Reviewed,
UniProtKB/Swiss-Prot Q92870 (APBB2_HUMAN)
Last modified
November 24, 2009.
Version 77.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Amyloid beta A4 precursor protein-binding family B member 2 Alternative name(s): Fe65-like protein | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 758 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May modulate the internalization of beta-amyloid precursor protein. |
| Subunit structure | Binds to the intracellular domain of the beta-amyloid precursor protein. |
| Sequence similarities | Contains 2 PID domains. Contains 1 WW domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| APLP2 | Q06481 | 1 | EBI-79277,EBI-79306 | |
| APP | P05067 | 1 | EBI-79277,EBI-77613 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q92870-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q92870-2) The sequence of this isoform differs from the canonical sequence as follows: 348-368: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 758 | 758 | Amyloid beta A4 precursor protein-binding family B member 2 | PRO_0000076052 | |||||
Regions | |||||||||
| Domain | 290 – 322 | 33 | WW | ||||||
| Domain | 413 – 578 | 166 | PID 1 | ||||||
| Domain | 584 – 736 | 153 | PID 2 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 336 | 1 | Phosphoserine | ||||||
| Modified residue | 339 | 1 | Phosphothreonine | ||||||
| Modified residue | 343 | 1 | Phosphothreonine | ||||||
Natural variations | |||||||||
| Alternative sequence | 348 – 368 | 21 | Missing in isoform 2. | VSP_011660 | |||||
Experimental info | |||||||||
| Sequence conflict | 30 – 65 | 36 | NSPAT…STPPK → HTRTHRDTRHTYTHAHTDAH TCTHMHRDTQMHTHTI Ref.2 | ||||||
| Sequence conflict | 179 | 1 | Q → R in AAC50805. Ref.2 | ||||||
| Sequence conflict | 490 | 1 | L → W in AAC50805. Ref.2 | ||||||
| Sequence conflict | 577 | 1 | Missing in AAH27946. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung. |
| [2] | "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein." Guenette S.Y., Chen J., Jondro P.D., Tanzi R.E. Proc. Natl. Acad. Sci. U.S.A. 93:10832-10837(1996) [PubMed: 8855266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-758 (ISOFORM 1). Tissue: Fetal brain and Kidney. |
| [3] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; THR-339 AND THR-343, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| BC027946 mRNA. Translation: AAH27946.2. U62325 mRNA. Translation: AAC50805.1. | |
| IPI | IPI00470455. IPI00470456. |
| RefSeq | NP_775098.2. |
| UniGene | Hs.479602 |
3D structure databases | |
| SMR | Q92870. Positions 580-702. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q92870. 2 interactions. |
| STRING | Q92870. |
PTM databases | |
| PhosphoSite | Q92870. |
Proteomic databases | |
| PRIDE | Q92870. |
Genome annotation databases | |
| Ensembl | ENST00000316212; ENSP00000318965; ENSG00000163697; Homo sapiens. [Genome view] |
| GeneID | 323. |
| KEGG | hsa:323. |
| UCSC | uc003gvl.1. human. uc003gvm.1. human. |
Organism-specific databases | |
| CTD | 323. |
| GeneCards | GC04M040510. |
| H-InvDB | HIX0020340. |
| HGNC | HGNC:582. APBB2. |
| HPA | HPA023542. |
| MIM | 602710. gene. |
| PharmGKB | PA24874. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q92870. |
| HOVERGEN | Q92870. |
Gene expression databases | |
| ArrayExpress | Q92870. |
| Bgee | Q92870. |
| CleanEx | HS_APBB2. |
| Genevestigator | Q92870. |
| GermOnline | ENSG00000163697. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011993. PH_type. IPR006020. PTB_PID. IPR001202. WW_Rsp5_WWP. [Graphical view] |
| Gene3D | G3DSA:2.30.29.30. PH_type. 2 hits. |
| Pfam | PF00640. PID. 2 hits. PF00397. WW. 1 hit. [Graphical view] |
| SMART | SM00462. PTB. 2 hits. SM00456. WW. 1 hit. [Graphical view] |
| PROSITE | PS01179. PID. 2 hits. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 1325. |
| SOURCE | Search... |
Entry information
| Entry name | APBB2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q92870 Secondary accession number(s): Q8IUI6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


