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Protein

Neurogenin-1

Gene

NEUROG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).By similarity

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • E-box binding Source: CAFA
  • protein homodimerization activity Source: CAFA
  • sequence-specific double-stranded DNA binding Source: CAFA
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • transcription factor activity, transcription factor binding Source: UniProtKB

GO - Biological processi

  • auditory behavior Source: CAFA
  • cell fate commitment Source: Ensembl
  • cochlea development Source: CAFA
  • cochlea morphogenesis Source: CAFA
  • craniofacial suture morphogenesis Source: CAFA
  • genitalia development Source: CAFA
  • genitalia morphogenesis Source: CAFA
  • hard palate morphogenesis Source: CAFA
  • inner ear development Source: CAFA
  • inner ear morphogenesis Source: CAFA
  • learned vocalization behavior Source: CAFA
  • mastication Source: CAFA
  • negative regulation of relaxation of muscle Source: CAFA
  • negative regulation of saliva secretion Source: CAFA
  • nervous system development Source: ProtInc
  • neuromuscular process controlling balance Source: CAFA
  • neuron differentiation Source: Ensembl
  • palate development Source: CAFA
  • peristalsis Source: CAFA
  • positive regulation of exit from mitosis Source: Ensembl
  • positive regulation of neuron differentiation Source: UniProtKB
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of muscle organ development Source: CAFA
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • thorax and anterior abdomen determination Source: CAFA
  • transcription, DNA-templated Source: UniProtKB-KW
  • trigeminal nerve development Source: CAFA
  • vestibulocochlear nerve formation Source: CAFA

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Class A basic helix-loop-helix protein 6
Short name:
bHLHa6
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name:
NeuroD3
Gene namesi
Name:NEUROG1
Synonyms:BHLHA6, NEUROD3, NGN, NGN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000181965.5.
HGNCiHGNC:7764. NEUROG1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4762.
OpenTargetsiENSG00000181965.
PharmGKBiPA31569.

Polymorphism and mutation databases

BioMutaiNEUROG1.
DMDMi37538313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273961 – 237Neurogenin-1Add BLAST237

Proteomic databases

PaxDbiQ92886.
PRIDEiQ92886.

PTM databases

iPTMnetiQ92886.
PhosphoSitePlusiQ92886.

Expressioni

Tissue specificityi

Expression restricted to the embryonic nervous system.

Gene expression databases

BgeeiENSG00000181965.
CleanExiHS_NEUROG1.
ExpressionAtlasiQ92886. baseline and differential.
GenevisibleiQ92886. HS.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158843EBI-10279647,EBI-533224

GO - Molecular functioni

  • protein homodimerization activity Source: CAFA

Protein-protein interaction databases

BioGridi110835. 7 interactors.
IntActiQ92886. 2 interactors.
STRINGi9606.ENSP00000317580.

Structurei

3D structure databases

DisProtiDP00672.
ProteinModelPortaliQ92886.
SMRiQ92886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 144bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiQ92886.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG091G0PNH.
PhylomeDBiQ92886.
TreeFamiTF315153.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
IPR032653. Ngn1.
PANTHERiPTHR19290:SF130. PTHR19290:SF130. 1 hit.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR
60 70 80 90 100
GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR
110 120 130 140 150
ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL
160 170 180 190 200
ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS
210 220 230
SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH
Length:237
Mass (Da):25,718
Last modified:October 3, 2003 - v2
Checksum:iE3702A0B3408D567
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51G → S in AAB37575 (PubMed:8816493).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63842 Genomic DNA. Translation: AAB37575.1.
BT019366 mRNA. Translation: AAV38173.1.
CH471062 Genomic DNA. Translation: EAW62214.1.
BC008687 mRNA. Translation: AAH08687.1.
BC028226 mRNA. Translation: AAH28226.1.
CCDSiCCDS4187.1.
RefSeqiNP_006152.2. NM_006161.2.
UniGeneiHs.248149.

Genome annotation databases

EnsembliENST00000314744; ENSP00000317580; ENSG00000181965.
GeneIDi4762.
KEGGihsa:4762.
UCSCiuc003lax.3. human.

Similar proteinsi

Entry informationi

Entry nameiNGN1_HUMAN
AccessioniPrimary (citable) accession number: Q92886
Secondary accession number(s): Q5U0Q9, Q96HE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2003
Last modified: October 25, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot