Q92908 (GATA6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor GATA-6

Alternative name(s):
GATA-binding factor 6

Gene names

Name:

GATA6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	595 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thought to be important for regulating terminal differentiation and/or proliferation.
Subunit structure	Interacts with LMCD1 By similarity.
Subcellular location	Nucleus.
Tissue specificity	Expressed in heart, gut and gut-derived tissues.
Domain	The GATA-type zinc fingers mediate interaction with LMCD1 By similarity.
Sequence similarities	Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative initiation
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	blood coagulation Traceable author statement. Source: Reactome cardiac vascular smooth muscle cell differentiation Inferred from mutant phenotype. Source: UniProtKB cellular response to hypoxia Inferred from direct assay. Source: UniProtKB intestinal epithelial cell differentiation Inferred from direct assay. Source: MGI male gonad development Inferred from expression pattern. Source: UniProtKB negative regulation of apoptotic process Inferred from mutant phenotype. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: UniProtKB negative regulation of transforming growth factor beta1 production Inferred from mutant phenotype. Source: UniProtKB negative regulation of transforming growth factor beta2 production Inferred from mutant phenotype. Source: UniProtKB outflow tract septum morphogenesis Inferred from mutant phenotype. Source: BHF-UCL positive regulation of angiogenesis Inferred from direct assay. Source: UniProtKB positive regulation of cell cycle arrest Inferred from direct assay. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: UniProtKB response to drug Inferred from mutant phenotype. Source: UniProtKB response to growth factor stimulus Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB protein kinase binding Inferred from physical interaction. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from direct assay. Source: UniProtKB transcription regulatory region DNA binding Inferred from direct assay. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform 1 (identifier: Q92908-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92908-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: Produced by alternative initiation at Met-147 of isoform 1.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 595	595	Transcription factor GATA-6		PRO_0000083423
Regions
	Zinc finger	390 – 414	25	GATA-type 1
	Zinc finger	444 – 468	25	GATA-type 2
	Compositional bias	173 – 183	11	Poly-Ala
	Compositional bias	324 – 333	10	Poly-His
	Compositional bias	449 – 453	5	Poly-Thr
Amino acid modifications
	Modified residue	266	1	Phosphoserine Ref.8
	Modified residue	268	1	Phosphoserine Ref.8
	Modified residue	534	1	Phosphothreonine Ref.9
Natural variations
	Alternative sequence	1 – 146	146	Missing in isoform 2.		VSP_035778
Experimental info
	Sequence conflict	281	1	G → V in CAA64997. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: C4D5410916543E0B	FASTA	595	60,033
	10 20 30 40 50 60 MALTDGGWCL PKRFGAAGAD ASDSRAFPAR EPSTPPSPIS SSSSSCSRGG ERGPGGASNC 70 80 90 100 110 120 GTPQLDTEAA AGPPARSLLL SSYASHPFGA PHGPSAPGVA GPGGNLSSWE DLLLFTDLDQ 130 140 150 160 170 180 AATASKLLWS SRGAKLSPFA PEQPEEMYQT LAALSSQGPA AYDGAPGGFV HSAAAAAAAA 190 200 210 220 230 240 AAASSPVYVP TTRVGSMLPG LPYHLQGSGS GPANHAGGAG AHPGWPQASA DSPPYGSGGG 250 260 270 280 290 300 AAGGGAAGPG GAGSAAAHVS ARFPYSPSPP MANGAAREPG GYAAAGSGGA GGVSGGGSSL 310 320 330 340 350 360 AAMGGREPQY SSLSAARPLN GTYHHHHHHH HHHPSPYSPY VGAPLTPAWP AGPFETPVLH 370 380 390 400 410 420 SLQSRAGAPL PVPRGPSADL LEDLSESREC VNCGSIQTPL WRRDGTGHYL CNACGLYSKM 430 440 450 460 470 480 NGLSRPLIKP QKRVPSSRRL GLSCANCHTT TTTLWRRNAE GEPVCNACGL YMKLHGVPRP 490 500 510 520 530 540 LAMKKEGIQT RKRKPKNINK SKTCSGNSNN SIPMTPTSTS SNSDDCSKNT SPTTQPTASG 550 560 570 580 590 AGAPVMTGAG ESTNPENSEL KYSGQDGLYI GVSLASPAEV TSSVRPDSWC ALALA
