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Q92887

- MRP2_HUMAN

UniProt

Q92887 - MRP2_HUMAN

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Protein

Canalicular multispecific organic anion transporter 1

Gene

ABCC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi671 – 6788ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1334 – 13418ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: ProtInc
  2. ATP binding Source: UniProtKB-KW
  3. organic anion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. cellular chloride ion homeostasis Source: Ensembl
  2. drug transmembrane transport Source: Ensembl
  3. prostaglandin transport Source: Ensembl
  4. response to arsenic-containing substance Source: Ensembl
  5. response to estrogen Source: Ensembl
  6. response to heat Source: Ensembl
  7. response to methotrexate Source: Ensembl
  8. response to oxidative stress Source: Ensembl
  9. thyroid hormone transport Source: Ensembl
  10. transmembrane transport Source: Reactome
  11. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15480. ABC-family proteins mediated transport.
SABIO-RKQ92887.

Protein family/group databases

TCDBi3.A.1.208.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Canalicular multidrug resistance protein
Multidrug resistance-associated protein 2
Gene namesi
Name:ABCC2
Synonyms:CMOAT, CMOAT1, CMRP, MRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:53. ABCC2.

Subcellular locationi

Apical cell membrane 1 Publication; Multi-pass membrane protein 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. cell surface Source: UniProtKB
  3. integral component of plasma membrane Source: ProtInc
  4. intercellular canaliculus Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.5 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti768 – 7681R → W in DJS. 3 Publications
Corresponds to variant rs56199535 [ dbSNP | Ensembl ].
VAR_000099
Natural varianti1150 – 11501R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. 1 Publication
VAR_013327
Natural varianti1173 – 11731I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. 1 Publication
VAR_013328
Natural varianti1382 – 13821Q → R in DJS. 1 Publication
VAR_010756
Natural varianti1392 – 13932Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation. 1 Publication
VAR_013329

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1254 – 12541W → A or C: Fails to transport methotrexate, leukotriene C4 and estradiol glucuronide. 1 Publication
Mutagenesisi1254 – 12541W → F: Fails to transport methotrexate and leukotriene C4. Does not affect estradiol glucuronide transport. 1 Publication
Mutagenesisi1254 – 12541W → Y: Fails to transport methotrexate; reduces leukotriene C4 transport. Does not affect estradiol glucuronide transport. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi237500. phenotype.
Orphaneti234. Dubin-Johnson syndrome.
PharmGKBiPA116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15451545Canalicular multispecific organic anion transporter 1PRO_0000093356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Modified residuei283 – 2831Phosphoserine1 Publication
Modified residuei878 – 8781Phosphoserine1 Publication
Glycosylationi1011 – 10111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ92887.
PaxDbiQ92887.
PRIDEiQ92887.

PTM databases

PhosphoSiteiQ92887.

Expressioni

Tissue specificityi

Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Gene expression databases

BgeeiQ92887.
CleanExiHS_ABCC2.
ExpressionAtlasiQ92887. baseline and differential.
GenevestigatoriQ92887.

Organism-specific databases

HPAiHPA004860.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NFKB1P198383EBI-3916193,EBI-300010

Protein-protein interaction databases

BioGridi107647. 46 interactions.
IntActiQ92887. 5 interactions.
MINTiMINT-5004989.
STRINGi9606.ENSP00000359478.

