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Q92886

- NGN1_HUMAN

UniProt

Q92886 - NGN1_HUMAN

Protein

Neurogenin-1

Gene

NEUROG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (03 Oct 2003)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. DNA binding Source: UniProtKB
    3. E-box binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc
    5. transcription factor binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. cell fate commitment Source: Ensembl
    2. inner ear morphogenesis Source: Ensembl
    3. nervous system development Source: ProtInc
    4. neuron differentiation Source: Ensembl
    5. positive regulation of exit from mitosis Source: Ensembl
    6. positive regulation of neuron differentiation Source: UniProtKB
    7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    9. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurogenin-1
    Short name:
    NGN-1
    Alternative name(s):
    Class A basic helix-loop-helix protein 6
    Short name:
    bHLHa6
    Neurogenic basic-helix-loop-helix protein
    Neurogenic differentiation factor 3
    Short name:
    NeuroD3
    Gene namesi
    Name:NEUROG1
    Synonyms:BHLHA6, NEUROD3, NGN, NGN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:7764. NEUROG1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. perikaryon Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31569.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237Neurogenin-1PRO_0000127396Add
    BLAST

    Proteomic databases

    PaxDbiQ92886.
    PeptideAtlasiQ92886.
    PRIDEiQ92886.

    PTM databases

    PhosphoSiteiQ92886.

    Expressioni

    Tissue specificityi

    Expression restricted to the embryonic nervous system.

    Gene expression databases

    ArrayExpressiQ92886.
    BgeeiQ92886.
    CleanExiHS_NEUROG1.
    GenevestigatoriQ92886.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Protein-protein interaction databases

    BioGridi110835. 6 interactions.
    STRINGi9606.ENSP00000317580.

    Structurei

    3D structure databases

    DisProtiDP00672.
    ProteinModelPortaliQ92886.
    SMRiQ92886. Positions 92-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini92 – 14453bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG275082.
    HOGENOMiHOG000063655.
    HOVERGENiHBG101129.
    InParanoidiQ92886.
    KOiK09081.
    OMAiYIWALAE.
    OrthoDBiEOG7TTQB1.
    PhylomeDBiQ92886.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92886-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR    50
    GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR 100
    ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL 150
    ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS 200
    SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH 237
    Length:237
    Mass (Da):25,718
    Last modified:October 3, 2003 - v2
    Checksum:iE3702A0B3408D567
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511G → S in AAB37575. (PubMed:8816493)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63842 Genomic DNA. Translation: AAB37575.1.
    BT019366 mRNA. Translation: AAV38173.1.
    CH471062 Genomic DNA. Translation: EAW62214.1.
    BC008687 mRNA. Translation: AAH08687.1.
    BC028226 mRNA. Translation: AAH28226.1.
    CCDSiCCDS4187.1.
    RefSeqiNP_006152.2. NM_006161.2.
    UniGeneiHs.248149.

    Genome annotation databases

    EnsembliENST00000314744; ENSP00000317580; ENSG00000181965.
    GeneIDi4762.
    KEGGihsa:4762.
    UCSCiuc003lax.3. human.

    Polymorphism databases

    DMDMi37538313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63842 Genomic DNA. Translation: AAB37575.1 .
    BT019366 mRNA. Translation: AAV38173.1 .
    CH471062 Genomic DNA. Translation: EAW62214.1 .
    BC008687 mRNA. Translation: AAH08687.1 .
    BC028226 mRNA. Translation: AAH28226.1 .
    CCDSi CCDS4187.1.
    RefSeqi NP_006152.2. NM_006161.2.
    UniGenei Hs.248149.

    3D structure databases

    DisProti DP00672.
    ProteinModelPortali Q92886.
    SMRi Q92886. Positions 92-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110835. 6 interactions.
    STRINGi 9606.ENSP00000317580.

    PTM databases

    PhosphoSitei Q92886.

    Polymorphism databases

    DMDMi 37538313.

    Proteomic databases

    PaxDbi Q92886.
    PeptideAtlasi Q92886.
    PRIDEi Q92886.

    Protocols and materials databases

    DNASUi 4762.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314744 ; ENSP00000317580 ; ENSG00000181965 .
    GeneIDi 4762.
    KEGGi hsa:4762.
    UCSCi uc003lax.3. human.

    Organism-specific databases

    CTDi 4762.
    GeneCardsi GC05M134897.
    HGNCi HGNC:7764. NEUROG1.
    MIMi 601726. gene.
    neXtProti NX_Q92886.
    PharmGKBi PA31569.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275082.
    HOGENOMi HOG000063655.
    HOVERGENi HBG101129.
    InParanoidi Q92886.
    KOi K09081.
    OMAi YIWALAE.
    OrthoDBi EOG7TTQB1.
    PhylomeDBi Q92886.
    TreeFami TF315153.

    Miscellaneous databases

    GeneWikii NEUROG1.
    GenomeRNAii 4762.
    NextBioi 18344.
    PROi Q92886.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92886.
    Bgeei Q92886.
    CleanExi HS_NEUROG1.
    Genevestigatori Q92886.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
      McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
      Mol. Cell. Biol. 16:5792-5800(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Eye.

    Entry informationi

    Entry nameiNGN1_HUMAN
    AccessioniPrimary (citable) accession number: Q92886
    Secondary accession number(s): Q5U0Q9, Q96HE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: October 3, 2003
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3