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Q92888

- ARHG1_HUMAN

UniProt

Q92888 - ARHG1_HUMAN

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Protein
Rho guanine nucleotide exchange factor 1
Gene
ARHGEF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.4 Publications

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. Rho guanyl-nucleotide exchange factor activity Source: ProtInc
  3. poly(A) RNA binding Source: UniProtKB
  4. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. Rho protein signal transduction Source: ProtInc
  2. cell proliferation Source: ProtInc
  3. negative regulation of axonogenesis Source: Reactome
  4. neurotrophin TRK receptor signaling pathway Source: Reactome
  5. regulation of Rho GTPase activity Source: GOC
  6. regulation of axonogenesis Source: Reactome
  7. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_13815. Axonal growth inhibition (RHOA activation).
REACT_18407. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 1
Alternative name(s):
115 kDa guanine nucleotide exchange factor
Short name:
p115-RhoGEF
Short name:
p115RhoGEF
Sub1.5
Gene namesi
Name:ARHGEF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:681. ARHGEF1.

Subcellular locationi

Cytoplasm. Membrane
Note: Translocated to the membrane by activated GNA13 or LPA stimulation.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi487 – 4871Y → F: No effect. 1 Publication
Mutagenesisi738 – 7381Y → F: Lowers the exchange activity. 1 Publication

Organism-specific databases

PharmGKBiPA24966.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 912912Rho guanine nucleotide exchange factor 1
PRO_0000080906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei738 – 7381Phosphotyrosine; by JAK21 Publication
Modified residuei863 – 8631Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92888.
PaxDbiQ92888.
PRIDEiQ92888.

PTM databases

PhosphoSiteiQ92888.

Miscellaneous databases

PMAP-CutDBQ92888.

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

ArrayExpressiQ92888.
BgeeiQ92888.
CleanExiHS_ARHGEF1.
GenevestigatoriQ92888.

Organism-specific databases

HPAiCAB009502.
HPA012924.

Interactioni

Subunit structurei

Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 By similarity. Interacts with CTNNAL1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GNA13Q143443EBI-465400,EBI-465387
Z5115Q7DB747EBI-465400,EBI-7864788From a different organism.

Protein-protein interaction databases

BioGridi114585. 19 interactions.
IntActiQ92888. 13 interactions.
MINTiMINT-2813461.
STRINGi9606.ENSP00000337261.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi18 – 203
Turni26 – 338
Helixi49 – 524
Helixi56 – 6914
Helixi73 – 8412
Helixi89 – 10315
Helixi116 – 1227
Turni127 – 1293
Helixi132 – 14413
Helixi147 – 16216
Helixi169 – 1768
Helixi183 – 20321
Helixi205 – 2073
Helixi212 – 22817
Turni399 – 4013
Helixi404 – 4074
Helixi413 – 44129
Helixi443 – 4497
Helixi454 – 4607
Helixi464 – 48421
Helixi493 – 5008
Helixi502 – 51716
Helixi519 – 53214
Helixi534 – 54411
Helixi547 – 5493
Helixi554 – 5574
Helixi560 – 57718
Helixi582 – 62140
Helixi625 – 6295
Helixi633 – 6353
Beta strandi636 – 6383
Beta strandi644 – 6463
Beta strandi648 – 66114
Beta strandi663 – 68119
Beta strandi684 – 6863
Beta strandi694 – 6974
Beta strandi706 – 7094
Helixi710 – 7123
Beta strandi713 – 7175
Beta strandi719 – 7213
Beta strandi724 – 7296
Beta strandi737 – 7415
Helixi745 – 76016

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IAPX-ray1.90A42-252[»]
1SHZX-ray2.85C/F7-239[»]
3AB3X-ray2.40B/D1-233[»]
3ODOX-ray2.90A/B395-766[»]
3ODWX-ray3.20A/B240-766[»]
3ODXX-ray3.20A/B353-766[»]
3P6AX-ray2.50A/B395-766[»]
ProteinModelPortaliQ92888.
SMRiQ92888. Positions 44-233, 395-761.

