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Q92876

- KLK6_HUMAN

UniProt

Q92876 - KLK6_HUMAN

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Protein

Kallikrein-6

Gene

KLK6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.6 Publications

Enzyme regulationi

Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin.2 Publications

Kineticsi

  1. KM=1562 µM for Tosyl-Gly-Pro-Arg-AMC2 Publications
  2. KM=777 µM for Tosyl-Gly-Pro-Lys-AMC2 Publications
  3. KM=0.410 mM for Phe-Ser-Arg-AMC2 Publications
  4. KM=0.455 mM for Gly-Gly-Arg-AMC2 Publications
  5. KM=0.335 mM for Asp-Pro-Arg-AMC2 Publications
  6. KM=0.758 mM for Gln-Gly-Arg-AMC2 Publications
  7. KM=0.625 mM for Pro-Phe-Arg-AMC2 Publications
  8. KM=0.271 mM for Val-Pro-Arg-AMC2 Publications
  9. KM=1.72 mM for Val-Leu-Lys-AMC2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay system1 Publication
Sitei80 – 812Cleavage; by autolysis
Active sitei106 – 1061Charge relay system1 Publication
Active sitei197 – 1971Charge relay system1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. amyloid precursor protein metabolic process Source: UniProtKB
  2. central nervous system development Source: UniProtKB
  3. collagen catabolic process Source: UniProtKB
  4. hormone metabolic process Source: UniProtKB
  5. myelination Source: UniProtKB
  6. neuron death Source: UniProt
  7. positive regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  8. protein autoprocessing Source: UniProtKB
  9. regulation of cell differentiation Source: UniProtKB
  10. regulation of neuron projection development Source: Ensembl
  11. response to wounding Source: UniProtKB
  12. tissue regeneration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

SABIO-RKQ92876.

Protein family/group databases

MEROPSiS01.236.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-6 (EC:3.4.21.-)
Alternative name(s):
Neurosin
Protease M
SP59
Serine protease 18
Serine protease 9
Zyme
Gene namesi
Name:KLK6
Synonyms:PRSS18, PRSS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6367. KLK6.

Subcellular locationi

Secreted. Nucleusnucleolus. Cytoplasm. Mitochondrion. Microsome
Note: In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: UniProt
  5. intercellular bridge Source: HPA
  6. microtubule cytoskeleton Source: HPA
  7. mitochondrion Source: UniProtKB-KW
  8. nuclear membrane Source: HPA
  9. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Propeptidei17 – 215Activation peptideSequence AnalysisPRO_0000027940
Chaini22 – 244223Kallikrein-6PRO_0000027941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 157
Disulfide bondi47 ↔ 63
Disulfide bondi131 ↔ 231
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi138 ↔ 203
Disulfide bondi168 ↔ 182
Disulfide bondi193 ↔ 218

Post-translational modificationi

Inactivated by autolytic cleavage after Arg-80.

Keywords - PTMi

Autocatalytic cleavage, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ92876.
PaxDbiQ92876.
PeptideAtlasiQ92876.
PRIDEiQ92876.

PTM databases

PhosphoSiteiQ92876.

Miscellaneous databases

PMAP-CutDBQ92876.

Expressioni

Tissue specificityi

In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.5 Publications

Inductioni

By spinal cord injury. This effect is particularly prominent in macrophages, microglia and reactive astrocytes.1 Publication

Gene expression databases

BgeeiQ92876.
CleanExiHS_KLK6.
ExpressionAtlasiQ92876. baseline and differential.
GenevestigatoriQ92876.

Organism-specific databases

HPAiHPA051837.

Interactioni

Protein-protein interaction databases

BioGridi111634. 1 interaction.
IntActiQ92876. 12 interactions.
STRINGi9606.ENSP00000309148.

