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Protein

Amyloid beta A4 precursor protein-binding family B member 2

Gene

APBB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate the internalization of beta-amyloid precursor protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163697-MONOMER.
SignaLinkiQ92870.

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 2
Alternative name(s):
Protein Fe65-like 1
Gene namesi
Name:APBB2
Synonyms:FE65L, FE65L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:582. APBB2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • growth cone Source: UniProtKB
  • lamellipodium Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
  • synapse Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi323.
MalaCardsiAPBB2.
OpenTargetsiENSG00000163697.
PharmGKBiPA24874.

Polymorphism and mutation databases

BioMutaiAPBB2.
DMDMi317373476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760521 – 758Amyloid beta A4 precursor protein-binding family B member 2Add BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92870.
MaxQBiQ92870.
PaxDbiQ92870.
PeptideAtlasiQ92870.
PRIDEiQ92870.

PTM databases

iPTMnetiQ92870.
PhosphoSitePlusiQ92870.

Expressioni

Gene expression databases

BgeeiENSG00000163697.
CleanExiHS_APBB2.
ExpressionAtlasiQ92870. baseline and differential.
GenevisibleiQ92870. HS.

Organism-specific databases

HPAiHPA023542.

Interactioni

Subunit structurei

Binds to the intracellular domain of the beta-amyloid precursor protein.

Binary interactionsi

WithEntry#Exp.IntActNotes
APPP050672EBI-79277,EBI-77613
EGFRP005336EBI-79277,EBI-297353

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106820. 31 interactors.
IntActiQ92870. 4 interactors.
MINTiMINT-1493142.
STRINGi9606.ENSP00000427211.

Structurei

3D structure databases

ProteinModelPortaliQ92870.
SMRiQ92870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 322WWPROSITE-ProRule annotationAdd BLAST33
Domaini413 – 578PID 1PROSITE-ProRule annotationAdd BLAST166
Domaini584 – 736PID 2PROSITE-ProRule annotationAdd BLAST153

Sequence similaritiesi

Contains 2 PID domains.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ92870.
KOiK04530.
OMAiTKNSTPP.
OrthoDBiEOG091G04HV.
PhylomeDBiQ92870.
TreeFamiTF314331.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92870-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN
60 70 80 90 100
AEIKHTETKN STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV
110 120 130 140 150
KNGENQLRKA AEQGQQDPNK NLSPTAVINI TSEKLEGKEP HPQDSSSCEI
160 170 180 190 200
LPSQPRRTKS FLNYYADLET SARELEQNRG NHHGTAEEKS QPVQGQASTI
210 220 230 240 250
IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI
260 270 280 290 300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS
310 320 330 340 350
DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP
360 370 380 390 400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP
410 420 430 440 450
HPDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL
460 470 480 490 500
SYCKNDIRDT VGIWGEGKDM YLILENDMLS LVDPMDRSVL HSQPIVSIRV
510 520 530 540 550
WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS LHEICSKIMA
560 570 580 590 600
ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV
610 620 630 640 650
DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV
660 670 680 690 700
ECRVRFLSFM GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA
710 720 730 740 750
ACMLRYQKCL VARPPSQKVR PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ

KRPVTEMP
Length:758
Mass (Da):83,374
Last modified:January 11, 2011 - v3
Checksum:i453521022CD548D5
GO
Isoform 2 (identifier: Q92870-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     577-577: Missing.

Show »
Length:736
Mass (Da):80,889
Checksum:i6D64F31F4772DB3B
GO
Isoform 3 (identifier: Q92870-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-548: Missing.

Show »
Length:210
Mass (Da):23,488
Checksum:i22E24FCE3101AB83
GO
Isoform 4 (identifier: Q92870-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: T → TA

Note: No experimental confirmation available.
Show »
Length:759
Mass (Da):83,445
Checksum:i5D32E0D35D43756E
GO

Sequence cautioni

The sequence AAC50805 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti490L → W in AAC50805 (PubMed:8855266).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069029179R → Q.2 PublicationsCorresponds to variant rs4861358dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442321 – 548Missing in isoform 3. 1 PublicationAdd BLAST548
Alternative sequenceiVSP_045042278T → TA in isoform 4. 1 Publication1
Alternative sequenceiVSP_040354348 – 368Missing in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_040355577Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299800 mRNA. Translation: BAG61676.1.
AK226179 mRNA. No translation available.
AC093804 Genomic DNA. No translation available.
AC096712 Genomic DNA. No translation available.
AC108937 Genomic DNA. No translation available.
AC131953 Genomic DNA. No translation available.
BC027946 mRNA. Translation: AAH27946.2.
U62325 mRNA. Translation: AAC50805.1. Sequence problems.
CCDSiCCDS43224.1. [Q92870-2]
CCDS54760.1. [Q92870-3]
CCDS54761.1. [Q92870-1]
CCDS54762.1. [Q92870-4]
RefSeqiNP_001159522.1. NM_001166050.1. [Q92870-1]
NP_001159523.1. NM_001166051.1. [Q92870-3]
NP_001159524.1. NM_001166052.1. [Q92870-3]
NP_001159525.1. NM_001166053.1. [Q92870-3]
NP_001159526.1. NM_001166054.1. [Q92870-3]
NP_001317585.1. NM_001330656.1.
NP_001317587.1. NM_001330658.1.
NP_775098.2. NM_173075.4. [Q92870-2]
XP_016863634.1. XM_017008145.1. [Q92870-4]
UniGeneiHs.479602.

