914.
KOiK04358.
OMAiCRSGRAW.
OrthoDBiEOG7J447D.
PhylomeDBiQ92914.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028253. FGF11.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF67. PTHR11486:SF67. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV
60 70 80 90 100
RLCGGRPARP DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS
110 120 130 140 150
FTHFNLIPVG LRVVTIQSAK LGHYMAMNAE GLLYSSPHFT AECRFKECVF
160 170 180 190 200
ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ VMKGNRVKKT KAAAHFLPKL
210 220
LEVAMYQEPS LHSVPEASPS SPPAP
Length:225
Mass (Da):25,005
Last modified:February 1, 1997 - v1
Checksum:i3176FF22053072DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631R → G.1 Publication
VAR_018886

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66199 mRNA. Translation: AAB18915.1.
AY049782 mRNA. Translation: AAL15439.1.
AY094623 Genomic DNA. Translation: AAM11871.1.
BC032502 mRNA. Translation: AAH32502.1.
BC108265 mRNA. Translation: AAI08266.1.
CCDSiCCDS11105.1.
RefSeqiNP_001290389.1. NM_001303460.1.
NP_004103.1. NM_004112.3.
UniGeneiHs.655193.

Genome annotation databases

EnsembliENST00000293829; ENSP00000293829; ENSG00000161958.
GeneIDi2256.
KEGGihsa:2256.
UCSCiuc002ggz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66199 mRNA. Translation: AAB18915.1.
AY049782 mRNA. Translation: AAL15439.1.
AY094623 Genomic DNA. Translation: AAM11871.1.
BC032502 mRNA. Translation: AAH32502.1.
BC108265 mRNA. Translation: AAI08266.1.
CCDSiCCDS11105.1.
RefSeqiNP_001290389.1. NM_001303460.1.
NP_004103.1. NM_004112.3.
UniGeneiHs.655193.

3D structure databases

ProteinModelPortaliQ92914.
SMRiQ92914. Positions 66-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000293829.

PTM databases

PhosphoSiteiQ92914.

Polymorphism and mutation databases

BioMutaiFGF11.
DMDMi2494457.

Proteomic databases

PaxDbiQ92914.
PRIDEiQ92914.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293829; ENSP00000293829; ENSG00000161958.
GeneIDi2256.
KEGGihsa:2256.
UCSCiuc002ggz.3. human.

Organism-specific databases

CTDi2256.
GeneCardsiGC17P007343.
H-InvDBHIX0079953.
HGNCiHGNC:3667. FGF11.
MIMi601514. gene.
neXtProtiNX_Q92914.
PharmGKBiPA28107.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG257340.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiQ92914.
KOiK04358.
OMAiCRSGRAW.
OrthoDBiEOG7J447D.
PhylomeDBiQ92914.
TreeFamiTF317805.

Miscellaneous databases

ChiTaRSiFGF11. human.
GenomeRNAii2256.
NextBioi9139.
PROiQ92914.
SOURCEiSearch...

Gene expression databases

BgeeiQ92914.
CleanExiHS_FGF11.
ExpressionAtlasiQ92914. baseline.
GenevisibleiQ92914. HS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028253. FGF11.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF67. PTHR11486:SF67. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
    Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Han C., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIEHS SNPs program
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-163.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.

Entry informationi

Entry nameiFGF11_HUMAN
AccessioniPrimary (citable) accession number: Q92914
Secondary accession number(s): Q2YDX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 22, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.