Reviewed, UniProtKB/Swiss-Prot Q92908 (GATA6_HUMAN)

Names and origin

Protein names

Recommended name:
    Transcription factor GATA-6
Alternative name(s):
    GATA-binding factor 6

Gene names

Name:

GATA6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	595 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Thought to be important for regulating terminal differentiation and/or proliferation.
Subcellular location	Nucleus.
Tissue specificity	Expressed in heart, gut and gut-derived tissues.
Sequence similarities	Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative initiation
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from physical interaction. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform 1 (identifier: Q92908-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92908-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: Produced by alternative initiation at Met-147 of isoform 1.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 595	595	Transcription factor GATA-6		PRO_0000083423
Regions
	Zinc finger	390 – 414	25	GATA-type 1
	Zinc finger	444 – 468	25	GATA-type 2
	Compositional bias	173 – 183	11	Poly-Ala
	Compositional bias	324 – 333	10	Poly-His
	Compositional bias	449 – 453	5	Poly-Thr
Amino acid modifications
	Modified residue	266	1	Phosphoserine Ref.8
	Modified residue	268	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 146	146	Missing in isoform 2.		VSP_035778
Experimental info
	Sequence conflict	281	1	G → V in CAA64997. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: C4D5410916543E0B	FASTA	595	60,033
	10 20 30 40 50 60 MALTDGGWCL PKRFGAAGAD ASDSRAFPAR EPSTPPSPIS SSSSSCSRGG ERGPGGASNC 70 80 90 100 110 120 GTPQLDTEAA AGPPARSLLL SSYASHPFGA PHGPSAPGVA GPGGNLSSWE DLLLFTDLDQ 130 140 150 160 170 180 AATASKLLWS SRGAKLSPFA PEQPEEMYQT LAALSSQGPA AYDGAPGGFV HSAAAAAAAA 190 200 210 220 230 240 AAASSPVYVP TTRVGSMLPG LPYHLQGSGS GPANHAGGAG AHPGWPQASA DSPPYGSGGG 250 260 270 280 290 300 AAGGGAAGPG GAGSAAAHVS ARFPYSPSPP MANGAAREPG GYAAAGSGGA GGVSGGGSSL 310 320 330 340 350 360 AAMGGREPQY SSLSAARPLN GTYHHHHHHH HHHPSPYSPY VGAPLTPAWP AGPFETPVLH 370 380 390 400 410 420 SLQSRAGAPL PVPRGPSADL LEDLSESREC VNCGSIQTPL WRRDGTGHYL CNACGLYSKM 430 440 450 460 470 480 NGLSRPLIKP QKRVPSSRRL GLSCANCHTT TTTLWRRNAE GEPVCNACGL YMKLHGVPRP 490 500 510 520 530 540 LAMKKEGIQT RKRKPKNINK SKTCSGNSNN SIPMTPTSTS SNSDDCSKNT SPTTQPTASG 550 560 570 580 590 AGAPVMTGAG ESTNPENSEL KYSGQDGLYI GVSLASPAEV TSSVRPDSWC ALALA
	Isoform 2. Checksum: 2A0C294757CC2E92	FASTA	449	45,386
	10 20 30 40 50 60 MYQTLAALSS QGPAAYDGAP GGFVHSAAAA AAAAAAASSP VYVPTTRVGS MLPGLPYHLQ 70 80 90 100 110 120 GSGSGPANHA GGAGAHPGWP QASADSPPYG SGGGAAGGGA AGPGGAGSAA AHVSARFPYS 130 140 150 160 170 180 PSPPMANGAA REPGGYAAAG SGGAGGVSGG GSSLAAMGGR EPQYSSLSAA RPLNGTYHHH 190 200 210 220 230 240 HHHHHHHPSP YSPYVGAPLT PAWPAGPFET PVLHSLQSRA GAPLPVPRGP SADLLEDLSE 250 260 270 280 290 300 SRECVNCGSI QTPLWRRDGT GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN 310 320 330 340 350 360 CHTTTTTLWR RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKTCSG 370 380 390 400 410 420 NSNNSIPMTP TSTSSNSDDC SKNTSPTTQP TASGAGAPVM TGAGESTNPE NSELKYSGQD 430 440 GLYIGVSLAS PAEVTSSVRP DSWCALALA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals." Suzuki E., Evans T., Lowry J., Truong L., Bell D.W., Testa J.R., Walsh K. Genomics 38:283-290(1996) [PubMed: 8975704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut." Huggon I.C., Davies A., Gove C., Moscoso G., Moniz C., Foss Y., Farzaneh F., Towner P. Biochim. Biophys. Acta 1353:98-102(1997) [PubMed: 9294001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Heart.
[3]	"GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells." Yoshida T., Sato R., Mahmood S., Kawasaki S., Futai M., Maeda M. FEBS Lett. 414:333-337(1997) [PubMed: 9315713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	NHLBI resequencing and genotyping service (RS&G) Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The human and mouse GATA-6 genes utilize two promoters and two initiation codons." Brewer A., Gove C., Davies A., McNulty C., Barrow D., Koutsourakis M., Farzaneh F., Pizzey J., Bomford A., Patient R. J. Biol. Chem. 274:38004-38016(1999) [PubMed: 10608869] [Abstract] Cited for: ALTERNATIVE INITIATION.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266 AND SER-268, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U66075 mRNA. Translation: AAC50941.1. X95701 mRNA. Translation: CAA64997.1. D87811 mRNA. Translation: BAA22621.1. EF444980 Genomic DNA. Translation: ACA05995.1. AC091588 Genomic DNA. No translation available. CH471088 Genomic DNA. Translation: EAX01137.1.
IPI	IPI00024236. IPI00915001.
RefSeq	NP_005248.2.
UniGene	Hs.514746
3D structure databases
HSSP	HSSP built from PDB template 1GNF based on UniProtKB P17679.
SMR	Q92908. Positions 239-283.
ModBase	Search...
PTM databases
PhosphoSite	Q92908.
Proteomic databases
PRIDE	Q92908.
Genome annotation databases
Ensembl	ENSG00000141448. Homo sapiens. [Contig view]
GeneID	2627.
KEGG	hsa:2627.
Organism-specific databases
GeneCards	GC18P018001.
H-InvDB	HIX0039732.
HGNC	HGNC:4174. GATA6.
MIM	601656. gene.
PharmGKB	PA28589.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q92908.
OMA	Q92908. SADSPPY.
Gene expression databases
ArrayExpress	Q92908.
Bgee	Q92908.
CleanEx	HS_GATA6.
GermOnline	ENSG00000141448. Homo sapiens.
Family and domain databases
InterPro	IPR008013. GATA_N. IPR000679. Znf_GATA. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:3.30.50.10. Znf_NHR/GATA. 2 hits.
Pfam	PF00320. GATA. 2 hits. PF05349. GATA-N. 1 hit. [Graphical view]
PRINTS	PR00619. GATAZNFINGER.
SMART	SM00401. ZnF_GATA. 2 hits. [Graphical view]
PROSITE	PS00344. GATA_ZN_FINGER_1. 2 hits. PS50114. GATA_ZN_FINGER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

GATA6_HUMAN

Accession

Primary (citable) accession number: Q92908
Secondary accession number(s): B0YJ17, P78327

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 25, 2008
Last modified:	June 16, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)