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Protein

Thioredoxin reductase

Gene

trxB

Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448FADBy similarity
Nucleotide bindingi279 – 28810FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Name:trxB
Ordered Locus Names:lin2621
OrganismiListeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000002513 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Thioredoxin reductasePRO_0000166735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi136 ↔ 139Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272626.lin2621.

Structurei

3D structure databases

ProteinModelPortaliQ928B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072911.
KOiK00384.
OMAiGQLEMNN.
OrthoDBiPOG091H02HU.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q928B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEEKIYDV IIIGAGPAGM TAALYTSRAD LDTLMIERGV PGGQMVNTAE
60 70 80 90 100
VENYPGFDSI LGPDLSDKML SGAKQFGAEY AYGDIKEVID GKEFKTVTAG
110 120 130 140 150
SKTYKARAII IATGAEHRKL GAAGEEELSG RGVSYCAVCD GAFFKNRELV
160 170 180 190 200
VVGGGDSAVE EGTYLTRYAD KVTIVHRRDK LRAQQILQDR AFKDEKVDFI
210 220 230 240 250
WNNTVEEIIG DGKKVTSVKL VSTVDGSESI MPVDGVFIYV GLVPLTKAFL
260 270 280 290 300
SLGITDEEGY IVTDEEMRTN LPGIFAAGDV RAKSLRQIVT ATGDGGLAGQ
310
NAQKYVEELK EALEAEAAK
Length:319
Mass (Da):34,244
Last modified:December 1, 2001 - v1
Checksum:iC77D54A952526CC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596173 Genomic DNA. Translation: CAC97848.1.
PIRiAH1759.
RefSeqiWP_003772358.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC97848; CAC97848; CAC97848.
KEGGilin:trxB.
PATRICi20302159. VBILisInn102668_2692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596173 Genomic DNA. Translation: CAC97848.1.
PIRiAH1759.
RefSeqiWP_003772358.1. NC_003212.1.

3D structure databases

ProteinModelPortaliQ928B5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272626.lin2621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC97848; CAC97848; CAC97848.
KEGGilin:trxB.
PATRICi20302159. VBILisInn102668_2692.

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072911.
KOiK00384.
OMAiGQLEMNN.
OrthoDBiPOG091H02HU.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXB_LISIN
AccessioniPrimary (citable) accession number: Q928B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.