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Q92903 (CDS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidate cytidylyltransferase 1

EC=2.7.7.41
Alternative name(s):
CDP-DAG synthase 1
CDP-DG synthase 1
CDP-diacylglycerol synthase 1
Short name=CDS 1
CDP-diglyceride pyrophosphorylase 1
CDP-diglyceride synthase 1
CTP:phosphatidate cytidylyltransferase 1
Gene names
Name:CDS1
Synonyms:CDS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Cofactor

Magnesium By similarity.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subunit structure

Interacts with FOS; this interaction may enhance catalytic activity By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Note: Cytoplasmic aspect of the endoplasmic reticulum By similarity.

Tissue specificity

Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver.

Sequence similarities

Belongs to the CDS family.

Ontologies

Keywords
   Biological processLipid biosynthesis
Lipid metabolism
Phospholipid biosynthesis
Phospholipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCDP-choline pathway

Non-traceable author statement Ref.2. Source: GOC

CDP-diacylglycerol biosynthetic process

Inferred from direct assay Ref.3. Source: UniProtKB

glycerophospholipid biosynthetic process

Traceable author statement. Source: Reactome

phosphatidylinositol biosynthetic process

Inferred from direct assay Ref.3. Source: UniProtKB

phospholipid metabolic process

Traceable author statement. Source: Reactome

phototransduction

Non-traceable author statement Ref.4. Source: UniProtKB

signal transduction

Non-traceable author statement Ref.2. Source: UniProtKB

small molecule metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentendoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum membrane

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondiacylglycerol cholinephosphotransferase activity

Non-traceable author statement Ref.2. Source: UniProtKB

phosphatidate cytidylyltransferase activity

Inferred from direct assay Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Phosphatidate cytidylyltransferase 1
PRO_0000090713

Regions

Transmembrane96 – 11621Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane357 – 37721Helical; Potential

Natural variations

Natural variant991L → F.
Corresponds to variant rs36068434 [ dbSNP | Ensembl ].
VAR_048736
Natural variant2041K → T in a breast cancer sample; somatic mutation. Ref.8
VAR_036129

Experimental info

Sequence conflict444 – 46118TLKTH…PTLKV → P in AAC50735. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q92903 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: E9D761BA285A5AB1

FASTA46153,304
        10         20         30         40         50         60 
MLELRHRGSC PGPREAVSPP HREGEAAGGD HETESTSDKE TDIDDRYGDL DSRTDSDIPE 

        70         80         90        100        110        120 
IPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF FLIIYMGSFM LMLLVLGIQV 

       130        140        150        160        170        180 
KCFHEIITIG YRVYHSYDLP WFRTLSWYFL LCVNYFFYGE TVADYFATFV QREEQLQFLI 

       190        200        210        220        230        240 
RYHRFISFAL YLAGFCMFVL SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI 

       250        260        270        280        290        300 
WFLVPISSVI CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVVF GFIAAYVLSK 

       310        320        330        340        350        360 
YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ TYSLPPFLKA VLRQERVSLY PFQIHSIALS 

       370        380        390        400        410        420 
TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF DCQYLMATFV HVYITSFIRG 

       430        440        450        460 
PNPSKVLQQL LVLQPEQQLN IYKTLKTHLI EKGILQPTLK V 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of CDP-diacylglycerol synthase from a human neuronal cell line."
Heacock A.M., Uhler M.D., Agranoff B.W.
J. Neurochem. 67:2200-2203(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Neuron.
[2]"Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA."
Weeks R., Dowhan W., Shen H., Balantac N., Meengs B., Nudelman E., Leung D.W.
DNA Cell Biol. 16:281-289(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leukocyte and Placenta.
[3]"The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content."
Lykidis A., Jackson P.D., Rock C.O., Jackowski S.
J. Biol. Chem. 272:33402-33409(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[4]"Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes."
Halford S., Dulai K.S., Daw S.C.M., Fitzgibbon J., Hunt D.M.
Genomics 54:140-144(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-204.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U65887 mRNA. Translation: AAC50735.1.
U60808 mRNA. Translation: AAC51184.1.
AK314245 mRNA. Translation: BAG36912.1.
CH471057 Genomic DNA. Translation: EAX05950.1.
BC074833 mRNA. Translation: AAH74833.1.
BC074881 mRNA. Translation: AAH74881.1.
CCDSCCDS3608.1.
RefSeqNP_001254.2. NM_001263.3.
UniGeneHs.654899.
Hs.708641.

3D structure databases

ProteinModelPortalQ92903.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107471. 2 interactions.
STRING9606.ENSP00000295887.

PTM databases

PhosphoSiteQ92903.

Polymorphism databases

DMDM3123204.

Proteomic databases

MaxQBQ92903.
PaxDbQ92903.
PRIDEQ92903.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295887; ENSP00000295887; ENSG00000163624.
GeneID1040.
KEGGhsa:1040.
UCSCuc011ccv.2. human.

Organism-specific databases

CTD1040.
GeneCardsGC04P085428.
HGNCHGNC:1800. CDS1.
HPAHPA036187.
MIM603548. gene.
neXtProtNX_Q92903.
PharmGKBPA26346.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0575.
HOGENOMHOG000209582.
HOVERGENHBG002485.
InParanoidQ92903.
KOK00981.
OMANFAWTHM.
OrthoDBEOG7M98G5.
PhylomeDBQ92903.
TreeFamTF313464.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
UniPathwayUPA00557; UER00614.

Gene expression databases

ArrayExpressQ92903.
BgeeQ92903.
CleanExHS_CDS1.
GenevestigatorQ92903.

Family and domain databases

InterProIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFPIRSF018269. PC_trans_euk. 1 hit.
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCDS1_(gene).
GenomeRNAi1040.
NextBio4365.
PROQ92903.
SOURCESearch...

Entry information

Entry nameCDS1_HUMAN
AccessionPrimary (citable) accession number: Q92903
Secondary accession number(s): B2RAL5, O00163
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM