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Q92887 (MRP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Canalicular multidrug resistance protein
Multidrug resistance-associated protein 2
Gene names
Name:ABCC2
Synonyms:CMOAT, CMOAT1, CMRP, MRP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1545 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Subcellular location

Apical cell membrane; Multi-pass membrane protein Ref.17.

Tissue specificity

Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Involvement in disease

Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular chloride ion homeostasis

Inferred from electronic annotation. Source: Ensembl

drug transmembrane transport

Inferred from electronic annotation. Source: Ensembl

prostaglandin transport

Inferred from electronic annotation. Source: Ensembl

response to arsenic-containing substance

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to heat

Inferred from electronic annotation. Source: Ensembl

response to methotrexate

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

thyroid hormone transport

Inferred from electronic annotation. Source: Ensembl

transmembrane transport

Traceable author statement. Source: Reactome

transport

Traceable author statement PubMed 7559771. Source: ProtInc

   Cellular_componentapical plasma membrane

Inferred from direct assay Ref.17. Source: UniProtKB

integral component of plasma membrane

Traceable author statement PubMed 7559771. Source: ProtInc

intercellular canaliculus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity, coupled to transmembrane movement of substances

Traceable author statement PubMed 7559771. Source: ProtInc

organic anion transmembrane transporter activity

Traceable author statement PubMed 7559771. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NFKB1P198383EBI-3916193,EBI-300010

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15451545Canalicular multispecific organic anion transporter 1
PRO_0000093356

Regions

Topological domain1 – 2727Extracellular By similarity
Transmembrane28 – 4821Helical; Name=1; By similarity
Topological domain49 – 6820Cytoplasmic By similarity
Transmembrane69 – 8921Helical; Name=2; By similarity
Topological domain90 – 934Extracellular By similarity
Transmembrane94 – 11421Helical; Name=3; By similarity
Topological domain115 – 12612Cytoplasmic By similarity
Transmembrane127 – 14721Helical; Name=4; By similarity
Topological domain148 – 16518Extracellular By similarity
Transmembrane166 – 18621Helical; Name=5; By similarity
Topological domain187 – 313127Cytoplasmic By similarity
Transmembrane314 – 33421Helical; Name=6; By similarity
Topological domain335 – 36026Extracellular By similarity
Transmembrane361 – 38121Helical; Name=7; By similarity
Topological domain382 – 43756Cytoplasmic By similarity
Transmembrane438 – 45821Helical; Name=8; By similarity
Topological domain459 – 4613Extracellular By similarity
Transmembrane462 – 48221Helical; Name=9; By similarity
Topological domain483 – 54462Cytoplasmic By similarity
Transmembrane545 – 56521Helical; Name=10; By similarity
Topological domain566 – 58722Extracellular By similarity
Transmembrane588 – 60821Helical; Name=11; By similarity
Topological domain609 – 971363Cytoplasmic By similarity
Transmembrane972 – 99221Helical; Name=12; By similarity
Topological domain993 – 103341Extracellular By similarity
Transmembrane1034 – 105421Helical; Name=13; By similarity
Topological domain1055 – 109743Cytoplasmic By similarity
Transmembrane1098 – 111821Helical; Name=14; By similarity
Topological domain11191Extracellular By similarity
Transmembrane1120 – 114021Helical; Name=15; By similarity
Topological domain1141 – 121171Cytoplasmic By similarity
Transmembrane1212 – 123221Helical; Name=16; By similarity
Topological domain1233 – 12342Extracellular By similarity
Transmembrane1235 – 125521Helical; Name=17; By similarity
Topological domain1256 – 1545290Cytoplasmic By similarity
Domain322 – 605284ABC transmembrane type-1 1
Domain637 – 861225ABC transporter 1
Domain979 – 1264286ABC transmembrane type-1 2
Domain1300 – 1534235ABC transporter 2
Nucleotide binding671 – 6788ATP 1 Potential
Nucleotide binding1334 – 13418ATP 2 Potential

Amino acid modifications

Modified residue2831Phosphoserine Ref.12
Modified residue8781Phosphoserine Ref.12
Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation10111N-linked (GlcNAc...) Potential

