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Q92886 (NGN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurogenin-1

Short name=NGN-1
Alternative name(s):
Class A basic helix-loop-helix protein 6
Short name=bHLHa6
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name=NeuroD3
Gene names
Name:NEUROG1
Synonyms:BHLHA6, NEUROD3, NGN, NGN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus Probable.

Tissue specificity

Expression restricted to the embryonic nervous system.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell fate commitment

Inferred from electronic annotation. Source: Ensembl

inner ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

nervous system development

Traceable author statement Ref.1. Source: ProtInc

neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of exit from mitosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

perikaryon

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

E-box binding

Inferred from sequence or structural similarity. Source: UniProtKB

chromatin binding

Inferred from sequence or structural similarity. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: ProtInc

transcription factor binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Neurogenin-1
PRO_0000127396

Regions

Domain92 – 14453bHLH

Experimental info

Sequence conflict511G → S in AAB37575. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q92886 [UniParc].

Last modified October 3, 2003. Version 2.
Checksum: E3702A0B3408D567

FASTA23725,718
        10         20         30         40         50         60 
MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE 

        70         80         90        100        110        120 
VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP 

       130        140        150        160        170        180 
SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA 

       190        200        210        220        230 
SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH 

« Hide

References

« Hide 'large scale' references
[1]"NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
Mol. Cell. Biol. 16:5792-5800(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U63842 Genomic DNA. Translation: AAB37575.1.
BT019366 mRNA. Translation: AAV38173.1.
CH471062 Genomic DNA. Translation: EAW62214.1.
BC008687 mRNA. Translation: AAH08687.1.
BC028226 mRNA. Translation: AAH28226.1.
CCDSCCDS4187.1.
RefSeqNP_006152.2. NM_006161.2.
UniGeneHs.248149.

3D structure databases

DisProtDP00672.
ProteinModelPortalQ92886.
SMRQ92886. Positions 92-149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110835. 6 interactions.
STRING9606.ENSP00000317580.

PTM databases

PhosphoSiteQ92886.

Polymorphism databases

DMDM37538313.

Proteomic databases

PaxDbQ92886.
PeptideAtlasQ92886.
PRIDEQ92886.

Protocols and materials databases

DNASU4762.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314744; ENSP00000317580; ENSG00000181965.
GeneID4762.
KEGGhsa:4762.
UCSCuc003lax.3. human.

Organism-specific databases

CTD4762.
GeneCardsGC05M134897.
HGNCHGNC:7764. NEUROG1.
MIM601726. gene.
neXtProtNX_Q92886.
PharmGKBPA31569.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG275082.
HOGENOMHOG000063655.
HOVERGENHBG101129.
InParanoidQ92886.
KOK09081.
OMAYIWALAE.
OrthoDBEOG7TTQB1.
PhylomeDBQ92886.
TreeFamTF315153.

Gene expression databases

ArrayExpressQ92886.
BgeeQ92886.
CleanExHS_NEUROG1.
GenevestigatorQ92886.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNEUROG1.
GenomeRNAi4762.
NextBio18344.
PROQ92886.
SOURCESearch...

Entry information

Entry nameNGN1_HUMAN
AccessionPrimary (citable) accession number: Q92886
Secondary accession number(s): Q5U0Q9, Q96HE1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2003
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM