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Q92886

- NGN1_HUMAN

UniProt

Q92886 - NGN1_HUMAN

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Protein
Neurogenin-1
Gene
NEUROG1, BHLHA6, NEUROD3, NGN, NGN1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. E-box binding Source: UniProtKB
  3. chromatin binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. transcription factor binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell fate commitment Source: Ensembl
  2. inner ear morphogenesis Source: Ensembl
  3. nervous system development Source: ProtInc
  4. neuron differentiation Source: Ensembl
  5. positive regulation of exit from mitosis Source: Ensembl
  6. positive regulation of neuron differentiation Source: UniProtKB
  7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  9. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Class A basic helix-loop-helix protein 6
Short name:
bHLHa6
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name:
NeuroD3
Gene namesi
Name:NEUROG1
Synonyms:BHLHA6, NEUROD3, NGN, NGN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:7764. NEUROG1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. perikaryon Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Neurogenin-1
PRO_0000127396Add
BLAST

Proteomic databases

PaxDbiQ92886.
PeptideAtlasiQ92886.
PRIDEiQ92886.

PTM databases

PhosphoSiteiQ92886.

Expressioni

Tissue specificityi

Expression restricted to the embryonic nervous system.

Gene expression databases

ArrayExpressiQ92886.
BgeeiQ92886.
CleanExiHS_NEUROG1.
GenevestigatoriQ92886.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

BioGridi110835. 6 interactions.
STRINGi9606.ENSP00000317580.

Structurei

3D structure databases

DisProtiDP00672.
ProteinModelPortaliQ92886.
SMRiQ92886. Positions 92-149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 14453bHLH
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG275082.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiQ92886.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG7TTQB1.
PhylomeDBiQ92886.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92886-1 [UniParc]FASTAAdd to Basket

« Hide

MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR    50
GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR 100
ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL 150
ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS 200
SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH 237
Length:237
Mass (Da):25,718
Last modified:October 3, 2003 - v2
Checksum:iE3702A0B3408D567
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511G → S in AAB37575. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63842 Genomic DNA. Translation: AAB37575.1.
BT019366 mRNA. Translation: AAV38173.1.
CH471062 Genomic DNA. Translation: EAW62214.1.
BC008687 mRNA. Translation: AAH08687.1.
BC028226 mRNA. Translation: AAH28226.1.
CCDSiCCDS4187.1.
RefSeqiNP_006152.2. NM_006161.2.
UniGeneiHs.248149.

Genome annotation databases

EnsembliENST00000314744; ENSP00000317580; ENSG00000181965.
GeneIDi4762.
KEGGihsa:4762.
UCSCiuc003lax.3. human.

Polymorphism databases

DMDMi37538313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63842 Genomic DNA. Translation: AAB37575.1 .
BT019366 mRNA. Translation: AAV38173.1 .
CH471062 Genomic DNA. Translation: EAW62214.1 .
BC008687 mRNA. Translation: AAH08687.1 .
BC028226 mRNA. Translation: AAH28226.1 .
CCDSi CCDS4187.1.
RefSeqi NP_006152.2. NM_006161.2.
UniGenei Hs.248149.

3D structure databases

DisProti DP00672.
ProteinModelPortali Q92886.
SMRi Q92886. Positions 92-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110835. 6 interactions.
STRINGi 9606.ENSP00000317580.

PTM databases

PhosphoSitei Q92886.

Polymorphism databases

DMDMi 37538313.

Proteomic databases

PaxDbi Q92886.
PeptideAtlasi Q92886.
PRIDEi Q92886.

Protocols and materials databases

DNASUi 4762.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314744 ; ENSP00000317580 ; ENSG00000181965 .
GeneIDi 4762.
KEGGi hsa:4762.
UCSCi uc003lax.3. human.

Organism-specific databases

CTDi 4762.
GeneCardsi GC05M134897.
HGNCi HGNC:7764. NEUROG1.
MIMi 601726. gene.
neXtProti NX_Q92886.
PharmGKBi PA31569.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275082.
HOGENOMi HOG000063655.
HOVERGENi HBG101129.
InParanoidi Q92886.
KOi K09081.
OMAi YIWALAE.
OrthoDBi EOG7TTQB1.
PhylomeDBi Q92886.
TreeFami TF315153.

Miscellaneous databases

GeneWikii NEUROG1.
GenomeRNAii 4762.
NextBioi 18344.
PROi Q92886.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92886.
Bgeei Q92886.
CleanExi HS_NEUROG1.
Genevestigatori Q92886.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
    McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
    Mol. Cell. Biol. 16:5792-5800(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Eye.

Entry informationi

Entry nameiNGN1_HUMAN
AccessioniPrimary (citable) accession number: Q92886
Secondary accession number(s): Q5U0Q9, Q96HE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2003
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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