ID RENT1_HUMAN Reviewed; 1118 AA. AC Q92900-2; DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot. DT 18-OCT-2001, sequence version 2. DT 27-MAR-2024, entry version 225. DE RecName: Full=Isoform 2 of Regulator of nonsense transcripts 1 {ECO:0000312|HGNC:HGNC:9962}; DE EC=3.6.4.12 {ECO:0000269|PubMed:10999600, ECO:0000269|PubMed:30218034}; DE EC=3.6.4.13 {ECO:0000305|PubMed:10999600}; DE AltName: Full=ATP-dependent helicase RENT1 {ECO:0000250|UniProtKB:Q9EPU0}; DE AltName: Full=Nonsense mRNA reducing factor 1 {ECO:0000312|HGNC:HGNC:9962}; DE Short=NORF1 {ECO:0000312|HGNC:HGNC:9962}; DE AltName: Full=Up-frameshift suppressor 1 homolog; DE Short=hUpf1; GN Name=UPF1 {ECO:0000312|HGNC:HGNC:9962}; GN Synonyms=KIAA0221, RENT1 {ECO:0000312|HGNC:HGNC:9962}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RC TISSUE=Heart; RX PubMed=8855285; DOI=10.1073/pnas.93.20.10928; RA Perlick H.A., Medghalchi S.M., Spencer F.A., Kendzior R.J. Jr., Dietz H.C.; RT "Mammalian orthologues of a yeast regulator of nonsense transcript RT stability."; RL Proc. Natl. Acad. Sci. U.S.A. 93:10928-10932(1996). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND CHARACTERIZATION. RX PubMed=9064659; DOI=10.1093/nar/25.4.814; RA Applequist S.E., Selg M., Raman C., Jaeck H.-M.; RT "Cloning and characterization of HUPF1, a human homolog of the RT Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein."; RL Nucleic Acids Res. 25:814-821(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-69. RC TISSUE=Bone marrow; RX PubMed=9039502; DOI=10.1093/dnares/3.5.321; RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., RA Tanaka A., Kotani H., Miyajima N., Nomura N.; RT "Prediction of the coding sequences of unidentified human genes. VI. The RT coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of RT cDNA clones from cell line KG-1 and brain."; RL DNA Res. 3:321-329(1996). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RX PubMed=10454541; DOI=10.1128/mcb.19.9.5943; RA Page M.F., Carr B., Anders K.R., Grimson A., Anderson P.; RT "SMG-2 is a phosphorylated protein required for mRNA surveillance in RT Caenorhabditis elegans and related to Upf1p of yeast."; RL Mol. Cell. Biol. 19:5943-5951(1999). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP FUNCTION IN NONSENSE-MEDIATED MRNA DECAY, INTERACTION WITH UPF2; UPF3A AND RP UPF3B, SUBCELLULAR LOCATION, AND MUTAGENESIS OF ARG-843. RX PubMed=11163187; DOI=10.1016/s0092-8674(00)00214-2; RA Lykke-Andersen J., Shu M.-D., Steitz J.A.; RT "Human Upf proteins target an mRNA for nonsense-mediated decay when bound RT downstream of a termination codon."; RL Cell 103:1121-1131(2000). RN [8] RP INTERACTION WITH UPF2. RX PubMed=11073994; DOI=10.1128/mcb.20.23.8944-8957.2000; RA Mendell J.T., Medghalchi S.M., Lake R.G., Noensie E.N., Dietz H.C.; RT "Novel Upf2p orthologues suggest a functional link between translation RT initiation and nonsense surveillance complexes."; RL Mol. Cell. Biol. 20:8944-8957(2000). RN [9] RP FUNCTION, ENZYME ACTIVITY, CATALYTIC ACTIVITY, RNA-BINDING, AND MUTAGENESIS RP OF 647-ASP-GLU-648. RX PubMed=10999600; DOI=10.1017/s1355838200000546; RA Bhattacharya A., Czaplinski K., Trifillis P., He F., Jacobson A., RA Peltz S.W.; RT "Characterization of the biochemical properties of the human Upf1 gene RT product that