Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q92914

- FGF11_HUMAN

UniProt

Q92914 - FGF11_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fibroblast growth factor 11

Gene

FGF11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.

GO - Molecular functioni

  1. growth factor activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. nervous system development Source: ProtInc
  3. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 11
Short name:
FGF-11
Alternative name(s):
Fibroblast growth factor homologous factor 3
Short name:
FHF-3
Gene namesi
Name:FGF11
Synonyms:FHF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:3667. FGF11.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Fibroblast growth factor 11PRO_0000147602Add
BLAST

Proteomic databases

PaxDbiQ92914.
PRIDEiQ92914.

PTM databases

PhosphoSiteiQ92914.

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiQ92914.
CleanExiHS_FGF11.
ExpressionAtlasiQ92914. baseline.
GenevestigatoriQ92914.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000293829.

Structurei

3D structure databases

ProteinModelPortaliQ92914.
SMRiQ92914. Positions 66-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG257340.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiQ92914.
KOiK04358.
OMAiCRSGRAW.
OrthoDBiEOG7J447D.
PhylomeDBiQ92914.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028253. FGF11.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF67. PTHR11486:SF67. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92914-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV
60 70 80 90 100
RLCGGRPARP DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS
110 120 130 140 150
FTHFNLIPVG LRVVTIQSAK LGHYMAMNAE GLLYSSPHFT AECRFKECVF
160 170 180 190 200
ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ VMKGNRVKKT KAAAHFLPKL
210 220
LEVAMYQEPS LHSVPEASPS SPPAP
Length:225
Mass (Da):25,005
Last modified:February 1, 1997 - v1
Checksum:i3176FF22053072DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631R → G.1 Publication
VAR_018886

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66199 mRNA. Translation: AAB18915.1.
AY049782 mRNA. Translation: AAL15439.1.
AY094623 Genomic DNA. Translation: AAM11871.1.
BC032502 mRNA. Translation: AAH32502.1.
BC108265 mRNA. Translation: AAI08266.1.
CCDSiCCDS11105.1.
RefSeqiNP_004103.1. NM_004112.2.
UniGeneiHs.655193.

Genome annotation databases

EnsembliENST00000293829; ENSP00000293829; ENSG00000161958.
GeneIDi2256.
KEGGihsa:2256.
UCSCiuc002ggz.3. human.

Polymorphism databases

DMDMi2494457.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66199 mRNA. Translation: AAB18915.1 .
AY049782 mRNA. Translation: AAL15439.1 .
AY094623 Genomic DNA. Translation: AAM11871.1 .
BC032502 mRNA. Translation: AAH32502.1 .
BC108265 mRNA. Translation: AAI08266.1 .
CCDSi CCDS11105.1.
RefSeqi NP_004103.1. NM_004112.2.
UniGenei Hs.655193.

3D structure databases

ProteinModelPortali Q92914.
SMRi Q92914. Positions 66-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000293829.

PTM databases

PhosphoSitei Q92914.

Polymorphism databases

DMDMi 2494457.

Proteomic databases

PaxDbi Q92914.
PRIDEi Q92914.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293829 ; ENSP00000293829 ; ENSG00000161958 .
GeneIDi 2256.
KEGGi hsa:2256.
UCSCi uc002ggz.3. human.

Organism-specific databases

CTDi 2256.
GeneCardsi GC17P007343.
H-InvDB HIX0079953.
HGNCi HGNC:3667. FGF11.
MIMi 601514. gene.
neXtProti NX_Q92914.
PharmGKBi PA28107.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257340.
GeneTreei ENSGT00760000118859.
HOGENOMi HOG000290676.
HOVERGENi HBG007580.
InParanoidi Q92914.
KOi K04358.
OMAi CRSGRAW.
OrthoDBi EOG7J447D.
PhylomeDBi Q92914.
TreeFami TF317805.

Miscellaneous databases

ChiTaRSi FGF11. human.
GenomeRNAii 2256.
NextBioi 9139.
PROi Q92914.
SOURCEi Search...

Gene expression databases

Bgeei Q92914.
CleanExi HS_FGF11.
ExpressionAtlasi Q92914. baseline.
Genevestigatori Q92914.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028253. FGF11.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF67. PTHR11486:SF67. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
    Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Han C., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIEHS SNPs program
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-163.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.

Entry informationi

Entry nameiFGF11_HUMAN
AccessioniPrimary (citable) accession number: Q92914
Secondary accession number(s): Q2YDX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3