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Protein

Golgi apparatus protein 1

Gene

GLG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

GO - Molecular functioni

  • fibroblast growth factor binding Source: GO_Central
  • receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Sialic acid

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090863-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apparatus protein 1
Alternative name(s):
CFR-1
Cysteine-rich fibroblast growth factor receptor
E-selectin ligand 1
Short name:
ESL-1
Golgi sialoglycoprotein MG-160
Gene namesi
Name:GLG1
Synonyms:CFR1, ESL1, MG160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:4316. GLG1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 1145ExtracellularSequence analysisAdd BLAST1116
Transmembranei1146 – 1166HelicalSequence analysisAdd BLAST21
Topological domaini1167 – 1179CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: HPA
  • Golgi membrane Source: ProtInc
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2734.
OpenTargetsiENSG00000090863.
PharmGKBiPA28719.

Polymorphism and mutation databases

BioMutaiGLG1.
DMDMi218512060.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001112030 – 1179Golgi apparatus protein 1Add BLAST1150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Glycosylationi581N-linked (GlcNAc...)Sequence analysis1
Glycosylationi677N-linked (GlcNAc...)1 Publication1
Glycosylationi786N-linked (GlcNAc...)Sequence analysis1
Modified residuei961PhosphoserineBy similarity1
Isoform 3 (identifier: Q92896-3)
Modified residuei1190PhosphoserineCombined sources1
Isoform 2 (identifier: Q92896-2)
Modified residuei1201PhosphoserineCombined sources1

Post-translational modificationi

Fucosylation is essential for binding to E-selectin.By similarity
N-glycosylated. Contains sialic acid residues (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ92896.
MaxQBiQ92896.
PaxDbiQ92896.
PeptideAtlasiQ92896.
PRIDEiQ92896.

PTM databases

iPTMnetiQ92896.
PhosphoSitePlusiQ92896.
SwissPalmiQ92896.

Expressioni

Tissue specificityi

Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.1 Publication

Developmental stagei

Expressed both in adult and fetal tissues.

Gene expression databases

BgeeiENSG00000090863.
CleanExiHS_GLG1.
ExpressionAtlasiQ92896. baseline and differential.
GenevisibleiQ92896. HS.

Organism-specific databases

HPAiHPA010815.

Interactioni

GO - Molecular functioni

  • fibroblast growth factor binding Source: GO_Central
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi108996. 22 interactors.
DIPiDIP-27582N.
IntActiQ92896. 9 interactors.
MINTiMINT-1137582.
STRINGi9606.ENSP00000205061.

Structurei

3D structure databases

ProteinModelPortaliQ92896.
SMRiQ92896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati116 – 149Cys-rich GLG1 1Add BLAST34
Repeati150 – 212Cys-rich GLG1 2Add BLAST63
Repeati215 – 278Cys-rich GLG1 3Add BLAST64
Repeati286 – 346Cys-rich GLG1 4Add BLAST61
Repeati347 – 413Cys-rich GLG1 5Add BLAST67
Repeati414 – 473Cys-rich GLG1 6Add BLAST60
Repeati475 – 537Cys-rich GLG1 7Add BLAST63
Repeati538 – 604Cys-rich GLG1 8Add BLAST67
Repeati609 – 668Cys-rich GLG1 9Add BLAST60
Repeati670 – 728Cys-rich GLG1 10Add BLAST59
Repeati729 – 788Cys-rich GLG1 11Add BLAST60
Repeati796 – 856Cys-rich GLG1 12Add BLAST61
Repeati858 – 911Cys-rich GLG1 13Add BLAST54
Repeati912 – 979Cys-rich GLG1 14Add BLAST68
Repeati980 – 1035Cys-rich GLG1 15Add BLAST56
Repeati1041 – 1101Cys-rich GLG1 16Add BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 57Poly-Gly4
Compositional biasi71 – 86Poly-GlnAdd BLAST16

Sequence similaritiesi

Contains 16 Cys-rich GLG1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3648. Eukaryota.
ENOG410XNWV. LUCA.
GeneTreeiENSGT00390000011262.
HOGENOMiHOG000047635.
HOVERGENiHBG051850.
InParanoidiQ92896.
KOiK06816.
OMAiNCQQALQ.
OrthoDBiEOG091G01KP.
PhylomeDBiQ92896.
TreeFamiTF106112.

