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Protein

Canalicular multispecific organic anion transporter 1

Gene

ABCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi671 – 678ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1334 – 1341ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000023839-MONOMER.
ReactomeiR-HSA-382556. ABC-family proteins mediated transport.
SABIO-RKQ92887.

Protein family/group databases

TCDBi3.A.1.208.2. the atp-binding cassette (abc) superfamily.

Chemistry databases

SwissLipidsiSLP:000001599.

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Canalicular multidrug resistance protein
Multidrug resistance-associated protein 2
Gene namesi
Name:ABCC2
Synonyms:CMOAT, CMOAT1, CMRP, MRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:53. ABCC2.

Subcellular locationi

  • Apical cell membrane 1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularBy similarityAdd BLAST27
Transmembranei28 – 48Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini49 – 68CytoplasmicBy similarityAdd BLAST20
Transmembranei69 – 89Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini90 – 93ExtracellularBy similarity4
Transmembranei94 – 114Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini115 – 126CytoplasmicBy similarityAdd BLAST12
Transmembranei127 – 147Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini148 – 165ExtracellularBy similarityAdd BLAST18
Transmembranei166 – 186Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini187 – 313CytoplasmicBy similarityAdd BLAST127
Transmembranei314 – 334Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini335 – 360ExtracellularBy similarityAdd BLAST26
Transmembranei361 – 381Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini382 – 437CytoplasmicBy similarityAdd BLAST56
Transmembranei438 – 458Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini459 – 461ExtracellularBy similarity3
Transmembranei462 – 482Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini483 – 544CytoplasmicBy similarityAdd BLAST62
Transmembranei545 – 565Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini566 – 587ExtracellularBy similarityAdd BLAST22
Transmembranei588 – 608Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini609 – 971CytoplasmicBy similarityAdd BLAST363
Transmembranei972 – 992Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini993 – 1033ExtracellularBy similarityAdd BLAST41
Transmembranei1034 – 1054Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1055 – 1097CytoplasmicBy similarityAdd BLAST43
Transmembranei1098 – 1118Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1119ExtracellularBy similarity1
Transmembranei1120 – 1140Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1141 – 1211CytoplasmicBy similarityAdd BLAST71
Transmembranei1212 – 1232Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1233 – 1234ExtracellularBy similarity2
Transmembranei1235 – 1255Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1256 – 1545CytoplasmicBy similarityAdd BLAST290

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intercellular canaliculus Source: Ensembl
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Dubin-Johnson syndrome (DJS)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
See also OMIM:237500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_000099768R → W in DJS. Corresponds to variant dbSNP:rs561995354 PublicationsEnsembl.1
Natural variantiVAR_0133271150R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. Corresponds to variant dbSNP:rs725582001 PublicationEnsembl.1
Natural variantiVAR_0133281173I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. Corresponds to variant dbSNP:rs725582012 PublicationsEnsembl.1
Natural variantiVAR_0107561382Q → R in DJS. Corresponds to variant dbSNP:rs725582021 PublicationEnsembl.1
Natural variantiVAR_0133291392 – 1393Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation. 2 Publications2

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1254W → A or C: Fails to transport methotrexate, leukotriene C4 and estradiol glucuronide. 1 Publication1
Mutagenesisi1254W → F: Fails to transport methotrexate and leukotriene C4. Does not affect estradiol glucuronide transport. 1 Publication1
Mutagenesisi1254W → Y: Fails to transport methotrexate; reduces leukotriene C4 transport. Does not affect estradiol glucuronide transport. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1244.
MalaCardsiABCC2.
MIMi237500. phenotype.
OpenTargetsiENSG00000023839.
Orphaneti234. Dubin-Johnson syndrome.
PharmGKBiPA116.

Chemistry databases

ChEMBLiCHEMBL5748.
DrugBankiDB00171. Adenosine triphosphate.
DB00345. Aminohippurate.
DB01169. Arsenic trioxide.
DB01076. Atorvastatin.
DB09060. Avibactam.
DB08907. Canagliflozin.
DB00564. Carbamazepine.
DB00958. Carboplatin.
DB02659. Cholic Acid.
DB00515. Cisplatin.
DB00257. Clotrimazole.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB00694. Daunorubicin.
DB01234. Dexamethasone.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB09272. Eluxadoline.
DB00876. Eprosartan.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB00973. Ezetimibe.
DB00695. Furosemide.
DB02703. Fusidic Acid.
DB08884. Gadoxetate.
DB00143. Glutathione.
DB01016. Glyburide.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00762. Irinotecan.
DB00602. Ivermectin.
DB00709. Lamivudine.
DB00650. Leucovorin.
DB01202. Levetiracetam.
DB00978. Lomefloxacin.
DB00227. Lovastatin.
DB00563. Methotrexate.
DB00688. Mycophenolate mofetil.
DB01115. Nifedipine.
DB00957. Norgestimate.
DB01165. Ofloxacin.
DB00275. Olmesartan.
DB00526. Oxaliplatin.
DB01229. Paclitaxel.
DB01174. Phenobarbital.
DB00252. Phenytoin.
DB08860. Pitavastatin.
DB01411. Pranlukast.
DB00175. Pravastatin.
DB01032. Probenecid.
DB00908. Quinidine.
DB00206. Reserpine.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB01232. Saquinavir.
DB00641. Simvastatin.
DB00398. Sorafenib.
DB01208. Sparfloxacin.
DB00421. Spironolactone.
DB00795. Sulfasalazine.
DB01138. Sulfinpyrazone.
DB01268. Sunitinib.
DB00675. Tamoxifen.
DB00966. Telmisartan.
DB00300. Tenofovir.
DB00116. Tetrahydrofolic acid.
DB01586. Ursodeoxycholic acid.
DB00067. Vasopressin.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.
GuidetoPHARMACOLOGYi780.

Polymorphism and mutation databases

BioMutaiABCC2.
DMDMi308153583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933561 – 1545Canalicular multispecific organic anion transporter 1Add BLAST1545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1
Modified residuei281PhosphoserineBy similarity1
Modified residuei283PhosphoserineCombined sources1
Modified residuei878PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1
Modified residuei930PhosphoserineCombined sources1
Modified residuei938PhosphoserineCombined sources1
Glycosylationi1011N-linked (GlcNAc...)Sequence analysis1
Modified residuei1438PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ92887.
MaxQBiQ92887.
PaxDbiQ92887.
PeptideAtlasiQ92887.
PRIDEiQ92887.

PTM databases

iPTMnetiQ92887.
PhosphoSitePlusiQ92887.

Expressioni

Tissue specificityi

Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Gene expression databases

BgeeiENSG00000023839.
CleanExiHS_ABCC2.
ExpressionAtlasiQ92887. baseline and differential.
GenevisibleiQ92887. HS.

Organism-specific databases

HPAiCAB037271.
HPA004860.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NFKB1P198383EBI-3916193,EBI-300010

Protein-protein interaction databases

BioGridi107647. 45 interactors.
IntActiQ92887. 5 interactors.
MINTiMINT-5004989.
STRINGi9606.ENSP00000359478.

Chemistry databases

BindingDBiQ92887.

Structurei

3D structure databases

ProteinModelPortaliQ92887.
SMRiQ92887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini322 – 605ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini637 – 861ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini979 – 1264ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST286
Domaini1300 – 1534ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiQ92887.
KOiK05666.
OMAiQTPGPFY.
OrthoDBiEOG091G00IN.
PhylomeDBiQ92887.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030247. ABCC2.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF176. PTHR24223:SF176. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH
60 70 80 90 100
VYKSRTKRSS TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR
110 120 130 140 150
YTNPSLYLGT WLLVLLIQYS RQWCVQKNSW FLSLFWILSI LCGTFQFQTL
160 170 180 190 200
IRTLLQGDNS NLAYSCLFFI SYGFQILILI FSAFSENNES SNNPSSIASF
210 220 230 240 250
LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS KFETHMKREL
260 270 280 290 300
QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG
310 320 330 340 350
TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA
360 370 380 390 400
SDRDTYLWIG YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV
410 420 430 440 450
YKKALTLSNL ARKEYTVGET VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL
460 470 480 490 500
SIFFLWRELG PSVLAGVGVM VLVIPINAIL STKSKTIQVK NMKNKDKRLK
510 520 530 540 550
IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS QLQCVVIFVF
560 570 580 590 600
QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI
610 620 630 640 650
SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS
660 670 680 690 700
EATVRDVNLD IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT
710 720 730 740 750
TAYVPQQSWI QNGTIKDNIL FGTEFNEKRY QQVLEACALL PDLEMLPGGD
760 770 780 790 800
LAEIGEKGIN LSGGQKQRIS LARATYQNLD IYLLDDPLSA VDAHVGKHIF
810 820 830 840 850
NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV EKGSYSALLA
860 870 880 890 900
KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS
910 920 930 940 950
ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK
960 970 980 990 1000
LIKKEFIETG KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL
1010 1020 1030 1040 1050
SAWTSDSKIF NSTDYPASQR DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV
1060 1070 1080 1090 1100
HASNILHKQL LNNILRAPMR FFDTTPTGRI VNRFAGDIST VDDTLPQSLR
1110 1120 1130 1140 1150
SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF YVSTSRQLRR
1160 1170 1180 1190 1200
LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW
1210 1220 1230 1240 1250
ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ
1260 1270 1280 1290 1300
TLNWLVRMTS EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI
1310 1320 1330 1340 1350
QFNNYQVRYR PELDLVLRGI TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI
1360 1370 1380 1390 1400
LEAAGGQIII DGVDIASIGL HDLREKLTII PQDPILFSGS LRMNLDPFNN
1410 1420 1430 1440 1450
YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG QRQLLCLGRA
1460 1470 1480 1490 1500
LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD
1510 1520 1530 1540
SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF
Length:1,545
Mass (Da):174,207
Last modified:October 5, 2010 - v3
Checksum:iC5F8984FFCDF9799
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1430V → G in CAB45309 (PubMed:10464142).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04715239Y → F. Corresponds to variant dbSNP:rs9273447 PublicationsEnsembl.1
Natural variantiVAR_029113246M → L. Corresponds to variant dbSNP:rs17222744Ensembl.1
Natural variantiVAR_013324281S → N. Corresponds to variant dbSNP:rs561316511 PublicationEnsembl.1
Natural variantiVAR_020226333D → G Decreased expression; altered subcellular localization; altered transporter activity. Corresponds to variant dbSNP:rs172226741 PublicationEnsembl.1
Natural variantiVAR_020227353R → H Altered transporter activity. Corresponds to variant dbSNP:rs70806811 PublicationEnsembl.1
Natural variantiVAR_013325417V → I. Corresponds to variant dbSNP:rs22736973 PublicationsEnsembl.1
Natural variantiVAR_070607486T → I Altered transporter activity. Corresponds to variant dbSNP:rs172225891 PublicationEnsembl.1
Natural variantiVAR_029115495K → E. Corresponds to variant dbSNP:rs17222561Ensembl.1
Natural variantiVAR_029116562F → L. Corresponds to variant dbSNP:rs17216233Ensembl.1
Natural variantiVAR_020228670I → T. Corresponds to variant dbSNP:rs172226321 PublicationEnsembl.1
Natural variantiVAR_000099768R → W in DJS. Corresponds to variant dbSNP:rs561995354 PublicationsEnsembl.1
Natural variantiVAR_013326789S → F. Corresponds to variant dbSNP:rs562203531 PublicationEnsembl.1
Natural variantiVAR_020229849L → R. Corresponds to variant dbSNP:rs17222617Ensembl.1
Natural variantiVAR_070608921G → S Altered transporter activity. Corresponds to variant dbSNP:rs413180291 PublicationEnsembl.1
Natural variantiVAR_029117982I → V. Corresponds to variant dbSNP:rs17222554Ensembl.1
Natural variantiVAR_0202301036I → T Polymorphism; no effect on transporter activity. Corresponds to variant dbSNP:rs454411991 PublicationEnsembl.1
Natural variantiVAR_0291181063N → S. Corresponds to variant dbSNP:rs17222540Ensembl.1
Natural variantiVAR_0133271150R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. Corresponds to variant dbSNP:rs725582001 PublicationEnsembl.1
Natural variantiVAR_0133281173I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. Corresponds to variant dbSNP:rs725582012 PublicationsEnsembl.1
Natural variantiVAR_0706091174R → H Decreased expression; altered subcellular localization; decreased transporter activity. Corresponds to variant dbSNP:rs1391882471 PublicationEnsembl.1
Natural variantiVAR_0202311181R → L Decreased expression. Corresponds to variant dbSNP:rs81876921 PublicationEnsembl.1
Natural variantiVAR_0202321188V → E. Corresponds to variant dbSNP:rs172227232 PublicationsEnsembl.1
Natural variantiVAR_0706101244N → K Decreased transporter activity. Corresponds to variant dbSNP:rs7571419051 PublicationEnsembl.1
Natural variantiVAR_0243601273T → A. Corresponds to variant dbSNP:rs8187699Ensembl.1
Natural variantiVAR_0202331291P → L Altered transporter activity. Corresponds to variant dbSNP:rs172163171 PublicationEnsembl.1
Natural variantiVAR_0107561382Q → R in DJS. Corresponds to variant dbSNP:rs725582021 PublicationEnsembl.1
Natural variantiVAR_0133291392 – 1393Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation. 2 Publications2
Natural variantiVAR_0133301450A → T. Corresponds to variant dbSNP:rs562963351 PublicationEnsembl.1
Natural variantiVAR_0202341515C → Y. Corresponds to variant dbSNP:rs81877102 PublicationsEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63970 mRNA. Translation: AAB39892.1.
U49248 mRNA. Translation: AAB09422.1.
X96395 mRNA. Translation: CAA65259.2.
AJ132244
, AJ132287, AJ245625, AJ132288, AJ132289, AJ132290, AJ132291, AJ132292, AJ132293, AJ132294, AJ132295, AJ132296, AJ132297, AJ132298, AJ132299, AJ132300, AJ132301, AJ132302, AJ132303, AJ245626, AJ132304, AJ132305, AJ132306, AJ132307, AJ132308, AJ245627, AJ132309, AJ132310, AJ132311, AJ132312, AJ132313, AJ132314 Genomic DNA. Translation: CAB45309.1.
AL392107, AL133353 Genomic DNA. Translation: CAI11010.1.
AL133353, AL392107 Genomic DNA. Translation: CAI14502.1.
CH471066 Genomic DNA. Translation: EAW49853.1.
BC136419 mRNA. Translation: AAI36420.1.
CCDSiCCDS7484.1.
PIRiS71841.
RefSeqiNP_000383.1. NM_000392.4.
UniGeneiHs.368243.

Genome annotation databases

EnsembliENST00000370449; ENSP00000359478; ENSG00000023839.
GeneIDi1244.
KEGGihsa:1244.
UCSCiuc001kqf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63970 mRNA. Translation: AAB39892.1.
U49248 mRNA. Translation: AAB09422.1.
X96395 mRNA. Translation: CAA65259.2.
AJ132244
, AJ132287, AJ245625, AJ132288, AJ132289, AJ132290, AJ132291, AJ132292, AJ132293, AJ132294, AJ132295, AJ132296, AJ132297, AJ132298, AJ132299, AJ132300, AJ132301, AJ132302, AJ132303, AJ245626, AJ132304, AJ132305, AJ132306, AJ132307, AJ132308, AJ245627, AJ132309, AJ132310, AJ132311, AJ132312, AJ132313, AJ132314 Genomic DNA. Translation: CAB45309.1.
AL392107, AL133353 Genomic DNA. Translation: CAI11010.1.
AL133353, AL392107 Genomic DNA. Translation: CAI14502.1.
CH471066 Genomic DNA. Translation: EAW49853.1.
BC136419 mRNA. Translation: AAI36420.1.
CCDSiCCDS7484.1.
PIRiS71841.
RefSeqiNP_000383.1. NM_000392.4.
UniGeneiHs.368243.

3D structure databases

ProteinModelPortaliQ92887.
SMRiQ92887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107647. 45 interactors.
IntActiQ92887. 5 interactors.
MINTiMINT-5004989.
STRINGi9606.ENSP00000359478.

Chemistry databases

BindingDBiQ92887.
ChEMBLiCHEMBL5748.
DrugBankiDB00171. Adenosine triphosphate.
DB00345. Aminohippurate.
DB01169. Arsenic trioxide.
DB01076. Atorvastatin.
DB09060. Avibactam.
DB08907. Canagliflozin.
DB00564. Carbamazepine.
DB00958. Carboplatin.
DB02659. Cholic Acid.
DB00515. Cisplatin.
DB00257. Clotrimazole.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB00694. Daunorubicin.
DB01234. Dexamethasone.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB09272. Eluxadoline.
DB00876. Eprosartan.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB00973. Ezetimibe.
DB00695. Furosemide.
DB02703. Fusidic Acid.
DB08884. Gadoxetate.
DB00143. Glutathione.
DB01016. Glyburide.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00762. Irinotecan.
DB00602. Ivermectin.
DB00709. Lamivudine.
DB00650. Leucovorin.
DB01202. Levetiracetam.
DB00978. Lomefloxacin.
DB00227. Lovastatin.
DB00563. Methotrexate.
DB00688. Mycophenolate mofetil.
DB01115. Nifedipine.
DB00957. Norgestimate.
DB01165. Ofloxacin.
DB00275. Olmesartan.
DB00526. Oxaliplatin.
DB01229. Paclitaxel.
DB01174. Phenobarbital.
DB00252. Phenytoin.
DB08860. Pitavastatin.
DB01411. Pranlukast.
DB00175. Pravastatin.
DB01032. Probenecid.
DB00908. Quinidine.
DB00206. Reserpine.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB01232. Saquinavir.
DB00641. Simvastatin.
DB00398. Sorafenib.
DB01208. Sparfloxacin.
DB00421. Spironolactone.
DB00795. Sulfasalazine.
DB01138. Sulfinpyrazone.
DB01268. Sunitinib.
DB00675. Tamoxifen.
DB00966. Telmisartan.
DB00300. Tenofovir.
DB00116. Tetrahydrofolic acid.
DB01586. Ursodeoxycholic acid.
DB00067. Vasopressin.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.
GuidetoPHARMACOLOGYi780.
SwissLipidsiSLP:000001599.

Protein family/group databases

TCDBi3.A.1.208.2. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ92887.
PhosphoSitePlusiQ92887.

Polymorphism and mutation databases

BioMutaiABCC2.
DMDMi308153583.

Proteomic databases

EPDiQ92887.
MaxQBiQ92887.
PaxDbiQ92887.
PeptideAtlasiQ92887.
PRIDEiQ92887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370449; ENSP00000359478; ENSG00000023839.
GeneIDi1244.
KEGGihsa:1244.
UCSCiuc001kqf.3. human.

Organism-specific databases

CTDi1244.
DisGeNETi1244.
GeneCardsiABCC2.
HGNCiHGNC:53. ABCC2.
HPAiCAB037271.
HPA004860.
MalaCardsiABCC2.
MIMi237500. phenotype.
601107. gene.
neXtProtiNX_Q92887.
OpenTargetsiENSG00000023839.
Orphaneti234. Dubin-Johnson syndrome.
PharmGKBiPA116.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiQ92887.
KOiK05666.
OMAiQTPGPFY.
OrthoDBiEOG091G00IN.
PhylomeDBiQ92887.
TreeFamiTF105199.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000023839-MONOMER.
ReactomeiR-HSA-382556. ABC-family proteins mediated transport.
SABIO-RKQ92887.

Miscellaneous databases

ChiTaRSiABCC2. human.
GeneWikiiMultidrug_resistance-associated_protein_2.
GenomeRNAii1244.
PROiQ92887.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000023839.
CleanExiHS_ABCC2.
ExpressionAtlasiQ92887. baseline and differential.
GenevisibleiQ92887. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030247. ABCC2.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF176. PTHR24223:SF176. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP2_HUMAN
AccessioniPrimary (citable) accession number: Q92887
Secondary accession number(s): B2RMT8
, Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 5, 2010
Last modified: January 18, 2017
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.