Q92887 (MRP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Canalicular multispecific organic anion transporter 1

Alternative name(s):
ATP-binding cassette sub-family C member 2
Canalicular multidrug resistance protein
Multidrug resistance-associated protein 2

Gene names

Name:	ABCC2
Synonyms:	CMOAT, CMOAT1, CMRP, MRP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1545 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Involvement in disease	Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	apical plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to plasma membrane Traceable author statement PubMed 7559771. Source: ProtInc intercellular canaliculus Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Traceable author statement PubMed 7559771. Source: ProtInc organic anion transmembrane transporter activity Traceable author statement PubMed 7559771. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NFKB1	P19838	3	EBI-3916193,EBI-300010

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1545	1545	Canalicular multispecific organic anion transporter 1		PRO_0000093356
Regions
	Topological domain	1 – 27	27	Extracellular By similarity
	Transmembrane	28 – 48	21	Helical; Name=1; By similarity
	Topological domain	49 – 68	20	Cytoplasmic By similarity
	Transmembrane	69 – 89	21	Helical; Name=2; By similarity
	Topological domain	90 – 93	4	Extracellular By similarity
	Transmembrane	94 – 114	21	Helical; Name=3; By similarity
	Topological domain	115 – 126	12	Cytoplasmic By similarity
	Transmembrane	127 – 147	21	Helical; Name=4; By similarity
	Topological domain	148 – 165	18	Extracellular By similarity
	Transmembrane	166 – 186	21	Helical; Name=5; By similarity
	Topological domain	187 – 313	127	Cytoplasmic By similarity
	Transmembrane	314 – 334	21	Helical; Name=6; By similarity
	Topological domain	335 – 360	26	Extracellular By similarity
	Transmembrane	361 – 381	21	Helical; Name=7; By similarity
	Topological domain	382 – 437	56	Cytoplasmic By similarity
	Transmembrane	438 – 458	21	Helical; Name=8; By similarity
	Topological domain	459 – 461	3	Extracellular By similarity
	Transmembrane	462 – 482	21	Helical; Name=9; By similarity
	Topological domain	483 – 544	62	Cytoplasmic By similarity
	Transmembrane	545 – 565	21	Helical; Name=10; By similarity
	Topological domain	566 – 587	22	Extracellular By similarity
	Transmembrane	588 – 608	21	Helical; Name=11; By similarity
	Topological domain	609 – 971	363	Cytoplasmic By similarity
	Transmembrane	972 – 992	21	Helical; Name=12; By similarity
	Topological domain	993 – 1033	41	Extracellular By similarity
	Transmembrane	1034 – 1054	21	Helical; Name=13; By similarity
	Topological domain	1055 – 1097	43	Cytoplasmic By similarity
	Transmembrane	1098 – 1118	21	Helical; Name=14; By similarity
	Topological domain	1119	1	Extracellular By similarity
	Transmembrane	1120 – 1140	21	Helical; Name=15; By similarity
	Topological domain	1141 – 1211	71	Cytoplasmic By similarity
	Transmembrane	1212 – 1232	21	Helical; Name=16; By similarity
	Topological domain	1233 – 1234	2	Extracellular By similarity
	Transmembrane	1235 – 1255	21	Helical; Name=17; By similarity
	Topological domain	1256 – 1545	290	Cytoplasmic By similarity
	Domain	322 – 605	284	ABC transmembrane type-1 1
	Domain	637 – 861	225	ABC transporter 1
	Domain	979 – 1264	286	ABC transmembrane type-1 2
	Domain	1300 – 1534	235	ABC transporter 2
	Nucleotide binding	671 – 678	8	ATP 1 Potential
	Nucleotide binding	1334 – 1341	8	ATP 2 Potential
Amino acid modifications
	Modified residue	283	1	Phosphoserine Ref.12
	Modified residue	878	1	Phosphoserine Ref.12
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	1011	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	39	1	Y → F. Ref.1 Ref.2 Ref.3 Ref.5 Ref.7 Ref.8 Corresponds to variant rs927344 [ dbSNP | Ensembl ].		VAR_047152
	Natural variant	246	1	M → L. Corresponds to variant rs17222744 [ dbSNP | Ensembl ].		VAR_029113
	Natural variant	281	1	S → N. Ref.18 Corresponds to variant rs56131651 [ dbSNP | Ensembl ].		VAR_013324
	Natural variant	333	1	D → G. Corresponds to variant rs17222674 [ dbSNP | Ensembl ].		VAR_020226