Natural variations

Natural variant391Y → F. Ref.1 Ref.2 Ref.3 Ref.5 Ref.7 Ref.8 Ref.20
Corresponds to variant rs927344 [ dbSNP | Ensembl ].
VAR_047152
Natural variant2461M → L.
Corresponds to variant rs17222744 [ dbSNP | Ensembl ].
VAR_029113
Natural variant2811S → N. Ref.18
Corresponds to variant rs56131651 [ dbSNP | Ensembl ].
VAR_013324
Natural variant3331D → G Decreased expression; altered subcellular localization; altered transporter activity. Ref.20
Corresponds to variant rs17222674 [ dbSNP | Ensembl ].
VAR_020226
Natural variant3531R → H Altered transporter activity. Ref.20
Corresponds to variant rs7080681 [ dbSNP | Ensembl ].
VAR_020227
Natural variant4171V → I. Ref.18 Ref.19
Corresponds to variant rs2273697 [ dbSNP | Ensembl ].
VAR_013325
Natural variant4861T → I Altered transporter activity. Ref.20
VAR_070607
Natural variant4951K → E.
Corresponds to variant rs17222561 [ dbSNP | Ensembl ].
VAR_029115
Natural variant5621F → L.
Corresponds to variant rs17216233 [ dbSNP | Ensembl ].
VAR_029116
Natural variant6701I → T. Ref.20
Corresponds to variant rs17222632 [ dbSNP | Ensembl ].
VAR_020228
Natural variant7681R → W in DJS. Ref.15 Ref.16 Ref.19
Corresponds to variant rs56199535 [ dbSNP | Ensembl ].
VAR_000099
Natural variant7891S → F. Ref.19
Corresponds to variant rs56220353 [ dbSNP | Ensembl ].
VAR_013326
Natural variant8491L → R.
Corresponds to variant rs17222617 [ dbSNP | Ensembl ].
VAR_020229
Natural variant9211G → S Altered transporter activity. Ref.20
VAR_070608
Natural variant9821I → V.
Corresponds to variant rs17222554 [ dbSNP | Ensembl ].
VAR_029117
Natural variant10361I → T. Ref.20
Corresponds to variant rs45441199 [ dbSNP | Ensembl ].
VAR_020230
Natural variant10631N → S.
Corresponds to variant rs17222540 [ dbSNP | Ensembl ].
VAR_029118
Natural variant11501R → H in DJS; protein is properly localized at the plasma membrane, but transporter activity is impaired. Ref.18
VAR_013327
Natural variant11731I → F in DJS; decreased expression and mislocation to the endoplasmic reticulum. Ref.18 Ref.20
VAR_013328
Natural variant11741R → H Decreased expression; altered subcellular localization; decreased transporter activity. Ref.20
Corresponds to variant rs139188247 [ dbSNP | Ensembl ].
VAR_070609
Natural variant11811R → L Decreased expression. Ref.20
Corresponds to variant rs8187692 [ dbSNP | Ensembl ].
VAR_020231
Natural variant11881V → E. Ref.2 Ref.20
Corresponds to variant rs17222723 [ dbSNP | Ensembl ].
VAR_020232
Natural variant12441N → K Decreased transporter activity. Ref.20
VAR_070610
Natural variant12731T → A.
Corresponds to variant rs8187699 [ dbSNP | Ensembl ].
VAR_024360
Natural variant12911P → L Altered transporter activity. Ref.20
Corresponds to variant rs17216317 [ dbSNP | Ensembl ].
VAR_020233
Natural variant13821Q → R in DJS. Ref.16
VAR_010756
Natural variant1392 – 13932Missing in DJS; impaired transport from the endoplasmic reticulum to the apical plasma membrane associated with impaired maturation.
VAR_013329
Natural variant14501A → T. Ref.19
Corresponds to variant rs56296335 [ dbSNP | Ensembl ].
VAR_013330
Natural variant15151C → Y. Ref.2 Ref.20
Corresponds to variant rs8187710 [ dbSNP | Ensembl ].
VAR_020234

Experimental info

Mutagenesis12541W → A or C: Fails to transport methotrexate, leukotriene C4 and estradiol glucuronide. Ref.10
Mutagenesis12541W → F: Fails to transport methotrexate and leukotriene C4. Does not affect estradiol glucuronide transport. Ref.10
Mutagenesis12541W → Y: Fails to transport methotrexate; reduces leukotriene C4 transport. Does not affect estradiol glucuronide transport. Ref.10
Sequence conflict14301V → G in CAB45309. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q92887 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: C5F8984FFCDF9799

FASTA1,545174,207
        10         20         30         40         50         60 
MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH VYKSRTKRSS 

        70         80         90        100        110        120 
TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR YTNPSLYLGT WLLVLLIQYS 