	Isoform 2 [UniParc]. Checksum: 2A0C294757CC2E92	FASTA	449	45,386
	10 20 30 40 50 60 MYQTLAALSS QGPAAYDGAP GGFVHSAAAA AAAAAAASSP VYVPTTRVGS MLPGLPYHLQ 70 80 90 100 110 120 GSGSGPANHA GGAGAHPGWP QASADSPPYG SGGGAAGGGA AGPGGAGSAA AHVSARFPYS 130 140 150 160 170 180 PSPPMANGAA REPGGYAAAG SGGAGGVSGG GSSLAAMGGR EPQYSSLSAA RPLNGTYHHH 190 200 210 220 230 240 HHHHHHHPSP YSPYVGAPLT PAWPAGPFET PVLHSLQSRA GAPLPVPRGP SADLLEDLSE 250 260 270 280 290 300 SRECVNCGSI QTPLWRRDGT GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN 310 320 330 340 350 360 CHTTTTTLWR RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKTCSG 370 380 390 400 410 420 NSNNSIPMTP TSTSSNSDDC SKNTSPTTQP TASGAGAPVM TGAGESTNPE NSELKYSGQD 430 440 GLYIGVSLAS PAEVTSSVRP DSWCALALA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals." Suzuki E., Evans T., Lowry J., Truong L., Bell D.W., Testa J.R., Walsh K. Genomics 38:283-290(1996) [PubMed: 8975704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut." Huggon I.C., Davies A., Gove C., Moscoso G., Moniz C., Foss Y., Farzaneh F., Towner P. Biochim. Biophys. Acta 1353:98-102(1997) [PubMed: 9294001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Heart.
[3]	"GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells." Yoshida T., Sato R., Mahmood S., Kawasaki S., Futai M., Maeda M. FEBS Lett. 414:333-337(1997) [PubMed: 9315713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	NHLBI resequencing and genotyping service (RS&G) Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The human and mouse GATA-6 genes utilize two promoters and two initiation codons." Brewer A., Gove C., Davies A., McNulty C., Barrow D., Koutsourakis M., Farzaneh F., Pizzey J., Bomford A., Patient R. J. Biol. Chem. 274:38004-38016(1999) [PubMed: 10608869] [Abstract] Cited for: ALTERNATIVE INITIATION.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266 AND SER-268, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-534, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66075 mRNA. Translation: AAC50941.1. X95701 mRNA. Translation: CAA64997.1. D87811 mRNA. Translation: BAA22621.1. EF444980 Genomic DNA. Translation: ACA05995.1. AC091588 Genomic DNA. No translation available. CH471088 Genomic DNA. Translation: EAX01137.1.
IPI	IPI00024236. IPI00915001.
RefSeq	NP_005248.2. NM_005257.3.
UniGene	Hs.514746.
3D structure databases
ProteinModelPortal	Q92908.
SMR	Q92908. Positions 386-422, 438-493.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92908. 2 interactions.
STRING	Q92908.
PTM databases
PhosphoSite	Q92908.
Polymorphism databases
DMDM	215273987.
Proteomic databases
PRIDE	Q92908.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269216; ENSP00000269216; ENSG00000141448.
GeneID	2627.
KEGG	hsa:2627.
UCSC	uc002ktt.1. human.
Organism-specific databases
CTD	2627.
GeneCards	GC18P019749.
H-InvDB	HIX0039732.
HGNC	HGNC:4174. GATA6.
HPA	CAB011581.
MIM	601656. gene.
neXtProt	NX_Q92908.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17015.
GeneTree	ENSGT00550000074470.
HOGENOM	HBG716943.
HOVERGEN	HBG051703.
InParanoid	Q92908.
OMA	GAHPGWP.
OrthoDB	EOG4TMR21.
PhylomeDB	Q92908.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q92908.
Bgee	Q92908.
CleanEx	HS_GATA6.
Genevestigator	Q92908.
GermOnline	ENSG00000141448. Homo sapiens.
Family and domain databases
InterPro	IPR008013. GATA_N. IPR000679. Znf_GATA. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:3.30.50.10. Znf_NHR/GATA. 2 hits.
KO	K09183.
Pfam	PF00320. GATA. 2 hits. PF05349. GATA-N. 1 hit. [Graphical view]
PRINTS	PR00619. GATAZNFINGER.
SMART	SM00401. ZnF_GATA. 2 hits. [Graphical view]
PROSITE	PS00344. GATA_ZN_FINGER_1. 2 hits. PS50114. GATA_ZN_FINGER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

GATA6_HUMAN

Accession

Primary (citable) accession number: Q92908
Secondary accession number(s): B0YJ17, P78327

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.