Miscellaneous databases

EvolutionaryTraceiQ92888.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 232192RGSL
Add
BLAST
Domaini416 – 605190DH
Add
BLAST
Domaini647 – 760114PH
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili865 – 89632 Reviewed prediction
Add
BLAST

Domaini

The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.
The DH domain is involved in interaction with CCPG1 By similarity.

Sequence similaritiesi

Contains 1 PH domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5422.
HOGENOMiHOG000034043.
HOVERGENiHBG050565.
KOiK12330.
OrthoDBiEOG7GJ6CF.
PhylomeDBiQ92888.
TreeFamiTF106495.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR016137. Regulat_G_prot_signal_superfam.
IPR015212. RGS-like_dom.
IPR015721. RhoGEF-like.
[Graphical view]
PANTHERiPTHR22825. PTHR22825. 1 hit.
PfamiPF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92888-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDFARGAAS PGPSRPGLVP VSIIGAEDED FENELETNSE EQNSQFQSLE    50
QVKRRPAHLM ALLQHVALQF EPGPLLCCLH ADMLGSLGPK EAKKAFLDFY 100
HSFLEKTAVL RVPVPPNVAF ELDRTRADLI SEDVQRRFVQ EVVQSQQVAV 150
GRQLEDFRSK RLMGMTPWEQ ELAQLEAWVG RDRASYEARE RHVAERLLMH 200
LEEMQHTIST DEEKSAAVVN AIGLYMRHLG VRTKSGDKKS GRNFFRKKVM 250
GNRRSDEPAK TKKGLSSILD AARWNRGEPQ VPDFRHLKAE VDAEKPGATD 300
RKGGVGMPSR DRNIGAPGQD TPGVSLHPLS LDSPDREPGA DAPLELGDSS 350
PQGPMSLESL APPESTDEGA ETESPEPGDE GEPGRSGLEL EPEEPPGWRE 400
LVPPDTLHSL PKSQVKRQEV ISELLVTEAA HVRMLRVLHD LFFQPMAECL 450
FFPLEELQNI FPSLDELIEV HSLFLDRLMK RRQESGYLIE EIGDVLLARF 500
DGAEGSWFQK ISSRFCSRQS FALEQLKAKQ RKDPRFCAFV QEAESRPRCR 550
RLQLKDMIPT EMQRLTKYPL LLQSIGQNTE EPTEREKVEL AAECCREILH 600
HVNQAVRDME DLLRLKDYQR RLDLSHLRQS SDPMLSEFKN LDITKKKLVH 650
EGPLTWRVTK DKAVEVHVLL LDDLLLLLQR QDERLLLKSH SRTLTPTPDG 700
KTMLRPVLRL TSAMTREVAT DHKAFYVLFT WDQEAQIYEL VAQTVSERKN 750
WCALITETAG SLKVPAPASR PKPRPSPSST REPLLSSSEN GNGGRETSPA 800
DARTERILSD LLPFCRPGPE GQLAATALRK VLSLKQLLFP AEEDNGAGPP 850
RDGDGVPGGG PLSPARTQEI QENLLSLEET MKQLEELEEE FCRLRPLLSQ 900
LGGNSVPQPG CT 912
Length:912
Mass (Da):102,435
Last modified:August 29, 2003 - v2
Checksum:i1E773D041652190D
GO
Isoform 2 (identifier: Q92888-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-108: Missing.

Note: No experimental confirmation available.

Show »
Length:879
Mass (Da):98,768
Checksum:i1D0863A5D1A57C9B
GO
Isoform 3 (identifier: Q92888-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MASLSTWSSPAEPREM

Note: No experimental confirmation available.