       130        140        150        160        170        180 
RQWCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLQGDNS NLAYSCLFFI SYGFQILILI 

       190        200        210        220        230        240 
FSAFSENNES SNNPSSIASF LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS 

       250        260        270        280        290        300 
KFETHMKREL QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG 

       310        320        330        340        350        360 
TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA SDRDTYLWIG 

       370        380        390        400        410        420 
YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV YKKALTLSNL ARKEYTVGET 

       430        440        450        460        470        480 
VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL SIFFLWRELG PSVLAGVGVM VLVIPINAIL 

       490        500        510        520        530        540 
STKSKTIQVK NMKNKDKRLK IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS 

       550        560        570        580        590        600 
QLQCVVIFVF QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI 

       610        620        630        640        650        660 
SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS EATVRDVNLD 

       670        680        690        700        710        720 
IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT TAYVPQQSWI QNGTIKDNIL 

       730        740        750        760        770        780 
FGTEFNEKRY QQVLEACALL PDLEMLPGGD LAEIGEKGIN LSGGQKQRIS LARATYQNLD 

       790        800        810        820        830        840 
IYLLDDPLSA VDAHVGKHIF NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV 

       850        860        870        880        890        900 
EKGSYSALLA KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS 

       910        920        930        940        950        960 
ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK LIKKEFIETG 

       970        980        990       1000       1010       1020 
KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL SAWTSDSKIF NSTDYPASQR 

      1030       1040       1050       1060       1070       1080 
DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV HASNILHKQL LNNILRAPMR FFDTTPTGRI 

      1090       1100       1110       1120       1130       1140 
VNRFAGDIST VDDTLPQSLR SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF 

      1150       1160       1170       1180       1190       1200 
YVSTSRQLRR LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW 

      1210       1220       1230       1240       1250       1260 
ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ TLNWLVRMTS 

      1270       1280       1290       1300       1310       1320 
EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI QFNNYQVRYR PELDLVLRGI 

      1330       1340       1350       1360       1370       1380 
TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI LEAAGGQIII DGVDIASIGL HDLREKLTII 

      1390       1400       1410       1420       1430       1440 
PQDPILFSGS LRMNLDPFNN YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG 

      1450       1460       1470       1480       1490       1500 
QRQLLCLGRA LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD 

      1510       1520       1530       1540 
SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF 

« Hide

References

« Hide 'large scale' references
[1]"A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation."
Taniguchi K., Wada M., Kohno K., Nakamura T., Kawabe T., Kawakami M., Kagotani K., Okumura K., Akiyama S., Kuwano M.
Cancer Res. 56:4124-4129(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-39.
[2]Kool M., de Haas M., Ponne N.J., Paulusma C.C., Oude-Elferink R.P.J., Baas F., Borst P.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-39; GLU-1188 AND TYR-1515.
[3]"cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats."
Buechler M., Koenig J., Brom M., Kartenbeck J., Spring H., Horie T., Keppler D.
J. Biol. Chem. 271:15091-15098(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-39.
[4]Keppler D.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[5]"Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome."
Tsujii H., Koenig J., Rost D., Stoeckel B., Leuschner U., Keppler D.
Gastroenterology 117:653-660(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PHE-39 AND DJS 1392-ARG-MET-1393 DEL.
[6]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-39.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-39.
[9]"Hepatic secretion of conjugated drugs and endogenous substances."
Keppler D., Koenig J.
Semin. Liver Dis. 20:265-272(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[10]"Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity."
Ito K., Oleschuk C.J., Westlake C., Vasa M.Z., Deeley R.G., Cole S.P.C.
J. Biol. Chem. 276:38108-38114(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF TRP-1254.
[11]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND SER-878, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome."
Wada M., Toh S., Taniguchi K., Nakamura T., Uchiumi T., Kohno K., Yoshida I., Kimura A., Sakisaka S., Adachi Y., Kuwano M.
Hum. Mol. Genet. 7:203-207(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT DJS TRP-768.
[16]"Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome."
Toh S., Wada M., Uchiumi T., Inokuchi A., Makino Y., Horie Y., Adachi Y., Sakisaka S., Kuwano M.
Am. J. Hum. Genet. 64:739-746(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS DJS TRP-768 AND ARG-1382.
[17]"Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome."
Keitel V., Kartenbeck J., Nies A.T., Spring H., Brom M., Keppler D.
Hepatology 32:1317-1328(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANT DJS 1392-ARG-MET-1393 DEL, SUBCELLULAR LOCATION.
[18]"Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome."
Mor-Cohen R., Zivelin A., Rosenberg N., Shani M., Muallem S., Seligsohn U.
J. Biol. Chem. 276:36923-36930(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS DJS HIS-1150 AND PHE-1173, VARIANTS ASN-281 AND ILE-417.
[19]"Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects."
Ito S., Ieiri I., Tanabe M., Suzuki A., Higuchi S., Otsubo K.
Pharmacogenetics 11:175-184(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT DJS TRP-768, VARIANTS ILE-417; PHE-789 AND THR-1450.
[20]"Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells."
Arlanov R., Porter A., Strand D., Brough R., Karpova D., Kerb R., Wojnowski L., Schwab M., Lang T.
Hum. Mutat. 33:750-762(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PHE-39; GLY-333; HIS-353; ILE-486; THR-670; SER-921; THR-1036; HIS-1174; LEU-1181; GLU-1188; LEU-1291 AND TYR-1515, CHARACTERIZATION OF VARIANTS DJS PHE-1173, CHARACTERIZATION OF VARIANTS GLY-333; HIS-353; ILE-486; SER-921; THR-1036; HIS-1174; LEU-1181; LYS-1244 AND LEU-1291.
+Additional computationally mapped references.

