Q92874 (DNSL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribonuclease-1-like 2
EC=3.1.21.-

Alternative name(s):
DNase I homolog protein DHP1
Deoxyribonuclease I-like 2
Short name=DNase I-like 2

Gene names

Name:	DNASE1L2
Synonyms:	DHP1, DNAS1L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Brain.
Sequence similarities	Belongs to the DNase I family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA catabolic process Inferred from electronic annotation. Source: InterPro DNA metabolic process Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Traceable author statement Ref.1. Source: ProtInc calcium ion binding Traceable author statement Ref.1. Source: ProtInc deoxyribonuclease activity Traceable author statement Ref.1. Source: ProtInc endodeoxyribonuclease activity, producing 5'-phosphomonoesters Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	1	EBI-1751995,EBI-375543
FYN	P06241	1	EBI-1751995,EBI-515315

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 299	279	Deoxyribonuclease-1-like 2		PRO_0000007286
Sites
	Active site	99	1	By similarity
	Active site	170	1	By similarity
Amino acid modifications
	Disulfide bond	209 ↔ 245		Essential for enzymatic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92874 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 1B66A5590D33D0A6	FASTA	299	32,853
	10 20 30 40 50 60 MGGPRALLAA LWALEAAGTA ALRIGAFNIQ SFGDSKVSDP ACGSIIAKIL AGYDLALVQE 70 80 90 100 110 120 VRDPDLSAVS ALMEQINSVS EHEYSFVSSQ PLGRDQYKEM YLFVYRKDAV SVVDTYLYPD 130 140 150 160 170 180 PEDVFSREPF VVKFSAPGTG ERAPPLPSRR ALTPPPLPAA AQNLVLIPLH AAPHQAVAEI 190 200 210 220 230 240 DALYDVYLDV IDKWGTDDML FLGDFNADCS YVRAQDWAAI RLRSSEVFKW LIPDSADTTV 250 260 270 280 290 GNSDCAYDRI VACGARLRRS LKPQSATVHD FQEEFGLDQT QALAISDHFP VEVTLKFHR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I." Rodriguez A.M., Rodin D., Nomura H., Morton C.C., Weremowicz S., Schneider M.C. Genomics 42:507-513(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U62647 mRNA. Translation: AAB63981.1. BC035205 mRNA. Translation: AAH35205.1. BC063710 mRNA. Translation: AAH63710.1.
IPI	IPI00023843.
RefSeq	NP_001365.1. NM_001374.2.
UniGene	Hs.103503.
3D structure databases
ProteinModelPortal	Q92874.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92874. 2 interactions.
MINT	MINT-4722563.
STRING	9606.ENSP00000316938.
Polymorphism databases
DMDM	2494172.
Proteomic databases
PaxDb	Q92874.
PRIDE	Q92874.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320700; ENSP00000316938; ENSG00000167968. ENST00000541838; ENSP00000445343; ENSG00000167968. ENST00000564065; ENSP00000454562; ENSG00000167968. ENST00000567494; ENSP00000455358; ENSG00000167968.
GeneID	1775.
KEGG	hsa:1775.
UCSC	uc002cpo.3. human.
Organism-specific databases
CTD	1775.
GeneCards	GC16P002285.
H-InvDB	HIX0038772.
HGNC	HGNC:2958. DNASE1L2.
HPA	HPA044714.
MIM	602622. gene.
neXtProt	NX_Q92874.
PharmGKB	PA27429.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46375.
HOGENOM	HOG000059570.
HOVERGEN	HBG051368.
InParanoid	Q92874.
KO	K11995.
OMA	QYPDPED.
Gene expression databases
ArrayExpress	Q92874.
Bgee	Q92874.
CleanEx	HS_DNASE1L2.
Genevestigator	Q92874.
GermOnline	ENSG00000167968. Homo sapiens.
Family and domain databases
InterPro	IPR018057. Deoxyribonuclease-1_AS. IPR016202. DNase_I-like. IPR008185. DNase_I_euk. IPR005135. Endo/exonuclease/phosphatase. [Graphical view]
PANTHER	PTHR11371. PTHR11371. 1 hit.
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
PIRSF	PIRSF000988. DNase_I_euk. 1 hit.
PRINTS	PR00130. DNASEI.
SMART	SM00476. DNaseIc. 1 hit. [Graphical view]
SUPFAM	SSF56219. Exo_endo_phos. 1 hit.
PROSITE	PS00919. DNASE_I_1. 1 hit. PS00918. DNASE_I_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1775.
NextBio	7227.
SOURCE	Search...

Entry information

Entry name

DNSL2_HUMAN

Accession

Primary (citable) accession number: Q92874

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.