Structurei

Secondary structure

1
244
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi27 – 293
Beta strandi36 – 416
Beta strandi44 – 5310
Beta strandi56 – 594
Helixi61 – 633
Beta strandi69 – 735
Beta strandi75 – 773
Beta strandi85 – 9410
Turni100 – 1023
Beta strandi108 – 1147
Beta strandi137 – 1448
Beta strandi146 – 1494
Beta strandi156 – 1638
Helixi165 – 1717
Turni173 – 1753
Beta strandi180 – 1845
Turni186 – 1883
Turni194 – 1985
Beta strandi200 – 2034
Beta strandi206 – 2138
Beta strandi221 – 2233
Beta strandi225 – 2295
Helixi230 – 2334
Helixi234 – 2374

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GVLX-ray1.80A21-243[»]
1L2EX-ray1.75A22-244[»]
1LO6X-ray1.56A22-237[»]
3VFEX-ray1.88A22-244[»]
4D8NX-ray1.68A22-244[»]
ProteinModelPortaliQ92876.
SMRiQ92876. Positions 22-242.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92876.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 242221Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ92876.
KOiK08667.
OMAiWIRKTIQ.
OrthoDBiEOG75B84T.
PhylomeDBiQ92876.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92876-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKLMVVLSL IAAAWAEEQN KLVHGGPCDK TSHPYQAALY TSGHLLCGGV
60 70 80 90 100
LIHPLWVLTA AHCKKPNLQV FLGKHNLRQR ESSQEQSSVV RAVIHPDYDA
110 120 130 140 150
ASHDQDIMLL RLARPAKLSE LIQPLPLERD CSANTTSCHI LGWGKTADGD
160 170 180 190 200
FPDTIQCAYI HLVSREECEH AYPGQITQNM LCAGDEKYGK DSCQGDSGGP
210 220 230 240
LVCGDHLRGL VSWGNIPCGS KEKPGVYTNV CRYTNWIQKT IQAK
Length:244
Mass (Da):26,856
Last modified:February 1, 1997 - v1
Checksum:iAEA03F9145D87AAB
GO
Isoform 2 (identifier: Q92876-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Show »
Length:137
Mass (Da):15,055
Checksum:i25A421C212869BEA
GO
Isoform 3 (identifier: Q92876-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-40: AWAEEQNKLVHGGPCDKTSHPYQAALY → GIFRSSWGSITFGKGRVPRSRVLLSGL
     41-244: Missing.

Show »
Length:40
Mass (Da):4,333
Checksum:i323721E6AE557378
GO

Mass spectrometryi

Molecular mass is 25866 Da from positions 22 - 244. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781R → W.
Corresponds to variant rs61469141 [ dbSNP | Ensembl ].
VAR_061776

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107Missing in isoform 2. 1 PublicationVSP_034403Add
BLAST
Alternative sequencei14 – 4027AWAEE…QAALY → GIFRSSWGSITFGKGRVPRS RVLLSGL in isoform 3. 1 PublicationVSP_034404Add
BLAST
Alternative sequencei41 – 244204Missing in isoform 3. 1 PublicationVSP_034405Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62801 mRNA. Translation: AAB07113.1.
D78203 mRNA. Translation: BAA11306.1.
AF013988 mRNA. Translation: AAB66483.1.
AF149289 Genomic DNA. Translation: AAD51475.1.
AF243527 Genomic DNA. Translation: AAG33359.1.
AY318867 mRNA. Translation: AAP82446.1.
AY318868 mRNA. No translation available.
AY318869 mRNA. Translation: AAP82448.1.
AY318870 mRNA. No translation available.
DQ223012 mRNA. Translation: ABB04464.1.
AK314897 mRNA. Translation: BAG37411.1.
BT006852 mRNA. Translation: AAP35498.1.
AC011483 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71953.1.
CH471135 Genomic DNA. Translation: EAW71954.1.
BC015525 mRNA. Translation: AAH15525.1.
CCDSiCCDS12811.1. [Q92876-1]
CCDS42599.1. [Q92876-2]
RefSeqiNP_001012982.1. NM_001012964.1. [Q92876-1]
NP_001012983.1. NM_001012965.1. [Q92876-2]
NP_002765.1. NM_002774.3. [Q92876-1]
UniGeneiHs.79361.

