Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q92887

- MRP2_HUMAN

UniProt

Q92887 - MRP2_HUMAN

Protein

Canalicular multispecific organic anion transporter 1

Gene

ABCC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi671 – 6788ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1334 – 13418ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: ProtInc
    2. ATP binding Source: UniProtKB-KW
    3. organic anion transmembrane transporter activity Source: ProtInc
    4. protein binding Source: IntAct

    GO - Biological processi

    1. cellular chloride ion homeostasis Source: Ensembl
    2. drug transmembrane transport Source: Ensembl
    3. prostaglandin transport Source: Ensembl
    4. response to arsenic-containing substance Source: Ensembl
    5. response to estrogen Source: Ensembl
    6. response to heat Source: Ensembl
    7. response to methotrexate Source: Ensembl
    8. response to oxidative stress Source: Ensembl
    9. thyroid hormone transport Source: Ensembl
    10. transmembrane transport Source: Reactome
    11. transport Source: ProtInc

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15480. ABC-family proteins mediated transport.
    SABIO-RKQ92887.

    Protein family/group databases

    TCDBi3.A.1.208.2. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Canalicular multispecific organic anion transporter 1
    Alternative name(s):
    ATP-binding cassette sub-family C member 2
    Canalicular multidrug resistance protein
    Multidrug resistance-associated protein 2
    Gene namesi
    Name:ABCC2
    Synonyms:CMOAT, CMOAT1, CMRP, MRP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:53. ABCC2.

    Subcellular locationi

    Apical cell membrane 1 Publication; Multi-pass membrane protein 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. intercellular canaliculus Source: Ensembl
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.5 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti768 – 7681R → W in DJS. 3 Publications
    Corresponds to variant rs56199535 [ dbSNP | Ensembl ].
    VAR_000099
    Natural varianti1150 – 11501R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. 1 Publication
    VAR_013327
    Natural varianti1173 – 11731I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. 1 Publication
    VAR_013328
    Natural varianti1382 – 13821Q → R in DJS. 1 Publication
    VAR_010756
    Natural varianti1392 – 13932Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation.
    VAR_013329

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1254 – 12541W → A or C: Fails to transport methotrexate, leukotriene C4 and estradiol glucuronide. 1 Publication
    Mutagenesisi1254 – 12541W → F: Fails to transport methotrexate and leukotriene C4. Does not affect estradiol glucuronide transport. 1 Publication
    Mutagenesisi1254 – 12541W → Y: Fails to transport methotrexate; reduces leukotriene C4 transport. Does not affect estradiol glucuronide transport. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi237500. phenotype.
    Orphaneti234. Dubin-Johnson syndrome.
    PharmGKBiPA116.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15451545Canalicular multispecific organic anion transporter 1PRO_0000093356Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Modified residuei283 – 2831Phosphoserine1 Publication
    Modified residuei878 – 8781Phosphoserine1 Publication
    Glycosylationi1011 – 10111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ92887.
    PaxDbiQ92887.
    PRIDEiQ92887.

    PTM databases

    PhosphoSiteiQ92887.

    Expressioni

    Tissue specificityi

    Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

    Gene expression databases

    ArrayExpressiQ92887.
    BgeeiQ92887.
    CleanExiHS_ABCC2.
    GenevestigatoriQ92887.

    Organism-specific databases

    HPAiHPA004860.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NFKB1P198383EBI-3916193,EBI-300010

    Protein-protein interaction databases

    BioGridi107647. 46 interactions.
    IntActiQ92887. 5 interactions.
    MINTiMINT-5004989.
    STRINGi9606.ENSP00000359478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92887.
    SMRiQ92887. Positions 642-862.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularBy similarityAdd
    BLAST
    Topological domaini49 – 6820CytoplasmicBy similarityAdd
    BLAST
    Topological domaini90 – 934ExtracellularBy similarity
    Topological domaini115 – 12612CytoplasmicBy similarityAdd
    BLAST
    Topological domaini148 – 16518ExtracellularBy similarityAdd
    BLAST
    Topological domaini187 – 313127CytoplasmicBy similarityAdd
    BLAST
    Topological domaini335 – 36026ExtracellularBy similarityAdd
    BLAST
    Topological domaini382 – 43756CytoplasmicBy similarityAdd
    BLAST
    Topological domaini459 – 4613ExtracellularBy similarity
    Topological domaini483 – 54462CytoplasmicBy similarityAdd
    BLAST
    Topological domaini566 – 58722ExtracellularBy similarityAdd
    BLAST
    Topological domaini609 – 971363CytoplasmicBy similarityAdd
    BLAST
    Topological domaini993 – 103341ExtracellularBy similarityAdd
    BLAST
    Topological domaini1055 – 109743CytoplasmicBy similarityAdd
    BLAST
    Topological domaini1119 – 11191ExtracellularBy similarity
    Topological domaini1141 – 121171CytoplasmicBy similarityAdd
    BLAST
    Topological domaini1233 – 12342ExtracellularBy similarity
    Topological domaini1256 – 1545290CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei69 – 8921Helical; Name=2PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei94 – 11421Helical; Name=3PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei166 – 18621Helical; Name=5PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=6PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei361 – 38121Helical; Name=7PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei438 – 45821Helical; Name=8PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei462 – 48221Helical; Name=9PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei545 – 56521Helical; Name=10PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei588 – 60821Helical; Name=11PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei972 – 99221Helical; Name=12PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1034 – 105421Helical; Name=13PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1098 – 111821Helical; Name=14PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1120 – 114021Helical; Name=15PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1212 – 123221Helical; Name=16PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1235 – 125521Helical; Name=17PROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini322 – 605284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini637 – 861225ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini979 – 1264286ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1300 – 1534235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOVERGENiHBG108314.
    InParanoidiQ92887.
    KOiK05666.
    OMAiSKFETHM.
    OrthoDBiEOG7MWGW0.
    PhylomeDBiQ92887.
    TreeFamiTF105199.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92887-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH     50
    VYKSRTKRSS TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR 100
    YTNPSLYLGT WLLVLLIQYS RQWCVQKNSW FLSLFWILSI LCGTFQFQTL 150
    IRTLLQGDNS NLAYSCLFFI SYGFQILILI FSAFSENNES SNNPSSIASF 200
    LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS KFETHMKREL 250
    QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG 300
    TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA 350
    SDRDTYLWIG YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV 400
    YKKALTLSNL ARKEYTVGET VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL 450
    SIFFLWRELG PSVLAGVGVM VLVIPINAIL STKSKTIQVK NMKNKDKRLK 500
    IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS QLQCVVIFVF 550
    QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI 600
    SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS 650
    EATVRDVNLD IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT 700
    TAYVPQQSWI QNGTIKDNIL FGTEFNEKRY QQVLEACALL PDLEMLPGGD 750
    LAEIGEKGIN LSGGQKQRIS LARATYQNLD IYLLDDPLSA VDAHVGKHIF 800
    NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV EKGSYSALLA 850
    KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS 900
    ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK 950
    LIKKEFIETG KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL 1000
    SAWTSDSKIF NSTDYPASQR DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV 1050
    HASNILHKQL LNNILRAPMR FFDTTPTGRI VNRFAGDIST VDDTLPQSLR 1100
    SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF YVSTSRQLRR 1150
    LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW 1200
    ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ 1250
    TLNWLVRMTS EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI 1300
    QFNNYQVRYR PELDLVLRGI TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI 1350
    LEAAGGQIII DGVDIASIGL HDLREKLTII PQDPILFSGS LRMNLDPFNN 1400
    YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG QRQLLCLGRA 1450
    LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD 1500
    SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF 1545
    Length:1,545
    Mass (Da):174,207
    Last modified:October 5, 2010 - v3
    Checksum:iC5F8984FFCDF9799
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1430 – 14301V → G in CAB45309. (PubMed:10464142)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391Y → F.7 Publications
    Corresponds to variant rs927344 [ dbSNP | Ensembl ].
    VAR_047152
    Natural varianti246 – 2461M → L.
    Corresponds to variant rs17222744 [ dbSNP | Ensembl ].
    VAR_029113
    Natural varianti281 – 2811S → N.1 Publication
    Corresponds to variant rs56131651 [ dbSNP | Ensembl ].
    VAR_013324
    Natural varianti333 – 3331D → G Decreased expression; altered subcellular localization; altered transporter activity. 1 Publication
    Corresponds to variant rs17222674 [ dbSNP | Ensembl ].
    VAR_020226
    Natural varianti353 – 3531R → H Altered transporter activity. 1 Publication
    Corresponds to variant rs7080681 [ dbSNP | Ensembl ].
    VAR_020227
    Natural varianti417 – 4171V → I.2 Publications
    Corresponds to variant rs2273697 [ dbSNP | Ensembl ].
    VAR_013325
    Natural varianti486 – 4861T → I Altered transporter activity. 1 Publication
    VAR_070607
    Natural varianti495 – 4951K → E.
    Corresponds to variant rs17222561 [ dbSNP | Ensembl ].
    VAR_029115
    Natural varianti562 – 5621F → L.
    Corresponds to variant rs17216233 [ dbSNP | Ensembl ].
    VAR_029116
    Natural varianti670 – 6701I → T.1 Publication
    Corresponds to variant rs17222632 [ dbSNP | Ensembl ].
    VAR_020228
    Natural varianti768 – 7681R → W in DJS. 3 Publications
    Corresponds to variant rs56199535 [ dbSNP | Ensembl ].
    VAR_000099
    Natural varianti789 – 7891S → F.1 Publication
    Corresponds to variant rs56220353 [ dbSNP | Ensembl ].
    VAR_013326
    Natural varianti849 – 8491L → R.
    Corresponds to variant rs17222617 [ dbSNP | Ensembl ].
    VAR_020229
    Natural varianti921 – 9211G → S Altered transporter activity. 1 Publication
    VAR_070608
    Natural varianti982 – 9821I → V.
    Corresponds to variant rs17222554 [ dbSNP | Ensembl ].
    VAR_029117
    Natural varianti1036 – 10361I → T Polymorphism with no effect on transporter activity. 1 Publication
    Corresponds to variant rs45441199 [ dbSNP | Ensembl ].
    VAR_020230
    Natural varianti1063 – 10631N → S.
    Corresponds to variant rs17222540 [ dbSNP | Ensembl ].
    VAR_029118
    Natural varianti1150 – 11501R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. 1 Publication
    VAR_013327
    Natural varianti1173 – 11731I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. 1 Publication
    VAR_013328
    Natural varianti1174 – 11741R → H Decreased expression; altered subcellular localization; decreased transporter activity. 1 Publication
    Corresponds to variant rs139188247 [ dbSNP | Ensembl ].
    VAR_070609
    Natural varianti1181 – 11811R → L Decreased expression. 1 Publication
    Corresponds to variant rs8187692 [ dbSNP | Ensembl ].
    VAR_020231
    Natural varianti1188 – 11881V → E.2 Publications
    Corresponds to variant rs17222723 [ dbSNP | Ensembl ].
    VAR_020232
    Natural varianti1244 – 12441N → K Decreased transporter activity.
    VAR_070610
    Natural varianti1273 – 12731T → A.
    Corresponds to variant rs8187699 [ dbSNP | Ensembl ].
    VAR_024360
    Natural varianti1291 – 12911P → L Altered transporter activity. 1 Publication
    Corresponds to variant rs17216317 [ dbSNP | Ensembl ].
    VAR_020233
    Natural varianti1382 – 13821Q → R in DJS. 1 Publication
    VAR_010756
    Natural varianti1392 – 13932Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation.
    VAR_013329
    Natural varianti1450 – 14501A → T.1 Publication
    Corresponds to variant rs56296335 [ dbSNP | Ensembl ].
    VAR_013330
    Natural varianti1515 – 15151C → Y.2 Publications
    Corresponds to variant rs8187710 [ dbSNP | Ensembl ].
    VAR_020234

