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Q92870 (APBB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amyloid beta A4 precursor protein-binding family B member 2
Alternative name(s):
Protein Fe65-like 1
Gene names
Name:APBB2
Synonyms:FE65L, FE65L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length758 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May modulate the internalization of beta-amyloid precursor protein.

Subunit structure

Binds to the intracellular domain of the beta-amyloid precursor protein.

Sequence similarities

Contains 2 PID domains.

Contains 1 WW domain.

Sequence caution

The sequence AAC50805.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Non-traceable author statement Ref.5. Source: UniProtKB

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from sequence or structural similarity. Source: UniProtKB

neuron migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

growth cone

Inferred from sequence or structural similarity. Source: UniProtKB

lamellipodium

Inferred from sequence or structural similarity. Source: UniProtKB

membrane

Non-traceable author statement Ref.5. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

synapse

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionbeta-amyloid binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.5. Source: UniProtKB

transcription factor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

APPP050672EBI-79277,EBI-77613
EGFRP005334EBI-79277,EBI-297353

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92870-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92870-2)

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     577-577: Missing.
Isoform 3 (identifier: Q92870-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-548: Missing.
Isoform 4 (identifier: Q92870-4)

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: T → TA
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 758758Amyloid beta A4 precursor protein-binding family B member 2
PRO_0000076052

Regions

Domain290 – 32233WW
Domain413 – 578166PID 1
Domain584 – 736153PID 2

Amino acid modifications

Modified residue1231Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 548548Missing in isoform 3.
VSP_044232
Alternative sequence2781T → TA in isoform 4.
VSP_045042
Alternative sequence348 – 36821Missing in isoform 2.
VSP_040354
Alternative sequence5771Missing in isoform 2.
VSP_040355
Natural variant1791R → Q. Ref.2 Ref.4
Corresponds to variant rs4861358 [ dbSNP | Ensembl ].
VAR_069029

Experimental info

Sequence conflict4901L → W in AAC50805. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: 453521022CD548D5

FASTA75883,374
        10         20         30         40         50         60 
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN AEIKHTETKN 

        70         80         90        100        110        120 
STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 

       130        140        150        160        170        180 
NLSPTAVINI TSEKLEGKEP HPQDSSSCEI LPSQPRRTKS FLNYYADLET SARELEQNRG 

       190        200        210        220        230        240 
NHHGTAEEKS QPVQGQASTI IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG 

       250        260        270        280        290        300 
AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS 

       310        320        330        340        350        360 
DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP WSDFAVLNGG 

       370        380        390        400        410        420 
KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP HPDDDDSCSI NSDPEAKCFA 

       430        440        450        460        470        480 
VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL SYCKNDIRDT VGIWGEGKDM YLILENDMLS 

       490        500        510        520        530        540 
LVDPMDRSVL HSQPIVSIRV WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS 

       550        560        570        580        590        600 
LHEICSKIMA ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV 

       610        620        630        640        650        660 
DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV ECRVRFLSFM 

       670        680        690        700        710        720 
GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA ACMLRYQKCL VARPPSQKVR 

       730        740        750 
PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ KRPVTEMP 

« Hide

Isoform 2 [UniParc].

Checksum: 6D64F31F4772DB3B
Show »

FASTA73680,889
Isoform 3 [UniParc].

Checksum: 22E24FCE3101AB83
Show »

FASTA21023,488
Isoform 4 [UniParc].

Checksum: 5D32E0D35D43756E
Show »

FASTA75983,445

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[2]"Homo sapiens protein coding cDNA."
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLN-179.
Tissue: Aortic endothelium.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLN-179.
Tissue: Lung.
[5]"Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein."
Guenette S.Y., Chen J., Jondro P.D., Tanzi R.E.
Proc. Natl. Acad. Sci. U.S.A. 93:10832-10837(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-758 (ISOFORM 1).
Tissue: Fetal brain and Kidney.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK299800 mRNA. Translation: BAG61676.1.
AK226179 mRNA. No translation available.
AC093804 Genomic DNA. No translation available.
AC096712 Genomic DNA. No translation available.
AC108937 Genomic DNA. No translation available.
AC131953 Genomic DNA. No translation available.
BC027946 mRNA. Translation: AAH27946.2.
U62325 mRNA. Translation: AAC50805.1. Sequence problems.
CCDSCCDS43224.1. [Q92870-2]
CCDS54760.1. [Q92870-3]
CCDS54761.1. [Q92870-1]
CCDS54762.1. [Q92870-4]
RefSeqNP_001159522.1. NM_001166050.1. [Q92870-1]
NP_001159523.1. NM_001166051.1. [Q92870-3]
NP_001159524.1. NM_001166052.1. [Q92870-3]
NP_001159525.1. NM_001166053.1. [Q92870-3]
NP_001159526.1. NM_001166054.1. [Q92870-3]
NP_775098.2. NM_173075.4. [Q92870-2]
UniGeneHs.479602.

3D structure databases

ProteinModelPortalQ92870.
SMRQ92870. Positions 291-320, 417-551, 580-702.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106820. 4 interactions.
IntActQ92870. 4 interactions.
MINTMINT-1493142.
STRING9606.ENSP00000295974.

PTM databases

PhosphoSiteQ92870.

Polymorphism databases

DMDM317373476.

Proteomic databases

MaxQBQ92870.
PaxDbQ92870.
PRIDEQ92870.

Protocols and materials databases

DNASU323.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295974; ENSP00000295974; ENSG00000163697. [Q92870-1]
ENST00000502841; ENSP00000425802; ENSG00000163697. [Q92870-3]
ENST00000504305; ENSP00000423765; ENSG00000163697. [Q92870-3]
ENST00000508593; ENSP00000427211; ENSG00000163697. [Q92870-4]
ENST00000513140; ENSP00000426018; ENSG00000163697. [Q92870-2]
ENST00000543538; ENSP00000439357; ENSG00000163697. [Q92870-3]
GeneID323.
KEGGhsa:323.
UCSCuc003gvk.3. human. [Q92870-3]
uc003gvl.3. human. [Q92870-1]
uc003gvm.3. human. [Q92870-2]

Organism-specific databases

CTD323.
GeneCardsGC04M040812.
HGNCHGNC:582. APBB2.
HPAHPA023542.
MIM602710. gene.
neXtProtNX_Q92870.
PharmGKBPA24874.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG76544.
HOGENOMHOG000033983.
HOVERGENHBG050524.
InParanoidQ92870.
KOK04530.
OMATKNSTPP.
OrthoDBEOG79W94P.
PhylomeDBQ92870.
TreeFamTF314331.

Enzyme and pathway databases

SignaLinkQ92870.

Gene expression databases

ArrayExpressQ92870.
BgeeQ92870.
CleanExHS_APBB2.
GenevestigatorQ92870.

Family and domain databases

Gene3D2.30.29.30. 2 hits.
InterProIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamPF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF51045. SSF51045. 1 hit.
PROSITEPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPBB2. human.
GeneWikiAPBB2.
GenomeRNAi323.
NextBio1325.
PROQ92870.
SOURCESearch...

Entry information

Entry nameAPBB2_HUMAN
AccessionPrimary (citable) accession number: Q92870
Secondary accession number(s): B4DSL4, E9PG87, Q8IUI6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM