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Q92870

- APBB2_HUMAN

UniProt

Q92870 - APBB2_HUMAN

Protein

Amyloid beta A4 precursor protein-binding family B member 2

Gene

APBB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    May modulate the internalization of beta-amyloid precursor protein.

    GO - Molecular functioni

    1. beta-amyloid binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: Ensembl
    2. cell cycle arrest Source: UniProtKB
    3. extracellular matrix organization Source: Ensembl
    4. intracellular signal transduction Source: UniProtKB
    5. negative regulation of apoptotic process Source: Ensembl
    6. negative regulation of cell growth Source: UniProtKB
    7. neuron migration Source: Ensembl
    8. positive regulation of apoptotic process Source: Ensembl
    9. regulation of transcription, DNA-templated Source: UniProtKB

    Enzyme and pathway databases

    SignaLinkiQ92870.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amyloid beta A4 precursor protein-binding family B member 2
    Alternative name(s):
    Protein Fe65-like 1
    Gene namesi
    Name:APBB2
    Synonyms:FE65L, FE65L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:582. APBB2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. growth cone Source: UniProtKB
    3. lamellipodium Source: UniProtKB
    4. membrane Source: UniProtKB
    5. nucleus Source: UniProtKB
    6. synapse Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24874.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 758758Amyloid beta A4 precursor protein-binding family B member 2PRO_0000076052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei123 – 1231Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ92870.
    PaxDbiQ92870.
    PRIDEiQ92870.

    PTM databases

    PhosphoSiteiQ92870.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92870.
    BgeeiQ92870.
    CleanExiHS_APBB2.
    GenevestigatoriQ92870.

    Organism-specific databases

    HPAiHPA023542.

    Interactioni

    Subunit structurei

    Binds to the intracellular domain of the beta-amyloid precursor protein.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPP050672EBI-79277,EBI-77613
    EGFRP005334EBI-79277,EBI-297353

    Protein-protein interaction databases

    BioGridi106820. 4 interactions.
    IntActiQ92870. 4 interactions.
    MINTiMINT-1493142.
    STRINGi9606.ENSP00000295974.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92870.
    SMRiQ92870. Positions 291-320, 417-551, 580-702.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini290 – 32233WWPROSITE-ProRule annotationAdd
    BLAST
    Domaini413 – 578166PID 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini584 – 736153PID 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PID domains.PROSITE-ProRule annotation
    Contains 1 WW domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG76544.
    HOGENOMiHOG000033983.
    HOVERGENiHBG050524.
    InParanoidiQ92870.
    KOiK04530.
    OMAiTKNSTPP.
    OrthoDBiEOG79W94P.
    PhylomeDBiQ92870.
    TreeFamiTF314331.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00640. PID. 2 hits.
    PF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 2 hits.
    SM00456. WW. 1 hit.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 1 hit.
    PROSITEiPS01179. PID. 2 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92870-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN    50
    AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV 100
    KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI 150
    LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI 200
    IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI 250
    QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS 300
    DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP 350
    WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP 400
    HPDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL 450
    SYCKNDIRDT VGIWGEGKDM YLILENDMLS LVDPMDRSVL HSQPIVSIRV 500
    WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS LHEICSKIMA 550
    ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV 600
    DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV 650
    ECRVRFLSFM GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA 700
    ACMLRYQKCL VARPPSQKVR PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ 750
    KRPVTEMP 758
    Length:758
    Mass (Da):83,374
    Last modified:January 11, 2011 - v3
    Checksum:i453521022CD548D5
    GO
    Isoform 2 (identifier: Q92870-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         348-368: Missing.
         577-577: Missing.

    Show »
    Length:736
    Mass (Da):80,889
    Checksum:i6D64F31F4772DB3B
    GO
    Isoform 3 (identifier: Q92870-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-548: Missing.

    Show »
    Length:210
    Mass (Da):23,488
    Checksum:i22E24FCE3101AB83
    GO
    Isoform 4 (identifier: Q92870-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         278-278: T → TA

    Note: No experimental confirmation available.

    Show »
    Length:759
    Mass (Da):83,445
    Checksum:i5D32E0D35D43756E
    GO

    Sequence cautioni

    The sequence AAC50805.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti490 – 4901L → W in AAC50805. (PubMed:8855266)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti179 – 1791R → Q.2 Publications
    Corresponds to variant rs4861358 [ dbSNP | Ensembl ].
    VAR_069029

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 548548Missing in isoform 3. 1 PublicationVSP_044232Add
    BLAST
    Alternative sequencei278 – 2781T → TA in isoform 4. 1 PublicationVSP_045042
    Alternative sequencei348 – 36821Missing in isoform 2. 1 PublicationVSP_040354Add
    BLAST
    Alternative sequencei577 – 5771Missing in isoform 2. 1 PublicationVSP_040355

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299800 mRNA. Translation: BAG61676.1.
    AK226179 mRNA. No translation available.
    AC093804 Genomic DNA. No translation available.
    AC096712 Genomic DNA. No translation available.
    AC108937 Genomic DNA. No translation available.
    AC131953 Genomic DNA. No translation available.
    BC027946 mRNA. Translation: AAH27946.2.
    U62325 mRNA. Translation: AAC50805.1. Sequence problems.
    CCDSiCCDS43224.1. [Q92870-2]
    CCDS54760.1. [Q92870-3]
    CCDS54761.1. [Q92870-1]
    CCDS54762.1. [Q92870-4]
    RefSeqiNP_001159522.1. NM_001166050.1. [Q92870-1]
    NP_001159523.1. NM_001166051.1. [Q92870-3]
    NP_001159524.1. NM_001166052.1. [Q92870-3]
    NP_001159525.1. NM_001166053.1. [Q92870-3]
    NP_001159526.1. NM_001166054.1. [Q92870-3]
    NP_775098.2. NM_173075.4. [Q92870-2]
    UniGeneiHs.479602.

    Genome annotation databases

    EnsembliENST00000295974; ENSP00000295974; ENSG00000163697. [Q92870-1]
    ENST00000502841; ENSP00000425802; ENSG00000163697. [Q92870-3]
    ENST00000504305; ENSP00000423765; ENSG00000163697. [Q92870-3]
    ENST00000508593; ENSP00000427211; ENSG00000163697. [Q92870-4]
    ENST00000513140; ENSP00000426018; ENSG00000163697. [Q92870-2]
    ENST00000543538; ENSP00000439357; ENSG00000163697. [Q92870-3]
    GeneIDi323.
    KEGGihsa:323.
    UCSCiuc003gvk.3. human. [Q92870-3]
    uc003gvl.3. human. [Q92870-1]
    uc003gvm.3. human. [Q92870-2]

    Polymorphism databases

    DMDMi317373476.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299800 mRNA. Translation: BAG61676.1 .
    AK226179 mRNA. No translation available.
    AC093804 Genomic DNA. No translation available.
    AC096712 Genomic DNA. No translation available.
    AC108937 Genomic DNA. No translation available.
    AC131953 Genomic DNA. No translation available.
    BC027946 mRNA. Translation: AAH27946.2 .
    U62325 mRNA. Translation: AAC50805.1 . Sequence problems.
    CCDSi CCDS43224.1. [Q92870-2 ]
    CCDS54760.1. [Q92870-3 ]
    CCDS54761.1. [Q92870-1 ]
    CCDS54762.1. [Q92870-4 ]
    RefSeqi NP_001159522.1. NM_001166050.1. [Q92870-1 ]
    NP_001159523.1. NM_001166051.1. [Q92870-3 ]
    NP_001159524.1. NM_001166052.1. [Q92870-3 ]
    NP_001159525.1. NM_001166053.1. [Q92870-3 ]
    NP_001159526.1. NM_001166054.1. [Q92870-3 ]
    NP_775098.2. NM_173075.4. [Q92870-2 ]
    UniGenei Hs.479602.

    3D structure databases

    ProteinModelPortali Q92870.
    SMRi Q92870. Positions 291-320, 417-551, 580-702.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106820. 4 interactions.
    IntActi Q92870. 4 interactions.
    MINTi MINT-1493142.
    STRINGi 9606.ENSP00000295974.

    PTM databases

    PhosphoSitei Q92870.

    Polymorphism databases

    DMDMi 317373476.

    Proteomic databases

    MaxQBi Q92870.
    PaxDbi Q92870.
    PRIDEi Q92870.

    Protocols and materials databases

    DNASUi 323.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295974 ; ENSP00000295974 ; ENSG00000163697 . [Q92870-1 ]
    ENST00000502841 ; ENSP00000425802 ; ENSG00000163697 . [Q92870-3 ]
    ENST00000504305 ; ENSP00000423765 ; ENSG00000163697 . [Q92870-3 ]
    ENST00000508593 ; ENSP00000427211 ; ENSG00000163697 . [Q92870-4 ]
    ENST00000513140 ; ENSP00000426018 ; ENSG00000163697 . [Q92870-2 ]
    ENST00000543538 ; ENSP00000439357 ; ENSG00000163697 . [Q92870-3 ]
    GeneIDi 323.
    KEGGi hsa:323.
    UCSCi uc003gvk.3. human. [Q92870-3 ]
    uc003gvl.3. human. [Q92870-1 ]
    uc003gvm.3. human. [Q92870-2 ]

    Organism-specific databases

    CTDi 323.
    GeneCardsi GC04M040812.
    HGNCi HGNC:582. APBB2.
    HPAi HPA023542.
    MIMi 602710. gene.
    neXtProti NX_Q92870.
    PharmGKBi PA24874.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76544.
    HOGENOMi HOG000033983.
    HOVERGENi HBG050524.
    InParanoidi Q92870.
    KOi K04530.
    OMAi TKNSTPP.
    OrthoDBi EOG79W94P.
    PhylomeDBi Q92870.
    TreeFami TF314331.

    Enzyme and pathway databases

    SignaLinki Q92870.

    Miscellaneous databases

    ChiTaRSi APBB2. human.
    GeneWikii APBB2.
    GenomeRNAii 323.
    NextBioi 1325.
    PROi Q92870.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92870.
    Bgeei Q92870.
    CleanExi HS_APBB2.
    Genevestigatori Q92870.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00640. PID. 2 hits.
    PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 2 hits.
    SM00456. WW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 1 hit.
    PROSITEi PS01179. PID. 2 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    2. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLN-179.
      Tissue: Aortic endothelium.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLN-179.
      Tissue: Lung.
    5. "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein."
      Guenette S.Y., Chen J., Jondro P.D., Tanzi R.E.
      Proc. Natl. Acad. Sci. U.S.A. 93:10832-10837(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-758 (ISOFORM 1).
      Tissue: Fetal brain and Kidney.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAPBB2_HUMAN
    AccessioniPrimary (citable) accession number: Q92870
    Secondary accession number(s): B4DSL4, E9PG87, Q8IUI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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