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Q92914

- FGF11_HUMAN

UniProt

Q92914 - FGF11_HUMAN

Protein

Fibroblast growth factor 11

Gene

FGF11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Probably involved in nervous system development and function.

    GO - Molecular functioni

    1. growth factor activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. nervous system development Source: ProtInc
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 11
    Short name:
    FGF-11
    Alternative name(s):
    Fibroblast growth factor homologous factor 3
    Short name:
    FHF-3
    Gene namesi
    Name:FGF11
    Synonyms:FHF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:3667. FGF11.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28107.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225Fibroblast growth factor 11PRO_0000147602Add
    BLAST

    Proteomic databases

    PaxDbiQ92914.
    PRIDEiQ92914.

    PTM databases

    PhosphoSiteiQ92914.

    Expressioni

    Tissue specificityi

    Nervous system.

    Gene expression databases

    BgeeiQ92914.
    CleanExiHS_FGF11.
    GenevestigatoriQ92914.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000293829.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92914.
    SMRiQ92914. Positions 66-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG257340.
    HOGENOMiHOG000290676.
    HOVERGENiHBG007580.
    InParanoidiQ92914.
    KOiK04358.
    OMAiCRSGRAW.
    OrthoDBiEOG7J447D.
    PhylomeDBiQ92914.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028253. FGF11.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF67. PTHR11486:SF67. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92914-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV    50
    RLCGGRPARP DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS 100
    FTHFNLIPVG LRVVTIQSAK LGHYMAMNAE GLLYSSPHFT AECRFKECVF 150
    ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ VMKGNRVKKT KAAAHFLPKL 200
    LEVAMYQEPS LHSVPEASPS SPPAP 225
    Length:225
    Mass (Da):25,005
    Last modified:February 1, 1997 - v1
    Checksum:i3176FF22053072DC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti163 – 1631R → G.1 Publication
    VAR_018886

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66199 mRNA. Translation: AAB18915.1.
    AY049782 mRNA. Translation: AAL15439.1.
    AY094623 Genomic DNA. Translation: AAM11871.1.
    BC032502 mRNA. Translation: AAH32502.1.
    BC108265 mRNA. Translation: AAI08266.1.
    CCDSiCCDS11105.1.
    RefSeqiNP_004103.1. NM_004112.2.
    UniGeneiHs.655193.

    Genome annotation databases

    EnsembliENST00000293829; ENSP00000293829; ENSG00000161958.
    GeneIDi2256.
    KEGGihsa:2256.
    UCSCiuc002ggz.3. human.

    Polymorphism databases

    DMDMi2494457.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66199 mRNA. Translation: AAB18915.1 .
    AY049782 mRNA. Translation: AAL15439.1 .
    AY094623 Genomic DNA. Translation: AAM11871.1 .
    BC032502 mRNA. Translation: AAH32502.1 .
    BC108265 mRNA. Translation: AAI08266.1 .
    CCDSi CCDS11105.1.
    RefSeqi NP_004103.1. NM_004112.2.
    UniGenei Hs.655193.

    3D structure databases

    ProteinModelPortali Q92914.
    SMRi Q92914. Positions 66-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000293829.

    PTM databases

    PhosphoSitei Q92914.

    Polymorphism databases

    DMDMi 2494457.

    Proteomic databases

    PaxDbi Q92914.
    PRIDEi Q92914.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293829 ; ENSP00000293829 ; ENSG00000161958 .
    GeneIDi 2256.
    KEGGi hsa:2256.
    UCSCi uc002ggz.3. human.

    Organism-specific databases

    CTDi 2256.
    GeneCardsi GC17P007342.
    H-InvDB HIX0079953.
    HGNCi HGNC:3667. FGF11.
    MIMi 601514. gene.
    neXtProti NX_Q92914.
    PharmGKBi PA28107.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257340.
    HOGENOMi HOG000290676.
    HOVERGENi HBG007580.
    InParanoidi Q92914.
    KOi K04358.
    OMAi CRSGRAW.
    OrthoDBi EOG7J447D.
    PhylomeDBi Q92914.
    TreeFami TF317805.

    Miscellaneous databases

    GenomeRNAii 2256.
    NextBioi 9139.
    PROi Q92914.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92914.
    CleanExi HS_FGF11.
    Genevestigatori Q92914.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028253. FGF11.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF67. PTHR11486:SF67. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
      Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
      Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. Han C., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. NIEHS SNPs program
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-163.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Skin.

    Entry informationi

    Entry nameiFGF11_HUMAN
    AccessioniPrimary (citable) accession number: Q92914
    Secondary accession number(s): Q2YDX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3