Q92896 (GSLG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Golgi apparatus protein 1

Alternative name(s):
CFR-1
Cysteine-rich fibroblast growth factor receptor
E-selectin ligand 1
Short name=ESL-1
Golgi sialoglycoprotein MG-160

Gene names

Name:	GLG1
Synonyms:	CFR1, ESL1, MG160

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
Subcellular location	Golgi apparatus membrane; Single-pass type I membrane protein Ref.7.
Tissue specificity	Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain. Ref.8
Developmental stage	Expressed both in adult and fetal tissues.
Post-translational modification	Fucosylation is essential for binding to E-selectin By similarity. N-glycosylated. Contains sialic acid residues By similarity. Ref.9
Sequence similarities	Contains 16 Cys-rich GLG1 repeats.
Sequence caution	The sequence AAB02178.1 differs from that shown. Reason: Frameshift at positions 27 and 35.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Sialic acid
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bone morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of protein processing Inferred from electronic annotation. Source: Compara negative regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of chondrocyte differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi membrane Traceable author statement Ref.1. Source: ProtInc extracellular matrix Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	receptor binding Traceable author statement PubMed 7531823. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92896-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92896-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1179-1179: R → RLQYRSETMAYKGLVWSQDVTGSPA

Note: Contains a phosphoserine at position 1201.

Isoform 3 (identifier: Q92896-3)

The sequence of this isoform differs from the canonical sequence as follows:
     147-157: Missing.
     1179-1179: R → RLQYRSETMAYKGLVWSQDVTGSPA

Note: No experimental confirmation available. Contains a phosphoserine at position 1190.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 1179	1150	Golgi apparatus protein 1		PRO_0000011120
Regions
	Topological domain	30 – 1145	1116	Extracellular Potential
	Transmembrane	1146 – 1166	21	Helical; Potential
	Topological domain	1167 – 1179	13	Cytoplasmic Potential
	Repeat	116 – 149	34	Cys-rich GLG1 1
	Repeat	150 – 212	63	Cys-rich GLG1 2
	Repeat	215 – 278	64	Cys-rich GLG1 3
	Repeat	286 – 346	61	Cys-rich GLG1 4
	Repeat	347 – 413	67	Cys-rich GLG1 5
	Repeat	414 – 473	60	Cys-rich GLG1 6
	Repeat	475 – 537	63	Cys-rich GLG1 7
	Repeat	538 – 604	67	Cys-rich GLG1 8
	Repeat	609 – 668	60	Cys-rich GLG1 9
	Repeat	670 – 728	59	Cys-rich GLG1 10
	Repeat	729 – 788	60	Cys-rich GLG1 11
	Repeat	796 – 856	61	Cys-rich GLG1 12
	Repeat	858 – 911	54	Cys-rich GLG1 13
	Repeat	912 – 979	68	Cys-rich GLG1 14
	Repeat	980 – 1035	56	Cys-rich GLG1 15
	Repeat	1041 – 1101	61	Cys-rich GLG1 16
	Compositional bias	54 – 57	4	Poly-Gly
	Compositional bias	71 – 86	16	Poly-Gln
Amino acid modifications
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
	Glycosylation	210	1	N-linked (GlcNAc...) Potential
	Glycosylation	581	1	N-linked (GlcNAc...) Potential
	Glycosylation	677	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	786	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	147 – 157	11	Missing in isoform 3.		VSP_043472
	Alternative sequence	1179	1	R → RLQYRSETMAYKGLVWSQDV TGSPA in isoform 2 and isoform 3.		VSP_035998
Experimental info
	Sequence conflict	33	1	Q → H in AAB06460. Ref.1
	Sequence conflict	67	1	P → L in AAB06460. Ref.1
	Sequence conflict	85	1	P → L in AAB06460. Ref.1
	Sequence conflict	99	1	Missing in AAB02178. Ref.2
	Sequence conflict	526	1	L → S in AAB02178. Ref.2
	Sequence conflict	702	1	N → T in AAB02178. Ref.2
	Sequence conflict	707	1	Missing in AAB02178. Ref.2
	Sequence conflict	1082	1	I → L in AAB02178. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 390F9923DC83C300	FASTA	1,179	134,552
	10 20 30 40 50 60 MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG 70 80 90 100 110 120 QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE 130 140 150 160 170 180 DVTRVCPKHT WSNNLAVLEC LQDVREPENE ISSDCNHLLW NYKLNLTTDP KFESVAREVC 190 200 210 220 230 240 KSTITEIKEC ADEPVGKGYM VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD 250 260 270 280 290 300 CKNDINILKC GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE 310 320 330 340 350 360 LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK CREALTTRQK 370 380 390 400 410 420 LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY LLMCLESAVH RGRQVSSECQ 430 440 450 460 470 480 GEMLDYRRML MEDFSLSPEI ILSCRGEIEH HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC 490 500 510 520 530 540 QQALQTLIQE TDPGADYRID RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE 550 560 570 580 590 600 DCEHRLLELQ YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA 610 620 630 640 650 660 YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK TETGQELECL 670 680 690 700 710 720 QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII QNFCHDVADN QIDSGDLMEC 730 740 750 760 770 780 LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR FSYKFKMACK EDVLKLCPNI KKKVDVVICL 790 800 810 820 830 840 STTVRNDTLQ EAKEHRVSLK CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG 850 860 870 880 890 900 NAQIIECLKE NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM 910 920 930 940 950 960 LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC HGILTKAKDD 970 980 990 1000 1010 1020 SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR LDPQLQLHCS DEISSLCAEE 1030 1040 1050 1060 1070 1080 AAAQEQTGQV EECLKVNLLK IKTELCKKEV LNMLKESKAD IFVDPVLHTA CALDIKHHCA 1090 1100 1110 1120 1130 1140 AITPGRGRQM SCLMEALEDK RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT 1150 1160 1170 SPSKNYILSV ISGSICILFL IGLMCGRITK RVTRELKDR
	Isoform 2 [UniParc]. Checksum: 58A86E4DE842CE3D	FASTA	1,203	137,222
	10 20 30 40 50 60 MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG 70 80 90 100 110 120 QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE 130 140 150 160 170 180 DVTRVCPKHT WSNNLAVLEC LQDVREPENE ISSDCNHLLW NYKLNLTTDP KFESVAREVC 190 200 210 220 230 240 KSTITEIKEC ADEPVGKGYM VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD 250 260 270 280 290 300 CKNDINILKC GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE 310 320 330 340 350 360 LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK CREALTTRQK 370 380 390 400 410 420 LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY LLMCLESAVH RGRQVSSECQ 430 440 450 460 470 480 GEMLDYRRML MEDFSLSPEI ILSCRGEIEH HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC 490 500 510 520 530 540 QQALQTLIQE TDPGADYRID RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE 550 560 570 580 590 600 DCEHRLLELQ YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA 610 620 630 640 650 660 YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK TETGQELECL 670 680 690 700 710 720 QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII QNFCHDVADN QIDSGDLMEC 730 740 750 760 770 780 LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR FSYKFKMACK EDVLKLCPNI KKKVDVVICL 790 800 810 820 830 840 STTVRNDTLQ EAKEHRVSLK CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG 850 860 870 880 890 900 NAQIIECLKE NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM 910 920 930 940 950 960 LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC HGILTKAKDD 970 980 990 1000 1010 1020 SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR LDPQLQLHCS DEISSLCAEE 1030 1040 1050 1060 1070 1080 AAAQEQTGQV EECLKVNLLK IKTELCKKEV LNMLKESKAD IFVDPVLHTA CALDIKHHCA 1090 1100 1110 1120 1130 1140 AITPGRGRQM SCLMEALEDK RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT 1150 1160 1170 1180 1190 1200 SPSKNYILSV ISGSICILFL IGLMCGRITK RVTRELKDRL QYRSETMAYK GLVWSQDVTG SPA
