Q92870 (APBB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 97.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Amyloid beta A4 precursor protein-binding family B member 2 Alternative name(s): Protein Fe65-like 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 758 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May modulate the internalization of beta-amyloid precursor protein. |
| Subunit structure | Binds to the intracellular domain of the beta-amyloid precursor protein. |
| Sequence similarities | Contains 2 PID domains. Contains 1 WW domain. |
| Sequence caution | The sequence AAC50805.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| APP | P05067 | 2 | EBI-79277,EBI-77613 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q92870-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q92870-2) The sequence of this isoform differs from the canonical sequence as follows: 348-368: Missing. 577-577: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 758 | 758 | Amyloid beta A4 precursor protein-binding family B member 2 | PRO_0000076052 | |||||
Regions | |||||||||
| Domain | 290 – 322 | 33 | WW | ||||||
| Domain | 413 – 578 | 166 | PID 1 | ||||||
| Domain | 584 – 736 | 153 | PID 2 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 336 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 339 | 1 | Phosphothreonine Ref.4 | ||||||
| Modified residue | 343 | 1 | Phosphothreonine Ref.4 | ||||||
Natural variations | |||||||||
| Alternative sequence | 348 – 368 | 21 | Missing in isoform 2. | VSP_040354 | |||||
| Alternative sequence | 577 | 1 | Missing in isoform 2. | VSP_040355 | |||||
Experimental info | |||||||||
| Sequence conflict | 179 | 1 | R → Q in AAH27946. Ref.2 | ||||||
| Sequence conflict | 490 | 1 | L → W in AAC50805. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung. |
| [3] | "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein." Guenette S.Y., Chen J., Jondro P.D., Tanzi R.E. Proc. Natl. Acad. Sci. U.S.A. 93:10832-10837(1996) [PubMed: 8855266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-758 (ISOFORM 1). Tissue: Fetal brain and Kidney. |
| [4] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; THR-339 AND THR-343, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC093804 Genomic DNA. No translation available. AC096712 Genomic DNA. No translation available. AC108937 Genomic DNA. No translation available. AC131953 Genomic DNA. No translation available. BC027946 mRNA. Translation: AAH27946.2. U62325 mRNA. Translation: AAC50805.1. Sequence problems. |
| IPI | IPI00470455. IPI00470456. |
| RefSeq | NP_001159522.1. NM_001166050.1. NP_775098.2. NM_173075.4. |
| UniGene | Hs.479602. |
3D structure databases | |
| ProteinModelPortal | Q92870. |
| SMR | Q92870. Positions 291-320, 417-702. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q92870. 2 interactions. |
| MINT | MINT-1493142. |
| STRING | Q92870. |
PTM databases | |
| PhosphoSite | Q92870. |
Polymorphism databases | |
| DMDM | 52788291. |
Proteomic databases | |
| PRIDE | Q92870. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000316212; ENSP00000318965; ENSG00000163697. |
| GeneID | 323. |
| KEGG | hsa:323. |
| UCSC | uc003gvl.1. human. uc003gvm.1. human. |
Organism-specific databases | |
| CTD | 323. |
| GeneCards | GC04M040812. |
| H-InvDB | HIX0020340. |
| HGNC | HGNC:582. APBB2. |
| HPA | HPA023542. |
| MIM | 602710. gene. |
| neXtProt | NX_Q92870. |
| GenAtlas | Search... |
Phylogenomic databases | |
| GeneTree | ENSGT00390000000002. |
| HOGENOM | HBG443527. |
| HOVERGEN | HBG050524. |
| InParanoid | Q92870. |
Gene expression databases | |
| ArrayExpress | Q92870. |
| Bgee | Q92870. |
| CleanEx | HS_APBB2. |
| Genevestigator | Q92870. |
| GermOnline | ENSG00000163697. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011993. PH_type. IPR006020. PTyr_interaction_dom. IPR001202. WW_Rsp5_WWP. [Graphical view] |
| Gene3D | G3DSA:2.20.70.10. G3DSA:2.20.70.10. 1 hit. G3DSA:2.30.29.30. PH_type. 2 hits. |
| KO | K04530. |
| Pfam | PF00640. PID. 2 hits. PF00397. WW. 1 hit. [Graphical view] |
| SMART | SM00462. PTB. 2 hits. SM00456. WW. 1 hit. [Graphical view] |
| SUPFAM | SSF51045. WW_Rsp5_WWP. 1 hit. |
| PROSITE | PS01179. PID. 2 hits. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 1325. |
| SOURCE | Search... |
Entry information
| Entry name | APBB2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q92870 Secondary accession number(s): Q8IUI6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with