is involved in nonsense-mediated mRNA decay."; RL RNA 6:1226-1235(2000). RN [10] RP FUNCTION, PHOSPHORYLATION AT SER-1089 AND SER-1107, AND MUTAGENESIS OF RP SER-1089; SER-1107 AND GLN-1108. RX PubMed=11544179; DOI=10.1101/gad.913001; RA Yamashita A., Ohnishi T., Kashima I., Taya Y., Ohno S.; RT "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, RT associates with components of the mRNA surveillance complex and is involved RT in the regulation of nonsense-mediated mRNA decay."; RL Genes Dev. 15:2215-2228(2001). RN [11] RP PHOSPHORYLATION. RX PubMed=11331269; DOI=10.1074/jbc.c100144200; RA Denning G., Jamieson L., Maquat L.E., Thompson E.A., Fields A.P.; RT "Cloning of a novel phosphatidylinositol kinase-related kinase: RT characterization of the human SMG-1 RNA surveillance protein."; RL J. Biol. Chem. 276:22709-22714(2001). RN [12] RP INTERACTION WITH UPF2, AND SUBCELLULAR LOCATION. RX PubMed=11113196; DOI=10.1128/mcb.21.1.209-223.2001; RA Serin G., Gersappe A., Black J.D., Aronoff R., Maquat L.E.; RT "Identification and characterization of human orthologues to Saccharomyces RT cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)."; RL Mol. Cell. Biol. 21:209-223(2001). RN [13] RP IDENTIFICATION IN A POST-SPLICING MRNP COMPLEX, AND ASSOCIATION WITH THE RP EJC COMPLEX. RX PubMed=11546874; DOI=10.1126/science.1062786; RA Lykke-Andersen J., Shu M.-D., Steitz J.A.; RT "Communication of the position of exon-exon junctions to the mRNA RT surveillance machinery by the protein RNPS1."; RL Science 293:1836-1839(2001). RN [14] RP PHOSPHORYLATION. RX PubMed=14636577; DOI=10.1016/s1097-2765(03)00443-x; RA Ohnishi T., Yamashita A., Kashima I., Schell T., Anders K.R., Grimson A., RA Hachiya T., Hentze M.W., Anderson P., Ohno S.; RT "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes RT containing hSMG-5 and hSMG-7."; RL Mol. Cell 12:1187-1200(2003). RN [15] RP FUNCTION, AND INTERACTION WITH EST1A. RX PubMed=12554878; DOI=10.1261/rna.2137903; RA Chiu S.-Y., Serin G., Ohara O., Maquat L.E.; RT "Characterization of human Smg5/7a: a protein with similarities to RT Caenorhabditis elegans SMG5 and SMG7 that functions in the RT dephosphorylation of Upf1."; RL RNA 9:77-87(2003). RN [16] RP INTERACTION WITH SMG7. RX PubMed=15721257; DOI=10.1016/j.molcel.2005.01.010; RA Fukuhara N., Ebert J., Unterholzner L., Lindner D., Izaurralde E., RA Conti E.; RT "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay RT pathway."; RL Mol. Cell 17:537-547(2005). RN [17] RP FUNCTION, INTERACTION WITH SLBP, AND MUTAGENESIS OF LYS-509 AND ARG-843. RX PubMed=16086026; DOI=10.1038/nsmb972; RA Kaygun H., Marzluff W.F.; RT "Regulated degradation of replication-dependent histone mRNAs requires both RT ATR and Upf1."; RL Nat. Struct. Mol. Biol. 12:794-800(2005). RN [18] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling RT networks."; RL Cell 127:635-648(2006). RN [19] RP IDENTIFICATION IN THE SURF COMPLEX, PHOSPHORYLATION AT SER-1089 AND RP SER-1107, AND MUTAGENESIS OF CYS-126; LYS-509; SER-1084; SER-1089; SER-1107 RP AND SER-1127. RX PubMed=16452507; DOI=10.1101/gad.1389006; RA Kashima I., Yamashita A., Izumi N., Kataoka N., Morishita R., Hoshino S., RA Ohno M., Dreyfuss G., Ohno S.; RT "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon RT junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA RT decay."; RL Genes Dev. 20:355-367(2006). RN [20] RP INTERACTION WITH AGO1 AND AGO2. RX PubMed=17932509; DOI=10.1038/sj.embor.7401088; RA Hoeck J., Weinmann L., Ender C., Ruedel S., Kremmer E., Raabe M., RA Urlaub H., Meister G.; RT "Proteomic and functional analysis of Argonaute-containing mRNA-protein RT complexes in human cells."; RL EMBO Rep. 8:1052-1060(2007). RN [21] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Embryonic kidney; RX PubMed=17525332; DOI=10.1126/science.1140321; RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., RA Gygi S.P., Elledge S.J.; RT "ATM and ATR substrate analysis reveals extensive protein networks RT responsive to DNA damage."; RL Science 316:1160-1166(2007). RN [22] RP FUNCTION IN HISTONE MRNA DEGRADATION ACTIVITY. RX PubMed=18172165; DOI=10.1101/gad.1622708; RA Mullen T.E., Marzluff W.F.; RT "Degradation of histone mRNA requires oligouridylation followed by RT decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to RT 5'."; RL Genes Dev. 22:50-65(2008). RN [23] RP FUNCTION, AND INTERACTION WITH GSPT2. RX PubMed=18447585; DOI=10.1371/journal.pbio.0060111; RA Singh G., Rebbapragada I., Lykke-Andersen J.; RT "A competition between stimulators and antagonists of Upf complex RT recruitment governs human nonsense-mediated mRNA decay."; RL PLoS Biol. 6:E111-E111(2008). RN [24] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [25] RP INTERACTION WITH ADAR, AND SUBCELLULAR LOCATION. RX PubMed=18362360; DOI=10.1073/pnas.0710576105; RA Agranat L., Raitskin O., Sperling J., Sperling R.; RT "The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact RT in the cell nucleus."; RL Proc. Natl. Acad. Sci. U.S.A. 105:5028-5033(2008). RN [26] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [27] RP FUNCTION, ASSOCIATION WITH THE SMG1C COMPLEX, AND MUTAGENESIS OF CYS-126. RX PubMed=19417104; DOI=10.1101/gad.1767209; RA Yamashita A., Izumi N., Kashima I., Ohnishi T., Saari B., Katsuhata Y., RA Muramatsu R., Morita T., Iwamatsu A., Hachiya T., Kurata R., Hirano H., RA Anderson P., Ohno S.; RT "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate RT remodeling of the mRNA surveillance complex during nonsense-mediated mRNA RT decay."; RL Genes Dev. 23:1091-1105(2009). RN [28] RP INTERACTION WITH CPSF6. RX PubMed=19864460; DOI=10.1091/mbc.e09-05-0389; RA Ruepp M.D., Aringhieri C., Vivarelli S., Cardinale S., Paro S., RA Schuemperli D., Barabino S.M.; RT "Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA RT export."; RL Mol. Biol. Cell 20:5211-5223(2009). RN [29] RP SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH PNRC2, AND RP MUTAGENESIS OF 506-GLY--GLY-508. RX PubMed=19150429; DOI=10.1016/j.molcel.2008.11.022; RA Cho H., Kim K.M., Kim Y.K.; RT "Human proline-rich nuclear receptor coregulatory protein 2 mediates an RT interaction between mRNA surveillance machinery and decapping complex."; RL Mol. Cell 33:75-86(2009). RN [30] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [31] RP FUNCTION IN MRNP DISASSEMBLY. RX PubMed=21145460; DOI=10.1016/j.cell.2010.11.043; RA Franks T.M., Singh G., Lykke-Andersen J.; RT "Upf1 ATPase-dependent mRNP disassembly is required for completion of RT nonsense- mediated mRNA decay."; RL Cell 143:938-950(2010). RN [32] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107; SER-1110 AND SER-1127, RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [33] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [34] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107 AND SER-1110, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [35] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-565; SER-956 AND SER-1107, RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [36] RP FUNCTION, INTERACTION WITH DHX34; PABPC1 AND UPF2, AND MUTAGENESIS OF RP CYS-126; 181-LEU--TYR-184; 204-VAL--VAL-205; GLY-506; GLY-508 AND LYS-509. RX PubMed=25220460; DOI=10.1016/j.celrep.2014.08.020; RA Hug N., Caceres J.F.; RT "The RNA helicase DHX34 activates NMD by promoting a transition from the RT surveillance to the decay-inducing complex."; RL Cell Rep. 8:1845-1856(2014). RN [37] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-31, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [38] RP FUNCTION, AND INTERACTION WITH MOV10. RX PubMed=24726324; DOI=10.1016/j.molcel.2014.03.017; RA Gregersen L.H., Schueler M., Munschauer M., Mastrobuoni G., Chen W., RA Kempa S., Dieterich C., Landthaler M.; RT "MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target RT degradation by translocation along 3' UTRs."; RL Mol. Cell 54:573-585(2014). RN [39] RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-1019, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Colon carcinoma; RX PubMed=24129315; DOI=10.1074/mcp.o113.027870; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V., RA Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). RN [40] RP INTERACTION WITH ZC3H12A, AND MUTAGENESIS OF 647-ASP-GLU-648. RX PubMed=26000482; DOI=10.1016/j.cell.2015.04.029; RA Mino T., Murakawa Y., Fukao A., Vandenbon A., Wessels H.H., Ori D., RA Uehata T., Tartey S., Akira S., Suzuki Y., Vinuesa C.G., Ohler U., RA Standley D.M., Landthaler M., Fujiwara T., Takeuchi O.; RT "Regnase-1 and Roquin regulate a common element in inflammatory mRNAs by RT spatiotemporally distinct mechanisms."; RL Cell 161:1058-1073(2015). RN [41] RP IDENTIFICATION IN A COMPLEX WITH DHX34 AND SMG1, INTERACTION WITH DHX34 AND RP SMG1, AND MUTAGENESIS OF CYS-126. RX PubMed=26841701; DOI=10.1038/ncomms10585; RA Melero R., Hug N., Lopez-Perrote A., Yamashita A., Caceres J.F., Llorca O.; RT "The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 RT phosphorylation."; RL Nat. Commun. 7:10585-10585(2016). RN [42] RP INTERACTION WITH SHFL. RX PubMed=27974568; DOI=10.1128/jvi.01606-16; RA Balinsky C.A., Schmeisser H., Wells A.I., Ganesan S., Jin T., Singh K., RA Zoon K.C.; RT "IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity RT against Dengue Virus, Interacts with MOV10."; RL J. Virol. 91:0-0(2017). RN [43] RP INTERACTION WITH HUMAN T-CELL LEUKEMIA VIRUS 1/HTLV-1 PROTEIN TAX. RX PubMed=29382845; DOI=10.1038/s41467-017-02793-6; RA Fiorini F., Robin J.P., Kanaan J., Borowiak M., Croquette V., Le Hir H., RA Jalinot P., Mocquet V.; RT "HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated RT mRNA decay inhibition."; RL Nat. Commun. 9:431-431(2018). RN [44] RP FUNCTION, AND CATALYTIC ACTIVITY. RX PubMed=30218034; DOI=10.1038/s41467-018-06313-y; RA Kanaan J., Raj S., Decourty L., Saveanu C., Croquette V., Le Hir H.; RT "UPF1-like helicase grip on nucleic acids dictates processivity."; RL Nat. Commun. 