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63970 mRNA. Translation: AAB39892.1.
    U49248 mRNA. Translation: AAB09422.1.
    X96395 mRNA. Translation: CAA65259.2.
    AJ132244
    , AJ132287, AJ245625, AJ132288, AJ132289, AJ132290, AJ132291, AJ132292, AJ132293, AJ132294, AJ132295, AJ132296, AJ132297, AJ132298, AJ132299, AJ132300, AJ132301, AJ132302, AJ132303, AJ245626, AJ132304, AJ132305, AJ132306, AJ132307, AJ132308, AJ245627, AJ132309, AJ132310, AJ132311, AJ132312, AJ132313, AJ132314 Genomic DNA. Translation: CAB45309.1.
    AL392107, AL133353 Genomic DNA. Translation: CAI11010.1.
    AL133353, AL392107 Genomic DNA. Translation: CAI14502.1.
    CH471066 Genomic DNA. Translation: EAW49853.1.
    BC136419 mRNA. Translation: AAI36420.1.
    CCDSiCCDS7484.1.
    PIRiS71841.
    RefSeqiNP_000383.1. NM_000392.4.
    UniGeneiHs.368243.

    Genome annotation databases

    EnsembliENST00000370449; ENSP00000359478; ENSG00000023839.
    GeneIDi1244.
    KEGGihsa:1244.
    UCSCiuc001kqf.2. human.

    Polymorphism databases

    DMDMi308153583.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63970 mRNA. Translation: AAB39892.1 .
    U49248 mRNA. Translation: AAB09422.1 .
    X96395 mRNA. Translation: CAA65259.2 .
    AJ132244
    , AJ132287 , AJ245625 , AJ132288 , AJ132289 , AJ132290 , AJ132291 , AJ132292 , AJ132293 , AJ132294 , AJ132295 , AJ132296 , AJ132297 , AJ132298 , AJ132299 , AJ132300 , AJ132301 , AJ132302 , AJ132303 , AJ245626 , AJ132304 , AJ132305 , AJ132306 , AJ132307 , AJ132308 , AJ245627 , AJ132309 , AJ132310 , AJ132311 , AJ132312 , AJ132313 , AJ132314 Genomic DNA. Translation: CAB45309.1 .
    AL392107 , AL133353 Genomic DNA. Translation: CAI11010.1 .
    AL133353 , AL392107 Genomic DNA. Translation: CAI14502.1 .
    CH471066 Genomic DNA. Translation: EAW49853.1 .
    BC136419 mRNA. Translation: AAI36420.1 .
    CCDSi CCDS7484.1.
    PIRi S71841.
    RefSeqi NP_000383.1. NM_000392.4.
    UniGenei Hs.368243.

    3D structure databases

    ProteinModelPortali Q92887.
    SMRi Q92887. Positions 642-862.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107647. 46 interactions.
    IntActi Q92887. 5 interactions.
    MINTi MINT-5004989.
    STRINGi 9606.ENSP00000359478.

    Chemistry

    BindingDBi Q92887.
    ChEMBLi CHEMBL5748.
    DrugBanki DB00171. Adenosine triphosphate.
    DB00345. Aminohippurate.
    DB01169. Arsenic trioxide.
    DB01076. Atorvastatin.
    DB08907. Canagliflozin.
    DB00564. Carbamazepine.
    DB00958. Carboplatin.
    DB00515. Cisplatin.
    DB00257. Clotrimazole.
    DB00286. Conjugated Estrogens.
    DB00091. Cyclosporine.
    DB00694. Daunorubicin.
    DB01234. Dexamethasone.
    DB01248. Docetaxel.
    DB00997. Doxorubicin.
    DB00876. Eprosartan.
    DB00977. Ethinyl Estradiol.
    DB00773. Etoposide.
    DB00973. Ezetimibe.
    DB00695. Furosemide.
    DB02703. Fusidic Acid.
    DB08884. Gadoxetate.
    DB00143. Glutathione.
    DB01016. Glyburide.
    DB00224. Indinavir.
    DB00328. Indomethacin.
    DB00762. Irinotecan.
    DB00602. Ivermectin.
    DB00709. Lamivudine.
    DB00650. Leucovorin.
    DB01202. Levetiracetam.
    DB00978. Lomefloxacin.
    DB00227. Lovastatin.
    DB00563. Methotrexate.
    DB00688. Mycophenolate mofetil.
    DB01115. Nifedipine.
    DB00957. Norgestimate.
    DB01165. Ofloxacin.
    DB00275. Olmesartan.
    DB00526. Oxaliplatin.
    DB01229. Paclitaxel.
    DB01174. Phenobarbital.
    DB00252. Phenytoin.
    DB08860. Pitavastatin.
    DB01411. Pranlukast.
    DB00175. Pravastatin.
    DB01032. Probenecid.
    DB00908. Quinidine.
    DB00206. Reserpine.
    DB01045. Rifampicin.
    DB00503. Ritonavir.
    DB01232. Saquinavir.
    DB00641. Simvastatin.
    DB00398. Sorafenib.
    DB01208. Sparfloxacin.
    DB00421. Spironolactone.
    DB00795. Sulfasalazine.
    DB01138. Sulfinpyrazone.
    DB01268. Sunitinib.
    DB00675. Tamoxifen.
    DB00966. Telmisartan.
    DB00300. Tenofovir.
    DB00116. Tetrahydrofolic acid.
    DB01586. Ursodeoxycholic acid.
    DB00067. Vasopressin.
    DB00661. Verapamil.
    DB00570. Vinblastine.
    DB00541. Vincristine.

    Protein family/group databases

    TCDBi 3.A.1.208.2. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei Q92887.

    Polymorphism databases

    DMDMi 308153583.

    Proteomic databases

    MaxQBi Q92887.
    PaxDbi Q92887.
    PRIDEi Q92887.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370449 ; ENSP00000359478 ; ENSG00000023839 .
    GeneIDi 1244.
    KEGGi hsa:1244.
    UCSCi uc001kqf.2. human.