Structurei

3D structure databases

ProteinModelPortaliQ92887.
SMRiQ92887. Positions 642-862.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularBy similarityAdd
BLAST
Topological domaini49 – 6820CytoplasmicBy similarityAdd
BLAST
Topological domaini90 – 934ExtracellularBy similarity
Topological domaini115 – 12612CytoplasmicBy similarityAdd
BLAST
Topological domaini148 – 16518ExtracellularBy similarityAdd
BLAST
Topological domaini187 – 313127CytoplasmicBy similarityAdd
BLAST
Topological domaini335 – 36026ExtracellularBy similarityAdd
BLAST
Topological domaini382 – 43756CytoplasmicBy similarityAdd
BLAST
Topological domaini459 – 4613ExtracellularBy similarity
Topological domaini483 – 54462CytoplasmicBy similarityAdd
BLAST
Topological domaini566 – 58722ExtracellularBy similarityAdd
BLAST
Topological domaini609 – 971363CytoplasmicBy similarityAdd
BLAST
Topological domaini993 – 103341ExtracellularBy similarityAdd
BLAST
Topological domaini1055 – 109743CytoplasmicBy similarityAdd
BLAST
Topological domaini1119 – 11191ExtracellularBy similarity
Topological domaini1141 – 121171CytoplasmicBy similarityAdd
BLAST
Topological domaini1233 – 12342ExtracellularBy similarity
Topological domaini1256 – 1545290CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Transmembranei69 – 8921Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Transmembranei94 – 11421Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Transmembranei127 – 14721Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Transmembranei166 – 18621Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Transmembranei314 – 33421Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Transmembranei361 – 38121Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Transmembranei438 – 45821Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Transmembranei462 – 48221Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Transmembranei545 – 56521Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Transmembranei588 – 60821Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Transmembranei972 – 99221Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Transmembranei1034 – 105421Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Transmembranei1098 – 111821Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Transmembranei1120 – 114021Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Transmembranei1212 – 123221Helical; Name=16PROSITE-ProRule annotationAdd
BLAST
Transmembranei1235 – 125521Helical; Name=17PROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini322 – 605284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini637 – 861225ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini979 – 1264286ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1300 – 1534235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00760000119056.
HOVERGENiHBG108314.
InParanoidiQ92887.
KOiK05666.
OMAiSKFETHM.
OrthoDBiEOG7MWGW0.
PhylomeDBiQ92887.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92887-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH
60 70 80 90 100
VYKSRTKRSS TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR
110 120 130 140 150
YTNPSLYLGT WLLVLLIQYS RQWCVQKNSW FLSLFWILSI LCGTFQFQTL
160 170 180 190 200
IRTLLQGDNS NLAYSCLFFI SYGFQILILI FSAFSENNES SNNPSSIASF
210 220 230 240 250
LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS KFETHMKREL
260 270 280 290 300
QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG
310 320 330 340 350
TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA
360 370 380 390 400
SDRDTYLWIG YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV
410 420 430 440 450
YKKALTLSNL ARKEYTVGET VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL
460 470 480 490 500
SIFFLWRELG PSVLAGVGVM VLVIPINAIL STKSKTIQVK NMKNKDKRLK
510 520 530 540 550
IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS QLQCVVIFVF
560 570 580 590 600
QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI
610 620 630 640 650
SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS
660 670 680 690 700
EATVRDVNLD IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT
710 720 730 740 750
TAYVPQQSWI QNGTIKDNIL FGTEFNEKRY QQVLEACALL PDLEMLPGGD
760 770 780 790 800
LAEIGEKGIN LSGGQKQRIS LARATYQNLD IYLLDDPLSA VDAHVGKHIF
810 820 830 840 850
NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV EKGSYSALLA
860 870 880 890 900
KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS
910 920 930 940 950
ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK
960 970 980 990 1000
LIKKEFIETG KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL
1010 1020 1030 1040 1050
SAWTSDSKIF NSTDYPASQR DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV
1060 1070 1080 1090 1100
HASNILHKQL LNNILRAPMR FFDTTPTGRI VNRFAGDIST VDDTLPQSLR
1110 1120 1130 1140 1150
SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF YVSTSRQLRR
1160 1170 1180 1190 1200
LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW
1210 1220 1230 1240 1250
ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ
1260 1270 1280 1290 1300
TLNWLVRMTS EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI
1310 1320 1330 1340 1350
QFNNYQVRYR PELDLVLRGI TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI
1360 1370 1380 1390 1400
LEAAGGQIII DGVDIASIGL HDLREKLTII PQDPILFSGS LRMNLDPFNN
1410 1420 1430 1440 1450
YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG QRQLLCLGRA
1460 1470 1480 1490 1500
LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD
1510 1520 1530 1540
SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF
Length:1,545
Mass (Da):174,207
Last modified:October 5, 2010 - v3
Checksum:iC5F8984FFCDF9799
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1430 – 14301V → G in CAB45309. (PubMed:10464142)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391Y → F.7 Publications
Corresponds to variant rs927344 [ dbSNP | Ensembl ].
VAR_047152
Natural varianti246 – 2461M → L.
Corresponds to variant rs17222744 [ dbSNP | Ensembl ].
VAR_029113
Natural varianti281 – 2811S → N.1 Publication
Corresponds to variant rs56131651 [ dbSNP | Ensembl ].
VAR_013324
Natural varianti333 – 3331D → G Decreased expression; altered subcellular localization; altered transporter activity. 1 Publication
Corresponds to variant rs17222674 [ dbSNP | Ensembl ].
VAR_020226
Natural varianti353 – 3531R → H Altered transporter activity. 1 Publication
Corresponds to variant rs7080681 [ dbSNP | Ensembl ].
VAR_020227
Natural varianti417 – 4171V → I.2 Publications
Corresponds to variant rs2273697 [ dbSNP | Ensembl ].
VAR_013325
Natural varianti486 – 4861T → I Altered transporter activity. 1 Publication
VAR_070607
Natural varianti495 – 4951K → E.
Corresponds to variant rs17222561 [ dbSNP | Ensembl ].
VAR_029115
Natural varianti562 – 5621F → L.
Corresponds to variant rs17216233 [ dbSNP | Ensembl ].
VAR_029116
Natural varianti670 – 6701I → T.1 Publication
Corresponds to variant rs17222632 [ dbSNP | Ensembl ].
VAR_020228
Natural varianti768 – 7681R → W in DJS. 3 Publications
Corresponds to variant rs56199535 [ dbSNP | Ensembl ].
VAR_000099
Natural varianti789 – 7891S → F.1 Publication
Corresponds to variant rs56220353 [ dbSNP | Ensembl ].
VAR_013326
Natural varianti849 – 8491L → R.
Corresponds to variant rs17222617 [ dbSNP | Ensembl ].
VAR_020229
Natural varianti921 – 9211G → S Altered transporter activity. 1 Publication
VAR_070608
Natural varianti982 – 9821I → V.
Corresponds to variant rs17222554 [ dbSNP | Ensembl ].
VAR_029117
Natural varianti1036 – 10361I → T Polymorphism with no effect on transporter activity. 1 Publication
Corresponds to variant rs45441199 [ dbSNP | Ensembl ].
VAR_020230
Natural varianti1063 – 10631N → S.
Corresponds to variant rs17222540 [ dbSNP | Ensembl ].
VAR_029118
Natural varianti1150 – 11501R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. 1 Publication
VAR_013327
Natural varianti1173 – 11731I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. 1 Publication
VAR_013328
Natural varianti1174 – 11741R → H Decreased expression; altered subcellular localization; decreased transporter activity. 1 Publication
Corresponds to variant rs139188247 [ dbSNP | Ensembl ].
VAR_070609
Natural varianti1181 – 11811R → L Decreased expression. 1 Publication
Corresponds to variant rs8187692 [ dbSNP | Ensembl ].
VAR_020231
Natural varianti1188 – 11881V → E.2 Publications
Corresponds to variant rs17222723 [ dbSNP | Ensembl ].
VAR_020232
Natural varianti1244 – 12441N → K Decreased transporter activity.
VAR_070610
Natural varianti1273 – 12731T → A.
Corresponds to variant rs8187699 [ dbSNP | Ensembl ].
VAR_024360
Natural varianti1291 – 12911P → L Altered transporter activity. 1 Publication
Corresponds to variant rs17216317 [ dbSNP | Ensembl ].
VAR_020233
Natural varianti1382 – 13821Q → R in DJS. 1 Publication
VAR_010756
Natural varianti1392 – 13932Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation. 1 Publication
VAR_013329
Natural varianti1450 – 14501A → T.1 Publication
Corresponds to variant rs56296335 [ dbSNP | Ensembl ].
VAR_013330
Natural varianti1515 – 15151C → Y.2 Publications
Corresponds to variant rs8187710 [ dbSNP | Ensembl ].
VAR_020234