Genome annotation databases

EnsembliENST00000310157; ENSP00000309148; ENSG00000167755. [Q92876-1]
ENST00000376851; ENSP00000366047; ENSG00000167755. [Q92876-1]
ENST00000391808; ENSP00000375684; ENSG00000167755. [Q92876-2]
ENST00000594641; ENSP00000470482; ENSG00000167755. [Q92876-1]
ENST00000597379; ENSP00000469630; ENSG00000167755. [Q92876-3]
ENST00000599881; ENSP00000471948; ENSG00000167755. [Q92876-3]
GeneIDi5653.
KEGGihsa:5653.
UCSCiuc002puh.3. human. [Q92876-1]

Polymorphism databases

DMDMi3914480.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62801 mRNA. Translation: AAB07113.1 .
D78203 mRNA. Translation: BAA11306.1 .
AF013988 mRNA. Translation: AAB66483.1 .
AF149289 Genomic DNA. Translation: AAD51475.1 .
AF243527 Genomic DNA. Translation: AAG33359.1 .
AY318867 mRNA. Translation: AAP82446.1 .
AY318868 mRNA. No translation available.
AY318869 mRNA. Translation: AAP82448.1 .
AY318870 mRNA. No translation available.
DQ223012 mRNA. Translation: ABB04464.1 .
AK314897 mRNA. Translation: BAG37411.1 .
BT006852 mRNA. Translation: AAP35498.1 .
AC011483 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71953.1 .
CH471135 Genomic DNA. Translation: EAW71954.1 .
BC015525 mRNA. Translation: AAH15525.1 .
CCDSi CCDS12811.1. [Q92876-1 ]
CCDS42599.1. [Q92876-2 ]
RefSeqi NP_001012982.1. NM_001012964.1. [Q92876-1 ]
NP_001012983.1. NM_001012965.1. [Q92876-2 ]
NP_002765.1. NM_002774.3. [Q92876-1 ]
UniGenei Hs.79361.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GVL X-ray 1.80 A 21-243 [» ]
1L2E X-ray 1.75 A 22-244 [» ]
1LO6 X-ray 1.56 A 22-237 [» ]
3VFE X-ray 1.88 A 22-244 [» ]
4D8N X-ray 1.68 A 22-244 [» ]
ProteinModelPortali Q92876.
SMRi Q92876. Positions 22-242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111634. 1 interaction.
IntActi Q92876. 12 interactions.
STRINGi 9606.ENSP00000309148.

Chemistry

BindingDBi Q92876.
ChEMBLi CHEMBL4448.

Protein family/group databases

MEROPSi S01.236.

PTM databases

PhosphoSitei Q92876.

Polymorphism databases

DMDMi 3914480.

Proteomic databases

MaxQBi Q92876.
PaxDbi Q92876.
PeptideAtlasi Q92876.
PRIDEi Q92876.

Protocols and materials databases

DNASUi 5653.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310157 ; ENSP00000309148 ; ENSG00000167755 . [Q92876-1 ]
ENST00000376851 ; ENSP00000366047 ; ENSG00000167755 . [Q92876-1 ]
ENST00000391808 ; ENSP00000375684 ; ENSG00000167755 . [Q92876-2 ]
ENST00000594641 ; ENSP00000470482 ; ENSG00000167755 . [Q92876-1 ]
ENST00000597379 ; ENSP00000469630 ; ENSG00000167755 . [Q92876-3 ]
ENST00000599881 ; ENSP00000471948 ; ENSG00000167755 . [Q92876-3 ]
GeneIDi 5653.
KEGGi hsa:5653.
UCSCi uc002puh.3. human. [Q92876-1 ]

Organism-specific databases

CTDi 5653.
GeneCardsi GC19M051461.
HGNCi HGNC:6367. KLK6.
HPAi HPA051837.
MIMi 602652. gene.
neXtProti NX_Q92876.
PharmGKBi PA30156.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi Q92876.
KOi K08667.
OMAi WIRKTIQ.
OrthoDBi EOG75B84T.
PhylomeDBi Q92876.
TreeFami TF331065.

Enzyme and pathway databases

SABIO-RK Q92876.

Miscellaneous databases

EvolutionaryTracei Q92876.
GeneWikii KLK6.
GenomeRNAii 5653.
NextBioi 21966.
PMAP-CutDB Q92876.
PROi Q92876.
SOURCEi Search...

