Q92886 (NGN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurogenin-1
Short name=NGN-1

Alternative name(s):
Class A basic helix-loop-helix protein 6
Short name=bHLHa6
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name=NeuroD3

Gene names

Name:	NEUROG1
Synonyms:	BHLHA6, NEUROD3, NGN, NGN1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular location	Nucleus Probable.
Tissue specificity	Expression restricted to the embryonic nervous system.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell fate commitment Inferred from electronic annotation. Source: Compara inner ear morphogenesis Inferred from electronic annotation. Source: Compara neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of exit from mitosis Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell perikaryon Inferred from electronic annotation. Source: Compara
Molecular_function	E-box binding Inferred from sequence or structural similarity. Source: UniProtKB chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc transcription factor binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Neurogenin-1		PRO_0000127396
Regions
	Domain	92 – 144	53	bHLH
Experimental info
	Sequence conflict	51	1	G → S in AAB37575. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q92886 [UniParc]. Last modified October 3, 2003. Version 2. Checksum: E3702A0B3408D567	FASTA	237	25,718
	10 20 30 40 50 60 MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE 70 80 90 100 110 120 VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP 130 140 150 160 170 180 SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA 190 200 210 220 230 SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family." McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J. Mol. Cell. Biol. 16:5792-5800(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U63842 Genomic DNA. Translation: AAB37575.1. BT019366 mRNA. Translation: AAV38173.1. CH471062 Genomic DNA. Translation: EAW62214.1. BC008687 mRNA. Translation: AAH08687.1. BC028226 mRNA. Translation: AAH28226.1.
IPI	IPI00023867.
RefSeq	NP_006152.2. NM_006161.2.
UniGene	Hs.248149.
3D structure databases
ProteinModelPortal	Q92886.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000317580.
PTM databases
PhosphoSite	Q92886.
Polymorphism databases
DMDM	37538313.
Proteomic databases
PaxDb	Q92886.
PeptideAtlas	Q92886.
PRIDE	Q92886.
Protocols and materials databases
DNASU	4762.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314744; ENSP00000317580; ENSG00000181965.
GeneID	4762.
KEGG	hsa:4762.
UCSC	uc003lax.3. human.
Organism-specific databases
CTD	4762.
GeneCards	GC05M134897.
HGNC	HGNC:7764. NEUROG1.
MIM	601726. gene.
neXtProt	NX_Q92886.
PharmGKB	PA31569.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG275082.
HOGENOM	HOG000063655.
HOVERGEN	HBG101129.
InParanoid	Q92886.
KO	K09081.
OMA	LLPPQCV.
OrthoDB	EOG4THVVQ.
PhylomeDB	Q92886.
Gene expression databases
ArrayExpress	Q92886.
Bgee	Q92886.
CleanEx	HS_NEUROG1.
Genevestigator	Q92886.
GermOnline	ENSG00000181965. Homo sapiens.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. [Graphical view]
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4762.
NextBio	18344.
SOURCE	Search...

Entry information

Entry name

NGN1_HUMAN

Accession

Primary (citable) accession number: Q92886
Secondary accession number(s): Q5U0Q9, Q96HE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	October 3, 2003
Last modified:	May 1, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.