Reviewed, UniProtKB/Swiss-Prot Q928R9 (DCEB_LISIN)

Names and origin

Protein names

Recommended name:
    Glutamate decarboxylase beta
      Short name=GAD-beta
    EC=4.1.1.15

Gene names

Name:	gadB
Ordered Locus Names:	lin2463

Organism

Listeria innocua [Complete proteome] [HAMAP]

Taxonomic identifier

1642 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid By similarity.
Catalytic activity	L-glutamate = 4-aminobutanoate + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutamate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glutamate decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Glutamate decarboxylase beta		PRO_0000146989
Amino acid modifications
	Modified residue	275	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q928R9-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4C35CD1395ADF481	FASTA	464	53,600
	10 20 30 40 50 60 MLYSKENKES YLEPVFGSSA EDRDIPKYTL AKEPLEPRIA YRLVKDELLD EGSARQNLAT 70 80 90 100 110 120 FCQTYMEDEA TKLMSETLEK NAIDKSEYPR TAELENRCVN IIADLWHAPK DQKFMGTSTI 130 140 150 160 170 180 GSSEACMLGG MAMKFAWRKR AEKLGLDIYA QKPNLVISSG YQVCWEKFCV YWDIDMRVVP 190 200 210 220 230 240 MDKDHMQLNT DQVLDYVDEY TIGVVGILGI TYTGRYDDIY ALNEKLEEYN SKTDYKVYIH 250 260 270 280 290 300 VDAASGGFFT PFVEPDIIWD FRLKNVISIN TSGHKYGLVY PGIGWVLWKD ESYLPEELIF 310 320 330 340 350 360 KVSYLGGEMP TMQINFSRSA SHIIGQYYNF LRYGFEGYRT IHQKTSDVAQ YLAHAVEQTG 370 380 390 400 410 420 YFDIYNDGSH LPIVCYKLKD DANVKWTLYD LADRLQMRGW QVPAYPLPKN LENIIIQRYV 430 440 450 460 CRADLGFNMA EEFIQDFQAS IQELNNAHIL FHDTQQSGVH GFTH

References

[1]

"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIP 11262 / Serovar 6a.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL596172 Genomic DNA. Translation: CAC97690.1.
PIR	AB1740.
RefSeq	NP_471793.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1131252.
GenomeReviews	Gene locus lin2463 in contig AL592022_GR.
KEGG	lin:lin2463.
NMPDR	fig|272626.1.peg.2446.
Organism-specific databases
ListiList	LIN02463.
CMR	Search...
Phylogenomic databases
HOGENOM	Q928R9.
OMA	AVDEDTI.
Enzyme and pathway databases
BioCyc	LINN272626:LIN2463-MON.
BRENDA	4.1.1.15. 270396.
Family and domain databases
InterPro	IPR010107. Glutamate_decarboxylase. IPR002129. PyrdxlP-dep_de-COase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11999:SF1. Glu_decarb_GAD. 1 hit. PTHR11999. Pyridoxal_deC. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01788. Glu-decarb-GAD. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCEB_LISIN

Accession

Primary (citable) accession number: Q928R9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)