Fibroblast growth factor 13 - Homo sapiens (Human)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

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Entry information

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Reviewed, UniProtKB/Swiss-Prot Q92913 (FGF13_HUMAN)

Last modified November 3, 2009. Version 87. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Protein names

Recommended name:
    Fibroblast growth factor 13
      Short name=FGF-13
Alternative name(s):
    Fibroblast growth factor homologous factor 2
      Short name=FHF-2

Gene names

Name:	FGF13
Synonyms:	FHF2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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Function	Probably involved in nervous system development and function.
Tissue specificity	Nervous system.
Sequence similarities	Belongs to the heparin-binding growth factors family.

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Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Growth factor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	MAPKKK cascade Inferred from direct assay. Source: MGI cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc nervous system development Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from physical interaction. Source: MGI nucleus Ref.1 Inferred from direct assay. Source: MGI
Molecular function	growth factor activity Ref.1 Traceable author statement. Source: ProtInc protein kinase activator activity Inferred from genetic interaction. Source: MGI
Complete GO annotation...

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Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 245

245

Fibroblast growth factor 13

PRO_0000147607

Alternative sequence

1 – 62

MAAAI…RRRRP → MALLRKSYS in isoform 1B.

VSP_001529

Natural variant

197

K → Q

VAR_020945

245

Helix Strand Turn

Details...

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Sequence		Length	Mass (Da)
Isoform 1A [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 30FB62C6B2669F29 Show »	FASTA	245	27,564
10 20 30 40 50 60 MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR 70 80 90 100 110 120 RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK 130 140 150 160 170 180 LYLAMNSEGY LYTSELFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM 190 200 210 220 230 240 KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS HNEST « Hide
Isoform 1B. Checksum: 1C5B15BB67B2F232 Show »	FASTA	192	21,581
10 20 30 40 50 60 MALLRKSYSE PQLKGIVTKL YSRQGYHLQL QADGTIDGTK DEDSTYTLFN LIPVGLRVVA 70 80 90 100 110 120 IQGVQTKLYL AMNSEGYLYT SELFTPECKF KESVFENYYV TYSSMIYRQQ QSGRGWYLGL 130 140 150 160 170 180 NKEGEIMKGN HVKKNKPAAH FLPKPLKVAM YKEPSLHDLT EFSRSGSGTP TKSRSVSGVL 190 NGGKSMSHNE ST « Hide

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	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development." Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J. Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed: 8790420] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A). Tissue: Retina.
[2]	"Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient." Gecz J., Baker E., Donnelly A., Ming J.E., McDonnald-McGinn D.M., Spinner N.B., Zackai E.H., Sutherland G.R., Mulley J.C. Hum. Genet. 104:56-63(1999) [PubMed: 10071193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B). Tissue: Brain.
[3]	NIEHS SNPs program Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-197.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A). Tissue: Lung and Skin.
+	Additional computationally mapped references.

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NIEHS-SNPs

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U66198 mRNA. Translation: AAB18914.1.
AF100143 mRNA. Translation: AAD16400.1.
AF100144 mRNA. Translation: AAD16401.1.
AY672645 Genomic DNA. Translation: AAT70720.1.
BC012347 mRNA. Translation: AAH12347.1.
BC034340 mRNA. Translation: AAH34340.1.

IPI

IPI00024251.
IPI00066574.

RefSeq

NP_001132970.1.
NP_001132972.1.
NP_001132973.1.
NP_001132974.1.
NP_004105.1.
NP_378668.1.

UniGene

Hs.6540

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3HBW	X-ray	1.90	A/B	53-245	[»]

SMR

Q92913. Positions 64-201.

ModBase

Search...

IntAct

Q92913. 1 interaction.

STRING

Q92913.

PRIDE

Q92913.

Ensembl

GeneID

2258.

KEGG

hsa:2258.

UCSC

uc004fam.1. human.
uc004fan.1. human.

CTD

2258.

GeneCards

GC0XM137541.

H-InvDB

HIX0017088.

HGNC

HGNC:3670. FGF13.

HPA

HPA002809.

MIM

300070. gene.

PharmGKB

PA28109.

GenAtlas

Search...

HOVERGEN

Q92913.

OMA

VCELAVP.

ArrayExpress

Q92913.

Bgee

Q92913.

CleanEx

HS_FGF13.

Genevestigator

Q92913.

GermOnline

ENSG00000129682. Homo sapiens.

InterPro

IPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]

PANTHER

PTHR11486. IL1_HBGF. 1 hit.

Pfam

PF00167. FGF. 1 hit.
[Graphical view]

PRINTS

PR00263. HBGFFGF.
PR00262. IL1HBGF.

ProDom

PD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00442. FGF. 1 hit.
[Graphical view]

PROSITE

PS00247. HBGF_FGF. 1 hit.
[Graphical view]

ProtoNet

Search...

NextBio

9149.

SOURCE

Search...

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This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1A (identifier: Q92913-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1B (identifier: Q92913-2)

The sequence of this isoform differs from the canonical sequence as follows:
1-62: MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRP → MALLRKSYS

Entry name

FGF13_HUMAN

Accession

Primary (citable) accession number: Q92913
Secondary accession number(s): O95830

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 3, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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