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Protein

Fibroblast growth factor 11

Gene

FGF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.

GO - Molecular functioni

  • growth factor activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • nervous system development Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-5576892 Phase 0 - rapid depolarisation
SIGNORiQ92914

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 11
Short name:
FGF-11
Alternative name(s):
Fibroblast growth factor homologous factor 3
Short name:
FHF-3
Gene namesi
Name:FGF11
Synonyms:FHF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161958.10
HGNCiHGNC:3667 FGF11
MIMi601514 gene
neXtProtiNX_Q92914

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi2256
OpenTargetsiENSG00000161958
PharmGKBiPA28107

Polymorphism and mutation databases

BioMutaiFGF11
DMDMi2494457

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476021 – 225Fibroblast growth factor 11Add BLAST225

Proteomic databases

EPDiQ92914
PaxDbiQ92914
PRIDEiQ92914

PTM databases

PhosphoSitePlusiQ92914

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiENSG00000161958
CleanExiHS_FGF11
ExpressionAtlasiQ92914 baseline and differential
GenevisibleiQ92914 HS

Organism-specific databases

HPAiHPA066605

Interactioni

GO - Molecular functioni

  • growth factor activity Source: ProtInc

Protein-protein interaction databases

BioGridi108547, 50 interactors
IntActiQ92914, 4 interactors
STRINGi9606.ENSP00000293829

Structurei

3D structure databases

ProteinModelPortaliQ92914
SMRiQ92914
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000290676
HOVERGENiHBG007580
InParanoidiQ92914
KOiK22413
OMAiCRHGFYL
OrthoDBiEOG091G0NAY
PhylomeDBiQ92914
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028253 FGF11
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF67 PTHR11486:SF67, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Q92914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV
60 70 80 90 100
RLCGGRPARP DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS
110 120 130 140 150
FTHFNLIPVG LRVVTIQSAK LGHYMAMNAE GLLYSSPHFT AECRFKECVF
160 170 180 190 200
ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ VMKGNRVKKT KAAAHFLPKL
210 220
LEVAMYQEPS LHSVPEASPS SPPAP
Length:225
Mass (Da):25,005
Last modified:February 1, 1997 - v1
Checksum:i3176FF22053072DC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018886163R → G1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66199 mRNA Translation: AAB18915.1
AY049782 mRNA Translation: AAL15439.1
AY094623 Genomic DNA Translation: AAM11871.1
BC032502 mRNA Translation: AAH32502.1
BC108265 mRNA Translation: AAI08266.1
CCDSiCCDS11105.1
RefSeqiNP_001290389.1, NM_001303460.1
NP_004103.1, NM_004112.3
UniGeneiHs.655193

Genome annotation databases

EnsembliENST00000293829; ENSP00000293829; ENSG00000161958
ENST00000639021; ENSP00000491684; ENSG00000283903
GeneIDi2256
KEGGihsa:2256
UCSCiuc002ggz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFGF11_HUMAN
AccessioniPrimary (citable) accession number: Q92914
Secondary accession number(s): Q2YDX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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