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Protein

Neurogenin-1

Gene

NEUROG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. DNA binding Source: UniProtKB
  3. E-box binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. transcription factor binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell fate commitment Source: Ensembl
  2. inner ear morphogenesis Source: Ensembl
  3. nervous system development Source: ProtInc
  4. neuron differentiation Source: Ensembl
  5. positive regulation of exit from mitosis Source: Ensembl
  6. positive regulation of neuron differentiation Source: UniProtKB
  7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  9. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Class A basic helix-loop-helix protein 6
Short name:
bHLHa6
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name:
NeuroD3
Gene namesi
Name:NEUROG1
Synonyms:BHLHA6, NEUROD3, NGN, NGN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:7764. NEUROG1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. perikaryon Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Neurogenin-1PRO_0000127396Add
BLAST

Proteomic databases

PaxDbiQ92886.
PeptideAtlasiQ92886.
PRIDEiQ92886.

PTM databases

PhosphoSiteiQ92886.

Expressioni

Tissue specificityi

Expression restricted to the embryonic nervous system.

Gene expression databases

BgeeiQ92886.
CleanExiHS_NEUROG1.
GenevestigatoriQ92886.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

BioGridi110835. 7 interactions.
STRINGi9606.ENSP00000317580.

Structurei

3D structure databases

DisProtiDP00672.
ProteinModelPortaliQ92886.
SMRiQ92886. Positions 92-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 14453bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG275082.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiQ92886.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG7TTQB1.
PhylomeDBiQ92886.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR
60 70 80 90 100
GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR
110 120 130 140 150
ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL
160 170 180 190 200
ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS
210 220 230
SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH
Length:237
Mass (Da):25,718
Last modified:October 2, 2003 - v2
Checksum:iE3702A0B3408D567
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511G → S in AAB37575 (PubMed:8816493).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63842 Genomic DNA. Translation: AAB37575.1.
BT019366 mRNA. Translation: AAV38173.1.
CH471062 Genomic DNA. Translation: EAW62214.1.
BC008687 mRNA. Translation: AAH08687.1.
BC028226 mRNA. Translation: AAH28226.1.
CCDSiCCDS4187.1.
RefSeqiNP_006152.2. NM_006161.2.
UniGeneiHs.248149.

Genome annotation databases

EnsembliENST00000314744; ENSP00000317580; ENSG00000181965.
GeneIDi4762.
KEGGihsa:4762.
UCSCiuc003lax.3. human.

Polymorphism databases

DMDMi37538313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63842 Genomic DNA. Translation: AAB37575.1.
BT019366 mRNA. Translation: AAV38173.1.
CH471062 Genomic DNA. Translation: EAW62214.1.
BC008687 mRNA. Translation: AAH08687.1.
BC028226 mRNA. Translation: AAH28226.1.
CCDSiCCDS4187.1.
RefSeqiNP_006152.2. NM_006161.2.
UniGeneiHs.248149.

3D structure databases

DisProtiDP00672.
ProteinModelPortaliQ92886.
SMRiQ92886. Positions 92-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110835. 7 interactions.
STRINGi9606.ENSP00000317580.

PTM databases

PhosphoSiteiQ92886.

Polymorphism databases

DMDMi37538313.

Proteomic databases

PaxDbiQ92886.
PeptideAtlasiQ92886.
PRIDEiQ92886.

Protocols and materials databases

DNASUi4762.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314744; ENSP00000317580; ENSG00000181965.
GeneIDi4762.
KEGGihsa:4762.
UCSCiuc003lax.3. human.

Organism-specific databases

CTDi4762.
GeneCardsiGC05M134897.
HGNCiHGNC:7764. NEUROG1.
MIMi601726. gene.
neXtProtiNX_Q92886.
PharmGKBiPA31569.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG275082.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiQ92886.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG7TTQB1.
PhylomeDBiQ92886.
TreeFamiTF315153.

Miscellaneous databases

GeneWikiiNEUROG1.
GenomeRNAii4762.
NextBioi18344.
PROiQ92886.
SOURCEiSearch...

Gene expression databases

BgeeiQ92886.
CleanExiHS_NEUROG1.
GenevestigatoriQ92886.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
    McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
    Mol. Cell. Biol. 16:5792-5800(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Eye.

Entry informationi

Entry nameiNGN1_HUMAN
AccessioniPrimary (citable) accession number: Q92886
Secondary accession number(s): Q5U0Q9, Q96HE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: October 2, 2003
Last modified: February 3, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.