Q92870 (APBB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amyloid beta A4 precursor protein-binding family B member 2

Alternative name(s):
Protein Fe65-like 1

Gene names

Name:	APBB2
Synonyms:	FE65L, FE65L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	758 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May modulate the internalization of beta-amyloid precursor protein.
Subunit structure	Binds to the intracellular domain of the beta-amyloid precursor protein.
Sequence similarities	Contains 2 PID domains. Contains 1 WW domain.
Sequence caution	The sequence AAC50805.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle arrest Inferred from sequence or structural similarity. Source: UniProtKB intracellular signal transduction Non-traceable author statement Ref.5. Source: UniProtKB negative regulation of S phase of mitotic cell cycle Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell growth Inferred from sequence or structural similarity. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	growth cone Inferred from sequence or structural similarity. Source: UniProtKB lamellipodium Inferred from sequence or structural similarity. Source: UniProtKB membrane Non-traceable author statement Ref.5. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB synapse Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	beta-amyloid binding Inferred from sequence or structural similarity. Source: UniProtKB transcription factor binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APP	P05067	2	EBI-79277,EBI-77613

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92870-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92870-2)

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     577-577: Missing.

Isoform 3 (identifier: Q92870-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-548: Missing.

Isoform 4 (identifier: Q92870-4)