Gene expression databases

Bgeei Q92876.
CleanExi HS_KLK6.
ExpressionAtlasi Q92876. baseline and differential.
Genevestigatori Q92876.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protease homolog differentially expressed in breast and ovarian cancer."
    Anisowicz A., Sotiropoulou G., Stenman G., Mok S.C., Sager R.
    Mol. Med. 2:624-636(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain."
    Yamashiro K., Tsuruoka N., Kodama S., Tsujimoto M., Yamamura Y., Tanaka T., Nakazato H., Yamaguchi N.
    Biochim. Biophys. Acta 1350:11-14(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease."
    Yousef G.M., Luo L.Y., Scherer S.W., Sotiropoulou G., Diamandis E.P.
    Genomics 62:251-259(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
    Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
    Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Cloning and characterization of novel isoforms of the human kallikrein 6 gene."
    Pampalakis G., Kurlender L., Diamandis E.P., Sotiropoulou G.
    Biochem. Biophys. Res. Commun. 320:54-61(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Testis.
  7. "Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer."
    Pampalakis G., Sotiropoulou G.
    Biol. Chem. 387:773-782(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  13. "Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications."
    Diamandis E.P., Yousef G.M., Soosaipillai A.R., Grass L., Porter A., Little S., Sotiropoulou G.
    Clin. Biochem. 33:369-375(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  14. "Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease."
    Ogawa K., Yamada T., Tsujioka Y., Taguchi J., Takahashi M., Tsuboi Y., Fujino Y., Nakajima M., Yamamoto T., Akatsu H., Mitsui S., Yamaguchi N.
    Psychiatry Clin. Neurosci. 54:419-426(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  15. "The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry."
    Petraki C.D., Karavana V.N., Skoufogiannis P.T., Little S.P., Howarth D.J.C., Yousef G.M., Diamandis E.P.
    J. Histochem. Cytochem. 49:1431-1441(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  16. "Characterization of the enzymatic activity of human kallikrein 6: autoactivation, substrate specificity, and regulation by inhibitors."
    Magklara A., Mellati A.A., Wasney G.A., Little S.P., Sotiropoulou G., Becker G.W., Diamandis E.P.
    Biochem. Biophys. Res. Commun. 307:948-955(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, AUTOCATALYTIC CLEAVAGE.
  17. "Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies."
    Iwata A., Maruyama M., Akagi T., Hashikawa T., Kanazawa I., Tsuji S., Nukina N.
    Hum. Mol. Genet. 12:2625-2635(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  18. "Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells."
    Ghosh M.C., Grass L., Soosaipillai A., Sotiropoulou G., Diamandis E.P.
    Tumor Biol. 25:193-199(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. Cited for: FUNCTION, INDUCTION.
  20. "Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects."
    Angelo P.F., Lima A.R., Alves F.M., Blaber S.I., Scarisbrick I.A., Blaber M., Juliano L., Juliano M.A.
    J. Biol. Chem. 281:3116-3126(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION.
  21. "The autolytic regulation of human kallikrein-related peptidase 6."
    Blaber S.I., Yoon H., Scarisbrick I.A., Juliano M.A., Blaber M.
    Biochemistry 46:5209-5217(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: AUTOCATALYTIC CLEAVAGE.
  22. "The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family."
    Gomis-Rueth F.X., Bayes A., Sotiropoulou G., Pampalakis G., Tsetsenis T., Villegas V., Aviles F.X., Coll M.
    J. Biol. Chem. 277:27273-27281(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 21-243, AUTOCATALYTIC CLEAVAGE, ACTIVE SITES, DISULFIDE BONDS.
  23. "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system."
    Bernett M.J., Blaber S.I., Scarisbrick I.A., Dhanarajan P., Thompson S.M., Blaber M.
    J. Biol. Chem. 277:24562-24570(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 22-244, PROTEIN SEQUENCE OF 22-25, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, AUTOCATALYTIC CLEAVAGE, DISULFIDE BONDS, MASS SPECTROMETRY.

Entry informationi

Entry nameiKLK6_HUMAN
AccessioniPrimary (citable) accession number: Q92876
Secondary accession number(s): A6NJA1, A8MW09, Q6H301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3