Family and domain databases

InterProiIPR001893. Cys-rich_GLG1_repeat.
IPR017873. Cys-rich_GLG1_repeat_euk.
[Graphical view]
PfamiPF00839. Cys_rich_FGFR. 15 hits.
[Graphical view]
PROSITEiPS51289. GLG1_C_RICH. 16 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92896-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV
60 70 80 90 100
GQAGGGGPAG QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR
110 120 130 140 150
RGGAGAGGGW KLAEEESCRE DVTRVCPKHT WSNNLAVLEC LQDVREPENE
160 170 180 190 200
ISSDCNHLLW NYKLNLTTDP KFESVAREVC KSTITEIKEC ADEPVGKGYM
210 220 230 240 250
VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD CKNDINILKC
260 270 280 290 300
GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE
310 320 330 340 350
LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK
360 370 380 390 400
CREALTTRQK LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY
410 420 430 440 450
LLMCLESAVH RGRQVSSECQ GEMLDYRRML MEDFSLSPEI ILSCRGEIEH
460 470 480 490 500
HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC QQALQTLIQE TDPGADYRID
510 520 530 540 550
RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE DCEHRLLELQ
560 570 580 590 600
YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA
610 620 630 640 650
YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK
660 670 680 690 700
TETGQELECL QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII
710 720 730 740 750
QNFCHDVADN QIDSGDLMEC LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR
760 770 780 790 800
FSYKFKMACK EDVLKLCPNI KKKVDVVICL STTVRNDTLQ EAKEHRVSLK
810 820 830 840 850
CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG NAQIIECLKE
860 870 880 890 900
NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM
910 920 930 940 950
LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC
960 970 980 990 1000
HGILTKAKDD SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR
1010 1020 1030 1040 1050
LDPQLQLHCS DEISSLCAEE AAAQEQTGQV EECLKVNLLK IKTELCKKEV
1060 1070 1080 1090 1100
LNMLKESKAD IFVDPVLHTA CALDIKHHCA AITPGRGRQM SCLMEALEDK
1110 1120 1130 1140 1150
RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT SPSKNYILSV
1160 1170
ISGSICILFL IGLMCGRITK RVTRELKDR
Length:1,179
Mass (Da):134,552
Last modified:December 16, 2008 - v2
Checksum:i390F9923DC83C300
GO
Isoform 2 (identifier: Q92896-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1179-1179: R → RLQYRSETMAYKGLVWSQDVTGSPA

Show »
Length:1,203
Mass (Da):137,222
Checksum:i58A86E4DE842CE3D
GO
Isoform 3 (identifier: Q92896-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-157: Missing.
     1179-1179: R → RLQYRSETMAYKGLVWSQDVTGSPA

Note: No experimental confirmation available.Combined sources
Show »
Length:1,192
Mass (Da):135,996
Checksum:i5D35130D531317ED
GO

Sequence cautioni

The sequence AAB02178 differs from that shown. Reason: Frameshift at positions 27 and 35.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33Q → H in AAB06460 (PubMed:8985126).Curated1
Sequence conflicti67P → L in AAB06460 (PubMed:8985126).Curated1
Sequence conflicti85P → L in AAB06460 (PubMed:8985126).Curated1
Sequence conflicti99Missing in AAB02178 (Ref. 2) Curated1
Sequence conflicti526L → S in AAB02178 (Ref. 2) Curated1
Sequence conflicti702N → T in AAB02178 (Ref. 2) Curated1
Sequence conflicti707Missing in AAB02178 (Ref. 2) Curated1
Sequence conflicti1082I → L in AAB02178 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043472147 – 157Missing in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0359981179R → RLQYRSETMAYKGLVWSQDV TGSPA in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64791 mRNA. Translation: AAB06460.1.
U28811 mRNA. Translation: AAB02178.1. Frameshift.
AK304156 mRNA. Translation: BAH14120.1.
AC009053 Genomic DNA. No translation available.
AC009153 Genomic DNA. No translation available.
AC109599 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95683.1.
CH471114 Genomic DNA. Translation: EAW95682.1.
CH471114 Genomic DNA. Translation: EAW95686.1.
BC060822 mRNA. Translation: AAH60822.1.
CCDSiCCDS32485.1. [Q92896-2]
CCDS45526.1. [Q92896-3]
CCDS45527.1. [Q92896-1]
RefSeqiNP_001139138.1. NM_001145666.1. [Q92896-3]
NP_001139139.1. NM_001145667.1. [Q92896-1]
NP_036333.2. NM_012201.5. [Q92896-2]
UniGeneiHs.109731.