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63970 mRNA. Translation: AAB39892.1.
U49248 mRNA. Translation: AAB09422.1.
X96395 mRNA. Translation: CAA65259.2.
AJ132244
, AJ132287, AJ245625, AJ132288, AJ132289, AJ132290, AJ132291, AJ132292, AJ132293, AJ132294, AJ132295, AJ132296, AJ132297, AJ132298, AJ132299, AJ132300, AJ132301, AJ132302, AJ132303, AJ245626, AJ132304, AJ132305, AJ132306, AJ132307, AJ132308, AJ245627, AJ132309, AJ132310, AJ132311, AJ132312, AJ132313, AJ132314 Genomic DNA. Translation: CAB45309.1.
AL392107, AL133353 Genomic DNA. Translation: CAI11010.1.
AL133353, AL392107 Genomic DNA. Translation: CAI14502.1.
CH471066 Genomic DNA. Translation: EAW49853.1.
BC136419 mRNA. Translation: AAI36420.1.
CCDSiCCDS7484.1.
PIRiS71841.
RefSeqiNP_000383.1. NM_000392.4.
UniGeneiHs.368243.

Genome annotation databases

EnsembliENST00000370449; ENSP00000359478; ENSG00000023839.
GeneIDi1244.
KEGGihsa:1244.
UCSCiuc001kqf.2. human.

Polymorphism databases

DMDMi308153583.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63970 mRNA. Translation: AAB39892.1 .
U49248 mRNA. Translation: AAB09422.1 .
X96395 mRNA. Translation: CAA65259.2 .
AJ132244
, AJ132287 , AJ245625 , AJ132288 , AJ132289 , AJ132290 , AJ132291 , AJ132292 , AJ132293 , AJ132294 , AJ132295 , AJ132296 , AJ132297 , AJ132298 , AJ132299 , AJ132300 , AJ132301 , AJ132302 , AJ132303 , AJ245626 , AJ132304 , AJ132305 , AJ132306 , AJ132307 , AJ132308 , AJ245627 , AJ132309 , AJ132310 , AJ132311 , AJ132312 , AJ132313 , AJ132314 Genomic DNA. Translation: CAB45309.1 .
AL392107 , AL133353 Genomic DNA. Translation: CAI11010.1 .
AL133353 , AL392107 Genomic DNA. Translation: CAI14502.1 .
CH471066 Genomic DNA. Translation: EAW49853.1 .
BC136419 mRNA. Translation: AAI36420.1 .
CCDSi CCDS7484.1.
PIRi S71841.
RefSeqi NP_000383.1. NM_000392.4.
UniGenei Hs.368243.

3D structure databases

ProteinModelPortali Q92887.
SMRi Q92887. Positions 642-862.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107647. 46 interactions.
IntActi Q92887. 5 interactions.
MINTi MINT-5004989.
STRINGi 9606.ENSP00000359478.

Chemistry

BindingDBi Q92887.
ChEMBLi CHEMBL5748.
DrugBanki DB00171. Adenosine triphosphate.
DB00345. Aminohippurate.
DB01169. Arsenic trioxide.
DB01076. Atorvastatin.
DB08907. Canagliflozin.
DB00564. Carbamazepine.
DB00958. Carboplatin.
DB00515. Cisplatin.
DB00257. Clotrimazole.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB00694. Daunorubicin.
DB01234. Dexamethasone.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB00876. Eprosartan.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB00973. Ezetimibe.
DB00695. Furosemide.
DB02703. Fusidic Acid.
DB08884. Gadoxetate.
DB00143. Glutathione.
DB01016. Glyburide.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00762. Irinotecan.
DB00602. Ivermectin.
DB00709. Lamivudine.
DB00650. Leucovorin.
DB01202. Levetiracetam.
DB00978. Lomefloxacin.
DB00227. Lovastatin.
DB00563. Methotrexate.
DB00688. Mycophenolate mofetil.
DB01115. Nifedipine.
DB00957. Norgestimate.
DB01165. Ofloxacin.
DB00275. Olmesartan.
DB00526. Oxaliplatin.
DB01229. Paclitaxel.
DB01174. Phenobarbital.
DB00252. Phenytoin.
DB08860. Pitavastatin.
DB01411. Pranlukast.
DB00175. Pravastatin.
DB01032. Probenecid.
DB00908. Quinidine.
DB00206. Reserpine.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB01232. Saquinavir.
DB00641. Simvastatin.
DB00398. Sorafenib.
DB01208. Sparfloxacin.
DB00421. Spironolactone.
DB00795. Sulfasalazine.
DB01138. Sulfinpyrazone.
DB01268. Sunitinib.
DB00675. Tamoxifen.
DB00966. Telmisartan.
DB00300. Tenofovir.
DB00116. Tetrahydrofolic acid.
DB01586. Ursodeoxycholic acid.
DB00067. Vasopressin.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.

Protein family/group databases

TCDBi 3.A.1.208.2. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei Q92887.

Polymorphism databases

DMDMi 308153583.

Proteomic databases

MaxQBi Q92887.
PaxDbi Q92887.
PRIDEi Q92887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370449 ; ENSP00000359478 ; ENSG00000023839 .
GeneIDi 1244.
KEGGi hsa:1244.
UCSCi uc001kqf.2. human.

Organism-specific databases

CTDi 1244.
GeneCardsi GC10P101532.
HGNCi HGNC:53. ABCC2.
HPAi HPA004860.
MIMi 237500. phenotype.
601107. gene.
neXtProti NX_Q92887.
Orphaneti 234. Dubin-Johnson syndrome.
PharmGKBi PA116.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00760000119056.
HOVERGENi HBG108314.
InParanoidi Q92887.
KOi K05666.
OMAi SKFETHM.
OrthoDBi EOG7MWGW0.
PhylomeDBi Q92887.
TreeFami TF105199.

Enzyme and pathway databases

Reactomei REACT_15480. ABC-family proteins mediated transport.
SABIO-RK Q92887.

Miscellaneous databases

GeneWikii Multidrug_resistance-associated_protein_2.
GenomeRNAii 1244.
NextBioi 5071.
PROi Q92887.
SOURCEi Search...

Gene expression databases

Bgeei Q92887.
CleanExi HS_ABCC2.
ExpressionAtlasi Q92887. baseline and differential.
Genevestigatori Q92887.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation."
    Taniguchi K., Wada M., Kohno K., Nakamura T., Kawabe T., Kawakami M., Kagotani K., Okumura K., Akiyama S., Kuwano M.
    Cancer Res. 56:4124-4129(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-39.
  2. Kool M., de Haas M., Ponne N.J., Paulusma C.C., Oude-Elferink R.P.J., Baas F., Borst P.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-39; GLU-1188 AND TYR-1515.
  3. "cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats."
    Buechler M., Koenig J., Brom M., Kartenbeck J., Spring H., Horie T., Keppler D.
    J. Biol. Chem. 271:15091-15098(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-39.
  4. Keppler D.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome."
    Tsujii H., Koenig J., Rost D., Stoeckel B., Leuschner U., Keppler D.
    Gastroenterology 117:653-660(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PHE-39 AND DJS 1392-ARG-MET-1393 DEL.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-39.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-39.
  9. "Hepatic secretion of conjugated drugs and endogenous substances."
    Keppler D., Koenig J.
    Semin. Liver Dis. 20:265-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity."
    Ito K., Oleschuk C.J., Westlake C., Vasa M.Z., Deeley R.G., Cole S.P.C.
    J. Biol. Chem. 276:38108-38114(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF TRP-1254.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND SER-878, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome."
    Wada M., Toh S., Taniguchi K., Nakamura T., Uchiumi T., Kohno K., Yoshida I., Kimura A., Sakisaka S., Adachi Y., Kuwano M.
    Hum. Mol. Genet. 7:203-207(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DJS TRP-768.
  16. "Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome."
    Toh S., Wada M., Uchiumi T., Inokuchi A., Makino Y., Horie Y., Adachi Y., Sakisaka S., Kuwano M.
    Am. J. Hum. Genet. 64:739-746(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS DJS TRP-768 AND ARG-1382.
  17. "Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome."
    Keitel V., Kartenbeck J., Nies A.T., Spring H., Brom M., Keppler D.
    Hepatology 32:1317-1328(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANT DJS 1392-ARG-MET-1393 DEL, SUBCELLULAR LOCATION.
  18. "Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome."
    Mor-Cohen R., Zivelin A., Rosenberg N., Shani M., Muallem S., Seligsohn U.
    J. Biol. Chem. 276:36923-36930(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS DJS HIS-1150 AND PHE-1173, VARIANTS ASN-281 AND ILE-417.
  19. "Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects."
    Ito S., Ieiri I., Tanabe M., Suzuki A., Higuchi S., Otsubo K.
    Pharmacogenetics 11:175-184(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DJS TRP-768, VARIANTS ILE-417; PHE-789 AND THR-1450.
  20. "Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells."
    Arlanov R., Porter A., Strand D., Brough R., Karpova D., Kerb R., Wojnowski L., Schwab M., Lang T.
    Hum. Mutat. 33:750-762(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PHE-39; GLY-333; HIS-353; ILE-486; THR-670; SER-921; THR-1036; HIS-1174; LEU-1181; GLU-1188; LEU-1291 AND TYR-1515, CHARACTERIZATION OF VARIANTS DJS PHE-1173, CHARACTERIZATION OF VARIANTS GLY-333; HIS-353; ILE-486; SER-921; THR-1036; HIS-1174; LEU-1181; LYS-1244 AND LEU-1291.

Entry informationi

Entry nameiMRP2_HUMAN
AccessioniPrimary (citable) accession number: Q92887
Secondary accession number(s): B2RMT8
, Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3