Genome annotation databases

EnsembliENST00000295974; ENSP00000295974; ENSG00000163697. [Q92870-1]
ENST00000502841; ENSP00000425802; ENSG00000163697. [Q92870-3]
ENST00000504305; ENSP00000423765; ENSG00000163697. [Q92870-3]
ENST00000508593; ENSP00000427211; ENSG00000163697. [Q92870-4]
ENST00000513140; ENSP00000426018; ENSG00000163697. [Q92870-2]
ENST00000543538; ENSP00000439357; ENSG00000163697. [Q92870-3]
GeneIDi323.
KEGGihsa:323.
UCSCiuc003gvk.4. human. [Q92870-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299800 mRNA. Translation: BAG61676.1.
AK226179 mRNA. No translation available.
AC093804 Genomic DNA. No translation available.
AC096712 Genomic DNA. No translation available.
AC108937 Genomic DNA. No translation available.
AC131953 Genomic DNA. No translation available.
BC027946 mRNA. Translation: AAH27946.2.
U62325 mRNA. Translation: AAC50805.1. Sequence problems.
CCDSiCCDS43224.1. [Q92870-2]
CCDS54760.1. [Q92870-3]
CCDS54761.1. [Q92870-1]
CCDS54762.1. [Q92870-4]
RefSeqiNP_001159522.1. NM_001166050.1. [Q92870-1]
NP_001159523.1. NM_001166051.1. [Q92870-3]
NP_001159524.1. NM_001166052.1. [Q92870-3]
NP_001159525.1. NM_001166053.1. [Q92870-3]
NP_001159526.1. NM_001166054.1. [Q92870-3]
NP_001317585.1. NM_001330656.1.
NP_001317587.1. NM_001330658.1.
NP_775098.2. NM_173075.4. [Q92870-2]
XP_016863634.1. XM_017008145.1. [Q92870-4]
UniGeneiHs.479602.

3D structure databases

ProteinModelPortaliQ92870.
SMRiQ92870.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106820. 31 interactors.
IntActiQ92870. 4 interactors.
MINTiMINT-1493142.
STRINGi9606.ENSP00000427211.

PTM databases

iPTMnetiQ92870.
PhosphoSitePlusiQ92870.

Polymorphism and mutation databases

BioMutaiAPBB2.
DMDMi317373476.

Proteomic databases

EPDiQ92870.
MaxQBiQ92870.
PaxDbiQ92870.
PeptideAtlasiQ92870.
PRIDEiQ92870.

Protocols and materials databases

DNASUi323.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295974; ENSP00000295974; ENSG00000163697. [Q92870-1]
ENST00000502841; ENSP00000425802; ENSG00000163697. [Q92870-3]
ENST00000504305; ENSP00000423765; ENSG00000163697. [Q92870-3]
ENST00000508593; ENSP00000427211; ENSG00000163697. [Q92870-4]
ENST00000513140; ENSP00000426018; ENSG00000163697. [Q92870-2]
ENST00000543538; ENSP00000439357; ENSG00000163697. [Q92870-3]
GeneIDi323.
KEGGihsa:323.
UCSCiuc003gvk.4. human. [Q92870-1]

Organism-specific databases

CTDi323.
DisGeNETi323.
GeneCardsiAPBB2.
HGNCiHGNC:582. APBB2.
HPAiHPA023542.
MalaCardsiAPBB2.
MIMi602710. gene.
neXtProtiNX_Q92870.
OpenTargetsiENSG00000163697.
PharmGKBiPA24874.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ92870.
KOiK04530.
OMAiTKNSTPP.
OrthoDBiEOG091G04HV.
PhylomeDBiQ92870.
TreeFamiTF314331.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163697-MONOMER.
SignaLinkiQ92870.

Miscellaneous databases

ChiTaRSiAPBB2. human.
GeneWikiiAPBB2.
GenomeRNAii323.
PROiQ92870.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163697.
CleanExiHS_APBB2.
ExpressionAtlasiQ92870. baseline and differential.
GenevisibleiQ92870. HS.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPBB2_HUMAN
AccessioniPrimary (citable) accession number: Q92870
Secondary accession number(s): B4DSL4, E9PG87, Q8IUI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.