Web resources

GeneReviews
ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U63970 mRNA. Translation: AAB39892.1.
U49248 mRNA. Translation: AAB09422.1.
X96395 mRNA. Translation: CAA65259.2.
AJ132244 expand/collapse EMBL AC list , AJ132287, AJ245625, AJ132288, AJ132289, AJ132290, AJ132291, AJ132292, AJ132293, AJ132294, AJ132295, AJ132296, AJ132297, AJ132298, AJ132299, AJ132300, AJ132301, AJ132302, AJ132303, AJ245626, AJ132304, AJ132305, AJ132306, AJ132307, AJ132308, AJ245627, AJ132309, AJ132310, AJ132311, AJ132312, AJ132313, AJ132314 Genomic DNA. Translation: CAB45309.1.
AL392107, AL133353 Genomic DNA. Translation: CAI11010.1.
AL133353, AL392107 Genomic DNA. Translation: CAI14502.1.
CH471066 Genomic DNA. Translation: EAW49853.1.
BC136419 mRNA. Translation: AAI36420.1.
PIRS71841.
RefSeqNP_000383.1. NM_000392.3.
UniGeneHs.368243.

3D structure databases

ProteinModelPortalQ92887.
SMRQ92887. Positions 642-862.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107647. 46 interactions.
IntActQ92887. 5 interactions.
MINTMINT-5004989.
STRING9606.ENSP00000359478.

Chemistry

BindingDBQ92887.
ChEMBLCHEMBL5748.
DrugBankDB00171. Adenosine triphosphate.
DB00957. Norgestimate.
DB00175. Pravastatin.
DB01232. Saquinavir.
DB01138. Sulfinpyrazone.

Protein family/group databases

TCDB3.A.1.208.2. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteQ92887.

Polymorphism databases

DMDM308153583.

Proteomic databases

PaxDbQ92887.
PRIDEQ92887.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370449; ENSP00000359478; ENSG00000023839.
GeneID1244.
KEGGhsa:1244.
UCSCuc001kqf.2. human.

Organism-specific databases

CTD1244.
GeneCardsGC10P101532.
HGNCHGNC:53. ABCC2.
HPAHPA004860.
MIM237500. phenotype.
601107. gene.
neXtProtNX_Q92887.
Orphanet234. Dubin-Johnson syndrome.
PharmGKBPA116.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1132.
HOVERGENHBG108314.
InParanoidQ92887.
KOK05666.
OMATIQNEFA.
OrthoDBEOG7MWGW0.
PhylomeDBQ92887.
TreeFamTF105199.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
SABIO-RKQ92887.

Gene expression databases

ArrayExpressQ92887.
BgeeQ92887.
CleanExHS_ABCC2.
GenevestigatorQ92887.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMultidrug_resistance-associated_protein_2.
GenomeRNAi1244.
NextBio5071.
PROQ92887.
SOURCESearch...

Entry information

Entry nameMRP2_HUMAN
AccessionPrimary (citable) accession number: Q92887
Secondary accession number(s): B2RMT8 expand/collapse secondary AC list , Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM