ID Q928V6_LISIN Unreviewed; 452 AA. AC Q928V6; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 27-MAR-2024, entry version 120. DE SubName: Full=Integrase [Bacteriophage A118] {ECO:0000313|EMBL:CAC97653.1}; GN Name=int {ECO:0000313|EMBL:CAC97653.1}; OS Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262). OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria. OX NCBI_TaxID=272626 {ECO:0000313|EMBL:CAC97653.1, ECO:0000313|Proteomes:UP000002513}; RN [1] {ECO:0000313|EMBL:CAC97653.1, ECO:0000313|Proteomes:UP000002513} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-680 / CLIP 11262 {ECO:0000313|Proteomes:UP000002513}; RX PubMed=11679669; DOI=10.1126/science.1063447; RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., RA Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., RA Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., RA Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.D., RA Fsihi H., Portillo F.G., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., RA Hain T., Hauf J., Jackson D., Jones L.M., Kaerst U., Kreft J., Kuhn M., RA Kunst F., Kurapkat G., Madueno E., Maitournam A., Vicente J.M., Ng E., RA Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.C., RA Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., RA Vazquez-Boland J.A., Voss H., Wehland J., Cossart P.; RT "Comparative genomics of Listeria species."; RL Science 294:849-852(2001). RN [2] {ECO:0007829|PDB:4KIS} RP X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 133-452 IN COMPLEX WITH ZINC. RX PubMed=23821671; DOI=10.1093/nar/gkt580; RA Rutherford K., Yuan P., Perry K., Sharp R., Van Duyne G.D.; RT "Attachment site recognition and regulation of directionality by the serine RT integrases."; RL Nucleic Acids Res. 41:8341-8356(2013). RN [3] {ECO:0007829|PDB:5U96, ECO:0007829|PDB:5UAE} RP X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS) OF 133-452. RX PubMed=28549184; DOI=10.1093/nar/gkx474; RA Gupta K., Sharp R., Yuan J.B., Li H., Van Duyne G.D.; RT "Coiled-coil interactions mediate serine integrase directionality."; RL Nucleic Acids Res. 45:7339-7353(2017). RN [4] {ECO:0007829|PDB:6DNW} RP X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 134-452 IN COMPLEX WITH ZN(2+). RX PubMed=30227134; DOI=10.1016/j.jmb.2018.09.007; RA Li H., Sharp R., Rutherford K., Gupta K., Van Duyne G.D.; RT "Serine Integrase attP Binding and Specificity."; RL J. Mol. Biol. 430:4401-4418(2018). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL596172; CAC97653.1; -; Genomic_DNA. DR PIR; AE1735; AE1735. DR RefSeq; WP_010991183.1; NC_003212.1. DR PDB; 4KIS; X-ray; 3.20 A; A/B/C/D=133-452. DR PDB; 5U96; X-ray; 1.95 A; A/B/C/D/E/F/G/H=350-400. DR PDB; 5UAE; X-ray; 2.75 A; A/B/C/D=344-405. DR PDB; 5UDO; X-ray; 2.54 A; A/B/C/D/E/F/G/H=133-452. DR PDB; 6DNW; X-ray; 2.85 A; A=134-452. DR PDBsum; 4KIS; -. DR PDBsum; 5U96; -. DR PDBsum; 5UAE; -. DR PDBsum; 5UDO; -. DR PDBsum; 6DNW; -. DR AlphaFoldDB; Q928V6; -. DR SMR; Q928V6; -. DR STRING; 272626.gene:17566787; -. DR KEGG; lin:int; -. DR eggNOG; COG1961; Bacteria. DR HOGENOM; CLU_010686_18_3_9; -. DR OrthoDB; 9811097at2; -. DR Proteomes; UP000002513; Chromosome. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW. DR CDD; cd03768; SR_ResInv; 1. DR DisProt; DP02495; -. DR Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1. DR InterPro; IPR038109; DNA_bind_recomb_sf. DR InterPro; IPR011109; DNA_bind_recombinase_dom. DR InterPro; IPR006118; Recombinase_CS. DR InterPro; IPR006119; Resolv_N. DR InterPro; IPR036162; Resolvase-like_N_sf. DR InterPro; IPR025827; Zn_ribbon_recom_dom. DR PANTHER; PTHR30461:SF23; DNA RECOMBINASE-RELATED; 1. DR PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1. DR Pfam; PF07508; Recombinase; 1. DR Pfam; PF00239; Resolvase; 1. DR Pfam; PF13408; Zn_ribbon_recom; 1. DR SMART; SM00857; Resolvase; 1. DR SUPFAM; SSF53041; Resolvase-like; 1. DR PROSITE; PS51737; RECOMBINASE_DNA_BIND; 1. DR PROSITE; PS00397; RECOMBINASES_1; 1. DR PROSITE; PS51736; RECOMBINASES_3; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:4KIS, ECO:0007829|PDB:5U96}; KW DNA integration {ECO:0000256|ARBA:ARBA00022908}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Metal-binding {ECO:0007829|PDB:4KIS, ECO:0007829|PDB:6DNW}; KW Zinc {ECO:0007829|PDB:4KIS, ECO:0007829|PDB:6DNW}. FT DOMAIN 2..147 FT /note="Resolvase/invertase-type recombinase catalytic" FT /evidence="ECO:0000259|PROSITE:PS51736" FT DOMAIN 157..257 FT /note="Recombinase" FT /evidence="ECO:0000259|PROSITE:PS51737" FT ACT_SITE 10 FT /note="O-(5'-phospho-DNA)-serine intermediate" FT /evidence="ECO:0000256|PIRSR:PIRSR606118-50, FT ECO:0000256|PROSITE-ProRule:PRU10137" FT BINDING 274 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4KIS, ECO:0007829|PDB:6DNW" FT BINDING 276 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4KIS" FT BINDING 277 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4KIS, ECO:0007829|PDB:6DNW" FT BINDING 302 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4KIS, ECO:0007829|PDB:6DNW" FT BINDING 314 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4KIS, ECO:0007829|PDB:6DNW" SQ SEQUENCE 452 AA; 53087 MW; A1FB6F8F18541FAF CRC64; MKAAIYIRVS TQEQVENYSI QAQTEKLTAL CRSKDWDVYD TFIDGGYSGS NMNRPALNEM LSKLHEIDAV VVYRLDRLSR SQKDTITLIE EYFLKNNVEF VSLSETLDTS SPFGRAMIGI LSVFAQLERE TIRDRMVMGK IKRIEAGLPL TTAKGRTFGY DVIDTKLYIN EEEAKQLRLI YDIFEEEQSI TFLQKRLKKL GFKVRTYNRY NNWLTNDLYC GYVSYKDKVH VKGIHEPIIS EEQFYRVQEI FSRMGKNPNM NKESASLLNN LVVCSKCGLG FVHRRKDTVS RGKKYHYRYY SCKTYKHTHE LEKCGNKIWR ADKLEELIID RVNNYSFASR NIDKEDELDS LNEKLKIEHA KKKRLFDLYI NGSYEVSELD SMMNDIDAQI NYYEAQIEAN EELKKNKKIQ ENLADLATVD FNSLEFREKQ LYLKSLINKI YIDGEQVTIE WL //