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Protein

Sodium/iodide cotransporter

Gene

SLC5A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates iodide uptake in the thyroid gland.

GO - Molecular functioni

  • iodide transmembrane transporter activity Source: UniProtKB
  • sodium:iodide symporter activity Source: GO_Central

GO - Biological processi

  • cellular response to cAMP Source: UniProtKB
  • cellular response to gonadotropin stimulus Source: UniProtKB
  • iodide transport Source: UniProtKB
  • ion transport Source: Reactome
  • thyroid hormone generation Source: GO_Central
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105641-MONOMER.
ReactomeiR-HSA-209968. Thyroxine biosynthesis.
R-HSA-428643. Organic anion transporters.

Protein family/group databases

TCDBi2.A.21.5.1. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/iodide cotransporter
Short name:
Na(+)/I(-) cotransporter
Alternative name(s):
Sodium-iodide symporter
Short name:
Na(+)/I(-) symporter
Solute carrier family 5 member 5
Gene namesi
Name:SLC5A5
Synonyms:NIS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:11040. SLC5A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 53CytoplasmicSequence analysisAdd BLAST16
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 88ExtracellularSequence analysisAdd BLAST14
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 136CytoplasmicSequence analysisAdd BLAST27
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 163ExtracellularSequence analysis6
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 186CytoplasmicSequence analysis2
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 241ExtracellularSequence analysisAdd BLAST34
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 286CytoplasmicSequence analysisAdd BLAST24
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 326ExtracellularSequence analysisAdd BLAST19
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 391CytoplasmicSequence analysisAdd BLAST44
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 416ExtracellularSequence analysis4
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 444CytoplasmicSequence analysis7
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 525ExtracellularSequence analysisAdd BLAST60
Transmembranei526 – 546HelicalSequence analysisAdd BLAST21
Topological domaini547 – 643CytoplasmicSequence analysisAdd BLAST97

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular vesicle Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • nucleus Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Thyroid dyshormonogenesis 1 (TDH1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism.
See also OMIM:274400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01026393G → R in TDH1. 1 PublicationCorresponds to variant rs121909178dbSNPEnsembl.1
Natural variantiVAR_010265267Q → E in TDH1. 1 PublicationCorresponds to variant rs121909176dbSNPEnsembl.1
Natural variantiVAR_010266354T → P in TDH1. 2 PublicationsCorresponds to variant rs121909174dbSNPEnsembl.1
Natural variantiVAR_010267395G → R in TDH1. 1 PublicationCorresponds to variant rs121909180dbSNPEnsembl.1
Natural variantiVAR_010269543G → E in TDH1. 1 PublicationCorresponds to variant rs121909179dbSNPEnsembl.1

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNETi6528.
MalaCardsiSLC5A5.
MIMi274400. phenotype.
OpenTargetsiENSG00000105641.
Orphaneti95716. Familial thyroid dyshormonogenesis.
PharmGKBiPA35905.

Polymorphism and mutation databases

BioMutaiSLC5A5.
DMDMi12643359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053831 – 643Sodium/iodide cotransporterAdd BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi489N-linked (GlcNAc...)Sequence analysis1
Glycosylationi502N-linked (GlcNAc...)Sequence analysis1
Modified residuei556Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ92911.
PaxDbiQ92911.
PeptideAtlasiQ92911.
PRIDEiQ92911.

PTM databases

iPTMnetiQ92911.
PhosphoSitePlusiQ92911.

Expressioni

Tissue specificityi

Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.2 Publications

Gene expression databases

BgeeiENSG00000105641.
CleanExiHS_SLC5A5.
GenevisibleiQ92911. HS.

Organism-specific databases

HPAiCAB022364.
HPA049055.

Interactioni

Protein-protein interaction databases

BioGridi112419. 11 interactors.
IntActiQ92911. 1 interactor.
STRINGi9606.ENSP00000222248.