9:3752-3752(2018). RN [45] RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 295-914, AND MUTAGENESIS OF RP LYS-509; 610-LYS--ARG-612; ARG-615; 647-ASP-GLU-648; GLN-676; ARG-714 AND RP ARG-876. RX PubMed=17159905; DOI=10.1038/sj.emboj.7601464; RA Cheng Z., Muhlrad D., Lim M.K., Parker R., Song H.; RT "Structural and functional insights into the human Upf1 helicase core."; RL EMBO J. 26:253-264(2007). RN [46] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 115-914 IN COMPLEX WITH UPF2. RX PubMed=19556969; DOI=10.1038/emboj.2009.175; RA Clerici M., Mourao A., Gutsche I., Gehring N.H., Hentze M.W., Kulozik A., RA Kadlec J., Sattler M., Cusack S.; RT "Unusual bipartite mode of interaction between the nonsense-mediated decay RT factors, UPF1 and UPF2."; RL EMBO J. 28:2293-2306(2009). RN [47] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 295-925 IN COMPLEX WITH ATP ANALOG RP AND RNA, AND FUNCTION. RX PubMed=21419344; DOI=10.1016/j.molcel.2011.02.010; RA Chakrabarti S., Jayachandran U., Bonneau F., Fiorini F., Basquin C., RA Domcke S., Le Hir H., Conti E.; RT "Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its RT regulation by Upf2."; RL Mol. Cell 41:693-703(2011). CC -!- INTERACTION: CC Q92900-2; Q14152: EIF3A; NbExp=5; IntAct=EBI-373492, EBI-366617; CC Q92900-2; Q9UPR3: SMG5; NbExp=2; IntAct=EBI-373492, EBI-3400861; CC Q92900-2; Q86US8: SMG6; NbExp=2; IntAct=EBI-373492, EBI-3232100; CC Q92900-2; Q9HAU5: UPF2; NbExp=9; IntAct=EBI-373492, EBI-372073; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q92900-1; Sequence=Displayed; CC Name=2; CC IsoId=Q92900-2; Sequence=VSP_003393; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR CCDS; CCDS12386.1; -. DR RefSeq; NP_002902.2; NM_002911.3. DR ProteomicsDB; 75582; -. DR Ensembl; ENST00000262803.10; ENSP00000262803.5; ENSG00000005007.14. DR MANE-Select; ENST00000262803.10; ENSP00000262803.5; NM_002911.4; NP_002902.2. DR Proteomes; UP000005640; Chromosome 19. PE 1: Evidence at protein level; SQ SEQUENCE 1118 AA; 123036 MW; A485D3ED52C39D06 CRC64; MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG PGGPGGGGAG GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL AELNFEEDEE DTYYTKDLPI HACSYCGIHD PACVVYCNTS KKWFCNGRGN TSGSHIVNHL VRAKCKEVTL HKDGPLGETV LECYNCGCRN VFLLGFIPAK ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS WLVKIPSEQE QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT DSDMRLMQGD EICLRYKGDL APLWKGIGHV IKVPDNYGDE IAIELRSSVG APVEVTHNFQ VDFVWKSTSF DRMQSALKTF AVDETSVSGY IYHKLLGHEV EDVIIKCQLP KRFTAQGLPD LNHSQVYAVK TVLQRPLSLI QGPPGTGKTV TSATIVYHLA RQGNGPVLVC APSNIAVDQL TEKIHQTGLK VVRLCAKSRE AIDSPVSFLA LHNQIRNMDS MPELQKLQQL KDETGELSSA DEKRYRALKR TAERELLMNA DVICCTCVGA GDPRLAKMQF RSILIDESTQ ATEPECMVPV VLGAKQLILV GDHCQLGPVV MCKKAAKAGL SQSLFERLVV LGIRPIRLQV QYRMHPALSA FPSNIFYEGS LQNGVTAADR VKKGFDFQWP QPDKPMFFYV TQGQEEIASS GTSYLNRTEA ANVEKITTKL LKAGAKPDQI GIITPYEGQR SYLVQYMQFS GSLHTKLYQE VEIASVDAFQ GREKDFIILS CVRANEHQGI GFLNDPRRLN VALTRARYGV IIVGNPKALS KQPLWNHLLN YYKEQKVLVE GPLNNLRESL MQFSKPRKLV NTINPGARFM TTAMYDAREA IIPGSVYDRS SQGRPSSMYF QTHDQIGMIS AGPSHVAAMN IPIPFNLVMP PMPPPGYFGQ ANGPAAGRGT PKGKTGRGGR QKNRFGLPGP SQTNLPNSQA SQDVASQPFS QGALTQGYIS MSQPSQMSQP GLSQPELSQD SYLGDEFKSQ IDVALSQDST YQGERAYQHG GVTGLSQY //