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Protein

Osteoclast-stimulating factor 1

Gene

OSTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.1 Publication

GO - Biological processi

  • ossification Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134996-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-stimulating factor 1
Gene namesi
Name:OSTF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8510. OSTF1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • intracellular Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi26578.
OpenTargetsiENSG00000134996.
PharmGKBiPA32839.

Polymorphism and mutation databases

BioMutaiOSTF1.
DMDMi108885279.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000670352 – 214Osteoclast-stimulating factor 1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei200PhosphothreonineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92882.
MaxQBiQ92882.
PaxDbiQ92882.
PeptideAtlasiQ92882.
PRIDEiQ92882.

PTM databases

iPTMnetiQ92882.
PhosphoSitePlusiQ92882.

Expressioni

Tissue specificityi

Ubiquitously expressed. Present in osteoclasts (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000134996.
CleanExiHS_OSTF1.
GenevisibleiQ92882. HS.

Organism-specific databases

HPAiHPA020514.

Interactioni

Subunit structurei

Interacts with SRC and SMN1. Interacts with FASLG.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EFSO432813EBI-1051152,EBI-718488
HTTP428585EBI-1051152,EBI-466029
RELQ048643EBI-1051152,EBI-307352
SDCBPO005603EBI-1051152,EBI-727004
TRIM54Q9BYV23EBI-1051152,EBI-2130429

Protein-protein interaction databases

BioGridi117747. 31 interactors.
IntActiQ92882. 11 interactors.
MINTiMINT-209894.
STRINGi9606.ENSP00000340836.

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 21Combined sources7
Beta strandi38 – 43Combined sources6
Beta strandi46 – 54Combined sources9
Beta strandi57 – 62Combined sources6
Helixi63 – 65Combined sources3
Beta strandi66 – 68Combined sources3
Beta strandi70 – 74Combined sources5
Helixi76 – 83Combined sources8
Helixi86 – 94Combined sources9
Helixi109 – 115Combined sources7
Helixi119 – 125Combined sources7
Helixi143 – 150Combined sources8
Helixi153 – 162Combined sources10
Helixi176 – 179Combined sources4
Helixi183 – 189Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X2KNMR-A15-69[»]
1ZLMX-ray1.07A12-69[»]
3EHQX-ray2.57A/B1-214[»]
3EHRX-ray1.95A/B1-214[»]
ProteinModelPortaliQ92882.
SMRiQ92882.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92882.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 71SH3PROSITE-ProRule annotationAdd BLAST60
Repeati72 – 101ANK 1Add BLAST30
Repeati105 – 135ANK 2Add BLAST31
Repeati139 – 168ANK 3Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 11Pro-rich8

Domaini

The SH3 domain mediates interaction with SMN1.

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IIWQ. Eukaryota.
ENOG410XR45. LUCA.
GeneTreeiENSGT00780000121977.
HOGENOMiHOG000286040.
HOVERGENiHBG053379.
InParanoidiQ92882.
OMAiVELNQQN.
OrthoDBiEOG091G0HJ5.
PhylomeDBiQ92882.
TreeFamiTF314534.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTNWW
60 70 80 90 100
KGTSKGRTGL IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN
110 120 130 140 150
GLDKAGSTAL YWACHGGHKD IVEMLFTQPN IELNQQNKLG DTALHAAAWK
160 170 180 190 200
GYADIVQLLL AKGARTDLRN IEKKLAFDMA TNAACASLLK KKQGTDAVRT
210
LSNAEDYLDD EDSD
Length:214
Mass (Da):23,787
Last modified:May 30, 2006 - v2
Checksum:i6C37F3D2B68578C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11P → PGEG in AAH07459 (PubMed:15489334).Curated1
Sequence conflicti144 – 145LH → FD in AAB06396 (PubMed:10092216).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04830948N → S.Corresponds to variant rs2295862dbSNPEnsembl.1
Natural variantiVAR_026573159L → F.1 PublicationCorresponds to variant rs17850197dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63717 mRNA. Translation: AAB06396.1.
AK222596 mRNA. Translation: BAD96316.1.
AL133548 Genomic DNA. Translation: CAH71573.1.
BC007459 mRNA. Translation: AAH07459.1.
CCDSiCCDS6651.1.
RefSeqiNP_036515.4. NM_012383.4.
UniGeneiHs.494192.

Genome annotation databases

EnsembliENST00000346234; ENSP00000340836; ENSG00000134996.
GeneIDi26578.
KEGGihsa:26578.
UCSCiuc004ajv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63717 mRNA. Translation: AAB06396.1.
AK222596 mRNA. Translation: BAD96316.1.
AL133548 Genomic DNA. Translation: CAH71573.1.
BC007459 mRNA. Translation: AAH07459.1.
CCDSiCCDS6651.1.
RefSeqiNP_036515.4. NM_012383.4.
UniGeneiHs.494192.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X2KNMR-A15-69[»]
1ZLMX-ray1.07A12-69[»]
3EHQX-ray2.57A/B1-214[»]
3EHRX-ray1.95A/B1-214[»]
ProteinModelPortaliQ92882.
SMRiQ92882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117747. 31 interactors.
IntActiQ92882. 11 interactors.
MINTiMINT-209894.
STRINGi9606.ENSP00000340836.

PTM databases

iPTMnetiQ92882.
PhosphoSitePlusiQ92882.

Polymorphism and mutation databases

BioMutaiOSTF1.
DMDMi108885279.

Proteomic databases

EPDiQ92882.
MaxQBiQ92882.
PaxDbiQ92882.
PeptideAtlasiQ92882.
PRIDEiQ92882.

Protocols and materials databases

DNASUi26578.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346234; ENSP00000340836; ENSG00000134996.
GeneIDi26578.
KEGGihsa:26578.
UCSCiuc004ajv.5. human.

Organism-specific databases

CTDi26578.
DisGeNETi26578.
GeneCardsiOSTF1.
HGNCiHGNC:8510. OSTF1.
HPAiHPA020514.
MIMi610180. gene.
neXtProtiNX_Q92882.
OpenTargetsiENSG00000134996.
PharmGKBiPA32839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIWQ. Eukaryota.
ENOG410XR45. LUCA.
GeneTreeiENSGT00780000121977.
HOGENOMiHOG000286040.
HOVERGENiHBG053379.
InParanoidiQ92882.
OMAiVELNQQN.
OrthoDBiEOG091G0HJ5.
PhylomeDBiQ92882.
TreeFamiTF314534.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134996-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiOSTF1. human.
EvolutionaryTraceiQ92882.
GeneWikiiOSTF1.
GenomeRNAii26578.
PROiQ92882.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134996.
CleanExiHS_OSTF1.
GenevisibleiQ92882. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTF1_HUMAN
AccessioniPrimary (citable) accession number: Q92882
Secondary accession number(s): Q5W126, Q96IJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 30, 2006
Last modified: November 30, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.