Structurei

3D structure databases

ProteinModelPortaliQ92911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ92911.
KOiK14385.
OMAiATFGAWD.
OrthoDBiEOG091G07OC.
PhylomeDBiQ92911.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVETGERP TFGAWDYGVF ALMLLVSTGI GLWVGLARGG QRSAEDFFTG
60 70 80 90 100
GRRLAALPVG LSLSASFMSA VQVLGVPSEA YRYGLKFLWM CLGQLLNSVL
110 120 130 140 150
TALLFMPVFY RLGLTSTYEY LEMRFSRAVR LCGTLQYIVA TMLYTGIVIY
160 170 180 190 200
APALILNQVT GLDIWASLLS TGIICTFYTA VGGMKAVVWT DVFQVVVMLS
210 220 230 240 250
GFWVVLARGV MLVGGPRQVL TLAQNHSRIN LMDFNPDPRS RYTFWTFVVG
260 270 280 290 300
GTLVWLSMYG VNQAQVQRYV ACRTEKQAKL ALLINQVGLF LIVSSAACCG
310 320 330 340 350
IVMFVFYTDC DPLLLGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG
360 370 380 390 400
TLSTASTSIN AMAAVTVEDL IKPRLRSLAP RKLVIISKGL SLIYGSACLT
410 420 430 440 450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FILGMFLPAC NTPGVLAGLG
460 470 480 490 500
AGLALSLWVA LGATLYPPSE QTMRVLPSSA ARCVALSVNA SGLLDPALLP
510 520 530 540 550
ANDSSRAPSS GMDASRPALA DSFYAISYLY YGALGTLTTV LCGALISCLT
560 570 580 590 600
GPTKRSTLAP GLLWWDLARQ TASVAPKEEV AILDDNLVKG PEELPTGNKK
610 620 630 640
PPGFLPTNED RLFFLGQKEL EGAGSWTPCV GHDGGRDQQE TNL
Length:643
Mass (Da):68,666
Last modified:February 1, 1997 - v1
Checksum:i02D361A27B2FDA43
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01026393G → R in TDH1. 1 PublicationCorresponds to variant rs121909178dbSNPEnsembl.1
Natural variantiVAR_010264102A → P.1 Publication1
Natural variantiVAR_010265267Q → E in TDH1. 1 PublicationCorresponds to variant rs121909176dbSNPEnsembl.1
Natural variantiVAR_052490298C → G.Corresponds to variant rs8108188dbSNPEnsembl.1
Natural variantiVAR_010266354T → P in TDH1. 2 PublicationsCorresponds to variant rs121909174dbSNPEnsembl.1
Natural variantiVAR_010267395G → R in TDH1. 1 PublicationCorresponds to variant rs121909180dbSNPEnsembl.1
Natural variantiVAR_010268536T → Q Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_010269543G → E in TDH1. 1 PublicationCorresponds to variant rs121909179dbSNPEnsembl.1
Natural variantiVAR_010270556S → Q Requires 2 nucleotide substitutions. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66088 mRNA. Translation: AAB17378.1.
AC005796 Genomic DNA. Translation: AAC62827.1.
D87920 mRNA. Translation: BAA24835.1.
BC105047 mRNA. Translation: AAI05048.1.
BC105049 mRNA. Translation: AAI05050.1.
AF260700 mRNA. Translation: AAF70339.1.
CCDSiCCDS12368.1.
PIRiJC4974.
RefSeqiNP_000444.1. NM_000453.2.
UniGeneiHs.584804.

Genome annotation databases

EnsembliENST00000222248; ENSP00000222248; ENSG00000105641.
GeneIDi6528.
KEGGihsa:6528.
UCSCiuc002nhr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66088 mRNA. Translation: AAB17378.1.
AC005796 Genomic DNA. Translation: AAC62827.1.
D87920 mRNA. Translation: BAA24835.1.
BC105047 mRNA. Translation: AAI05048.1.
BC105049 mRNA. Translation: AAI05050.1.
AF260700 mRNA. Translation: AAF70339.1.
CCDSiCCDS12368.1.
PIRiJC4974.
RefSeqiNP_000444.1. NM_000453.2.
UniGeneiHs.584804.

3D structure databases

ProteinModelPortaliQ92911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112419. 11 interactors.
IntActiQ92911. 1 interactor.
STRINGi9606.ENSP00000222248.

Protein family/group databases

TCDBi2.A.21.5.1. the solute:sodium symporter (sss) family.

PTM databases

iPTMnetiQ92911.
PhosphoSitePlusiQ92911.

Polymorphism and mutation databases

BioMutaiSLC5A5.
DMDMi12643359.

Proteomic databases

EPDiQ92911.
PaxDbiQ92911.
PeptideAtlasiQ92911.
PRIDEiQ92911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222248; ENSP00000222248; ENSG00000105641.
GeneIDi6528.
KEGGihsa:6528.
UCSCiuc002nhr.4. human.

Organism-specific databases

CTDi6528.
DisGeNETi6528.
GeneCardsiSLC5A5.
HGNCiHGNC:11040. SLC5A5.
HPAiCAB022364.
HPA049055.
MalaCardsiSLC5A5.
MIMi274400. phenotype.
601843. gene.
neXtProtiNX_Q92911.
OpenTargetsiENSG00000105641.
Orphaneti95716. Familial thyroid dyshormonogenesis.
PharmGKBiPA35905.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ92911.
KOiK14385.
OMAiATFGAWD.
OrthoDBiEOG091G07OC.
PhylomeDBiQ92911.
TreeFamiTF316728.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105641-MONOMER.
ReactomeiR-HSA-209968. Thyroxine biosynthesis.
R-HSA-428643. Organic anion transporters.

Miscellaneous databases

ChiTaRSiSLC5A5. human.
GeneWikiiSodium-iodide_symporter.
GenomeRNAii6528.
PROiQ92911.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105641.
CleanExiHS_SLC5A5.
GenevisibleiQ92911. HS.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A5_HUMAN
AccessioniPrimary (citable) accession number: Q92911
Secondary accession number(s): O43702, Q2M335, Q9NYB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.