Genome annotation databases

EnsembliENST00000205061; ENSP00000205061; ENSG00000090863. [Q92896-2]
ENST00000422840; ENSP00000405984; ENSG00000090863. [Q92896-1]
ENST00000447066; ENSP00000406946; ENSG00000090863. [Q92896-3]
GeneIDi2734.
KEGGihsa:2734.
UCSCiuc002fcw.5. human. [Q92896-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64791 mRNA. Translation: AAB06460.1.
U28811 mRNA. Translation: AAB02178.1. Frameshift.
AK304156 mRNA. Translation: BAH14120.1.
AC009053 Genomic DNA. No translation available.
AC009153 Genomic DNA. No translation available.
AC109599 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95683.1.
CH471114 Genomic DNA. Translation: EAW95682.1.
CH471114 Genomic DNA. Translation: EAW95686.1.
BC060822 mRNA. Translation: AAH60822.1.
CCDSiCCDS32485.1. [Q92896-2]
CCDS45526.1. [Q92896-3]
CCDS45527.1. [Q92896-1]
RefSeqiNP_001139138.1. NM_001145666.1. [Q92896-3]
NP_001139139.1. NM_001145667.1. [Q92896-1]
NP_036333.2. NM_012201.5. [Q92896-2]
UniGeneiHs.109731.

3D structure databases

ProteinModelPortaliQ92896.
SMRiQ92896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108996. 22 interactors.
DIPiDIP-27582N.
IntActiQ92896. 9 interactors.
MINTiMINT-1137582.
STRINGi9606.ENSP00000205061.

PTM databases

iPTMnetiQ92896.
PhosphoSitePlusiQ92896.
SwissPalmiQ92896.

Polymorphism and mutation databases

BioMutaiGLG1.
DMDMi218512060.

Proteomic databases

EPDiQ92896.
MaxQBiQ92896.
PaxDbiQ92896.
PeptideAtlasiQ92896.
PRIDEiQ92896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000205061; ENSP00000205061; ENSG00000090863. [Q92896-2]
ENST00000422840; ENSP00000405984; ENSG00000090863. [Q92896-1]
ENST00000447066; ENSP00000406946; ENSG00000090863. [Q92896-3]
GeneIDi2734.
KEGGihsa:2734.
UCSCiuc002fcw.5. human. [Q92896-1]

Organism-specific databases

CTDi2734.
DisGeNETi2734.
GeneCardsiGLG1.
H-InvDBHIX0013234.
HGNCiHGNC:4316. GLG1.
HPAiHPA010815.
MIMi600753. gene.
neXtProtiNX_Q92896.
OpenTargetsiENSG00000090863.
PharmGKBiPA28719.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3648. Eukaryota.
ENOG410XNWV. LUCA.
GeneTreeiENSGT00390000011262.
HOGENOMiHOG000047635.
HOVERGENiHBG051850.
InParanoidiQ92896.
KOiK06816.
OMAiNCQQALQ.
OrthoDBiEOG091G01KP.
PhylomeDBiQ92896.
TreeFamiTF106112.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090863-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

ChiTaRSiGLG1. human.
GeneWikiiGLG1.
GenomeRNAii2734.
PROiQ92896.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090863.
CleanExiHS_GLG1.
ExpressionAtlasiQ92896. baseline and differential.
GenevisibleiQ92896. HS.

Family and domain databases

InterProiIPR001893. Cys-rich_GLG1_repeat.
IPR017873. Cys-rich_GLG1_repeat_euk.
[Graphical view]
PfamiPF00839. Cys_rich_FGFR. 15 hits.
[Graphical view]
PROSITEiPS51289. GLG1_C_RICH. 16 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSLG1_HUMAN
AccessioniPrimary (citable) accession number: Q92896
Secondary accession number(s): B7Z8Y4
, D3DUJ7, Q13221, Q6P9D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.