	Natural variant	353	1	R → H. Corresponds to variant rs7080681 [ dbSNP | Ensembl ].		VAR_020227
	Natural variant	417	1	V → I. Ref.18 Ref.19 Corresponds to variant rs2273697 [ dbSNP | Ensembl ].		VAR_013325
	Natural variant	495	1	K → E. Corresponds to variant rs17222561 [ dbSNP | Ensembl ].		VAR_029115
	Natural variant	562	1	F → L. Corresponds to variant rs17216233 [ dbSNP | Ensembl ].		VAR_029116
	Natural variant	670	1	I → T. Corresponds to variant rs17222632 [ dbSNP | Ensembl ].		VAR_020228
	Natural variant	768	1	R → W in DJS. Ref.15 Ref.16 Ref.19 Corresponds to variant rs56199535 [ dbSNP | Ensembl ].		VAR_000099
	Natural variant	789	1	S → F. Ref.19 Corresponds to variant rs56220353 [ dbSNP | Ensembl ].		VAR_013326
	Natural variant	849	1	L → R. Corresponds to variant rs17222617 [ dbSNP | Ensembl ].		VAR_020229
	Natural variant	982	1	I → V. Corresponds to variant rs17222554 [ dbSNP | Ensembl ].		VAR_029117
	Natural variant	1036	1	I → T. Corresponds to variant rs45441199 [ dbSNP | Ensembl ].		VAR_020230
	Natural variant	1063	1	N → S. Corresponds to variant rs17222540 [ dbSNP | Ensembl ].		VAR_029118
	Natural variant	1150	1	R → H in DJS; protein is properly localized at the plasma membrane, but transport activity is impaired. Ref.18		VAR_013327
	Natural variant	1173	1	I → F in DJS; low expression and mislocation to the endoplasmic reticulum. Ref.18		VAR_013328
	Natural variant	1181	1	R → L. Corresponds to variant rs8187692 [ dbSNP | Ensembl ].		VAR_020231
	Natural variant	1188	1	V → E. Ref.2 Corresponds to variant rs17222723 [ dbSNP | Ensembl ].		VAR_020232
	Natural variant	1273	1	T → A. Corresponds to variant rs8187699 [ dbSNP | Ensembl ].		VAR_024360
	Natural variant	1291	1	P → L. Corresponds to variant rs17216317 [ dbSNP | Ensembl ].		VAR_020233
	Natural variant	1382	1	Q → R in DJS. Ref.16		VAR_010756
	Natural variant	1392 – 1393	2	Missing in DJS; impaired maturation and intercompartmental trafficking.		VAR_013329
	Natural variant	1450	1	A → T. Ref.19 Corresponds to variant rs56296335 [ dbSNP | Ensembl ].		VAR_013330
	Natural variant	1515	1	C → Y. Ref.2 Corresponds to variant rs8187710 [ dbSNP | Ensembl ].		VAR_020234
Experimental info
	Mutagenesis	1254	1	W → A or C: Fails to transport methotrexate, leukotriene C4 and estradiol glucuronide. Ref.10
	Mutagenesis	1254	1	W → F: Fails to transport methotrexate and leukotriene C4. Does not affect estradiol glucuronide transport. Ref.10
	Mutagenesis	1254	1	W → Y: Fails to transport methotrexate; reduces leukotriene C4 transport. Does not affect estradiol glucuronide transport. Ref.10
	Sequence conflict	1430	1	V → G in CAB45309. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q92887 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: C5F8984FFCDF9799	FASTA	1,545	174,207
	10 20 30 40 50 60 MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH VYKSRTKRSS 70 80 90 100 110 120 TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR YTNPSLYLGT WLLVLLIQYS 130 140 150 160 170 180 RQWCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLQGDNS NLAYSCLFFI SYGFQILILI 190 200 210 220 230 240 FSAFSENNES SNNPSSIASF LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS 250 260 270 280 290 300 KFETHMKREL QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG 310 320 330 340 350 360 TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA SDRDTYLWIG 370 380 390 400 410 420 YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV YKKALTLSNL ARKEYTVGET 430 440 450 460 470 480 VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL SIFFLWRELG PSVLAGVGVM VLVIPINAIL 490 500 510 520 530 540 STKSKTIQVK NMKNKDKRLK IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS 550 560 570 580 590 600 QLQCVVIFVF QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI 610 620 630 640 650 660 SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS EATVRDVNLD 670 680 690 700 710 720 IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT TAYVPQQSWI QNGTIKDNIL 730 740 750 760 770 780 FGTEFNEKRY QQVLEACALL PDLEMLPGGD LAEIGEKGIN LSGGQKQRIS LARATYQNLD 790 800 810 820 830 840 IYLLDDPLSA VDAHVGKHIF NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV 850 860 870 880 890 900 EKGSYSALLA KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS 910 920 930 940 950 960 ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK LIKKEFIETG 970 980 990 1000 1010 1020 KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL SAWTSDSKIF NSTDYPASQR 1030 1040 1050 1060 1070 1080 DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV HASNILHKQL LNNILRAPMR FFDTTPTGRI 1090 1100 1110 1120 1130 1140 VNRFAGDIST VDDTLPQSLR SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF 1150 1160 1170 1180 1190 1200 YVSTSRQLRR LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW 1210 1220 1230 1240 1250 1260 ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ TLNWLVRMTS 1270 1280 1290 1300 1310 1320 EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI QFNNYQVRYR PELDLVLRGI 1330 1340 1350 1360 1370 1380 TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI LEAAGGQIII DGVDIASIGL HDLREKLTII 1390 1400 1410 1420 1430 1440 PQDPILFSGS LRMNLDPFNN YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG 1450 1460 1470 1480 1490 1500 QRQLLCLGRA LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD 1510 1520 1530 1540 SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation." Taniguchi K., Wada M., Kohno K., Nakamura T., Kawabe T., Kawakami M., Kagotani K., Okumura K., Akiyama S., Kuwano M. Cancer Res. 56:4124-4129(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-39.
[2]	Kool M., de Haas M., Ponne N.J., Paulusma C.C., Oude-Elferink R.P.J., Baas F., Borst P. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-39; GLU-1188 AND TYR-1515.
[3]	"cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats." Buechler M., Koenig J., Brom M., Kartenbeck J., Spring H., Horie T., Keppler D. J. Biol. Chem. 271:15091-15098(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-39.
[4]	Keppler D. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome." Tsujii H., Koenig J., Rost D., Stoeckel B., Leuschner U., Keppler D. Gastroenterology 117:653-660(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PHE-39 AND DJS 1392-ARG-MET-1393 DEL.
[6]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-39.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-39.
[9]	"Hepatic secretion of conjugated drugs and endogenous substances." Keppler D., Koenig J. Semin. Liver Dis. 20:265-272(2000) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[10]	"Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity." Ito K., Oleschuk C.J., Westlake C., Vasa M.Z., Deeley R.G., Cole S.P.C. J. Biol. Chem. 276:38108-38114(2001) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS OF TRP-1254.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND SER-878, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome." Wada M., Toh S., Taniguchi K., Nakamura T., Uchiumi T., Kohno K., Yoshida I., Kimura A., Sakisaka S., Adachi Y., Kuwano M. Hum. Mol. Genet. 7:203-207(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT DJS TRP-768.
[16]	"Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome." Toh S., Wada M., Uchiumi T., Inokuchi A., Makino Y., Horie Y., Adachi Y., Sakisaka S., Kuwano M. Am. J. Hum. Genet. 64:739-746(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS DJS TRP-768 AND ARG-1382.
[17]	"Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome." Keitel V., Kartenbeck J., Nies A.T., Spring H., Brom M., Keppler D. Hepatology 32:1317-1328(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANT DJS 1392-ARG-MET-1393 DEL.
[18]	"Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome." Mor-Cohen R., Zivelin A., Rosenberg N., Shani M., Muallem S., Seligsohn U. J. Biol. Chem. 276:36923-36930(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS DJS HIS-1150 AND PHE-1173, VARIANTS ASN-281 AND ILE-417.
[19]	"Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects." Ito S., Ieiri I., Tanabe M., Suzuki A., Higuchi S., Otsubo K. Pharmacogenetics 11:175-184(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT DJS TRP-768, VARIANTS ILE-417; PHE-789 AND THR-1450.
+	Additional computationally mapped references.

Web resources

GeneReviews

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases
EMBL GenBank DDBJ	U63970 mRNA. Translation: AAB39892.1. U49248 mRNA. Translation: AAB09422.1. X96395 mRNA. Translation: CAA65259.2. AJ132244 , AJ132287, AJ245625, AJ132288, AJ132289, AJ132290, AJ132291, AJ132292, AJ132293, AJ132294, AJ132295, AJ132296, AJ132297, AJ132298, AJ132299, AJ132300, AJ132301, AJ132302, AJ132303, AJ245626, AJ132304, AJ132305, AJ132306, AJ132307, AJ132308, AJ245627, AJ132309, AJ132310, AJ132311, AJ132312, AJ132313, AJ132314 Genomic DNA. Translation: CAB45309.1. AL392107, AL133353 Genomic DNA. Translation: CAI11010.1. AL133353, AL392107 Genomic DNA. Translation: CAI14502.1. CH471066 Genomic DNA. Translation: EAW49853.1. BC136419 mRNA. Translation: AAI36420.1.
IPI	IPI00023868.
PIR	S71841.
RefSeq	NP_000383.1. NM_000392.3.
UniGene	Hs.368243.
3D structure databases
ProteinModelPortal	Q92887.
SMR	Q92887. Positions 311-862, 963-1535.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92887. 5 interactions.
STRING	9606.ENSP00000359478.
Protein family/group databases
TCDB	3.A.1.208.2. ATP-binding cassette (ABC) superfamily.
PTM databases
PhosphoSite	Q92887.
Polymorphism databases
DMDM	308153583.
Proteomic databases
PaxDb	Q92887.
PRIDE	Q92887.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370449; ENSP00000359478; ENSG00000023839.
GeneID	1244.
KEGG	hsa:1244.
UCSC	uc001kqf.2. human.
Organism-specific databases
CTD	1244.
GeneCards	GC10P101532.
HGNC	HGNC:53. ABCC2.
HPA	HPA004860.
MIM	237500. phenotype. 601107. gene.
neXtProt	NX_Q92887.
Orphanet	234. Dubin-Johnson syndrome.
PharmGKB	PA116.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1132.
HOVERGEN	HBG108314.
InParanoid	Q92887.
KO	K05666.
OMA	HVYKSRT.
OrthoDB	EOG4B8JC6.
PhylomeDB	Q92887.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
SABIO-RK	Q92887.
Gene expression databases
ArrayExpress	Q92887.
Bgee	Q92887.
CleanEx	HS_ABCC2.
Genevestigator	Q92887.
GermOnline	ENSG00000023839. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR005292. Multidrug-R_assoc. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
TIGRFAMs	TIGR00957. MRP_assoc_pro. 1 hit.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q92887.
ChEMBL	CHEMBL5748.
DrugBank	DB00171. Adenosine triphosphate. DB00957. Norgestimate. DB00175. Pravastatin. DB01232. Saquinavir. DB01138. Sulfinpyrazone.
GenomeRNAi	1244.
NextBio	5071.
SOURCE	Search...

Entry information

Entry name

MRP2_HUMAN

Accession

Primary (citable) accession number: Q92887
Secondary accession number(s): B2RMT8 , Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 131 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.