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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901Proton donorUniRule annotation
Active sitei311 – 3111UniRule annotation
Active sitei425 – 4251UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:lin2466
OrganismiListeria innocua serovar 6a (strain CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002513 Componenti: Chromosome

Organism-specific databases

GenoListiLIN2466.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Glucose-6-phosphate isomerasePRO_0000180667Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272626.lin2466.

Structurei

3D structure databases

ProteinModelPortaliQ928R6.
SMRiQ928R6. Positions 4-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q928R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHIKFDYSK ALRFFEEREL DYLEPAVKAA HDSLHNGTGA GNDALGWINL
60 70 80 90 100
PTDYDKEEFA RIKKATEKIH SDSDVLIVIG IGGSYLGARA AIETLNHSFY
110 120 130 140 150
NVLEKGARKT PQVFFAGNSI SSSYLHDLIE VVGDRDFSVN VISKSGTTTE
160 170 180 190 200
PAIAFRVFKE LLIKKYGEEG AKKRIYATTD KAKGALKTLA DNEGYETFVV
210 220 230 240 250
PDDVGGRFSV LTAVGLLPIA VSGVDIDALM NGAAAASKDF DKPELKNNIA
260 270 280 290 300
YQYAAARNVL YRKGKVTELL ISYEPGLQYF NEWWKQLFGE SEGKDKKGIY
310 320 330 340 350
PSSANFSTDL HSIGQYIQDG RRNLFETVIK VDKPRHNLTI NKEEVDLDGL
360 370 380 390 400
NYLAGETVDF VNTKAFEGTL LAHTDGEVPN FVVEVPELDA YTFGYLVYFF
410 420 430 440 450
EKAVAISGYL NGVNPFDQPG VEAYKANMFA LLGKPGFEDK KAELEKRLND
Length:450
Mass (Da):49,894
Last modified:December 1, 2001 - v1
Checksum:iC42DD441EBAD2D80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596172 Genomic DNA. Translation: CAC97693.1.
PIRiAE1740.
RefSeqiNP_471796.1. NC_003212.1.
WP_003728418.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC97693; CAC97693; CAC97693.
KEGGilin:lin2466.
PATRICi20301823. VBILisInn102668_2525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596172 Genomic DNA. Translation: CAC97693.1.
PIRiAE1740.
RefSeqiNP_471796.1. NC_003212.1.
WP_003728418.1. NC_003212.1.

3D structure databases

ProteinModelPortaliQ928R6.
SMRiQ928R6. Positions 4-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272626.lin2466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC97693; CAC97693; CAC97693.
KEGGilin:lin2466.
PATRICi20301823. VBILisInn102668_2525.

Organism-specific databases

GenoListiLIN2466.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP 11262.

Entry informationi

Entry nameiG6PI_LISIN
AccessioniPrimary (citable) accession number: Q928R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.