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: T → TA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 758	758	Amyloid beta A4 precursor protein-binding family B member 2		PRO_0000076052
Regions
	Domain	290 – 322	33	WW
	Domain	413 – 578	166	PID 1
	Domain	584 – 736	153	PID 2
Amino acid modifications
	Modified residue	123	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 548	548	Missing in isoform 3.		VSP_044232
	Alternative sequence	278	1	T → TA in isoform 4.		VSP_045042
	Alternative sequence	348 – 368	21	Missing in isoform 2.		VSP_040354
	Alternative sequence	577	1	Missing in isoform 2.		VSP_040355
	Natural variant	179	1	R → Q. Ref.2 Ref.4 Corresponds to variant rs4861358 [ dbSNP | Ensembl ].		VAR_069029
Experimental info
	Sequence conflict	490	1	L → W in AAC50805. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: 453521022CD548D5	FASTA	758	83,374
	10 20 30 40 50 60 MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN AEIKHTETKN 70 80 90 100 110 120 STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 130 140 150 160 170 180 NLSPTAVINI TSEKLEGKEP HPQDSSSCEI LPSQPRRTKS FLNYYADLET SARELEQNRG 190 200 210 220 230 240 NHHGTAEEKS QPVQGQASTI IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG 250 260 270 280 290 300 AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS 310 320 330 340 350 360 DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP WSDFAVLNGG 370 380 390 400 410 420 KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP HPDDDDSCSI NSDPEAKCFA 430 440 450 460 470 480 VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL SYCKNDIRDT VGIWGEGKDM YLILENDMLS 490 500 510 520 530 540 LVDPMDRSVL HSQPIVSIRV WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS 550 560 570 580 590 600 LHEICSKIMA ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV 610 620 630 640 650 660 DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV ECRVRFLSFM 670 680 690 700 710 720 GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA ACMLRYQKCL VARPPSQKVR 730 740 750 PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ KRPVTEMP
	Isoform 2 [UniParc]. Checksum: 6D64F31F4772DB3B	FASTA	736	80,889
	10 20 30 40 50 60 MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN AEIKHTETKN 70 80 90 100 110 120 STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 130 140 150 160 170 180 NLSPTAVINI TSEKLEGKEP HPQDSSSCEI LPSQPRRTKS FLNYYADLET SARELEQNRG 190 200 210 220 230 240 NHHGTAEEKS QPVQGQASTI IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG 250 260 270 280 290 300 AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS 310 320 330 340 350 360 DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEDLH AATVNPDPSL 370 380 390 400 410 420 KEFEGATLRY ASLKLRNAPH PDDDDSCSIN SDPEAKCFAV RSLGWVEMAE EDLAPGKSSV 430 440 450 460 470 480 AVNNCIRQLS YCKNDIRDTV GIWGEGKDMY LILENDMLSL VDPMDRSVLH SQPIVSIRVW 490 500 510 520 530 540 GVGRDNGRDF AYVARDKDTR ILKCHVFRCD TPAKAIATSL HEICSKIMAE RKNAKALACS 550 560 570 580 590 600 SLQERANVNL DVPLQDFPTP KTELVQKFHV QYLGMLPVDK PVGMDILNSA IENLMTSSNK 610 620 630 640 650 660 EDWLSVNMNV ADATVTVISE KNEEEVLVEC RVRFLSFMGV GKDVHTFAFI MDTGNQRFEC 670 680 690 700 710 720 HVFWCEPNAG NVSEAVQAAC MLRYQKCLVA RPPSQKVRPP PPPADSVTRR VTTNVKRGVL 730 SLIDTLKQKR PVTEMP
	Isoform 3 [UniParc]. Checksum: 22E24FCE3101AB83	FASTA	210	23,488
	10 20 30 40 50 60 MAERKNAKAL ACSSLQERAN VNLDVPLQVD FPTPKTELVQ KFHVQYLGML PVDKPVGMDI 70 80 90 100 110 120 LNSAIENLMT SSNKEDWLSV NMNVADATVT VISEKNEEEV LVECRVRFLS FMGVGKDVHT 130 140 150 160 170 180 FAFIMDTGNQ RFECHVFWCE PNAGNVSEAV QAACMLRYQK CLVARPPSQK VRPPPPPADS 190 200 210 VTRRVTTNVK RGVLSLIDTL KQKRPVTEMP
	Isoform 4 [UniParc]. Checksum: 5D32E0D35D43756E	FASTA	759	83,445
	10 20 30 40 50 60 MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN AEIKHTETKN 70 80 90 100 110 120 STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 130 140 150 160 170 180 NLSPTAVINI TSEKLEGKEP HPQDSSSCEI LPSQPRRTKS FLNYYADLET SARELEQNRG 190 200 210 220 230 240 NHHGTAEEKS QPVQGQASTI IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG 250 260 270 280 290 300 AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETAD IWSDHSFQTD PDLPPGWKRV 310 320 330 340 350 360 SDIAGTYYWH IPTGTTQWER PVSIPADLQG SRKGSLSSVT PSPTPENEKQ PWSDFAVLNG 370 380 390 400 410 420 GKINSDIWKD LHAATVNPDP SLKEFEGATL RYASLKLRNA PHPDDDDSCS INSDPEAKCF 430 440 450 460 470 480 AVRSLGWVEM AEEDLAPGKS SVAVNNCIRQ LSYCKNDIRD TVGIWGEGKD MYLILENDML 490 500 510 520 530 540 SLVDPMDRSV LHSQPIVSIR VWGVGRDNGR DFAYVARDKD TRILKCHVFR CDTPAKAIAT 550 560 570 580 590 600 SLHEICSKIM AERKNAKALA CSSLQERANV NLDVPLQVDF PTPKTELVQK FHVQYLGMLP 610 620 630 640 650 660 VDKPVGMDIL NSAIENLMTS SNKEDWLSVN MNVADATVTV ISEKNEEEVL VECRVRFLSF 670 680 690 700 710 720 MGVGKDVHTF AFIMDTGNQR FECHVFWCEP NAGNVSEAVQ AACMLRYQKC LVARPPSQKV 730 740 750 RPPPPPADSV TRRVTTNVKR GVLSLIDTLK QKRPVTEMP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[2]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLN-179. Tissue: Aortic endothelium.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLN-179. Tissue: Lung.
[5]	"Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein." Guenette S.Y., Chen J., Jondro P.D., Tanzi R.E. Proc. Natl. Acad. Sci. U.S.A. 93:10832-10837(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-758 (ISOFORM 1). Tissue: Fetal brain and Kidney.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK299800 mRNA. Translation: BAG61676.1. AK226179 mRNA. No translation available. AC093804 Genomic DNA. No translation available. AC096712 Genomic DNA. No translation available. AC108937 Genomic DNA. No translation available. AC131953 Genomic DNA. No translation available. BC027946 mRNA. Translation: AAH27946.2. U62325 mRNA. Translation: AAC50805.1. Sequence problems.
IPI	IPI00470455. IPI00470456. IPI00947448.
RefSeq	NP_001159522.1. NM_001166050.1. NP_001159523.1. NM_001166051.1. NP_001159524.1. NM_001166052.1. NP_001159525.1. NM_001166053.1. NP_001159526.1. NM_001166054.1. NP_775098.2. NM_173075.4.
UniGene	Hs.479602.
3D structure databases
ProteinModelPortal	Q92870.
SMR	Q92870. Positions 291-320, 417-551, 580-702.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92870. 2 interactions.
MINT	MINT-1493142.
STRING	9606.ENSP00000295974.
PTM databases
PhosphoSite	Q92870.
Polymorphism databases
DMDM	52788291.
Proteomic databases
PaxDb	Q92870.
PRIDE	Q92870.
Protocols and materials databases
DNASU	323.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295974; ENSP00000295974; ENSG00000163697. ENST00000502841; ENSP00000425802; ENSG00000163697. ENST00000504305; ENSP00000423765; ENSG00000163697. ENST00000508593; ENSP00000427211; ENSG00000163697. ENST00000513140; ENSP00000426018; ENSG00000163697. ENST00000543538; ENSP00000439357; ENSG00000163697.
GeneID	323.
KEGG	hsa:323.
UCSC	uc003gvl.3. human. uc003gvm.3. human.
Organism-specific databases
CTD	323.
GeneCards	GC04M040812.
HGNC	HGNC:582. APBB2.
HPA	HPA023542.
MIM	602710. gene.
neXtProt	NX_Q92870.
PharmGKB	PA24874.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG76544.
HOGENOM	HOG000033983.
HOVERGEN	HBG050524.
InParanoid	Q92870.
KO	K04530.
OMA	TKNSTPP.
Gene expression databases
ArrayExpress	Q92870.
Bgee	Q92870.
CleanEx	HS_APBB2.
Genevestigator	Q92870.
GermOnline	ENSG00000163697. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 2 hits.
InterPro	IPR011993. PH_like_dom. IPR006020. PTyr_interaction_dom. IPR001202. WW_dom. [Graphical view]
Pfam	PF00640. PID. 2 hits. PF00397. WW. 1 hit. [Graphical view]
SMART	SM00462. PTB. 2 hits. SM00456. WW. 1 hit. [Graphical view]
SUPFAM	SSF51045. WW_Rsp5_WWP. 1 hit.
PROSITE	PS01179. PID. 2 hits. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	APBB2. human.
GenomeRNAi	323.
NextBio	1325.
SOURCE	Search...

Entry information

Entry name

APBB2_HUMAN

Accession

Primary (citable) accession number: Q92870
Secondary accession number(s): B4DSL4, E9PG87, Q8IUI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 112 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.