    Organism-specific databases

    CTDi 1244.
    GeneCardsi GC10P101532.
    HGNCi HGNC:53. ABCC2.
    HPAi HPA004860.
    MIMi 237500. phenotype.
    601107. gene.
    neXtProti NX_Q92887.
    Orphaneti 234. Dubin-Johnson syndrome.
    PharmGKBi PA116.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOVERGENi HBG108314.
    InParanoidi Q92887.
    KOi K05666.
    OMAi SKFETHM.
    OrthoDBi EOG7MWGW0.
    PhylomeDBi Q92887.
    TreeFami TF105199.

    Enzyme and pathway databases

    Reactomei REACT_15480. ABC-family proteins mediated transport.
    SABIO-RK Q92887.

    Miscellaneous databases

    GeneWikii Multidrug_resistance-associated_protein_2.
    GenomeRNAii 1244.
    NextBioi 5071.
    PROi Q92887.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92887.
    Bgeei Q92887.
    CleanExi HS_ABCC2.
    Genevestigatori Q92887.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation."
      Taniguchi K., Wada M., Kohno K., Nakamura T., Kawabe T., Kawakami M., Kagotani K., Okumura K., Akiyama S., Kuwano M.
      Cancer Res. 56:4124-4129(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-39.
    2. Kool M., de Haas M., Ponne N.J., Paulusma C.C., Oude-Elferink R.P.J., Baas F., Borst P.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-39; GLU-1188 AND TYR-1515.
    3. "cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats."
      Buechler M., Koenig J., Brom M., Kartenbeck J., Spring H., Horie T., Keppler D.
      J. Biol. Chem. 271:15091-15098(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-39.
    4. Keppler D.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome."
      Tsujii H., Koenig J., Rost D., Stoeckel B., Leuschner U., Keppler D.
      Gastroenterology 117:653-660(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PHE-39 AND DJS 1392-ARG-MET-1393 DEL.
    6. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-39.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-39.
    9. "Hepatic secretion of conjugated drugs and endogenous substances."
      Keppler D., Koenig J.
      Semin. Liver Dis. 20:265-272(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity."
      Ito K., Oleschuk C.J., Westlake C., Vasa M.Z., Deeley R.G., Cole S.P.C.
      J. Biol. Chem. 276:38108-38114(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF TRP-1254.
    11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND SER-878, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome."
      Wada M., Toh S., Taniguchi K., Nakamura T., Uchiumi T., Kohno K., Yoshida I., Kimura A., Sakisaka S., Adachi Y., Kuwano M.
      Hum. Mol. Genet. 7:203-207(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DJS TRP-768.
    16. "Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome."
      Toh S., Wada M., Uchiumi T., Inokuchi A., Makino Y., Horie Y., Adachi Y., Sakisaka S., Kuwano M.
      Am. J. Hum. Genet. 64:739-746(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS DJS TRP-768 AND ARG-1382.
    17. "Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome."
      Keitel V., Kartenbeck J., Nies A.T., Spring H., Brom M., Keppler D.
      Hepatology 32:1317-1328(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT DJS 1392-ARG-MET-1393 DEL, SUBCELLULAR LOCATION.
    18. "Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome."
      Mor-Cohen R., Zivelin A., Rosenberg N., Shani M., Muallem S., Seligsohn U.
      J. Biol. Chem. 276:36923-36930(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS DJS HIS-1150 AND PHE-1173, VARIANTS ASN-281 AND ILE-417.
    19. "Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects."
      Ito S., Ieiri I., Tanabe M., Suzuki A., Higuchi S., Otsubo K.
      Pharmacogenetics 11:175-184(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DJS TRP-768, VARIANTS ILE-417; PHE-789 AND THR-1450.
    20. "Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells."
      Arlanov R., Porter A., Strand D., Brough R., Karpova D., Kerb R., Wojnowski L., Schwab M., Lang T.
      Hum. Mutat. 33:750-762(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PHE-39; GLY-333; HIS-353; ILE-486; THR-670; SER-921; THR-1036; HIS-1174; LEU-1181; GLU-1188; LEU-1291 AND TYR-1515, CHARACTERIZATION OF VARIANTS DJS PHE-1173, CHARACTERIZATION OF VARIANTS GLY-333; HIS-353; ILE-486; SER-921; THR-1036; HIS-1174; LEU-1181; LYS-1244 AND LEU-1291.

    Entry informationi

    Entry nameiMRP2_HUMAN
    AccessioniPrimary (citable) accession number: Q92887
    Secondary accession number(s): B2RMT8
    , Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 147 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3