Show »
Length:927
Mass (Da):104,066
Checksum:iB2E593D5B2DCE417
GO

Sequence cautioni

The sequence CAA70356.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
The sequence CAA70356.1 differs from that shown. Reason: Frameshift at position 904.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti165 – 1651M → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035969
Natural varianti375 – 3751P → L.
Corresponds to variant rs2303797 [ dbSNP | Ensembl ].
VAR_033521

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MASLSTWSSPAEPREM in isoform 3.
VSP_037766
Alternative sequencei76 – 10833Missing in isoform 2.
VSP_008125Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2593EPA → DPP in AAB17896. 1 Publication
Sequence conflicti305 – 3084VGMP → GGDA in CAA70356. 1 Publication
Sequence conflicti339 – 3391Missing in CAA70356. 1 Publication
Sequence conflicti346 – 3527LGDSSPQ → PGGLIPA in CAA70356. 1 Publication
Sequence conflicti549 – 5491C → S in CAA70356. 1 Publication
Sequence conflicti752 – 7521C → S in CAA70356. 1 Publication
Sequence conflicti776 – 7761S → R in AAB17896. 1 Publication
Sequence conflicti862 – 8621L → R in CAA70356. 1 Publication
Sequence conflicti876 – 8761S → R in CAA70356. 1 Publication
Sequence conflicti883 – 8831Q → T in CAA70356. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64105 mRNA. Translation: AAB17896.1.
BC005155 mRNA. Translation: AAH05155.2.
BC011726 mRNA. Translation: AAH11726.1.
BC015652 mRNA. No translation available.
BC034013 mRNA. Translation: AAH34013.2.
Y09160 mRNA. Translation: CAA70356.1. Sequence problems.
BT007421 mRNA. Translation: AAP36089.1.
CCDSiCCDS12590.1. [Q92888-3]
CCDS12591.1. [Q92888-1]
CCDS12592.1. [Q92888-2]
RefSeqiNP_004697.2. NM_004706.3. [Q92888-1]
NP_945328.1. NM_198977.1. [Q92888-2]
NP_945353.1. NM_199002.1. [Q92888-3]
UniGeneiHs.631550.

Genome annotation databases

EnsembliENST00000337665; ENSP00000337261; ENSG00000076928. [Q92888-3]
ENST00000347545; ENSP00000344429; ENSG00000076928. [Q92888-2]
ENST00000354532; ENSP00000346532; ENSG00000076928. [Q92888-1]
GeneIDi9138.
KEGGihsa:9138.
UCSCiuc002orx.3. human. [Q92888-1]
uc002ory.3. human. [Q92888-2]
uc002osa.3. human. [Q92888-3]

Polymorphism databases

DMDMi34395524.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64105 mRNA. Translation: AAB17896.1 .
BC005155 mRNA. Translation: AAH05155.2 .
BC011726 mRNA. Translation: AAH11726.1 .
BC015652 mRNA. No translation available.
BC034013 mRNA. Translation: AAH34013.2 .
Y09160 mRNA. Translation: CAA70356.1 . Sequence problems.
BT007421 mRNA. Translation: AAP36089.1 .
CCDSi CCDS12590.1. [Q92888-3 ]
CCDS12591.1. [Q92888-1 ]
CCDS12592.1. [Q92888-2 ]
RefSeqi NP_004697.2. NM_004706.3. [Q92888-1 ]
NP_945328.1. NM_198977.1. [Q92888-2 ]
NP_945353.1. NM_199002.1. [Q92888-3 ]
UniGenei Hs.631550.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IAP X-ray 1.90 A 42-252 [» ]
1SHZ X-ray 2.85 C/F 7-239 [» ]
3AB3 X-ray 2.40 B/D 1-233 [» ]
3ODO X-ray 2.90 A/B 395-766 [» ]
3ODW X-ray 3.20 A/B 240-766 [» ]
3ODX X-ray 3.20 A/B 353-766 [» ]
3P6A X-ray 2.50 A/B 395-766 [» ]
ProteinModelPortali Q92888.
SMRi Q92888. Positions 44-233, 395-761.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114585. 19 interactions.
IntActi Q92888. 13 interactions.
MINTi MINT-2813461.
STRINGi 9606.ENSP00000337261.

PTM databases

PhosphoSitei Q92888.

Polymorphism databases

DMDMi 34395524.

Proteomic databases

MaxQBi Q92888.
PaxDbi Q92888.
PRIDEi Q92888.

Protocols and materials databases

DNASUi 9138.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337665 ; ENSP00000337261 ; ENSG00000076928 . [Q92888-3 ]
ENST00000347545 ; ENSP00000344429 ; ENSG00000076928 . [Q92888-2 ]
ENST00000354532 ; ENSP00000346532 ; ENSG00000076928 . [Q92888-1 ]
GeneIDi 9138.
KEGGi hsa:9138.
UCSCi uc002orx.3. human. [Q92888-1 ]
uc002ory.3. human. [Q92888-2 ]
uc002osa.3. human. [Q92888-3 ]

Organism-specific databases

CTDi 9138.
GeneCardsi GC19P042387.
HGNCi HGNC:681. ARHGEF1.
HPAi CAB009502.
HPA012924.
MIMi 601855. gene.
neXtProti NX_Q92888.
PharmGKBi PA24966.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5422.
HOGENOMi HOG000034043.
HOVERGENi HBG050565.
KOi K12330.
OrthoDBi EOG7GJ6CF.
PhylomeDBi Q92888.
TreeFami TF106495.

Enzyme and pathway databases

Reactomei REACT_13815. Axonal growth inhibition (RHOA activation).
REACT_18407. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSi ARHGEF1. human.
EvolutionaryTracei Q92888.
GeneWikii ARHGEF1.
GenomeRNAii 9138.
NextBioi 34263.
PMAP-CutDB Q92888.
PROi Q92888.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92888.
Bgeei Q92888.
CleanExi HS_ARHGEF1.
Genevestigatori Q92888.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR016137. Regulat_G_prot_signal_superfam.
IPR015212. RGS-like_dom.
IPR015721. RhoGEF-like.
[Graphical view ]
PANTHERi PTHR22825. PTHR22825. 1 hit.
Pfami PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel guanine nucleotide exchange factor for the rho GTPase."
    Hart M.J., Sharma S., el Masry N., Qiu R.-G., McCabe P., Polakis P., Bollag G.
    J. Biol. Chem. 271:25452-25458(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RHOA, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: B-cell, Muscle and Placenta.
  3. "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues."
    Aasheim H.-C., Pedeutour F., Smeland E.B.
    Oncogene 14:1747-1752(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-912 (ISOFORM 1), TISSUE SPECIFICITY.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-912 (ISOFORM 1).
  5. "p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13."
    Kozasa T., Jiang X., Hart M.J., Sternweis P.M., Singer W.D., Gilman A.G., Bollag G., Sternweis P.C.
    Science 280:2109-2111(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13."
    Hart M.J., Jiang X., Kozasa T., Roscoe W., Singer W.D., Gilman A.G., Sternweis P.C., Bollag G.
    Science 280:2112-2114(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GNA13.
  7. "Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding."
    Bhattacharyya R., Wedegaertner P.B.
    J. Biol. Chem. 275:14992-14999(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation."
    Park B., Nguyen N.T., Dutt P., Merdek K.D., Bashar M., Sterpetti P., Tosolini A., Testa J.R., Toksoz D.
    J. Biol. Chem. 277:45361-45370(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNAL1.
  9. "PKCa-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement."
    Holinstat M., Mehta D., Kozasa T., Minshall R.D., Malik A.B.
    J. Biol. Chem. 278:28793-28798(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY PKCA.
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-863, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure."
    Guilluy C., Bregeon J., Toumaniantz G., Rolli-Derkinderen M., Retailleau K., Loufrani L., Henrion D., Scalbert E., Bril A., Torres R.M., Offermanns S., Pacaud P., Loirand G.
    Nat. Med. 16:183-190(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT TYR-738, MUTAGENESIS OF TYR-487 AND TYR-738.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-863, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 42-252.
  17. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-165.

Entry informationi

Entry nameiARHG1_HUMAN
AccessioniPrimary (citable) accession number: Q92888
Secondary accession number(s): O00513
, Q8N4J4, Q96BF4, Q96F17, Q9BSB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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