	Isoform 3 [UniParc]. Checksum: 5D35130D531317ED	FASTA	1,192	135,996
	10 20 30 40 50 60 MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG 70 80 90 100 110 120 QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE 130 140 150 160 170 180 DVTRVCPKHT WSNNLAVLEC LQDVRELLWN YKLNLTTDPK FESVAREVCK STITEIKECA 190 200 210 220 230 240 DEPVGKGYMV SCLVDHRGNI TEYQCHQYIT KMTAIIFSDY RLICGFMDDC KNDINILKCG 250 260 270 280 290 300 SIRLGEKDAH SQGEVVSCLE KGLVKEAEER EPKIQVSELC KKAILRVAEL SSDDFHLDRH 310 320 330 340 350 360 LYFACRDDRE RFCENTQAGE GRVYKCLFNH KFEESMSEKC REALTTRQKL IAQDYKVSYS 370 380 390 400 410 420 LAKSCKSDLK KYRCNVENLP RSREARLSYL LMCLESAVHR GRQVSSECQG EMLDYRRMLM 430 440 450 460 470 480 EDFSLSPEII LSCRGEIEHH CSGLHRKGRT LHCLMKVVRG EKGNLGMNCQ QALQTLIQET 490 500 510 520 530 540 DPGADYRIDR ALNEACESVI QTACKHIRSG DPMILSCLME HLYTEKMVED CEHRLLELQY 550 560 570 580 590 600 FISRDWKLDP VLYRKCQGDA SRLCHTHGWN ETSEFMPQGA VFSCLYRHAY RTEEQGRRLS 610 620 630 640 650 660 RECRAEVQRI LHQRAMDVKL DPALQDKCLI DLGKWCSEKT ETGQELECLQ DHLDDLVVEC 670 680 690 700 710 720 RDIVGNLTEL ESEDIQIEAL LMRACEPIIQ NFCHDVADNQ IDSGDLMECL IQNKHQKDMN 730 740 750 760 770 780 EKCAIGVTHF QLVQMKDFRF SYKFKMACKE DVLKLCPNIK KKVDVVICLS TTVRNDTLQE 790 800 810 820 830 840 AKEHRVSLKC RRQLRVEELE MTEDIRLEPD LYEACKSDIK NFCSAVQYGN AQIIECLKEN 850 860 870 880 890 900 KKQLSTRCHQ KVFKLQETEM MDPELDYTLM RVCKQMIKRF CPEADSKTML QCLKQNKNSE 910 920 930 940 950 960 LMDPKCKQMI TKRQITQNTD YRLNPMLRKA CKADIPKFCH GILTKAKDDS ELEGQVISCL 970 980 990 1000 1010 1020 KLRYADQRLS SDCEDQIRII IQESALDYRL DPQLQLHCSD EISSLCAEEA AAQEQTGQVE 1030 1040 1050 1060 1070 1080 ECLKVNLLKI KTELCKKEVL NMLKESKADI FVDPVLHTAC ALDIKHHCAA ITPGRGRQMS 1090 1100 1110 1120 1130 1140 CLMEALEDKR VRLQPECKKR LNDRIEMWSY AAKVAPADGF SDLAMQVMTS PSKNYILSVI 1150 1160 1170 1180 1190 SGSICILFLI GLMCGRITKR VTRELKDRLQ YRSETMAYKG LVWSQDVTGS PA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus." Mourelatos Z., Gonatas J.O., Cinato E., Gonatas N.K. DNA Cell Biol. 15:1121-1128(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain and Lymphoblast.
[2]	Wu M., Chen J., Tan Y.H., Hong W.J., Ting R. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Trachea.
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[7]	"Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus." Croul S., Mezitis S.G.E., Stieber A., Chen Y.J., Gonatas J.O., Goud B., Gonatas N.K. J. Histochem. Cytochem. 38:957-963(1990) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[8]	"Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160." Olofsson A., Hellman U., Ten Dijke P., Grimsby S., Ichijo H., Moren A., Miyazono K., Heldin C.-H. Biochem. J. 324:427-434(1997) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." Zhang H., Li X.-J., Martin D.B., Aebersold R. Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-677.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1201 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1190 (ISOFORM 3), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U64791 mRNA. Translation: AAB06460.1. U28811 mRNA. Translation: AAB02178.1. Frameshift. AK304156 mRNA. Translation: BAH14120.1. AC009053 Genomic DNA. No translation available. AC009153 Genomic DNA. No translation available. AC109599 Genomic DNA. No translation available. CH471114 Genomic DNA. Translation: EAW95683.1. CH471114 Genomic DNA. Translation: EAW95682.1. CH471114 Genomic DNA. Translation: EAW95686.1. BC060822 mRNA. Translation: AAH60822.1.
IPI	IPI00414717. IPI00641153. IPI00923461.
RefSeq	NP_001139138.1. NM_001145666.1. NP_001139139.1. NM_001145667.1. NP_036333.2. NM_012201.5.
UniGene	Hs.109731.
3D structure databases
ProteinModelPortal	Q92896.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27582N.
IntAct	Q92896. 3 interactions.
MINT	MINT-1137582.
STRING	9606.ENSP00000205061.
PTM databases
PhosphoSite	Q92896.
Polymorphism databases
DMDM	218512060.
Proteomic databases
PaxDb	Q92896.
PRIDE	Q92896.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000205061; ENSP00000205061; ENSG00000090863. ENST00000422840; ENSP00000405984; ENSG00000090863. ENST00000447066; ENSP00000406946; ENSG00000090863.
GeneID	2734.
KEGG	hsa:2734.
UCSC	uc002fcx.3. human. uc002fcy.4. human.
Organism-specific databases
CTD	2734.
GeneCards	GC16M074481.
H-InvDB	HIX0013234.
HGNC	HGNC:4316. GLG1.
HPA	HPA010815.
MIM	600753. gene.
neXtProt	NX_Q92896.
PharmGKB	PA28719.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG318507.
HOGENOM	HOG000047635.
HOVERGEN	HBG051850.
InParanoid	Q92896.
KO	K06816.
OMA	CGSIRLG.
PhylomeDB	Q92896.
Gene expression databases
ArrayExpress	Q92896.
Bgee	Q92896.
CleanEx	HS_GLG1.
Genevestigator	Q92896.
GermOnline	ENSG00000090863. Homo sapiens.
Family and domain databases
InterPro	IPR001893. Cys-rich_GLG1_repeat. IPR017873. Cys-rich_GLG1_repeat_euk. [Graphical view]
Pfam	PF00839. Cys_rich_FGFR. 15 hits. [Graphical view]
PROSITE	PS51289. GLG1_C_RICH. 16 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GLG1. human.
GenomeRNAi	2734.
NextBio	10776.
SOURCE	Search...

Entry information

Entry name

GSLG1_HUMAN

Accession

Primary (citable) accession number: Q92896
Secondary accession number(s): B7Z8Y4 , D3DUJ7, Q13221, Q6P9D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	December 16, 2008
Last modified:	April 3, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.