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Q92896 (GSLG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgi apparatus protein 1
Alternative name(s):
CFR-1
Cysteine-rich fibroblast growth factor receptor
E-selectin ligand 1
Short name=ESL-1
Golgi sialoglycoprotein MG-160
Gene names
Name:GLG1
Synonyms:CFR1, ESL1, MG160
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1179 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Subcellular location

Golgi apparatus membrane; Single-pass type I membrane protein Ref.7.

Tissue specificity

Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain. Ref.8

Developmental stage

Expressed both in adult and fetal tissues.

Post-translational modification

Fucosylation is essential for binding to E-selectin By similarity.

N-glycosylated. Contains sialic acid residues By similarity. Ref.9

Sequence similarities

Contains 16 Cys-rich GLG1 repeats.

Sequence caution

The sequence AAB02178.1 differs from that shown. Reason: Frameshift at positions 27 and 35.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92896-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92896-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1179-1179: R → RLQYRSETMAYKGLVWSQDVTGSPA
Note: Contains a phosphoserine at position 1201.
Isoform 3 (identifier: Q92896-3)

The sequence of this isoform differs from the canonical sequence as follows:
     147-157: Missing.
     1179-1179: R → RLQYRSETMAYKGLVWSQDVTGSPA
Note: No experimental confirmation available. Contains a phosphoserine at position 1190.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 11791150Golgi apparatus protein 1
PRO_0000011120

Regions

Topological domain30 – 11451116Extracellular Potential
Transmembrane1146 – 116621Helical; Potential
Topological domain1167 – 117913Cytoplasmic Potential
Repeat116 – 14934Cys-rich GLG1 1
Repeat150 – 21263Cys-rich GLG1 2
Repeat215 – 27864Cys-rich GLG1 3
Repeat286 – 34661Cys-rich GLG1 4
Repeat347 – 41367Cys-rich GLG1 5
Repeat414 – 47360Cys-rich GLG1 6
Repeat475 – 53763Cys-rich GLG1 7
Repeat538 – 60467Cys-rich GLG1 8
Repeat609 – 66860Cys-rich GLG1 9
Repeat670 – 72859Cys-rich GLG1 10
Repeat729 – 78860Cys-rich GLG1 11
Repeat796 – 85661Cys-rich GLG1 12
Repeat858 – 91154Cys-rich GLG1 13
Repeat912 – 97968Cys-rich GLG1 14
Repeat980 – 103556Cys-rich GLG1 15
Repeat1041 – 110161Cys-rich GLG1 16
Compositional bias54 – 574Poly-Gly
Compositional bias71 – 8616Poly-Gln

Amino acid modifications

Glycosylation1651N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation5811N-linked (GlcNAc...) Potential
Glycosylation6771N-linked (GlcNAc...) Ref.9
Glycosylation7861N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence147 – 15711Missing in isoform 3.
VSP_043472
Alternative sequence11791R → RLQYRSETMAYKGLVWSQDV TGSPA in isoform 2 and isoform 3.
VSP_035998

Experimental info

Sequence conflict331Q → H in AAB06460. Ref.1
Sequence conflict671P → L in AAB06460. Ref.1
Sequence conflict851P → L in AAB06460. Ref.1
Sequence conflict991Missing in AAB02178. Ref.2
Sequence conflict5261L → S in AAB02178. Ref.2
Sequence conflict7021N → T in AAB02178. Ref.2
Sequence conflict7071Missing in AAB02178. Ref.2
Sequence conflict10821I → L in AAB02178. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 390F9923DC83C300

FASTA1,179134,552
        10         20         30         40         50         60 
MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG 

        70         80         90        100        110        120 
QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE 

       130        140        150        160        170        180 
DVTRVCPKHT WSNNLAVLEC LQDVREPENE ISSDCNHLLW NYKLNLTTDP KFESVAREVC 

       190        200        210        220        230        240 
KSTITEIKEC ADEPVGKGYM VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD 

       250        260        270        280        290        300 
CKNDINILKC GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE 

       310        320        330        340        350        360 
LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK CREALTTRQK 

       370        380        390        400        410        420 
LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY LLMCLESAVH RGRQVSSECQ 

       430        440        450        460        470        480 
GEMLDYRRML MEDFSLSPEI ILSCRGEIEH HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC 

       490        500        510        520        530        540 
QQALQTLIQE TDPGADYRID RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE 

       550        560        570        580        590        600 
DCEHRLLELQ YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA 

       610        620        630        640        650        660 
YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK TETGQELECL 

       670        680        690        700        710        720 
QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII QNFCHDVADN QIDSGDLMEC 

       730        740        750        760        770        780 
LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR FSYKFKMACK EDVLKLCPNI KKKVDVVICL 

       790        800        810        820        830        840 
STTVRNDTLQ EAKEHRVSLK CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG 

       850        860        870        880        890        900 
NAQIIECLKE NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM 

       910        920        930        940        950        960 
LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC HGILTKAKDD 

       970        980        990       1000       1010       1020 
SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR LDPQLQLHCS DEISSLCAEE 

      1030       1040       1050       1060       1070       1080 
AAAQEQTGQV EECLKVNLLK IKTELCKKEV LNMLKESKAD IFVDPVLHTA CALDIKHHCA 

      1090       1100       1110       1120       1130       1140 
AITPGRGRQM SCLMEALEDK RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT 

      1150       1160       1170 
SPSKNYILSV ISGSICILFL IGLMCGRITK RVTRELKDR 

« Hide

Isoform 2 [UniParc].

