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Q92908 (GATA6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene names
Name:GATA6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length595 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thought to be important for regulating terminal differentiation and/or proliferation.

Subunit structure

Interacts with LMCD1 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in heart, gut and gut-derived tissues.

Domain

The GATA-type zinc fingers mediate interaction with LMCD1 By similarity.

Sequence similarities

Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative initiation
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processblood coagulation

Traceable author statement. Source: Reactome

cardiac vascular smooth muscle cell differentiation

Inferred from mutant phenotype. Source: UniProtKB

cellular response to hypoxia

Inferred from direct assay. Source: UniProtKB

intestinal epithelial cell differentiation

Inferred from direct assay. Source: MGI

male gonad development

Inferred from expression pattern. Source: UniProtKB

negative regulation of apoptotic process

Inferred from mutant phenotype. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: UniProtKB

negative regulation of transforming growth factor beta1 production

Inferred from mutant phenotype. Source: UniProtKB

negative regulation of transforming growth factor beta2 production

Inferred from mutant phenotype. Source: UniProtKB

outflow tract septum morphogenesis

Inferred from mutant phenotype. Source: BHF-UCL

positive regulation of angiogenesis

Inferred from direct assay. Source: UniProtKB

positive regulation of cell cycle arrest

Inferred from direct assay. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: UniProtKB

response to drug

Inferred from mutant phenotype. Source: UniProtKB

response to growth factor stimulus

Inferred from direct assay. Source: UniProtKB

   Molecular functionprotein binding

Inferred from physical interaction. Source: UniProtKB

protein kinase binding

Inferred from physical interaction. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from direct assay. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform 1 (identifier: Q92908-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92908-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.
Note: Produced by alternative initiation at Met-147 of isoform 1.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 595595Transcription factor GATA-6
PRO_0000083423

Regions

Zinc finger390 – 41425GATA-type 1
Zinc finger444 – 46825GATA-type 2
Compositional bias173 – 18311Poly-Ala
Compositional bias324 – 33310Poly-His
Compositional bias449 – 4535Poly-Thr

Amino acid modifications

Modified residue2661Phosphoserine Ref.8
Modified residue2681Phosphoserine Ref.8
Modified residue5341Phosphothreonine Ref.9

Natural variations

Alternative sequence1 – 146146Missing in isoform 2.
VSP_035778

Experimental info

Sequence conflict2811G → V in CAA64997. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: C4D5410916543E0B

FASTA59560,033
        10         20         30         40         50         60 
MALTDGGWCL PKRFGAAGAD ASDSRAFPAR EPSTPPSPIS SSSSSCSRGG ERGPGGASNC 

        70         80         90        100        110        120 
GTPQLDTEAA AGPPARSLLL SSYASHPFGA PHGPSAPGVA GPGGNLSSWE DLLLFTDLDQ 

       130        140        150        160        170        180 
AATASKLLWS SRGAKLSPFA PEQPEEMYQT LAALSSQGPA AYDGAPGGFV HSAAAAAAAA 

       190        200        210        220        230        240 
AAASSPVYVP TTRVGSMLPG LPYHLQGSGS GPANHAGGAG AHPGWPQASA DSPPYGSGGG 

       250        260        270        280        290        300 
AAGGGAAGPG GAGSAAAHVS ARFPYSPSPP MANGAAREPG GYAAAGSGGA GGVSGGGSSL 

       310        320        330        340        350        360 
AAMGGREPQY SSLSAARPLN GTYHHHHHHH HHHPSPYSPY VGAPLTPAWP AGPFETPVLH 

       370        380        390        400        410        420 
SLQSRAGAPL PVPRGPSADL LEDLSESREC VNCGSIQTPL WRRDGTGHYL CNACGLYSKM 

       430        440        450        460        470        480 
NGLSRPLIKP QKRVPSSRRL GLSCANCHTT TTTLWRRNAE GEPVCNACGL YMKLHGVPRP 

       490        500        510        520        530        540 
LAMKKEGIQT RKRKPKNINK SKTCSGNSNN SIPMTPTSTS SNSDDCSKNT SPTTQPTASG 

       550        560        570        580        590 
AGAPVMTGAG ESTNPENSEL KYSGQDGLYI GVSLASPAEV TSSVRPDSWC ALALA 

« Hide

Isoform 2 [UniParc].

Checksum: 2A0C294757CC2E92
Show »

FASTA44945,386

References

« Hide 'large scale' references
[1]"The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals."
Suzuki E., Evans T., Lowry J., Truong L., Bell D.W., Testa J.R., Walsh K.
Genomics 38:283-290(1996) [PubMed: 8975704] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut."
Huggon I.C., Davies A., Gove C., Moscoso G., Moniz C., Foss Y., Farzaneh F., Towner P.
Biochim. Biophys. Acta 1353:98-102(1997) [PubMed: 9294001] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Heart.
[3]"GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells."
Yoshida T., Sato R., Mahmood S., Kawasaki S., Futai M., Maeda M.
FEBS Lett. 414:333-337(1997) [PubMed: 9315713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]NHLBI resequencing and genotyping service (RS&G)
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed: 16177791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The human and mouse GATA-6 genes utilize two promoters and two initiation codons."
Brewer A., Gove C., Davies A., McNulty C., Barrow D., Koutsourakis M., Farzaneh F., Pizzey J., Bomford A., Patient R.
J. Biol. Chem. 274:38004-38016(1999) [PubMed: 10608869] [Abstract]
Cited for: ALTERNATIVE INITIATION.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266 AND SER-268, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-534, MASS SPECTROMETRY.
Tissue: Embryonic kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66075 mRNA. Translation: AAC50941.1.
X95701 mRNA. Translation: CAA64997.1.
D87811 mRNA. Translation: BAA22621.1.
EF444980 Genomic DNA. Translation: ACA05995.1.
AC091588 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01137.1.
IPIIPI00024236.
IPI00915001.
RefSeqNP_005248.2. NM_005257.3.
UniGeneHs.514746.

3D structure databases

ProteinModelPortalQ92908.
SMRQ92908. Positions 386-422, 438-493.
ModBaseSearch...

Protein-protein interaction databases

IntActQ92908. 2 interactions.
STRINGQ92908.

PTM databases

PhosphoSiteQ92908.

Polymorphism databases

DMDM215273987.

Proteomic databases

PRIDEQ92908.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269216; ENSP00000269216; ENSG00000141448.
GeneID2627.
KEGGhsa:2627.
UCSCuc002ktt.1. human.

Organism-specific databases

CTD2627.
GeneCardsGC18P019749.
H-InvDBHIX0039732.
HGNCHGNC:4174. GATA6.
HPACAB011581.
MIM601656. gene.
neXtProtNX_Q92908.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG17015.
GeneTreeENSGT00550000074470.
HOGENOMHBG716943.
HOVERGENHBG051703.
InParanoidQ92908.
OMAGAHPGWP.
OrthoDBEOG4TMR21.
PhylomeDBQ92908.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

ArrayExpressQ92908.
BgeeQ92908.
CleanExHS_GATA6.
GenevestigatorQ92908.
GermOnlineENSG00000141448. Homo sapiens.

Family and domain databases

InterProIPR008013. GATA_N.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
Gene3DG3DSA:3.30.50.10. Znf_NHR/GATA. 2 hits.
KOK09183.
PfamPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PRINTSPR00619. GATAZNFINGER.
SMARTSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameGATA6_HUMAN
AccessionPrimary (citable) accession number: Q92908
Secondary accession number(s): B0YJ17, P78327
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: January 25, 2012
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families