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Protein

60S ribosomal protein L3-like

Gene

RPL3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L3-like
Gene namesi
Name:RPL3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:10351. RPL3L.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • membrane Source: UniProtKB
  • ribosome Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34746.

Polymorphism and mutation databases

BioMutaiRPL3L.
DMDMi2500230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 40740760S ribosomal protein L3-likePRO_0000077233Add
BLAST

Proteomic databases

EPDiQ92901.
MaxQBiQ92901.
PaxDbiQ92901.
PeptideAtlasiQ92901.
PRIDEiQ92901.

PTM databases

iPTMnetiQ92901.
PhosphoSiteiQ92901.
SwissPalmiQ92901.

Expressioni

Gene expression databases

BgeeiQ92901.
CleanExiHS_RPL3L.
ExpressionAtlasiQ92901. baseline and differential.
GenevisibleiQ92901. HS.

Organism-specific databases

HPAiHPA049136.

Interactioni

Protein-protein interaction databases

BioGridi112043. 38 interactions.
IntActiQ92901. 2 interactions.
MINTiMINT-4132630.
STRINGi9606.ENSP00000268661.

Structurei

3D structure databases

ProteinModelPortaliQ92901.
SMRiQ92901. Positions 7-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L3P family.Curated

Phylogenomic databases

eggNOGiKOG0746. Eukaryota.
COG0087. LUCA.
GeneTreeiENSGT00390000017606.
HOGENOMiHOG000107319.
HOVERGENiHBG001864.
InParanoidiQ92901.
KOiK02925.
OMAiGCFQTAQ.
OrthoDBiEOG7HF1JK.
PhylomeDBiQ92901.
TreeFamiTF300555.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRKFSAPR HGHLGFLPHK RSHRHRGKVK TWPRDDPSQP VHLTAFLGYK
60 70 80 90 100
AGMTHTLREV HRPGLKISKR EEVEAVTIVE TPPLVVVGVV GYVATPRGLR
110 120 130 140 150
SFKTIFAEHL SDECRRRFYK DWHKSKKKAF TKACKRWRDT DGKKQLQKDF
160 170 180 190 200
AAMKKYCKVI RVIVHTQMKL LPFRQKKAHI MEIQLNGGTV AEKVAWAQAR
210 220 230 240 250
LEKQVPVHSV FSQSEVIDVI AVTKGRGVKG VTSRWHTKKL PRKTHKGLRK
260 270 280 290 300
VACIGAWHPA RVGCSIARAG QKGYHHRTEL NKKIFRIGRG PHMEDGKLVK
310 320 330 340 350
NNASTSYDVT AKSITPLGGF PHYGEVNNDF VMLKGCIAGT KKRVITLRKS
360 370 380 390 400
LLVHHSRQAV ENIELKFIDT TSKFGHGRFQ TAQEKRAFMG PQKKHLEKET

PETSGDL
Length:407
Mass (Da):46,296
Last modified:January 23, 2007 - v3
Checksum:i1965327E225F80D2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti291 – 2911P → L.
Corresponds to variant rs34265469 [ dbSNP | Ensembl ].
VAR_034461

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65581 mRNA. Translation: AAC50777.1.
AE006640 Genomic DNA. Translation: AAK61301.1.
BC050413 mRNA. Translation: AAH50413.1.
CCDSiCCDS10450.1.
RefSeqiNP_005052.1. NM_005061.2.
UniGeneiHs.657266.

Genome annotation databases

EnsembliENST00000268661; ENSP00000268661; ENSG00000140986.
GeneIDi6123.
KEGGihsa:6123.
UCSCiuc002cnh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65581 mRNA. Translation: AAC50777.1.
AE006640 Genomic DNA. Translation: AAK61301.1.
BC050413 mRNA. Translation: AAH50413.1.
CCDSiCCDS10450.1.
RefSeqiNP_005052.1. NM_005061.2.
UniGeneiHs.657266.

3D structure databases

ProteinModelPortaliQ92901.
SMRiQ92901. Positions 7-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112043. 38 interactions.
IntActiQ92901. 2 interactions.
MINTiMINT-4132630.
STRINGi9606.ENSP00000268661.

PTM databases

iPTMnetiQ92901.
PhosphoSiteiQ92901.
SwissPalmiQ92901.

Polymorphism and mutation databases

BioMutaiRPL3L.
DMDMi2500230.

Proteomic databases

EPDiQ92901.
MaxQBiQ92901.
PaxDbiQ92901.
PeptideAtlasiQ92901.
PRIDEiQ92901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268661; ENSP00000268661; ENSG00000140986.
GeneIDi6123.
KEGGihsa:6123.
UCSCiuc002cnh.4. human.

Organism-specific databases

CTDi6123.
GeneCardsiRPL3L.
HGNCiHGNC:10351. RPL3L.
HPAiHPA049136.
neXtProtiNX_Q92901.
PharmGKBiPA34746.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0746. Eukaryota.
COG0087. LUCA.
GeneTreeiENSGT00390000017606.
HOGENOMiHOG000107319.
HOVERGENiHBG001864.
InParanoidiQ92901.
KOiK02925.
OMAiGCFQTAQ.
OrthoDBiEOG7HF1JK.
PhylomeDBiQ92901.
TreeFamiTF300555.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

GenomeRNAii6123.
NextBioi23783.
PROiQ92901.

Gene expression databases

BgeeiQ92901.
CleanExiHS_RPL3L.
ExpressionAtlasiQ92901. baseline and differential.
GenevisibleiQ92901. HS.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region."
    van Raay T.J., Connors T.D., Klinger K.W., Landes G.M., Burn T.C.
    Genomics 37:172-176(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart muscle.
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.

Entry informationi

Entry nameiRL3L_HUMAN
AccessioniPrimary (citable) accession number: Q92901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: March 16, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.