Reviewed, UniProtKB/Swiss-Prot Q92914 (FGF11_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 11
      Short name=FGF-11
Alternative name(s):
    Fibroblast growth factor homologous factor 3
      Short name=FHF-3

Gene names

Name:	FGF11
Synonyms:	FHF3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probably involved in nervous system development and function.
Tissue specificity	Nervous system.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Growth factor
Gene Ontology (GO)
Biological process	cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc nervous system development Ref.1 Traceable author statement. Source: ProtInc signal transduction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	growth factor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Fibroblast growth factor 11		PRO_0000147602
Natural variations
	Natural variant	163	1	R → G		VAR_018886

Sequences

	Sequence		Length	Mass (Da)
	Q92914-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 3176FF22053072DC	FASTA	225	25,005
	10 20 30 40 50 60 MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV RLCGGRPARP 70 80 90 100 110 120 DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS FTHFNLIPVG LRVVTIQSAK 130 140 150 160 170 180 LGHYMAMNAE GLLYSSPHFT AECRFKECVF ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ 190 200 210 220 VMKGNRVKKT KAAAHFLPKL LEVAMYQEPS LHSVPEASPS SPPAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development." Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J. Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed: 8790420] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
[2]	Han C., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Rieder M.J., Braun A.C., Montoya M.A., Chung M.-W., Nguyen C.P., Nguyen D.A., Livingston R.J., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-163.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U66199 mRNA. Translation: AAB18915.1. AY049782 mRNA. Translation: AAL15439.1. AY094623 Genomic DNA. Translation: AAM11871.1. BC032502 mRNA. Translation: AAH32502.1. BC108265 mRNA. Translation: AAI08266.1.
RefSeq	NP_004103.1.
UniGene	Hs.655193
3D structure databases
HSSP	HSSP built from PDB template 1IJT based on UniProtKB P08620.
ModBase	Search...
Polymorphism databases
NIEHS-SNPs	Search...
Genome annotation databases
Ensembl	ENSG00000161958. Homo sapiens. [Contig view]
GeneID	2256.
KEGG	hsa:2256.
Organism-specific databases
H-InvDB	HIX0079953.
HGNC	HGNC:3667. FGF11.
MIM	601514. gene.
PharmGKB	PA28107.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q92914.
HOVERGEN	Q92914.
Gene expression databases
ArrayExpress	Q92914.
CleanEx	HS_FGF11.
GermOnline	ENSG00000161958. Homo sapiens.
Family and domain databases
InterPro	IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	9139.
SOURCE	Search...

Entry information

Entry name

FGF11_HUMAN

Accession

Primary (citable) accession number: Q92914
Secondary accession number(s): Q2YDX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 4, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)