Checksum: 58A86E4DE842CE3D
Show »

FASTA1,203137,222
Isoform 3 [UniParc].

Checksum: 5D35130D531317ED
Show »

FASTA1,192135,996

References

« Hide 'large scale' references
[1]"Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus."
Mourelatos Z., Gonatas J.O., Cinato E., Gonatas N.K.
DNA Cell Biol. 15:1121-1128(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain and Lymphoblast.
[2]Wu M., Chen J., Tan Y.H., Hong W.J., Ting R.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Trachea.
[4]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[7]"Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus."
Croul S., Mezitis S.G.E., Stieber A., Chen Y.J., Gonatas J.O., Goud B., Gonatas N.K.
J. Histochem. Cytochem. 38:957-963(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160."
Olofsson A., Hellman U., Ten Dijke P., Grimsby S., Ichijo H., Moren A., Miyazono K., Heldin C.-H.
Biochem. J. 324:427-434(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H., Li X.-J., Martin D.B., Aebersold R.
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-677.
[10]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1201 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1190 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U64791 mRNA. Translation: AAB06460.1.
U28811 mRNA. Translation: AAB02178.1. Frameshift.
AK304156 mRNA. Translation: BAH14120.1.
AC009053 Genomic DNA. No translation available.
AC009153 Genomic DNA. No translation available.
AC109599 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95683.1.
CH471114 Genomic DNA. Translation: EAW95682.1.
CH471114 Genomic DNA. Translation: EAW95686.1.
BC060822 mRNA. Translation: AAH60822.1.
CCDSCCDS32485.1. [Q92896-2]
CCDS45526.1. [Q92896-3]
CCDS45527.1. [Q92896-1]
RefSeqNP_001139138.1. NM_001145666.1. [Q92896-3]
NP_001139139.1. NM_001145667.1. [Q92896-1]
NP_036333.2. NM_012201.5. [Q92896-2]
UniGeneHs.109731.

3D structure databases

ProteinModelPortalQ92896.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108996. 9 interactions.
DIPDIP-27582N.
IntActQ92896. 4 interactions.
MINTMINT-1137582.
STRING9606.ENSP00000205061.

PTM databases

PhosphoSiteQ92896.

Polymorphism databases

DMDM218512060.

Proteomic databases

MaxQBQ92896.
PaxDbQ92896.
PRIDEQ92896.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000205061; ENSP00000205061; ENSG00000090863. [Q92896-2]
ENST00000422840; ENSP00000405984; ENSG00000090863. [Q92896-1]
ENST00000447066; ENSP00000406946; ENSG00000090863. [Q92896-3]
GeneID2734.
KEGGhsa:2734.
UCSCuc002fcw.4. human. [Q92896-3]
uc002fcx.3. human. [Q92896-2]
uc002fcy.4. human. [Q92896-1]

Organism-specific databases

CTD2734.
GeneCardsGC16M074481.
H-InvDBHIX0013234.
HGNCHGNC:4316. GLG1.
HPAHPA010815.
MIM600753. gene.
neXtProtNX_Q92896.
PharmGKBPA28719.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318507.
HOGENOMHOG000047635.
HOVERGENHBG051850.
InParanoidQ92896.
KOK06816.
OMANCQQALQ.
OrthoDBEOG7XH6P1.
PhylomeDBQ92896.
TreeFamTF106112.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

ArrayExpressQ92896.
BgeeQ92896.
CleanExHS_GLG1.
GenevestigatorQ92896.

Family and domain databases

InterProIPR001893. Cys-rich_GLG1_repeat.
IPR017873. Cys-rich_GLG1_repeat_euk.
[Graphical view]
PfamPF00839. Cys_rich_FGFR. 15 hits.
[Graphical view]
PROSITEPS51289. GLG1_C_RICH. 16 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGLG1. human.
GeneWikiGLG1.
GenomeRNAi2734.
NextBio10776.
PROQ92896.
SOURCESearch...

Entry information

Entry nameGSLG1_HUMAN
AccessionPrimary (citable) accession number: Q92896
Secondary accession number(s): B7Z8Y4 expand/collapse secondary AC list , D3DUJ7, Q13221, Q6P9D1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM