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Protein

Phosphatidate cytidylyltransferase 1

Gene

CDS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Cofactori

Mg2+By similarity

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 4 (GPAT4), Glycerol-3-phosphate acyltransferase 3 (GPAT3), Glycerol-3-phosphate acyltransferase 1, mitochondrial, Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (DKFZp451B1115)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), Lysocardiolipin acyltransferase 1 (LCLAT1)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), Phosphatidate cytidylyltransferase (CDS1), Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

  • diacylglycerol cholinephosphotransferase activity Source: UniProtKB
  • phosphatidate cytidylyltransferase activity Source: UniProtKB

GO - Biological processi

  • CDP-diacylglycerol biosynthetic process Source: UniProtKB
  • phosphatidylglycerol biosynthetic process Source: GO_Central
  • phosphatidylinositol biosynthetic process Source: UniProtKB
  • phototransduction Source: UniProtKB
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciZFISH:HS08895-MONOMER.
BRENDAi2.7.7.41. 2681.
ReactomeiR-HSA-1483226. Synthesis of PI.
SIGNORiQ92903.
UniPathwayiUPA00557; UER00614.

Chemistry databases

SwissLipidsiSLP:000000532.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 1 (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase 1
CDP-DG synthase 1
CDP-diacylglycerol synthase 1
Short name:
CDS 1
CDP-diglyceride pyrophosphorylase 1
CDP-diglyceride synthase 1
CTP:phosphatidate cytidylyltransferase 1
Gene namesi
Name:CDS1
Synonyms:CDS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:1800. CDS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1040.
MalaCardsiCDS1.
OpenTargetsiENSG00000163624.
PharmGKBiPA26346.

Polymorphism and mutation databases

BioMutaiCDS1.
DMDMi3123204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907131 – 461Phosphatidate cytidylyltransferase 1Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Omega-N-methylarginineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ92903.
MaxQBiQ92903.
PaxDbiQ92903.
PeptideAtlasiQ92903.
PRIDEiQ92903.

PTM databases

iPTMnetiQ92903.
PhosphoSitePlusiQ92903.

Expressioni

Tissue specificityi

Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver.

Gene expression databases

BgeeiENSG00000163624.
CleanExiHS_CDS1.
ExpressionAtlasiQ92903. baseline and differential.
GenevisibleiQ92903. HS.

Organism-specific databases

HPAiHPA036187.

Interactioni

Subunit structurei

Interacts with FOS; this interaction may enhance catalytic activity.By similarity

Protein-protein interaction databases

BioGridi107471. 13 interactors.
STRINGi9606.ENSP00000295887.

Structurei

3D structure databases

ProteinModelPortaliQ92903.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1440. Eukaryota.
COG0575. LUCA.
GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.
InParanoidiQ92903.
KOiK00981.
OMAiSARWKNW.
OrthoDBiEOG091G06CA.
PhylomeDBiQ92903.
TreeFamiTF313464.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELRHRGSC PGPREAVSPP HREGEAAGGD HETESTSDKE TDIDDRYGDL
60 70 80 90 100
DSRTDSDIPE IPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF
110 120 130 140 150
FLIIYMGSFM LMLLVLGIQV KCFHEIITIG YRVYHSYDLP WFRTLSWYFL
160 170 180 190 200
LCVNYFFYGE TVADYFATFV QREEQLQFLI RYHRFISFAL YLAGFCMFVL
210 220 230 240 250
SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI WFLVPISSVI
260 270 280 290 300
CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVVF GFIAAYVLSK
310 320 330 340 350
YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ TYSLPPFLKA VLRQERVSLY
360 370 380 390 400
PFQIHSIALS TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF
410 420 430 440 450
DCQYLMATFV HVYITSFIRG PNPSKVLQQL LVLQPEQQLN IYKTLKTHLI
460
EKGILQPTLK V
Length:461
Mass (Da):53,304
Last modified:July 15, 1998 - v2
Checksum:iE9D761BA285A5AB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti444 – 461TLKTH…PTLKV → P in AAC50735 (PubMed:8863531).CuratedAdd BLAST18

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04873699L → F.Corresponds to variant rs36068434dbSNPEnsembl.1
Natural variantiVAR_036129204K → T in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65887 mRNA. Translation: AAC50735.1.
U60808 mRNA. Translation: AAC51184.1.
AK314245 mRNA. Translation: BAG36912.1.
CH471057 Genomic DNA. Translation: EAX05950.1.
BC074833 mRNA. Translation: AAH74833.1.
BC074881 mRNA. Translation: AAH74881.1.
CCDSiCCDS3608.1.
RefSeqiNP_001254.2. NM_001263.3.
UniGeneiHs.654899.
Hs.708641.

Genome annotation databases

EnsembliENST00000295887; ENSP00000295887; ENSG00000163624.
GeneIDi1040.
KEGGihsa:1040.
UCSCiuc011ccv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65887 mRNA. Translation: AAC50735.1.
U60808 mRNA. Translation: AAC51184.1.
AK314245 mRNA. Translation: BAG36912.1.
CH471057 Genomic DNA. Translation: EAX05950.1.
BC074833 mRNA. Translation: AAH74833.1.
BC074881 mRNA. Translation: AAH74881.1.
CCDSiCCDS3608.1.
RefSeqiNP_001254.2. NM_001263.3.
UniGeneiHs.654899.
Hs.708641.

3D structure databases

ProteinModelPortaliQ92903.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107471. 13 interactors.
STRINGi9606.ENSP00000295887.

Chemistry databases

SwissLipidsiSLP:000000532.

PTM databases

iPTMnetiQ92903.
PhosphoSitePlusiQ92903.

Polymorphism and mutation databases

BioMutaiCDS1.
DMDMi3123204.

Proteomic databases

EPDiQ92903.
MaxQBiQ92903.
PaxDbiQ92903.
PeptideAtlasiQ92903.
PRIDEiQ92903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295887; ENSP00000295887; ENSG00000163624.
GeneIDi1040.
KEGGihsa:1040.
UCSCiuc011ccv.3. human.

Organism-specific databases

CTDi1040.
DisGeNETi1040.
GeneCardsiCDS1.
HGNCiHGNC:1800. CDS1.
HPAiHPA036187.
MalaCardsiCDS1.
MIMi603548. gene.
neXtProtiNX_Q92903.
OpenTargetsiENSG00000163624.
PharmGKBiPA26346.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1440. Eukaryota.
COG0575. LUCA.
GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.
InParanoidiQ92903.
KOiK00981.
OMAiSARWKNW.
OrthoDBiEOG091G06CA.
PhylomeDBiQ92903.
TreeFamiTF313464.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.
BioCyciZFISH:HS08895-MONOMER.
BRENDAi2.7.7.41. 2681.
ReactomeiR-HSA-1483226. Synthesis of PI.
SIGNORiQ92903.

Miscellaneous databases

ChiTaRSiCDS1. human.
GeneWikiiCDS1_(gene).
GenomeRNAii1040.
PROiQ92903.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163624.
CleanExiHS_CDS1.
ExpressionAtlasiQ92903. baseline and differential.
GenevisibleiQ92903. HS.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDS1_HUMAN
AccessioniPrimary (citable) accession number: Q92903
Secondary accession number(s): B2RAL5, O00163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.